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INDONESIA
Jurnal Farmasi Indonesia
Published by Ikatan Apoteker Indonesia
ISSN : 14121107     EISSN : 2355696X     DOI : https://doi.org/10.35617/jfionline
Core Subject : Health,
Medicine & Pharmacology
Jurnal Farmasi Indonesia adalah jurnal nasional (peer-reviewed) yang diterbitkan oleh Ikatan Apoteker Indonesia dua kali dalam setahun sebagai sarana diseminasi ilmu pengetahuan di bidang farmasi, yaitu: farmasi klinis, farmasi masyarakat/komunitas, kimia farmasi, biologi farmasi/famakognosi, farmakologi, pengembangan obat/kimia medisinal, formulasi dan bidang terkait. Artikel yang dipublikasi berupa hasil penelitian dan mini-review. JFIOnline telah mulai diterbitkan sejak tahun 2009 dalam edisi cetak. Pada tahun 2014 mulai dibuat edisi online. Akses artikel pada jurnal tidak berbayar, tetapi dikenakan biaya proses publikasi untuk penulis (open access journal). Mulai bulan Juli 2019 jurnal ini dapat diakses di alamat yang baru yaitu www.jfi-online.org dari alamat sebelumnya www.jfionline.org.
Arjuna Subject : Profesi Kesehatan - Farmasi
Articles 162 Documents
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Pengetahuan Apoteker terkait Covid-19 selama Pandemi Fatiha, Chilmia Nurul; Rahmadani, Azmi; Widyaningrum, Naniek
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 17 No. 2 (2025): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v17i2.228

Abstract

Pharmacists’ role during Covid-19 pandemic is important in order to prevent and reduce the transmission rate. Pharmacist need to have good level of knowledge to ensure the role. This study aims to determine the level of pharmacists’ knowledge regarding Covid-19 and related factors. This is an observational study with cross-sectional approach. A questionnaire regarding Covid-19 was distributed to webinar participants in December 2021. The questionnaire is consisted of demographic questions and 15 Covid-19 knowledge questions. A total of 333 pharmacists responded, consisting of 32.4% community pharmacists, 33.9% hospital pharmacists, 24.0% clinical pharmacists, and 9.6% public health center pharmacists. Pharmacists have good knowledge of the causative virus (92%), symptoms (95.3%), supporting examinations (90.2%), therapy (95.8%), and prevention of Covid-19 transmission (94.4%) . Pharmacists' knowledge that needs to be improved is regarding vaccine storage (69.4%) and antibiotic use (56.1%). Semarang City pharmacists have good knowledge about Covid-19. Pharmacist knowledge was related to workplace (p<0.001) and length of work (p<0.001).
Optimasi Perolehan dan Karakterisasi Serbuk Mucilago Hibiscus rosa-sinensis L. (MHR) sebagai Binder Tablet Prabowo, Imam; Putra, Iqbal Julian Rianda Pradana; Rifkia, Via
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 17 No. 1 (2025): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v17i1.162

Abstract

This study aims to optimize the yield of MHR powder because the research conducted by Shah and Patel in 2010 was still very small, namely around 8%. Optimization was carried out by varying the soaking and heating times and then characterizing the MHR powder to test whether the MHR powder was a good candidate as a tablet binder. Characterization tests performed were organoleptic tests, particle size distribution, polysaccharide identification, swelling ratio, solubility, flow properties, viscosity, and water content. The most optimal MHR powder recovery was 1 hour of soaking time and 6 hours of heating time with a yield of 11.50 ± 1.40%. The results of the characterization of the MHR powder included: organoleptic test of the MHR powder was light brown, had a distinctive herbal odor and was tasteless, the particle size distribution test was in the range of 100-400 microns with the highest percentage of particles in the size of 186 μm, the swelling ratio was at 23 .47 ± 0.41, positive polysaccharide identification test, solubility was at 0.000426 ± 0.000034, viscosity was at 4520 ± 1224.42. Broadly speaking, MHR powder is a potential candidate as a tablet binder, that was proved from tablet formulation using MHR powder as binder resulted hardness, friability and disintegration time as well as formulation that using Avicel PH102 as binder.
Pengaruh Edukasi melalui Leaflet terhadap Kepatuhan Pasien Hipertensi di Puskesmas Leuwiliang Nhestricia, Nhadira; Indriani, Lusi; Sulistio, Eko Nugraha
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 17 No. 2 (2025): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v17i2.89

Abstract

Leaflet merupakan salah satu media yang dapat digunakan dalam edukasi untuk meningkatkan pemahaman dan kepatuhan pasien dalam minum obat terutama bagi pasien yang memiliki regimen terapi yang kompleks, seperti hipertensi. Penelitian yang dilakukan di Puskesmas Leuwiliang bertujuan untuk menganalisis pengaruh pemberian edukasi melalui media leaflet terhadap peningkatan kepatuhan minum obat pasien hipertensi. Penelitian ini menggunakan metode quasi-eksperimental dengan rancangan Pretest-Posttest Design. Sejumlah 47 responden yang memenuhi kriteria bersedia mengikuti penelitian, berusia lebih dari 18 tahun, dan yang menjalani kontrol perawatan rutin hipertensi selama 3 bulan terakhir diwawancara untuk diukur kepatuhannya dalam minum obat, kemudian diberikan edukasi melalui leaflet. Setelah 1 bulan kepatuhan responden dalam minum obat kembali diukur. Data yang diperoleh dianalisis menggunakan uji wilcoxon dan menunjukkan bahwa pemberian edukasi melalui leaflet memberikan pengaruh sangat nyata terhadap peningkatan kepatuhan minum obat (p<0,020). Terdapat hubungan yang signifikan antara tingkat kepatuhan dengan tekanan darah sesudah diberikan intervensi pemberian informasi menggunakan media leaflet (p<0,003). Terdapat hubungan yang signifikan antara tingkat kepatuhan dengan kontrol tekanan darah (p=0,000). Penelitian ini menunjukkan bahwa edukasi melalui media leaflet berpengaruh sangat nyata dalam meningkatkan kepatuhan minum obat pasien hipertensi di Puskesmas Leuwiliang.
A Validated RP-HPLC-PDA with Buffer-Free Gradient Elution for Simultaneous Plasma Analysis of Trimethoprim and Sulfamethoxazole Edmund, Nicholas; Gunawan, Untung; Notario, Dion
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 17 No. 2 (2025): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v17i2.498

Abstract

A simple, cost-effective, and validated reversed-phase high-performance liquid chromatography (RP-HPLC) method is crucial for accurately monitoring trimethoprim and sulfamethoxazole therapy. However, conventional HPLC methods often rely on buffered mobile phases and additives, which can lead to column blockage and shorten column lifespan. To address this issue, we developed and validated a reversed-phase HPLC method with a photodiode array (PDA) detector, using a buffer-free and additive-free mobile phase with gradient elution. Sample preparation was performed using organic solvent-based deproteinization to minimize matrix effects. Chromatographic separation was performed on a ZORBAX Eclipse Plus C18 column (250 × 4.6 mm, 5 µm) using a mobile phase of acetic acid (pH 2.3), methanol, and acetonitrile at a flow rate of 1 mL/min. Detection was carried out at 270 nm with a total run time of 17 minutes. The analytical method exhibited linearity, precision, and accuracy, with adequate sensitivity for the analytes of interest. Stability testing yielded favorable results under various storage conditions, including the autosampler, freeze-thaw cycles, and long-term storage. However, the trimethoprim stock solution was only stable for two days and must be freshly prepared. Full validation was conducted in accordance with FDA and ICH bioanalytical guidelines, confirming its suitability for clinical application.
Hubungan Kepatuhan Obat Terhadap Indeks Glikemik Pada Pasien Usia Lanjut: Hubungan Kepatuhan Obat Terhadap Indeks Glikemik Pada Pasien Usia Lanjut Sabiti, Farrah Bintang; Sa’dyah, Nur Anna Chalimah; Pranata, Meki; Tsalitsa, Mutiarani Nur
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 17 No. 2 (2025): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v17i2.236

Abstract

Abstract: Diabetes mellitus is a chronic disease that can affect someone who is entering old age. Diabetes mellitus is characterized by excess fasting blood sugar values (≥126mg/dl) and HbA1C values ≥7%. A total of 147,734 cases of diabetes mellitus were found in Semarang city health centers. Medication adherence may be one of the factors in such high cases. With high medication adherence in elderly patients, it is expected that appropriate clinical outcomes will be achieved. The purpose of this study was to determine the relationship between sociodemographics and compliance with the use of diabetes mellitus drugs in elderly patients. This study is an analytical observational study conducted with a cross section study approach. This study was conducted at Halmahera Health Center and Gayamsari Health Center. This study used the chi square test which obtained a p value <0.05 which concluded that there was a relationship between sociodemographics and compliance with the use of diabetes mellitus drugs in elderly patients. This study can be concluded that there is a relationship between sociodemographics and compliance with the use of diabetes mellitus drugs in elderly patients
A Pemantauan Kadar Obat Dalam Darah Bedaquilin dan Linezolid Pada Pasien Tuberculosis Resistensi Obat : Literatur Review Yeni, Ai Yeni Herlinawati; Andrajati, Retnosari; Purnasari, Santi
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 17 No. 2 (2025): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v17i2.320

Abstract

Tuberculosis remains a leading cause of global mortality and morbidity. Current TB elimination programs have not yet met their targets. Drug resistance poses a significant challenge, necessitating effective alternative treatments for drug-resistant TB patients. Bedaquiline and Linezolid are primary drugs (Category A) used to combat drug-resistant TB. However, they come with side effects and toxicity, have narrow therapeutic window, and exhibit pharmacokinetic variability. Therefore, therapeutic drug monitoring (TDM) is recommended to achieve desired treatment outcomes and prevent or minimize potential side effects or toxicity. The objective of this study is to assess the urgency of TDM implementation to address these issues. This research is a literature review involving the synthesis of data from six studies that met inclusion and exclusion criteria. Data sources include Science Direct, PubMed, and Nature. The results indicate that Bedaquiline and Linezolid exhibit pharmacokinetic variability and the occurrence of side effects. Therefore, TDM is recommended for Bedaquiline and Linezolid to achieve desired therapeutic effects and avoid the onset of side effects or toxicity
Formulasi Dan Optimasi Sediaan Salep Luka Akut Berbasis Daun Wungu Graptophyllum Pictum L. Griff Dan Madu Klanceng Oktaviyani, Tiwi; Wijayatri, Ratna; Wahyuningtyas, Eka Sakti; Handayani, Estrin; Kamal, Sodiq
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 17 No. 2 (2025): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v17i2.409

Abstract

Abstract: Acute wounds require quick and appropriate treatment to prevent complications such as infection and scar tissue formation. This study aims to develop and optimize an ointment formula based on Graptophyllum pictum L. Griff wungu leaf extract and klanceng honey, which is intended to prepare for the healing of acute wounds. Graptophyllum pictum L Griff leaves are known to have anti-inflammatory and antimicrobial properties, while klanceng honey is famous for its ability to accelerate tissue regeneration. The research process included the determination of Graptophyllum pictum L Griff leaves to ensure the authenticity of the ingredients, extraction using the maceration method with 96% ethanol and the manufacture of Graptophyllum pictum L Griff leaves ointment with concentrations of F1 10%, F2 7.5% and F3 5%. Evaluation of physical properties through a series of preparation tests to assess organoleptic, homogeneity, pH, dispersibility, adhesion, and stability. The optimization of the ointment preparation of the combination of Graptophyllum pictum L Griff leaves and klanceng honey showed that the ointment met all quality criteria as an ointment preparation intended for acute wounds, the preparation also had excellent stability. This research is expected to be the basis for the development of natural products for the treatment of acute wounds that are more effective, and safe to use.
FORMULASI DAN UJI IRITASI SEDIAAN MASKER PEEL OFF GEL KOMBINASI EKSTRAK ETANOL BUNGA TELANG (Clitoria ternatea L.) DAN KUNYIT PUTIH (Curcuma zedoaria) Putri, Safira Amalia; Annisa Fatmawati; Eva Nurinda; Didik Yuni Prasetya
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 17 No. 2 (2025): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v17i2.328

Abstract

Butterfly pea flower (Clitoria ternatea L.) and white turmeric (Curcuma zedoaria) have antioxidant activity and can be combined to make a peel off gel mask. To ensure the quality and safety of the peel off gel mask, it is necessary to evaluate its physical properties and test for irritation. The manufacturing process involves extracting butterfly pea flower and white turmeric using a maceration method using 70% ethanol solvent. The resulting extract was tested for phytochemistry to identify alkaloids, saponins, flavonoids and tannins. The preparation was formulated with variations in extract concentrations: FI (1:3), FII (2:2) and FIII (3:1). Evaluation of physical properties includes organoleptic tests, pH, spreadability, homogeneity, stickiness, drying time and viscosity. Irritation tests were carried out on New Zealand rabbits. The result indicated that the peel off gel mask with various extract concentrations met most of the physical property evaluation requirements even though the pH test did not meet the standards. The EEBT and EEKP combination peel off gel mask did not cause irritation in New Zealand rabbits during 72 hours of observation.
Evaluasi Pelayanan Swamedikasi oleh Tenaga Teknis Kefarmasian di Apotek X Kota Tangerang Rangka, Febbyasi Megawaty; Sinurat, Selvina; Andriyania, Andriyania; Novia, Jessica; Munthe, Sri Wahyu Ningsih
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 17 No. 1 (2025): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v17i1.204

Abstract

Self-medication or self-treatment is one way to treat diseases experienced without a doctor's prescription. Limited public knowledge about drugs can cause medication errors from drug selection, drug dosage and how to use drugs. Drug abuse and inappropriate drug use are often because the public does not get education or pharmacists give wrong drug recommendations. This study aims to evaluate the implementation of self-medication services by TTK at Pharmacy X, Tangerang City and the drug recommendations given. Quantitative research method with a prospective descriptive approach. Data were obtained through direct observation using a form on self-medication services by 6 TTK for 30 working days from February 1 to March 2, 2021. The sample consisted of 105 consumers who bought drugs without a doctor's prescription and the data was analyzed descriptively using Microsoft Excel with percentage calculations. The results of the study showed that consumer characteristics were dominated by men 55.24% and adults aged 26-45 years 46.67%. The implementation of self-medication that was not carried out 100% was the method of using drugs 55.23% and storing drugs 0%. The most common complaint was a dry cough in 20 cases (19.05%) accompanied by flu in 10 cases, colds in 6 cases, itchy throat in 3 cases and stomach ulcers in 1 caseInconsistency of drug recommendations occurred in complaints of dry cough, namely drugs containing guaifenesin indicated for phlegmy cough in 9 cases and phlegmy cough containing dextromethorphan HBr in 1 case which is an antitussive that can inhibit the cough reflex to expel phlegm. This shows a lack of understanding by TTK regarding the composition of drugs according to complaints and drug indications. TTK self-medication services need to be improved, especially aspects of drug storage education and drug recommendations based on complaints to minimize medication errors and improve the quality of pharmaceutical services at the community level.
Evaluasi Drug Related Problems (DRPs) Pada Pasien Congestive Heart Failure (CHF) Di Instalasi Rawat Inap RSUD Dr. Soedirman Tahun 2022 Dewi, Rahmatia Candra; Ainni, Ayu Nissa; Miyarso, Chondrosuro; Widiatuti, Tri Cahyani
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 17 No. 1 (2025): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v17i1.208

Abstract

Congestive Heart Failure (CHF) is a chronic condition in which the heart is unable to pump blood as it should. Comorbidities and the use of polypharmacy drugs in the treatment of Congestive Heart Failure (CHF) are risk factors that trigger Drug Related Problems (DRPs). The purpose of this study was to identify and evaluate Drug Related Problems (DRPs) in Congestive Heart Failure (CHF) patients at the inpatient ward of RSUD Dr. Soedirman Kebumen in 2022. This research is a descriptive non-experimental study with a retrospective method. DRPs analysis was carried out based on the type of DRPs found using the Pharmaceutical Care Network Europe (PCNE) V9.0 reference and then compared with the 2020 guidelines for the management of heart failure. Data obtained from 110 patients showed there were 49 DRP events which included 26 untreated indications (53.06%), 16 incidents of overdose (32.65%), 4 incidents of drugs without indications (8.16%), 3 incidents of therapeutic duplication (6.12%) and 0 incidents of underdose (0%). Based on the PCNE V9.0 classification, the most common cause of DRPs at RSUD Dr. Soedirman Kebumen in 2022 was untreated indications. As a recommendation, it is necessary to evaluate DRPs in CHF patients by observing potential side effects prospectively.

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