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Jurnal Farmasi Indonesia
Published by Ikatan Apoteker Indonesia
ISSN : 14121107     EISSN : 2355696X     DOI : https://doi.org/10.35617/jfionline
Core Subject : Health,
Medicine & Pharmacology
Jurnal Farmasi Indonesia adalah jurnal nasional (peer-reviewed) yang diterbitkan oleh Ikatan Apoteker Indonesia dua kali dalam setahun sebagai sarana diseminasi ilmu pengetahuan di bidang farmasi, yaitu: farmasi klinis, farmasi masyarakat/komunitas, kimia farmasi, biologi farmasi/famakognosi, farmakologi, pengembangan obat/kimia medisinal, formulasi dan bidang terkait. Artikel yang dipublikasi berupa hasil penelitian dan mini-review. JFIOnline telah mulai diterbitkan sejak tahun 2009 dalam edisi cetak. Pada tahun 2014 mulai dibuat edisi online. Akses artikel pada jurnal tidak berbayar, tetapi dikenakan biaya proses publikasi untuk penulis (open access journal). Mulai bulan Juli 2019 jurnal ini dapat diakses di alamat yang baru yaitu www.jfi-online.org dari alamat sebelumnya www.jfionline.org.
Arjuna Subject : Profesi Kesehatan - Farmasi
Articles 177 Documents
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Pengembangan Instrumen Penilaian Tingkat Pengetahuan, Sikap, Dan Perilaku Swamedikasi Batuk Versi Bahasa Indonesia Maria, Nisa; Apriani, Elvina; Sari, Kartika Citra Dewi Permata
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 17 No 1 (2025): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v17i1.220

Abstract

Cough is a symptom that people often treat with self-medication. Self-medication practice can be formed from knowledge and attitudes. The development of this instrument aimed to obtain a valid and reliable Indonesian language questionnaire to measure the level and relationship of knowledge, attitudes, and cough self-medication practice in adult patients. The questionnaire was prepared based on literature studies and developed by the Dagusibu concept and cough management. Three pharmacists from academia and the community became validators in the face and content validation test. Construct validation and reliability tests were obtained from 30 adult respondents who had carried out cough self-medication in Jabodetabek. Content validation was carried out in 2 stages. The results of the first stage test had an S-CVI score of 0.93, with 26 questions having an I-CVI value <0.79, so stage 2 validation was carried out, which met the I-CVI and S-CVI scores. The total number of questions from content validation was 143, divided into 6 parts. The final questionnaire had 137 questions consisting of sections A-B (8 questions) for personal and sociodemographic data; part C (30 questions) related to self-medication profile; part D (36 questions) about knowledge with a 3-point Guttman scale; part E (30 questions) related to attitudes with a 5-point Likert scale; and part F (33 questions) about behavior with a 2-point Guttman scale. The final questionnaire met the criteria of validity and reliability and could be filled in independently by respondents in Indonesia.
Efektivitas Antibakteri Krim Ekstrak Daun Sirih Merah (Piper crocatum) Terhadap Beberapa Bakteri Renaldy, Renaldy; Trinovita, Elsa; Furtuna, Dewi Klarita; Fatmaria, Fatmaria; Turnip, Oktaviani Naulita
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 17 No 1 (2025): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v17i1.264

Abstract

The prevalence of infectious diseases is increasing in developing countries such as Indonesia, and they have become a health problem. One infectious disease caused by Staphylococcus aureus and Escherichia coli bacteria is necrotizing fasciitis. The subcutaneous tissues and fascia necrosis characterize necrotizing fasciitis. Antibiotic therapy is one way to prevent the growth and development of bacteria, but continuous use can cause resistance to bacteria. This research aimed to determine the antibacterial effectiveness of red betel leaf extract in cream preparations against the growth activity of Staphylococcus aureus and Escherichia coli bacteria using the ditch plate method. Red betel leaves were extracted using the UAE method (temperature 600 C for 15 minutes), then made into a cream dosage form with a formulation of 20% extract concentration (F1), 40% extract concentration (F2), and 80% extract concentration (F3) then tested evaluation of cream preparations and antibacterial activity test using the ditch plate method. The extraction of red betel leaves used the UAE method in concentrations of 20%(F1), concentrations of 40%(F2), and concentrations of 80% (F3) in cream preparation form. The cream was evaluated, and antibacterial activity was tested using the ditch plate method. The red betel leaf extract cream inhibits Staphylococcus aureus growth by the ditch plate method but does not have antibacterial activity on Escherichia coli.
Analisis Persepsi Kemampuan Mahasiswa dengan Asesmen Mandiri dalam Pembelajaran Praktik Kerja Profesi Apoteker (PKPA) di Instalasi Farmasi RSUD Dr. Saiful Anwar Badriyah, Rani Nur; Puspitasari , Vicky; Widya, Reta Anggraeni
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 17 No 1 (2025): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v17i1.270

Abstract

Pharmacist Professional Work Practice (PKPA) provides a learning process for students to gain basic skills in pharmaceutical services. Student perceptions are important to be involved in the development of the PKPA curriculum at the Dr. Saiful Anwar Hospital Pharmacy Department. The purpose of the study was to determine the basic abilities of students in pharmaceutical services during the PKPA process. Perceptions were assessed by self-assessment in the form of a questionnaire containing 7 questions, namely the ability to reconcile drugs, need for drug, selection of drug, analyze Drug Related Problems (DRP), provision of drug product, medicines information and patient education, and Monitoring Drug Therapy (PTO) before starting PKPA (Pre) and after PKPA ended (Post) in 76 students. Students' perceptions of self-assessment provide results in the category of exceeding expectations (index 86.2%), but several abilities are the top priority for improvement, namely need for drug, medicines information and patient education. Based on this, it can be concluded that students have the perception of having overall pharmaceutical service skills but further assessment needs to be done to test the suitability of perceptions with the abilities possessed by students.
Aktivitas Antibakteri Minyak Biji Anggur terhadap Staphylococcus epidermidis dalam Sediaan Krim Puspadewi, Ririn; Anggreani, Wulan; Faradilla, Agny Vardha
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 17 No 1 (2025): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v17i1.342

Abstract

Grape seeds contain 75% unsaturated fats namely linoleic acid and vitamin E which contributes to its resistance to oxidation and is often chosen for use in the cosmetic, culinary, pharmaceutical, and health fields. The purpose of this study is to determine the activity of grape seed oil (Vitis vinifera L.) in inhibiting the growth of Staphylococcus epidermidis bacteria in cream preparations. The research was carried out through several stages, namely organoleptic examination of grape seed oil, making grape seed oil cream formula and its evaluation, testing antibacterial activity by disc diffusion method. Anti-acne cream preparations containing grape seed oil are made in 4 formulas, namely F0 (without grape seed oil), F1 (24%), F2 (30%), F3 (36%). All formulations during storage do not change shape, smell, and colour and homogeneity whereas pH and viscosity change during storage. The formulation of grape seed oil cream forms a stable cream from the results of freeze and thaw, showing no changes in globule size with globules <50μm. Based on the results of the antibacterial activity test, the best formula is F3, its provides the greatest inhibition against the growth of Staphylococcus epidermidis bacteria. Grape seed oil in cream preparations can inhibit the growth of Staphylococcus epidermidis.
Implementasi Lean Hospital dalam Menurunkan Waktu Tunggu Obat Pasien Rawat Jalan Instalasi Farmasi RSUD Dr Saiful Anwar (RSSA) Jawa Timur Widyastuti, Indri; Widya, Reta Anggraeni; Hamidah, Rif'atul; Risnawati, Vina
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 17 No 1 (2025): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v17i1.343

Abstract

The minimum service standards (MSS) for drug service- waiting time (26,16%) has not been achieved and the low usage of free delivery services (RAOS SAE) led Pharmacy Department to improve the services with lean hospital management approach. This research aimed to shorten the drug service waiting time at JKN outpatient pharmacy unit with lean hospital management concept. This research was designed with Participation action research (PAR) approach. The data obtained through observations and interviews, analyzed by comparing the waiting time of prescription screening and drug service time with independent t-test comparison.  There were 4 wastes resolved out of 8 wastes that successfully identified, They were; flow of personnel and prescriptions which did not match the process (motion and transportation), The time for  prescriptions screening (waiting) is too long, and the officer could not do the job effectively because of the slowness of online system. (Non Uti talent). The result of implementation decreased the waiting time of prescription screening from 73 minutes to 61 minutes, and the mean of drug service waiting time decreased from 101 minutes to 63 minutes. Comparing the data before and after lean management application for prescription screening waiting time did not statistically different p>0,05 (p=0,057), this activity increased the usage of RAOS SAE, reducing the number of overtime officer at JKN outpatient pharmacy unit. The implementation of lean hospital management reduced drug service waiting time, even though unachieved the MSS yet. There were external factors that could not be controlled causing insignificant decreases. Several improvements need to be done to achieve the established standards.
Sintesis dan Kajian Docking Molekular Senyawa 2’-Hidroksicalkon dan Flavonol Tersubstitusi Dimetoksi sebagai Inhibitor Kompleks NS2B-NS3 Serine Protease pada Virus Dengue-2 (DENV-2) Ikhtiarudin, Ihsan; Frimayanti, Neni; Hendra, Rudi; Teruna, Hilwan Yuda; Rahim, Fatma; Mora, Enda; Septama, Abdi Wira
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 17 No 1 (2025): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v17i1.347

Abstract

Exploration of the potential compounds as dengue antivirals is one of the efforts that must be considered, because no specific therapy has been found with antiviral drugs that is effective in treating dengue hemorrhagic fever (DHF) patients. The aim of this study is to synthesize and explore the potential of the (E)-3-(2,5-dimethoxyphenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one (compound 1) and 2-(2,5-dimethoxyphenyl)-3-hydroxy-4H-chromen-4-one (compound 2) as inhibitors of NS2B-NS3 serine protease complex of DENV-2. Synthesis of compounds 1 and 2 was carried out by stirring using a magnetic stirrer. The structures of the two synthesized compounds have been confirmed through UV-Vis, FT-IR and 1H NMR spectroscopic analyses. Molecular docking was performed using NS2B-NS3 complex (PDB ID: 2FOM) as a receptor. Compounds 1 and 2 were obtained in 21.11% and 66.84% yield, respectively. Based on the molecular docking studies, compounds 2 exhibited more negative binding free energy than compound 1 and panduratin A as a reference inhibitor. Compound 2 was observed to bind to the catalytic triad of NS2B-NS3 complex (His51, Asp75, Ser135) and form hydrogen bond with Gly153. Based on the results, it can be concluded that compounds 1 and 2 can be synthesized by stirring method and the compound 2 showed good potency to be developed as inhibitors of the NS2B-NS3 serine protease complex of DENV-2.
Analisis Ketersediaan Obat pada Sebelum dan Selama Pandemi COVID-19 di RSUD Bali Mandara Provinsi Bali Sitepu, Eme Stepani; Ayuningtyas, Dumilah; Junadi, Purnawan; Satibi, Satibi; Daniel, Rizki
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 17 No 1 (2025): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v17i1.356

Abstract

The availability of drugs needs to be guaranteed to meet the needs of patients both in terms of quantity and type. This can be realized if drug management in the hospital is carried out effectively and efficiently. Factors that influence this include the suitability of planning methods, drug procurement, availability of e-catalog, good human resource competence, and budget adequacy. The challenges in the COVID-19 pandemic situation in 2020 are activity restrictions that affect the distribution of drugs and raw materials while the demand for drugs increases. This study aims to analyze the level of drug availability before the pandemic and during the COVID-19 pandemic at the Bali Mandara Provincial General Hospital. This study was conducted from September to December 2023 using a quantitative approach. Data were collected retrospectively using stocks, and drug procurement from 2019 to 2022. The results showed no incidents of poor drug stocks in 2019-2022. However, there was an increase in the percentage of safe category for the needs of 12-18 months from 2019 to 2022 by 42.5%, 44.4%, 69.1%, and 65.7%, respectively. There are still excessive stocks above 18 months although the percentage is decreasing at 37.9%, 26.2%, 21.6%, and 28.8%, respectively. The decrease in drug items with availability levels of more than 60 months was 15.7%, 8.6%, 7.0%, and 4.1%, respectively. There were expired drugs before and during the COVID-19 pandemic but the value of expired items decreased from Rp. 370,221,269.27 in 2019 to Rp.93,787,747.28 in 2022. Conclusion: The Hospital Pharmacy Department can fulfill the need for drugs before and during the COVID-19 pandemic, indicated by no incidents of drug shortages. However, it is necessary to manage drugs more efficiently, because there are still drugs without use in a year and expired drugs, although the percentage has decreased during the COVID-19 pandemic.
Potensi Ekstrak Etil Asetat Batang Bajakah Tampala sebagai Tabir Surya Wulandari, Erna Tri; Bungadea, Dominica; Cholisna, Rizka Sauqi
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 17 No 1 (2025): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v17i1.362

Abstract

Currently, natural ingredients are widely used as raw materials for sunscreen. Bajakah Tampala stem (Spatholobus littoralis Hassk) contains phenolic compounds, especially flavonoids.  Flavonoids have chromophore groups that can absorb ultraviolet (UV) A and ultraviolet (UV) B and capture free radical due to exposure to UV and can be dissolved by ethyl acetate. This study aims to examine the potential of ethyl acetate extract from Bajakah Tampala stems as a sunscreen in vitro by measuring the SPF (Sun Protection Factor) value and antioxidant activity as well as total phenolic content, especially flavonoids. The research began with the extraction of Bajakah Tampala stem powder using the soxhletation method, then the SPF value of the dry extract was measured using the UV-Vis spectrophotometric method. Antioxidant activity was tested using the DPPH (2,2-diphenyl-1-picrylhydrazyl) method. The Folin-Ciocalteau method was used to determine total phenolic content (mg gallic acid equivalents [GAE] per gram of extract [mg GAE/g]). Total flavonoid content was measured colorimetrically with AlCl3 reagent (mg quercetin equivalents [QE] per gram of extract [mg QE/g]). In this study, it was found that Bajakah stem extract contained total phenols of 51.73 mg GAE/g extract, total flavonoids of 17.91 mg QE/g extract, an SPF value of 5.53 and had antioxidant activity with an IC50 value of 159.17 μg/mL. Bajakah Tampala stem ethyl acetate extract has potential as a sunscreen because it contains phenols, especially flavonoids and antioxidant properties.
Potensi Pengembangan Antioksidan/Antidiabetes Turunan Piridazinon sebagai Agen yang Menjanjikan untuk Terapi Penyakit Diabetes: Review Fatisa, Yuni; Frimayanti, Neni; Teruna, Hilwan Yuda; Jasril , Jasril
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 17 No 1 (2025): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v17i1.390

Abstract

Hyperglycemia can induce oxidative stress that can develop towards the pathogenesis of diabetic complications. Treatment strategies usually use antidiabetic and antioxidant drugs to help manage diabetes in patients. The discovery of drugs with dual activity properties will work on two targets at once and can minimize side effects. This review analyzes the potential for developing new antidiabetic and antioxidant agents from pyridazinone derivative compounds. The literature review study methodology uses the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) technique. Electronic database searches were conducted through Google Scholar, PubMed, and Science Direct to obtain relevant literature until 2024. The inclusion criteria were pyridazinone derivatives as antidiabetics and antioxidants using in silico, in vitro, and in vivo tests. A total of 24 original research journals have been described for the discussion of this review. The review results found that pyridazinone derivatives have the potential as α-Glucosidase inhibitors, antihyperglycemic, and aldose reductase inhibitors with moderate-strong activity levels. Several studies have also found that pyridazinone derivatives are antioxidants. These results are supported by the prediction through molecular docking approach studies.  However, only two studies have reported pyridazinone derivatives that have antidiabetic and antioxidant properties at the same time. There is a connection between the active groups bound to the pyridazinone ring and the strength of its pharmacological effects. This review opens up opportunities for the potential development of pyridazinone derivatives with dual bioactivity. In addition, broader and deeper research with structural modification of pyridazinone derivatives as candidate therapeutic agents for diabetes patients needs to be continued.
Optimasi Metode Ekstraksi Microwave Assisted Extraction Biji Markisa (Passiflora edulis Sims) terhadap Aktivitas Antioksidan Handayani, Virsa; Fauzan, Muh. Alif Noor; Nadya, Alifah Rifa; Widiastuti, Harti; Malik, Abd.; Ahmad, Aktsar Roskiana
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 17 No 1 (2025): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v17i1.394

Abstract

Passion fruit (Passiflora edulis Sims) is a trailing plant of non-native origin, belonging to the genus Passiflora. The utilisation of purple passion fruit seeds (Passiflora edulis Sims) has been extensively documented in traditional medicine. These seeds have been employed in various therapeutic applications, including antioxidant, anti-inflammatory, antipyretic, analgesic and hypotensive properties. The objective of the present study was to ascertain the potential for enhancing the antioxidant activity of passion fruit seed oil (Passiflora edulis Sims) through 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical-scavenging method. The extraction method used was Microwave Assisted Extraction (MAE) utilising n-Hexane as a solvent, with variations in temperature and time. The results obtained for passion fruit seed oil at low temperature (20°C) revealed an IC50 of 14.58 µg/mL after 10 minutes and 7.144 µg/mL after 20 minutes. At medium-low temperature (36°C), the IC50 was 4.67 µg/mL after 10 minutes and 2.68 µg/mL after 20 minutes. At medium temperature (95°C), the IC50 was 4.46 µg/mL after 10 minutes and 2.26 µg/mL after 20 minutes.

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