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Jurnal Penyakit Dalam Indonesia
Published by Universitas Indonesia
ISSN : 24068969     EISSN : 25490621     DOI : https://doi.org/10.7454/
Core Subject : Health,
Medicine & Pharmacology
Jurnal Penyakit Dalam Indonesia contains the publication of scientific papers that can fulfill the purpose of publishing this journal, which is to disseminate original articles, case reports, evidence-based case reports, and literature reviews in the field of internal medicine for internal medicine and general practitioners throughout Indonesia. Articles should provide new information, attract interest and be able to broaden practitioners insights in the field of internal medicine, as well as provide alternative solutions to problems, diagnosis, therapy, and prevention.
Arjuna Subject : Kedokteran - Kedokteran Internal
Articles 9 Documents
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Search results for , issue "Vol. 7, No. 3" : 9 Documents clear
Prognosic Factors Related to The Complete Hematologic Response (CHR) in 3 Months in Leukemia Granulositic Patients Administered with Imatinib Mesylate Rinaldi, Ikhwan; Reksodiputro, Arry H.
Jurnal Penyakit Dalam Indonesia Vol. 7, No. 3
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Introduction. The complete hematologic response is an integral part to achieve the complete cytogenetic response target and the major molecular response of imatinib mesylate therapy, although it does not determine the prognosis. The complete hematologic response in Indonesia is lower than in the world (74% vs. 95%). Sixty percent of chronic myeloid leukemia patients in Indonesia were administered hydroxyurea before imatinib mesylate. Chronic myeloid leukaemia (CML) patients in Indonesia are younger than in other countries. This study aimed to determine what prognostic factors which affect the complete hematological response of chronic phase CML patients who received imatinib mesylate in Indonesia. Methods. The study was done by retrospective cohort design using the medical records data of chronic myeloid leukemia patients who were treated at Teratai Clinic and hematology clinic RSCM and received imatinib mesylate therapy from January 2004-December 2011. Results. Most of the study subjects were male (61.5%), aged 26-40 years (47.4%), duration of diagnosis <12 months>(69.2%), duration of hydroxyurea therapy <6 months>(64.1%), hemoglobin concentration <12 g>/dl (69.2%), leukocyte count ≥50,000 (48.7%), platelet count 0 – <450,000 (42.3%), spleen size ≥10 cm (55.1%), low Sokal score (42.3%), and achieve a complete hematologic response within 3 months (57.7%). Duration of hydroxyurea therapy <6 months is prognostic factor higher CHR achievement. Conclusions. Clinical and laboratory characteristics CML patients in Indonesia are different than CML patients in the world. Duration of diagnosis until imatinib mesylate administration <12 months, duration of hydroxyurea administration <6 months, and hemoglobin concentration ≤12 g/dl were associated with the achievement of complete hematological response of chronic CML patients in Indonesia. Duration of hydroxyurea administration <6 months was identified as independent factor of achievement of complete hematological response of chronic CML patients in Indonesia.
Exogenous Cushing Syndrome: When do We Get the Benefit of Glucocorticoid Stress Dose? Soelistijo, Soebagijo Adi; Gunawan, Hendra; Primasatya, Chandra Adi Irawan; Ariana, Audy Meutia; Mudjanarko, Sony Wibisono; Pranoto, Agung
Jurnal Penyakit Dalam Indonesia Vol. 7, No. 3
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Exogenous cushing syndrome is the most common cushing syndrome found in clinical practice. Its most frequent etiology is the adverse effect of glucocorticoid therapy found in clinical practice or in the form of traditional medicine. The clinical manifestations of exogenous cushing syndrome are similar to the spontaneous counterpart, albeit with the presence of glucocorticoid consumption. We present a case series of exogenous cushing syndrome due to traditional medicine and glucocorticoid consumption with opportunistic infection as its initial manifestation. The first case did not need glucocorticoid supplementation while it was initiated in the second case. Comprehensive management of exogenous cushing syndrome should involve the decision of giving glucocorticoid stress dose, treatment to the underlying disease and education in order to prevent self-glucocorticoid consumption.
The Role of Continous Ambulatory Peritoneal Dialysis in Equity of Kidney Replacement Therapy in Indonesia Lydia, Aida
Jurnal Penyakit Dalam Indonesia Vol. 7, No. 3
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With the increasing incidence of chronic kidney disease in Indonesia, an effective, sustainable and widely available kidney replacement therapy (KRT) is needed. PD is one of the available modalities that can meet those criteria. To date, out of the two existing types of PD, only continuous ambulatory peritoneal dialysis (CAPD) is available in our country. Studies showed that residual kidney function is preserved better in CAPD patients compared to HD patients. With the use of CAPD as KRT, patients can do dialysis independently. Hence, it can be solution to the limitations and the difficulty of reaching HD units especially in remote areas. However, due to lack of knowledge or experience of clinicians regarding CAPD, the use of CAPD is scarce in Indonesia. Clinicians can increase their role in kidney services by increasing CAPD utilization. The key to improve CAPD utilization is a good understanding and optimal education about CAPD to patients and their families. This review aims to introduce and remind clinicians of the availability of CAPD besides HD and kidney transplant as one of the available modalities of KRT for patients with ESKD in Indonesia.
Adakah Perubahan Kesintasan Karsinoma Sel Hati di Indonesia? Jasirwan, Chyntia Olivia Maurine
Jurnal Penyakit Dalam Indonesia Vol. 7, No. 3
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The Association between Degree of Diabetic Peripheral Neuropathy with Ankle Brachial Index, Toe Brachial Index, and Transcutaneus Partial Oxygen Pressure in Patients with Type 2 Diabetes Mellitus Asir, Taufik Rizkian; Antono, Dono; Yunir, Em; Shatri, Hamzah
Jurnal Penyakit Dalam Indonesia Vol. 7, No. 3
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Introduction. Diabetic peripheral neuropathy (DPN) in the lower extremity caused by complications of diabetes in the microvascular which can damage nerve in the lower extremity. Then, it is necessary to be aware of the process of aterosclerosis elsewhere, both in the macro and microvascular arteries in the lower extremity. This study was conducted to assess the association of the degree of diabetic peripheral neuropathy assessed by Toronto clinical scoring system (TCSS) with the process of atherosclerosis in the blood vessels of the lower extremity, both macrovascular with ankle brachial index (ABI) and toe brachial index (TBI), as well as microvascular with transcutaneus partial oxygen pressure (TcPO2 ) in patients with type 2 diabetes mellitus. Methods. Cross-sectional study was carried out in patients with type 2 DM with DPN with TCSS values> 5 in the Integrated Cardiac Polyclinic, Endocrine and Metabolic Polyclinic, and Internal Medicine Polyclinics at Cipto Mangunkusumo Hospital. Data were obtained from interviews, medical records, as well as ABI, TBI and, TcPO2 examinations. Bivariate analysis of each variable was performed using Spearman test. Results. Total of 36 subjects who met the selection criteria were included in the study, the average age was 62 years (SD 9.2) with 20 (55.6%) of whom were women and the median duration of diabetes was 12 years. Based on bivariate analysis with the Spearman test, there was a statistically significant negative correlation with moderate correlation coefficient between the degree of diabetic peripheral neuropathy assessed by TCSS with ABI (r = -0.475, p = 0.003) and TBI (r = -0.421, p = 0.010). The TcPO2 examination also found a statistically significant negative correlation with moderate correlation coefficient (r = -0.399, p = 0.016). Conclusion. There is a statistically significant negative correlation between the degree of diabetic peripheral neuropaty with ABI, TBI, and TcPO2 examinations.
The Association between Academic-Induced Stress with An Incident of Dyspepsia on Grade XII Natural Science Majors at 81 Senior High School East Jakarta in 2019 Tamimi, Lamya Hisyam; Herardi, Ryan; Wahyuningsih, Sri
Jurnal Penyakit Dalam Indonesia Vol. 7, No. 3
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Introduction. Dyspepsia is a group of symptoms that are assumed to have it’s source from the upper digestive tract. However, one of the main causes of dyspepsia in adolescent is psychosocial, including stress. Stress in adolescent are commonly academic-induced. This study was aimed to observe the association between the level of academic-induced stress with an incident of dyspepsia, particularly of students who are in grade XII and major in natural sciences. Methods. This cross sectional study was conducted at 81 Senior High School East Jakarta using educational stress scale for adolescents (ESSA) questionnaire dan Short form-Leeds to dyspepsia questionnare (SF-LDQ). It also uses total sampling technique where 88 respondents have participated and then sampled. Bivariate analysis was performed by Chi-square test using the SPSS program. Results. The respondents were 88 students consisted of 41 (46.6%) boys, 47 (53.4%) girls, and were dominated by 17-year-old students (77.3%). Almost all respondents experience mid-to-high level of academic stress that around 64 students (72.7%) and dominated by girls and age 17. It is also shown that around 51 students (58%) have experienced dyspepsia and dominated by girl and age 17. This study also shown that the symptoms that were considered as the most disturbing by respondents that are suffering from dyspepsia were nausea that around 21 (41.2%), followed by indigestion that around 18 (35.3%). The result of bivariate analysis shows that there was a significant association between the level of academic-induced stress with an incident of dyspepsia (p<0.001; OR=7.1 [CI 95% 2.44-20.68]). Conclusion. There is apparently a significant association between academic-induced stress with an incident of dyspepsia on grade XII natural science majors at 81 Senior High School East Jakarta in 2019
Liver Function and Treatment Modalities are Predictors of Survival in Patients with Hepatocellular Carcinoma Hasan, Irsan; Loho, Imelda Maria; Lesmana, Cosmas Rinaldi; Gani, Rino A.
Jurnal Penyakit Dalam Indonesia Vol. 7, No. 3
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Introduction. Hepatocellular carcinoma (HCC) is a major health problem in Indonesia because most patients are diagnosed in late stages when curative treatment is no longer possible. The aim of this study is to evaluate one-year survival rate, prognostic factors, and treatment modalities of patients with hepatocellular carcinoma. Methods. A retrospective analysis was done in patients with HCC who were admitted to Cipto Mangunkusumo General Hospital (CMGH) between January 2013 and March 2014. Clinical parameters and treatment modalities were evaluated. Patients outcome at one-year of follow-up were recorded from medical records or patients were contacted by phone call. Survival curve was produced using Kaplan-Meier method and a multivariate analysis was conducted using Cox proportional hazards model. Results. A total of 114 patients were included in this study. Incidence of mortality was 57% and one-year survival rate was 29.4% with median survival as long as 135 days (approximately 4.5 months). According to the BCLC staging system, patients who were diagnosed as early, intermediate, late, and terminal stages were 2 (1.8%), 48 (42.1%), 32 (28.1%), and 32 (28.1%), respectively. Poor liver function (Child-Pugh C class) was diagnosed in 26.3% of patients. Only two patients were diagnosed during surveillance process. Proportion of patients treated with curative/palliative modalities and best supportive care were 34.2% and 65.8%, respectively. In multivariate analysis, Child-Pugh classification and treatment modalities were significant prognostic factors with p-value of <0,001 for both factors. Conclusion. Liver function and treatment modalities are predictors of survival in patients with HCC.
Factor Related to The Incidence of Ascites in Chronic Kidney Disease Patients Undergoing Hemodialysis at RSUD Dr Moewardi Surakarta: A Cross Sectional Study Yusman, Felizia Alika; Dewi, Ratih Tri Kusuma; Mashuri, Yusuf Ari; Nurhayatun, Evi; Giani, Maia Thalia
Jurnal Penyakit Dalam Indonesia Vol. 7, No. 3
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Introduction. Chronic kidney disease (CKD) is a global health issue with continuously rising prevalence. Fluid overload is a frequent systemic complication which occurs in CKD patients undergoing hemodialysis (HD). One of clinical manifestation of fluid overload in HD patients is ascites. This study aimed to determine the factors related to the incidence of ascites in CKD patients undergoing hemodialysis. Methods. An observational analytic study with a cross-sectional approach was conducted at Dr. Moewardi Hospital, Surakarta from September until October 2019. The subjects were end-stage CKD patients undergoing HD. Subjects were selected by total sampling technique. Data were obtained from medical records tracking. Furthermore, each variable was analyzed using Chi Square and Independent T-test analysis. P value less than 0.05 is considered statistically significant. Results. A total of 116 subjects were recruited in this study. Incidence of ascites was documented in 24 (20.7%) patients. The comorbid of chronic heart failure (CHF) was found in 23 (19.8%) subjects, where this condition was associated with the incidence of ascites [p = 0.003; PR 2.888 (95% CI=1.476–5.650)]. In the subjects with hypoalbuminemia was also related to higher incidence of ascites [p < 0.001; PR 7.800 (95% CI=3.153 – 19.293)]. Meanwhile gender, age, diabetes mellitus, the levels of hemoglobin, ureum, creatinine serum, albumin, hematocrit, and leukocyte were not associated with ascites in CKD patients undergoing HD (p > 0.05). Conclusions. Factors related to the incidence of ascites in patients with chronic kidney disease who have undergone hemodialysis is chronic heart failure and hypoalbuminemia.
Five Year Survival of Active Multiple Myeloma Patients Based on Durie-Salmon and International Myeloma Working Group 2003 Diagnostic Criteria Kurniawati, Sri Agustini; Reksodiputro, Ary Harryanto; Atmakusuma, Tubagus Djumhana
Jurnal Penyakit Dalam Indonesia Vol. 7, No. 3
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Introduction. Survival of active multiple myeloma (MM) patients is determined by early diagnosis and various prognostic factors. The development of MM diagnostic criteria from Durie-Salmon (DS) criteria to International Myeloma Working Group (IMWG) 2003 is an attempt to diagnose active MM earlier. However, due to limited resources, these diagnostic criteria cannot be fulfilled consistently in Indonesia. Based on this reason, it is necessary to know the proportion of MM based on DS and IMWG 2003 diagnostic criteria and also their impact on the survival of MM patients in Indonesia. Methods. This was a retrospective cohort study with survival analysis. Subjects were active MM patients in Cipto Mangunkusumo Hospital and Dharmais Cancer Hospital during 2005-2015. Data were presented in Kaplan-Meier survival curve and table with 95% confidence interval (CI). Results. This study involved 102 active MM patients with complete diagnostic data and survival for more than 1 month. As much as 56.9% of patients met DS diagnostic criteria and 72.5% met IMWG 2003 criteria. Median of overall survival (OS) based on DS criteria (77.8 months) was similar with IMWG 2003 criteria. Overall survival in the first, third, and fifth year of MM patients who met DS criteria were 89.9%, 77.5%, and 54.8%, respectively. Meanwhile overall survival in the first, third, and fifth year of MM patients who met IMWG 2003 criteria were 87.5%, 75.6% and 55.9%, respectively. Conclusions. The proportion of active MM patients who met IMWG 2003 diagnostic criteria was higher than those who met DS criteria. Overall survival of active MM patients who meet DS diagnostic criteria is similar with those who met IMWG 2003 criteria.

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