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Jurnal Farmasi Indonesia
Published by Ikatan Apoteker Indonesia
ISSN : 14121107     EISSN : 2355696X     DOI : https://doi.org/10.35617/jfionline
Core Subject : Health,
Medicine & Pharmacology
Jurnal Farmasi Indonesia adalah jurnal nasional (peer-reviewed) yang diterbitkan oleh Ikatan Apoteker Indonesia dua kali dalam setahun sebagai sarana diseminasi ilmu pengetahuan di bidang farmasi, yaitu: farmasi klinis, farmasi masyarakat/komunitas, kimia farmasi, biologi farmasi/famakognosi, farmakologi, pengembangan obat/kimia medisinal, formulasi dan bidang terkait. Artikel yang dipublikasi berupa hasil penelitian dan mini-review. JFIOnline telah mulai diterbitkan sejak tahun 2009 dalam edisi cetak. Pada tahun 2014 mulai dibuat edisi online. Akses artikel pada jurnal tidak berbayar, tetapi dikenakan biaya proses publikasi untuk penulis (open access journal). Mulai bulan Juli 2019 jurnal ini dapat diakses di alamat yang baru yaitu www.jfi-online.org dari alamat sebelumnya www.jfionline.org.
Arjuna Subject : Profesi Kesehatan - Farmasi
Articles 190 Documents
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Aktivitas Antibakteri Isolat Jamur Endofit Kulit Batang Rimbang (Solanum torvum Swartz) terhadap Beberapa Bakteri Melzi Octaviani; Salsabila Putri; Sri Lidya Rasihe; Kolista Sisilawati; Nofriyanti Nofriyanti; Rahmayati Rusnedy
Jurnal Farmasi Indonesia Vol 18 No 2 (2026): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v18i2.557

Abstract

Endophytic fungi are known as a promising alternative source of antibacterials due to their ability to synthesize secondary metabolites like their host plants. Although the presence of endophytic fungi associated with Solanum torvum has been reported in previous studies, no studies have focused on fungi isolated from the bark of Solanum torvum and the correlation between the phytochemical content of its fractions and antibacterial activity. The aim of this study was to isolate endophytic fungi from the bark of Solanum torvum and test the antibacterial activity and phytochemical profiles of the fractions from the isolates against pathogenic bacteria. Endophytic fungi were isolated using direct cultivation techniques after surface sterilization. The antibacterial activity test was evaluated using the disc diffusion method against Bacillus cereus ATCC 11778, Staphylococcus aureus ATCC 12600, Escherichia coli ATCC 11775, and Salmonella typhi ATCC 14028 bacteria. Five endophytic fungal isolates were obtained and identified, namely FEST-K1 (Artrographis), FEST-K2 (Acremonium sp.), FEST-K3 (Paecilomyces sp.), FEST-K4 (Lichtheimia), and FEST-K5 (Alternaria sp.). The supernatant was then extracted and fractionated using ethyl acetate, chloroform, and n-butanol. Phytochemical analysis showed that the fungal fraction contained alkaloids, terpenoids, and saponins. FEST-K1 showed the strongest inhibitory activity against S. aureus and B. cereus, with inhibition zone diameters of 15.09 mm and 13.69 mm, respectively. In contrast, the highest activity against E. coli and S. typhi was observed in FEST-K4 (13.78 mm) and FEST-K5 (15.45 mm). One-way ANOVA statistical analysis showed that the antibacterial activity of the fungal extracts was significantly different from the positive control (p < 0.05). These results indicate that endophytic fungi derived from the bark of S. torvum are a potential source of antibacterial compounds.
Potensi Kombinasi Pegagan dan Dadap Serep dalam Menurunkan Risiko Nonalcoholic Fatty Liver Disease Marita Kaniawati; Agus Sulaeman; Elis Susilawati; Nita Selifiana; Naida Kasihtheisya; Widi Syahyudin; Oktaviani Parasitia
Jurnal Farmasi Indonesia Vol 18 No 2 (2026): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v18i2.768

Abstract

Fructose has long been known as a sugar additive or sweetener, commonly found in soft drinks, pastries and other daily processed foods. An added sugar in large amount in the daily diet will increase the risk of suffering from various diseases due to metabolic disorders including Nonalcoholic Fatty Liver Diseases (NAFLD). The aims of the study is to determine the potential of a combination of ethanol extract of pegagan and dadap serep (EEPDS) to reduce the risk of NAFLD triggered by high fructose consumption. The parameters observed include inflammatory markers (represented by levels of Vascular Cell Adhesion Molecule-1 or VCAM-1), oxidative stress markers (represented by levels of Malondialdehyde or MDA), lipid parameters (represented by Triglycerides) and liver function parameters (represented by levels of Serum Glutamic Oxaloacetic Transaminase or SGOT and Serum Glutamic Pyruvic Transaminase or SGPT). The research method was arranged with Post Test Only Control Group Design using male Wistar rats as test animals for 60 days. This study used 6 treatment groups, namely the normal group (normal diet), induction group (normal diet + 60% fructose), comparison group (normal diet + 60% fructose + curcumin), test group 1 (normal diet + 60% fructose + EEPDS 50:100 mg/kgBW), test group 2 (normal diet + 60% fructose + EEPDS 100:100 mg/kgBW), and test group 3 (normal diet + 60% fructose + EEPDS 100:50 mg/kgBW). The results showed that the combination of ethanol extract of pegagan and dadap serep can reduce the risk of NAFLD, which is characterized by decreased levels of Triglycerides, SGOT, SGPT, MDA and inflammatory markers (VCAM-1). In conclusion, the combination of EEPDS can reduce the risk of NAFLD triggered by high fructose consumption.
Aktivitas Antiinflamasi dan Analgesik dari Kombinasi Ekstrak Daun Carica papaya dan Ocimum sanctum Eem Masaenah; Sofyan Ramani; Fredy Arifta Nasel; Zuliar Permana; Jenika Ariyani; Rihadatul Ayis Rahma; Rega Juwanda
Jurnal Farmasi Indonesia Vol 18 No 2 (2026): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Inflammation and inflammatory pain remain important clinical problems, and long-term use of anti-inflammatory or analgesic drugs is often associated with adverse effects. Papaya (Carica papaya) and basil (Ocimum sanctum) leaves are widely used in traditional Indonesian medicine, yet evidence regarding their combined use remains limited. This study evaluated the phytochemical profile, anti-inflammatory activity, and analgesic effects of ethanolic extracts prepared from papaya leaf simplicia (EP), basil leaf simplicia (EK), and combined simplicia extracts at ratios of 1:1 (EP1K1), 3:1 (EP3K1), and 1:3 (EP1K3).  Phytochemical screening revealed the presence of flavonoids, phenolics, alkaloids, saponins, and triterpenoids in all extracts, while tannins were detected only in basil extract. In vitro evaluation using the bovine serum albumin (BSA) protein denaturation assay showed that basil extract exhibited the strongest activity (IC₅₀ = 82.44 μg/mL), whereas the combined extracts predominantly exhibited additive effects. In vivo testing using the carrageenan-induced paw edema model showed that papaya extract produced the highest anti-inflammatory inhibition (64.41%), while basil extract showed comparable activity to diclofenac sodium. Analgesic evaluation using the acetic acid-induced writhing test indicated that the basil-rich combination (EP₁K₃) showed the highest analgesic protection among the tested combinations.  These findings indicate that papaya and basil extracts exhibit distinct yet complementary anti-inflammatory and analgesic activities. The combined simplicia extracts demonstrated additive pharmacological effects support the traditional use of these plants for the development of standardized herbal preparations.
Identifikasi Inhibitor Protease NS2B/NS3 Virus Dengue Berbasis Flavonol melalui Farmakologi Jaringan dan Penambatan Molekuler Neni Frimayanti; Haiyul Fadhli; Mazani Febrina
Jurnal Farmasi Indonesia Vol 18 No 2 (2026): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v18i2.970

Abstract

The dengue virus still poses a serious threat to world health, and there are still few effective inhibitors that target the NS2B/NS3 protease. This study used an integrated in silico methodology to find possible anti-dengue candidates from Artocarpus heterophyllus flavonol molecules. After investigating compound–target relationships using network pharmacology, structure-based molecular docking was used to evaluate binding affinities toward the NS2B/NS3 protease (PDB ID: 2FOM), and ADME profiling was included. Compounds 6 and 9 outperformed the other ligands in the evaluation in terms of expected binding energies and stable accommodation in the active site, which included close spatial interaction with the residues of the catalytic triad (His51, Asp75, and Ser135). For the most part, their anticipated pharmacokinetic characteristics were within reasonable bounds for early-stage medication candidates. All things considered, our findings suggest that the chosen flavonols would be good places to start when developing dengue antivirals; still, further experimental testing is necessary to confirm their biological activity.
Asam HidroksiAsam Hidroksisinamat dari Drynaria sparsisora ​​sebagai Agen Anti-Vibrio: Bukti Terintegrasi In Vitro dan In Silicosinamat dari Drynaria sparsisora sebagai Agen Anti-Vibrio: Bukti Terpadu Secara In Vitro dan In Silico Hesti Marliza; Fitra Perdana; Yuli Haryani; Hilwan Yuda Teruna; Rudi Hendra
Jurnal Farmasi Indonesia Vol 18 No 2 (2026): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v18i2.974

Abstract

Drynaria sparsisora is a fern species long utilized in ethnomedicine and recognized as a source of phenolic compounds. This study aims to isolate antibacterial ingredients from D. sparsisora, evaluate their efficacy against Vibrio species, and investigate potential molecular interactions by in silico docking analysis. Dried plant material was extracted with methanol and separated by liquid–liquid partitioning followed by chromatographic purification. Two main compounds were identified and structurally characterized using UV–Vis, FTIR, and ¹H/¹³C NMR spectroscopy. Spectroscopic measurements established the identification of the substances as ferulic acid (1) and caffeic acid (2). In vitro antibacterial activity was investigated against Vibrio alginolyticus, Vibrio parahaemolyticus, and Vibrio cholerae using a broth microdilution method to determine minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). Both isolated compounds displayed MIC values of 20 µg/mL and MBC values of 40 µg/mL against all tested strains, leading to an MBC/MIC ratio of 2, confirming bactericidal activity. Although chloramphenicol revealed higher efficacy (MIC 12.5 µg/mL), the separated phenylpropanoids showed consistent and repeatable suppression across all Vibrio species tested. To give mechanistic insight, molecular docking simulations were performed against three bacterial protein targets (PDB IDs: 2ZDQ, 1HNJ, and 3IL7). Both ferulic acid and caffeic acid displayed favorable binding energies and persistent interaction patterns inside the active regions of these proteins, involving hydrogen bonding and hydrophobic interactions. In selected models, docking affinities neared those of chloramphenicol, confirming the likelihood of target engagement. The multi-target binding behavior found suggests possible interference with important bacterial functions, including cell wall function, protein synthesis, and fatty acid production. Overall, the data reveal that D. sparsisora contains hydroxycinnamic acids with considerable bactericidal activity against Vibrio spp., backed by computational evidence of protein interaction. Further investigations are necessary to validate molecular targets and clarify antibacterial processes.
Kurkumin Memperbaiki Disfungsi Endotel Melalui Pengurangan Stres Oksidatif: Tinjauan Sistematis dan Meta-Analisis Studi Hewan Marita Feliana; Aghnia Nurvianti Nafilah; Hendra Mahakam Putra; Marita Kaniawati; Agus Sulaeman
Jurnal Farmasi Indonesia Vol 18 No 2 (2026): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v18i2.982

Abstract

Endothelial dysfunction is an early mechanism in cardiovascular disease and is closely linked to oxidative stress induced impairment of Nitric Oxide (NO) signaling. Curcumin, a bioactive polyphenol from Curcuma longa, exhibits antioxidant and vasoprotective properties. However, its mechanistic effects in preclinical models have not been quantitatively synthesized. This study evaluated the effects of curcumin on endothelial function and oxidative stress–related outcomes in animal models. A systematic search of PubMed, Embase, Scopus, and Web of Science was conducted according to PRISMA 2020 guidelines. Preclinical in vivo and ex vivo studies assessing curcumin monotherapy were included. Pooled standardized mean differences (SMDs) were calculated using a random-effects model. Risk of bias was assessed using SYRCLE, and certainty of evidence was evaluated using GRADE. Sixteen studies were included. Curcumin improved Endothelium-Dependent Vasodilation (EDV) (SMD = 1.44, 95% CI: 1.13 to 1.76, I² = 46%), increased endothelial Nitric Oxide Synthase (eNOS) expression or activity (SMD = 1.33, 95% CI: 0.75 to 1.90, I² = 68%), and enhanced NO levels (SMD = 1.15, 95% CI: 0.79 to 1.50, I² = 0%). It reduced superoxide (SMD = −2.14, 95% CI: −2.88 to −1.41, I² = 76%) and Malondialdehyde (MDA) (SMD = −1.65, 95% CI: −2.10 to −1.19, I² = 55%). Moderate to substantial heterogeneity was observed. SYRCLE indicated some concerns, and overall certainty was very low. Curcumin may ameliorates endothelial dysfunction via oxidative stress attenuation and restoration of NO signaling. However, these findings require confirmation in rigorously designed clinical studies.
Faktor-faktor yang Mempengaruhi Manajemen Perawatan Luka di Apotek Komunitas Indonesia: Sebuah Studi Lintas Sektoral Lusy Noviani; Dwi Arymbhi Sanjaya; Ni Kadek Refi Mariska; Pretty Falena Atmanda Kambira
Jurnal Farmasi Indonesia Vol 18 No 2 (2026): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v18i2.999

Abstract

Wound care remains a major public health problem, particularly in low- and middle-income countries (LMICs) such as Indonesia. Pharmacists practicing in community-based primary care settings are often the first point of contact for patients with minor wounds, yet evidence describing their wound care practices in routine care remains limited. This study aimed to describe wound care practices among pharmacists in community-based primary care settings in Indonesia and to examine factors associated with wound care product selection, product availability, and patient education. A cross-sectional online survey was conducted among pharmacists practicing in community-based primary care settings in Indonesia. The study used a non-probability convenience sampling approach, with recruitment through online pharmacist communication networks and professional social media platforms. A structured questionnaire was used to collect data on respondent characteristics, factors influencing wound care product selection, product availability, and patient education practices. Descriptive statistics were used to summarize the data, and associations between categorical variables were analyzed using the Fisher’s Exact test. A total of 303 pharmacists were included in the analysis. The median age of respondents was 33 years (range: 23–74 years). Most respondents practiced in community pharmacies (83.5%). Across all experience groups, wound type and severity were the most commonly considered factors in wound care product selection. Other clinical considerations and product availability varied by years of practice and practice setting. Most respondents reported routinely providing patient education during wound care consultations. These findings describe variation in wound care practices among pharmacists in community-based primary care settings in Indonesia.
Pengetahuan Masyarakat Terhadap Keamanan Obat Tradisional dan Risiko Bahan Kimia Obat di Indonesia Tina Wikara; Sri Astuti; Sri Nurhayati; Rotua Uli Carolina Simanjuntak; Evi Ratna Sari; Oktiva Rahmawati Dhewi
Jurnal Farmasi Indonesia Vol 18 No 2 (2026): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v18i2.791

Abstract

The use of traditional medicines in Indonesia is increasing, while some products still do not meet safety requirements and may contain chemical drug substances (CDS) that pose health risks. This situation requires adequate public knowledge in selecting traditional medicines that are safe and of good quality. This study aimed to assess the level of public knowledge in Indonesia regarding the safety of traditional medicines and understanding of the risks associated with CDS. A cross-sectional design was applied through a national survey conducted from July to September 2024, involving 20,610 respondents from 34 provinces using a stratified three-stage sampling method. The results showed that 74.24% of respondents had used traditional medicines in the past six months. Respondents’ knowledge of product safety indicators was in the good category, particularly regarding labels and expiration dates, while understanding of registration numbers was relatively lower. Knowledge about the risks of CDS content was still limited, with only 59.71% of respondents aware that traditional medicines may contain CDS and negatively affect health. Higher levels of knowledge were observed among women, individuals aged <35 years, urban residents, and respondents with higher educational attainment. There remains a gap in public knowledge in Indonesia regarding the safety of traditional medicines and the risks of BKO. More extensive and targeted public education efforts, along with strengthened regulatory oversight, are needed to prevent the circulation of traditional medicines containing CDS.
Pengaruh Penambahan Gliserol sebagai Plasticizer terhadap Biodegradable Film Kombinasi Glukomanan dari Umbi Porang (Amorphophallus oncophyllus) dan Natrium Alginat Agustina Putri Pitarisa Sudarsono; Nanda Dwi Akbar; Agus Sulaiman
Jurnal Farmasi Indonesia Vol 18 No 2 (2026): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v18i2.886

Abstract

Glucomannan is a polysaccharide of the hemicellulose type derived from porang tubers. Alginate has a colloidal structure that has the potential to form a biopolymer film component. Biodegradable films from porang flour have stiff and brittle properties so glycerol is used as a plasticizer. The purpose of this study was to determine the effect of adding glycerol in the formulation of biodegradable films containing glucomannan and sodium alginate. This research design is an experimental study. The material in this study was porang flour which was extracted in stages using 50 and 80% ethanol solvents. The biodegradable film formulation contains 2.5 grams of glucomannan, 2.5 grams of sodium alginate, 2 mL of 30% glycerol and 100 mL of distilled water. As a comparison, a biodegradable film formulation without glycerol was applied. Evaluation of the biodegradable film included organoleptic tests, swelling degree, biodegradation and FTIR. Data analysis was carried out using One Sample T-Test at a 95% confidence level. The evaluation results of biodegradable films showed that biodegradable films without glycerol were round with brownish color, brittle, stiff, tend to tear and less elastic, swelling degree of 39.98±0.091, thickness of 0.21±0.008 mm, and degraded for 21±1 days, while the addition of glycerol produced biodegradable films that were not stiff, torn and quite elastic, swelling degree of 30.41±0.079, thickness of 0.22±0.010 mm and degraded for 14±1 days. The results of data analysis using One Sample T-Test produced a p value > 0.05 in the thickness and swelling degree tests, while the biodegradation test produced a p value <0.05 at a 95% confidence level. This study concluded that the addition of 30% glycerol affected the biodegradation time of biodegradable films containing glucomannan and sodium alginate.
Desain, Formulasi dan Karakterisasi Tablet Kristal Multikomponen Sertralin sebagai Antidepresan Muhamad Reza Pahlevi; M. Ramadhan Saputro; Zahra Maharani Fatoni; Agus Sulaeman
Jurnal Farmasi Indonesia Vol 18 No 2 (2026): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v18i2.912

Abstract

Sertraline (BCS class II) has low solubility and dissolution rate. Modifying sertraline through multicomponent crystal formation is a strategy to enhance its physicochemical properties, particularly solubility and dissolution. This study aimed to design, formulate, and characterize sertraline tablets based on multicomponent crystals using L-tryptophan (S–L), saccharin (S–S), and nicotinic acid (S–N) as coformers. The crystals were synthesized by solvent evaporation and characterized using FTIR, DSC, PXRD, SEM, and solubility and dissolution studies, followed by evaluation of tablet properties using direct compression. The multicomponent crystals exhibited FTIR band shifts or broadening of –OH/–NH and C=O groups and new PXRD peaks, indicating the formation of multicomponent crystals. DSC showed distinct thermal transitions: S–L at 258 °C, S–S at 280.8 °C, and S–N at 242 °C. The highest solubility enhancement was observed for S–N (44.29 mg/10 mL, followed by S–L (15.44 mg/10 mL). In 0.1 N HCl medium, 60-minute dissolution reached >88% for S–N, 73% for S–L, 53% for S–S, and 52% for pure sertraline. The best tablet formulation (F6) demonstrated good flow and compressibility (compressibility index 23.55%, angle of repose 28.85°, flow rate 6.53 g/s) and met pharmacopeial criteria: uniform dimensions (8 mm diameter, 5.23 mm thickness), weight (284.22 mg), (friability (0.37%), hardness (6.66 kg/cm2), disintegration (5.47 seconds), and dissolution at pH 4.5 ≥85% in 30 minutes. Multicomponent crystals of sertraline-nicotinic acid are able to increase solubility up to 8.8 fold and can be produced by direct compression method and produce good evaluation of tablet preparations (uniformity of weight, friability, hardness, disintegration time test, and dissolution test) in immediate release tablet formulation.

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