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INDONESIA
Jurnal Farmasi Indonesia
Published by Ikatan Apoteker Indonesia
ISSN : 14121107     EISSN : 2355696X     DOI : https://doi.org/10.35617/jfionline
Core Subject : Health,
Medicine & Pharmacology
Jurnal Farmasi Indonesia adalah jurnal nasional (peer-reviewed) yang diterbitkan oleh Ikatan Apoteker Indonesia dua kali dalam setahun sebagai sarana diseminasi ilmu pengetahuan di bidang farmasi, yaitu: farmasi klinis, farmasi masyarakat/komunitas, kimia farmasi, biologi farmasi/famakognosi, farmakologi, pengembangan obat/kimia medisinal, formulasi dan bidang terkait. Artikel yang dipublikasi berupa hasil penelitian dan mini-review. JFIOnline telah mulai diterbitkan sejak tahun 2009 dalam edisi cetak. Pada tahun 2014 mulai dibuat edisi online. Akses artikel pada jurnal tidak berbayar, tetapi dikenakan biaya proses publikasi untuk penulis (open access journal). Mulai bulan Juli 2019 jurnal ini dapat diakses di alamat yang baru yaitu www.jfi-online.org dari alamat sebelumnya www.jfionline.org.
Arjuna Subject : Profesi Kesehatan - Farmasi
Articles 177 Documents
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17-2 Analisis Perbandingan Biaya Riil dan Tarif Ina-Cbg’s pada Pasien Rawat Jalan Onkologi dengan Terapi Morfin Sulfat (Mst) di RSUD Arifin Achmad Provinsi Riau Meirita, Efilia; Endri, Novtafia; Hari, Dewi Gulyla; Lifiani, Rialita
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 17 No 2 (2025): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v17i2.873

Abstract

Health service financing through the INA-CBG's (Indonesia Case-Based Groups) system aims for efficiency and transparency in the National Health Insurance (JKN) system. However, in practice, there are often discrepancies between INA-CBG's rates and the real costs incurred by health facilities, especially in oncology patients with Morphine Sulfate (MST) therapy. This study aims to analyze the comparison of real costs and INA-CBG's tariffs for oncology outpatients with morphine sulfate therapy (MST) at RSUD Arifin Achmad Riau Province. This study used descriptive observational research method with retrospective data collection obtained from medical records of oncology outpatients who received Morphine Sulfate (MST) therapy 10 mg and 15 mg tablets during the period January-March 2024. The data were analyzed by comparing the real costs incurred by the hospital with the rates paid by BPJS through the INA-CBG's system and the Mann-Whitney U test was performed. The results of the analysis showed that there was a significant difference between real costs and INA-CBG's tariffs. The average real cost of drugs (MST) was higher than the INA-CBG's tariff. The real cost of drugs that exceeded the INA-CBG's tariff amounted to 481 people, with a total cost difference (loss) of IDR 218,155,324. There was a difference between real costs and INA-CBG's rates (p = .047) and INA-CBG's rates (p = .113).
Kepuasan Pasien pada Telefarmasi vs Farmasi Konvensional: Analisis SERVQUAL Noviani, Lusy; Notario, Dion; Aurina, Wanda
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 18 No 1 (2026): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v18i1.572

Abstract

Telepharmacy offers a promising solution to overcome the geographical limitations of traditional pharmacies. However, concerns regarding the quality of services delivered through telepharmacy highlight the need for a comprehensive evaluation of patient satisfaction. This study aimed to compare patient satisfaction between telepharmacy and conventional pharmacy services and to identify areas for improvement. A cross-sectional study was conducted in March and April 2024, involving a sample of 136 customers from the Atma Jaya Teaching Pharmacy in North Jakarta. Patient satisfaction was measured using a validated questionnaire, and key satisfaction dimensions were identified through Importance-Performance Analysis (IPA). The analysis revealed that both telepharmacy and conventional pharmacy services demonstrated strengths in the dimensions of Assurance and Responsiveness, which are critical to customer satisfaction (quadrant II : keep up the good work). Meanwhile, Reliability and Empathy were perceived as less important in both service models (quadrant III : low priority). The Tangible dimension, however, was identified as an area requiring improvement (quadrant I : concentrate here). These findings suggest that telepharmacy can provide patient satisfaction comparable to conventional pharmacies, particularly in the dimensions of Assurance and Responsiveness. However, the Tangible dimension remains a key area for improvement.
Efektivitas Intervensi Pendidikan dan Penggunaan Obat Herbal dalam Mencegah Stunting: Sebuah Studi di Kalangan Kader Kesejahteraan Keluarga di Desa Ababi, Bali Sua, Viviana Bali; Widowati, I Gusti Ayu Rai; Putra, I.G.N Windra Wartana; Ardinata, I Putu Riska; Sutema, Ida Ayu Manik Partha
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 18 No 1 (2026): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v18i1.279

Abstract

Stunting remains a public health priority in Indonesia, including in Ababi Village, Karangasem, which has one of the highest stunting prevalence rates in Bali. This study aimed to evaluate the effectiveness of an educational intervention in improving knowledge among family welfare empowerment cadres regarding stunting and the use of herbal medicine for its prevention. A pre-experimental one-group pretest-posttest design was conducted in Ababi Village. The sample consisted of 40 purposively selected cadres who met the inclusion criteria of being active in community health promotion. The research instrument was a validated questionnaire developed based on the World Health Organization’s framework and previous literature, which included items on stunting and the use of herbal medicine for its prevention. The intervention included educational sessions and leaflet distribution. Data were analyzed using the Wilcoxon Signed Rank Test and chi-square test. Results showed that most respondents were aged 23–35 years (37.5%), were housewives (80%), had a primary education level (35%), and belonged to families with four to five members (50%). At baseline, 82.5% of participants had good knowledge of stunting, while only 60% demonstrated good knowledge of herbal medicine use. After the intervention, all respondents (100%) showed good knowledge in both areas, with a statistically significant improvement (p<0.001). Bivariate analysis indicated that occupation was significantly associated with knowledge of stunting (p=0.004), and education level was associated with knowledge of herbal medicine use (p=0.043). In conclusion, the educational intervention effectively improved the cadres’ knowledge about stunting and the use of herbal medicine for its prevention. This study supports the role of pharmacists and health educators in community-based stunting prevention efforts.
Profil Sitotoksik ekstrak Lithocarpus bancanus dan Fraksinya Terhadap Lini Sel Kanker Paru-Paru A549 Teruna, Hilwan Yuda; Hendra, Rudi; Lestari, Retno Puji; Nugroho, Titania Tjandrawati; Saryono, Saryono; Jasril, Jasril; Almurdani, Muhammad; Abdulah, Rizky
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 18 No 1 (2026): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v18i1.128

Abstract

Lithocarpus bancanus is a medicinal plant used by communities in Riau Province, Indonesia. This plant is a tree locally known in the province as mempening. In this study, the cytotoxic activity profiles of the methanolic extract, n-hexane fraction, dichloromethane fraction, and ethyl acetate fraction from L. bancanus leaves were evaluated against human lung cancer cells (A549 cell line) using the MTT assay. IC₅₀ values were calculated from dose–response curves analyzed using the 4-parameter logistic (4PL) model. The results showed IC₅₀ values of 455.1, 361.9, 132.9, and 304.7 µg/mL for the methanolic extract, n-hexane fraction, dichloromethane fraction, and ethyl acetate fraction, respectively, with the dichloromethane fraction exhibiting relatively higher cytotoxic activity (IC₅₀ = 132.9 µg/mL). Cisplatin was used as the positive control and showed an IC₅₀ of 103.9 µg/mL. Meanwhile, the methanolic extract as well as the n-hexane and ethyl acetate fractions showed low cytotoxic activity, with IC₅₀ values greater than 300 µg/mL. Therefore, the dichloromethane fraction can serve as a basis for further isolation to identify bioactive anticancer compounds.
Potensi Interaksi Obat Antihiperlipidemia Pada Pasien Stroke Iskemik Rawat Inap Di RS X Kabupaten Indragiri Hilir Tahun 2022 Nursyifa; Hadriyati, Armini; Yuliandani
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 17 No 2 (2025): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v17i2.196

Abstract

Abstract: Ischemic stroke is caused by a blockage or blood clot that occurs in the brain. Stroke has various risk factors and complications that cause patients to receive many medications (polypharmacy). Polypharmacy can increase the potential for drug interactions that can harm patients. One of the treatment options for ischemic stroke is antihyperlipidemic therapy. Antihyperlipidemia statin group is the first choice of treatment of hyperlipidemia. The purpose of this study was to determine the types of antihyperlipidemic drugs, types of comorbidities, types of mechanisms and severity in stroke patients receiving antihyperlipidemic therapy at X Hospital, Indragiri Hilir Regency in 2022. Data were collected retrospectively in the form of 57 medical records of ischemic stroke patients with therapy inpatient antihyperlipidemia. Data analysis was carried out descriptively. Based on the results of the study it was concluded that the potential for drug interactions occurred in 87 (26.69%) cases that experienced interactions and 239 cases (73.31%) did not experience drug interactions. Based on the type of interaction, there were 84 pharmacokinetic interactions (96.55%) and pharmacodynamic mechanisms in 3 cases (3.45%). Based on the strength of the interaction, major interactions were found in 15 (17.24%) cases, moderate severity in 71 (81.61%) cases, and minor severity in 1 (1.15%) cases. Based on the interacting drugs, there were 3 most, namely atorvastatin with amlodipine 27 cases (31,03%), atorvastatin with clopidogrel 16 cases (18,40%), and simvastatin with amlodipine 15 cases (17,24%). For the statistical analysis of the chi square test, there was a significant relationship between severity and the number of drugs p=0.004, severity and age p=0.003, and there was no significant relationship between severity and comorbidities p=0.236. Keywords: Antihyperlipidemia, Drug Interactions, Ischemic Stroke
Pengaruh Pelayanan Informasi Obat (PIO) terhadap Penurunan Intensitas Nyeri pada Pasien Swamedikasi di Banyumas Thorir, Thariq Ahmad; Kurnialandi, Alfarid; Utaminingrum, Wahyu; Setiawan, Didik
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 18 No 1 (2026): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v18i1.278

Abstract

Pain is health problem that affect human quality of life and often treated through self-medication, which possess risk in medication error. Drug information services take a role to avoid the medication errors, yet the implementation is far from optimal. Therefore, a study was conducted to overview the effectiveness of drug information services to reduce the pain intensity in Banyumas. The study used quasi experimental research with pretest-posttest design. The population was self-medication patients with pain symptom in 10 pharmacies in Banyumas. The sample consist of 200 respondents, including the intervention and control groups. The data was analyzed through univariate and bivariate (Mann-Whitney test). After self-medication was given, the average pain score in intervention group (given PIO) was 4.6 and the control group (did not given PIO) was 3.59 with p-value of 0.00 (α ≤ 0.05) indicating significant difference between two groups. This finding highlights the importance of drug information services by pharmacist to reduce the pain intensity and increase the treatment effectiveness among the self-medicated patients.
Molecular Docking Senyawa Bioaktif Tempuyung (Sonchus arvensis) Terhadap Reseptor ER-α Sebagai Inhibitor Kanker Payudara Asaumi, Suci; Azra, Fajriah; Kusnanda, Arif Juliari
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 18 No 1 (2026): Jurnal Farmasi Indonesia
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v18i1.414

Abstract

Breast cancer is a disease characterized by uncontrolled cell growth and division in breast tissue, leading to lump formation. The enzyme ER-α (Estrogen Receptor Alpha) plays a significant role in breast cancer development. This study aims to investigate the potential of bioactive compounds from the tempuyung plant (Sonchus arvensis) to inhibit the ER-α enzyme (PDB ID: 3ERT) through in silico methods for breast cancer drug development. The bioactive compounds in tempuyung are potential ER-α inhibitors. Methods used include Lipinski’s rule prediction, pharmacokinetics and toxicity analysis, and molecular docking simulations using MOE software. Among 25 screened bioactive compounds, luteolin showed binding to the active site of ER-α with a binding affinity of -6.34 kcal/mol and an RMSD of 0.77 Å, interacting with amino acids Glu 353, Gly 521, and Leu 346. These findings suggest luteolin as a promising candidate for breast cancer treatment.
Pengetahuan Ibu dan Pengobatan Mandiri untuk Batuk Balita: Studi Cross-Sectional di Apotek di Wilayah Tangerang (2024) Sianipar, Erlia Anggrainy; Himawan, Lidya; Arrang, Sherly Tandi
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 18 No 1 (2026): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v18i1.490

Abstract

Cough is a common symptom among toddlers, triggered by factors such as air pollution, weather changes, and allergies. In Tangerang, the prevalence of coughs in toddlers is notably high, leading many mothers to self-medicate their children. This study aims to assess the relationship between the mothers' knowledge and their self-medication behavior for treating toddler coughs at a pharmacy in Tangerang. This analytical observational study used a cross-sectional study involving 80 respondents. The data were collected through questionnaires, and univariate analysis was conducted to determine the frequency distribution of respondents by age, education, occupation, and sources of information regarding self-medication. Bivariate analysis using the Chi-Square method was employed to examine the relationships between these variables. The study found that most respondents were aged 18-44 years, with 38% having completed high school, 81.25% working as housewives, and 42.5% receiving information about self-medication from healthcare professionals. Despite 62.5% of the respondents having low knowledge about cough self-medication, 60% of them exhibited positive self-medication practices for treating coughs in toddlers. The analysis revealed no significant relationship between the mothers' knowledge levels and their self-medication behavior. In conclusion, the majority of mothers at Apotek Bintang Tangerang possess limited knowledge about self-medicating toddler coughs, yet they demonstrate positive self-medication behavior. Additionally, there is no significant correlation between their knowledge level and their behavior.
Karakterisasi Farmakognostik dan Skrining Fitokimia Daun Tabebuia rosea sebagai Bahan Baku Obat Herbal Prismawan, Deka; Michael, Michael; Natalia, Felicia
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 18 No 1 (2026): Jurnal Farmasi Indonesia
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v18i1.509

Abstract

Tabebuia rosea is a tropical plant with potential as a raw material for traditional medicine. Parts of this plant like leaves, bark, and flower, indicates potential biological activity like antiinflammation, antibacterial, antioxidant, antidiabetic, and antiproliferative. but its pharmacognostic and phytochemical characterization remains limited, especially in the leaves. This study aims to evaluate the pharmacognostic characteristics and phytochemical content of T. rosea leaves as a basis for standardization. Fresh T. rosea leaves were collected, dried, and ground into a fine powder. Evaluations included organoleptic and macroscopic analysis, microscopic examination, moisture content, total ash content, and phytochemical screening for secondary metabolites such as alkaloids, flavonoids, tannins, saponins, coumarins, triterpenoids, and phenolics. The leaves exhibited a lanceolate shape with smooth margins, pointed tips, and pinnate venation. Microscopic analysis revealed diagnostic features such as trichomes, calcium oxalate crystals, and parenchyma. The moisture content was 7.8%, and total ash content was 11.91%. Phytochemical screening confirmed the presence of flavonoids, tannins, phenolics, and alkaloids, while saponins and coumarins were not detected. This study provides fundamental data for the identification and standardization of T. rosea leaf simplisia. The presence of bioactive compounds, particularly flavonoids and alkaloids, supports its potential as a phytopharmaceutical raw material. Further research is needed to isolate and evaluate the pharmacological activities of these compounds.
Efektivitas Biaya Konseling Apoteker Pada Pasien Program Pengelolaan Penyakit Kronis Diabetes Melitus Tipe 2 Fajriansyah, Fajriansyah; Lestari, Keri; Puspitasari, Irma Melyani; Iskandarsyah, Aulia
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 18 No 1 (2026): Jurnal Farmasi Indonesia
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v18i1.800

Abstract

Type 2 Diabetes Mellitus (T2DM) imposes a substantial economic burden on healthcare systems. Evidence indicates that pharmacist involvement in medication management can improve glycemic control, adherence, quality of life, and reduce drug-related problems. However, the cost-effectiveness of pharmacist participation within the Prolanis program remains unclear. This study aimed to evaluate the cost-effectiveness of pharmacist counseling in managing T2DM under the Prolanis scheme compared with standard care. A cluster randomized clinical trial was conducted from 2017 to 2018 across four primary health centers in Makassar City. Eligible patients were allocated to an intervention group receiving structured pharmacist counseling or a control group receiving standard Prolanis services. Economic evaluation was performed from the payer and healthcare provider perspectives. A total of 220 patients met the inclusion criteria (109 intervention, 111 control). In the control group, the Average Cost-Effectiveness Ratio (ACER) based on direct medical costs was IDR –1.852.391,24 per 1% HbA1c reduction and IDR –9.725.054 per 1-point MMAS-8 improvement. Under capitation costs, ACERs were IDR –14.285,71 and IDR –75,000. In the intervention group, ACERs for direct medical costs were IDR 1.632.355,45 per 1% HbA1c reduction and IDR 1.300.783,25 per MMAS-8 point increase; for capitation costs, ACERs were IDR 11.764,71 and IDR 9.375. Cost-effectiveness mapping showed the intervention group in Quadrant II, indicating improved effectiveness with acceptable incremental costs. These findings support the economic value of integrating pharmacist counseling into Prolanis T2DM management.

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