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Journal of Pharmaceutical and Sciences.
Published by Universitas Tjut Nyak Dhien
ISSN : -     EISSN : 26563088     DOI : https://doi.org/10.36490/journal-jps.com
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 60 Documents
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Search results for , issue "JPS Volume 6 Nomor 4 (2023)" : 60 Documents clear
Analisis kadar natrium benzoat pada tauco yang dipasarkan dipajak kota Kisaran dengan metode spektrofometri ultraviolet Nur’aini Dalimunthe; Yulia Kusumanti; Farida Umamy
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.288

Abstract

Background; One of the preservatives that is permitted for use in food is sodium benzoate.Sodium benzoate is a salt or ester of benzoic acid (C6H5COOH) that is produced commercially through chemical synthesis. Sodium benzoate is also known as sodium benzoate or sodium benzoate. This preservative is a salt of sodium benzoic acid, a polyunsaturated fat that is approved for use by the United States Food and Drug Administration (FDA) and has been used by food and beverage manufacturers for more than 80 years to prevent microbial growth.Sodium benzoate has the molecular formula C7H5NaO2 and molecular weight Appears as odorless or almost odorless white crystalline granules or powder, soluble in 2.8 parts water and 90 parts ethanol (95%). Objective; This research aims to determine the extent of benzoate found in Tauco which is marketed in the Kisaran City Market. Method; The analysis was carried out using a qualitative method with the aim of determining the Tauco benzoate content using the FeCl3 test, esterification test and sublimation test, quantitative methods using UV-Vis spectrophotometry and to determine the sodium benzoate content according to established standards. Absorbance was measured by UV-Vis spectrophotometry at a maximum wavelength of 225 nm. Result;The results showed that the sodium benzoate content was Ten Tauco samples are A= 125.8555 mg/kg, B= 71.1929 mg/kg, C= 98.9557 mg/kg, D= 174.3942 mg/kg and E = 78.9945 mg/kg.. meet The standard requirement for the maximum use limit is 450 mg/kg. Conclusion; The conclusion of this research is that the sodium benzoate content meets the requirements and does not exceed the maximum threshold set by BPOM No. 36 of 2021, namely 450 mg/kg Tauco.
Uji Aktivitas Antipiretik Ekstrak Daun Bidara (Ziziphus Spina Christi L) Terhadap Mencit Jantan (Mus Musculus) Ferdinan Jalung; Mila Febrina Rindayani; Meity Christiani
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.289

Abstract

Background; Indonesia has thousands of types of plants spread across various regions. The existing biodiversity can be used as raw material for modern and traditional medicines. Indonesian people have long known and used traditional medicine to treat various diseases. The increasingly expensive price of modern medicine on the market is one reason to explore the use of traditional medicine again. Many types of medicinal plants in Indonesia have been used as raw materials for medicine, some of these plant species have even been clinically tested for their phytochemical content, efficacy and safety of use. Objectives; To find out that bidara leaf extract (Ziziphus spina-christi L.) has antipyretic activity. Method; This type of research is experimental research.Extraction is carried out to filter out polar compounds so 60% ethanol liquid is used. Results; From the results of research that has been carried out, it was found that the average difference in temperature reduction between time and fever temperature was from 30 minutes to 120 minutes. For doses of 100 mg/30 g, 150 mg/30 g BW of mice, 200mg/30 g BW of mice, NaCMC and Paracetamol at 30 minutes respectively were 0.27, 0.37, 0.44, 0 .04 and 0.8oC. For doses of 100 mg/30 g, 150 mg/30 g BW of mice, 200 mg/30 g BW of mice, NaCMC and Paracetamol at 60 minutes respectively were 0.6, 0.67, 0.94, 0.07 and 1.47oC. For doses of 100 mg/30 g, 150 mg/30 g BW of mice, 200 mg/30 g BW of mice, NaCMC and Paracetamol at 90 minutes respectively were 1.04, 1, 1.24, 0, 07 and 2.1oC. Conclusion; Bidara leaf extract (Ziziphus spina-christi L.) has antipyretic activity in mice. Bidara leaf extract (Ziziphus spina-christi L.) which has antipyretic activity is at a dose of 100 mg, 150 mg and 200 mg/30 grams of body weight for mice.
Uji Aktivitas Antioksidan Ekstrak Bunga Telang (Clitoria ternatea L.) Dengan Metode DPPH (2,2 DIiphenyl 1-1 Pickrylhydrzyl) Yulia Kusumanti; Eldesi Medisa Ilmawati; Usti Fina Hasanah Hasibuan
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.290

Abstract

Background: The current state of Indonesian society in general is concerning. People want to use motorized vehicles to travel instead of walking or cycling. All this leads to an increase in the amount of unfastened radicals inside the body. Antioxidants are needed to overcome the risks of unfastened radicals. Indonesia is very rich in herbal sources consisting of numerous flora, one of which is the telang flower (clitoria ternatea l.) which is thought to have antioxidants. Activity: To determine the antioxidant activity of telang flower (Clitoria ternatea L.) by dpph (2,2-Diphenyl 1-1 Picrylhydrazyl). Method: Antioxidant activity test can be done by using several kinds of methods, namely dpph, abts, etc..Results: Classification of secondary metabolite compounds found in flower telang (Clitoria ternatea L.) includes alkaloids, flavonoids, quinones, saponins, tannins, and steroids with the technique used with the DPPH test. The results of the test sample for the extract of telang flower (Clitoria ternatea L.) have an IC50 of 356.65 ppm and are classified as very weak. The ic50 value assessment of the ethanol extract of telang flower (Clitoria ternatea L.) with methanol as solvent has a value of 95.Conclusion: Assessment of antioxidant activity can be assessed from IC50. The IC50 assessment of the flower telang (Clitoria ternatea L.) has obtained different results, namely the weak and strong IC50. This can be influenced by the maximum wavelength used, as well as the storage temperature of the extract of a plant. In addition, a good solvent, namely methanol, is needed in measuring the IC50 of telang flower (Clitoria ternatea L.) using DPPH.
Profil penyimpanan dan pemeriksaan mutu obat di Puskesmas Mutiara Kisaran Mila Febrina Rindayani; Nur’aini Dalimunthe
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.291

Abstract

Background: Storage of Pharmaceutical Supplies is a regulatory activity for Pharmaceutical Supplies that are received so that they are safe (not lost), protected from physical and chemical damage, and the established requirements maintain their quality. Pharmaceutical preparations are drugs, medicinal materials, traditional medicines, and cosmetics. Objective: To determine the storage and quality inspection of medications at the Mutiara Health Center in Kisaran. Method: This type of research is descriptive observation research. Results: Mutiara Health Center has a separate drug warehouse from the service building. The space inside the drug storage is arranged according to the U flow so that it makes it easier for officers to move. The warehouse clerk's desk is placed near the warehouse exit. It is integrated with the medicine storage room because it is not partitioned, there is no particular workspace for the warehouse, and it has sufficient ventilation. Conclusion: The drug storage system at the Mutiara Health Center in Kisaran warehouse in 2019 is in the excellent category with a percentage value of 85% consisting of 80% spatial arrangement, 80% method of drug storage, 90% stock card recording, and 90% quality observation
Profil Obat Antihipertensi Pada Pasien Hipertensi Dengan Penyakit Ginjal Kronis Oki Nugraha Putra; Fitri Kamilia Krismianti; Ikadona Logos Kaukaba
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.227

Abstract

Hypertension is one of the cardiovascular complications of chronic kidney disease (CKD). Control of blood pressure can prevent the progression of CKD and reduce the risk of cardiovascular complications. Antihypertensive drugs are required to control blood pressure. This study aimed to describe the profile of antihypertensive drug use in hypertensive patients with CKD. It was a retrospective study using medical records of hypertensive patients with CKD at Syarifah Ambami Rato Ebu Hospital, Bangkalan, from January 2019 to August 2021. This study was conducted between November 2021 and February 2022. The profile of antihypertensive drug use is shown descriptively. Forty-two hypertensive patients with CKD who met the inclusion criteria were included in this study, with more than 90% including end-stage kidney disease. Anemia is the most common complication in hypertensive patients with CKD. Loop diuretics (furosemide) and calcium channel blockers (nicardipine, amlodipine) are the most widely used antihypertensive drugs, with percentages of 28%, 25%, and 19%, respectively. The most commonly used antihypertensive combinations were furosemide + nicardipine by 46% and the combination of furosemide + candesartan + nifedipine by 43%. This study concludes that loop diuretics and calcium channel blockers are the most widely used antihypertensive drugs in hypertensive patients with CKD.
Kepatuhan Minum Obat pada Pasien Diabetes Melitus Tipe 2: Profil HbA1c dan Lipid di Klinik Aulia Jombang 2020 Ronald Pratama A.; Cahya Yudha Laksmana Putra; Retno Budiarti; Oki Nugraha Putra; Angelica Kresnamurti; Sulistiawati Sulistiawati
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.230

Abstract

Diabetes Mellitus (DM) is a chronic metabolic disease characterized by high blood sugar levels due to insulin secretion or work defects. Poor treatment adherence leads to uncontrolled glycemic levels and complications. Therefore, ensuring patient adherence to therapy and reducing HbA1c and lipid profiles is essential. This research employs an observational, cross-sectional design, using non-probability purposive sampling to select 55 respondents via the Slovin formula. The study examines medication adherence as the independent variable, Hba1c levels, and lipid profile as the dependent variables. Data analysis involves SPSS, utilizing univariate and bivariate methods for ordinal and nominal scales. MMAS-8 questionnaire assesses the knowledge, while data comes from questionnaires and medical records of type 2 DM patients at Aulia Jombang Clinic. Study findings showed notable adherence to treatment, with 38 respondents (60.9%) complying and 17 (30.1%) not. Chi-square tests yielded significance, p values: HbA1c 0.012, LDL 0.035, total cholesterol 0.008, triacylglycerides 0.011, and HDL 0.002, based on MMAS-8 questionnaire data. In conclusion, the results indicate statistical significance (p-value < 0,05), so there is a positive correlation coefficient, indicating that higher levels of treatment adherence are associated with more optimal HbA1c control and lipid profiles.
Efektivitas antibakteri ekstrak etanol daun bisbul (Diospyros discolor Willd) terhadap bakteri Propionibacterium acnes Nanda Nadia; D. Elysa Putri Mambang; M. Pandapotan Nasution; Yayuk Putri Rahayu
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.240

Abstract

The bisbul plant (Dyospiros discolor Willd) is a plant whose fruit is often consumed by the public. Bisbul leaves are known to have antibacterial and antifungal activity. The purpose of this study was to determine whether the ethanol extract of bisbul leaves (Diospyros discolor Willd) has antibacterial effectiveness against Propionibacterium acnes bacteria. This research was conducted using experimental methods which included sample collection, macroscopic examination, microscopic examination, simplex preparation, characteristic examination, phytochemical screening, preparation of ethanol extract, and testing of antibacterial effectiveness against Propionibacterium acnes bacteria using the agar diffusion method. The results of the macroscopic examination conducted on the bisbul leaf simplex were brownish-green leaves, flat edges, 5 cm long leaves, 4 cm wide leaves, had a distinctive odor and a slightly bitter taste. The simplex characteristic results obtained water content of 4%, water-soluble essence content of 21%, 23% ethanol-soluble extract content, 4.8% total ash content and 0.3% acid-insoluble ash content. Phytochemical screening of simplex powder and ethanol extract of bisbul leaves showed the presence of alkaloids, tannins, flavonoids, steroids/triterpenoids, saponins and glycosides. The results of the antibacterial effectiveness test of the ethanol extract of bisbul leaves showed that the diameter of the inhibition zone was larger at a concentration of 80%, namely 15.98 mm, compared to concentrations of 70% and 60%, namely 15.43 mm and 14.18 mm. From the results of the study it can be concluded that the ethanol extract of bisbul leaves can provide antibacterial effectiveness against Propionibacterium acnes bacteria.
Skrining fitokimia dan uji aktivitas antibakteri ekstrak etanol daun kayu Jawa ((Lannea coromandelica) (Houtt) Merr terhadap bakteri Propionibacterium acnes dan Staphylococcus epidermidis Munaziatul Jannah; Haris Munandar Nasution; M. Pandapotan Nasution; Yayuk Putri Rahayu
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.241

Abstract

Jawa wood (Lannea coromandelica) (Houtt.) Merr. is a tropical plant that has potential as a medicinal plant. Almost all parts of this plant can be used in traditional medicine. This wild plant can be found easily in various locations such as home gardens, roadsides and community gardens. This study aims to evaluate the potential antibacterial activity of ethanol extract from the leaves of Kayu Jawa (Lannea coromandelica) (Houtt.) Merr. Against the growth of Propionibacterium acnes and Staphylococcus epidermidis bacteria. This research used experimental methods involving sample collection, macroscopic examination, microscopic examination, simplicia making, characteristic examination, Phytochemical Screening, and Antibacterial Activity Test using ethanol extract from Kayu Jawa ((Lannea coromandelica) (Houtt) Merr) against the bacteria Propionibacterium acnes and Staphylococcus epidermidis, using the agar diffusion method. Macroscopic examination results show that the leaves of Kayu Jawa have a tapered shape with a total of 7-11 strands. The flowers produced are single and yellowish-green in color, while the fruit has seeds of a certain length. Microscopic examination reveals the upper epidermis, palisade fragments, coral flowers, and wooden vessels with thickened spirals and stairs. The characteristics of simplicia show a water content of 4%, soluble essence content in water 21%, soluble essence content in ethanol 23%, total ash content of 4.8%, and insoluble ash content of 0.4% acid. The results of phytochemical screening on simplicia powder and ethanol extract of Kayu Jawa leaves showed contents such as alkaloids, tannins, flavonoids, steroids/triterpenoids, saponins and glycosides. The antibacterial activity test showed that Jawa wood showed potential as an antibacterial agent, with different inhibitory abilities depending on the concentration used. At a concentration of 20%, an inhibition zone of 6.85 mm was observed against Propionibacterium acnes and 5.75 mm against Staphylococcus epidermidis. Meanwhile, at a concentration of 80%, the area of inhibition increased to 14.15 mm against Propionibacterium acnes and 11.75 mm against Staphylococcus epidermidis.
Pengaruh Ekstrak etil Asetat dari Daun Sisik Naga (Pyrrosia piloselloides (L) Presl) terhadap Staphylococcus aureus Arfiandi Arfiandi; Neri Fadjria; Dewi Nofita; Putri Nandinanti
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.255

Abstract

The primary focus of this study revolves around the microbiological assessment of the effectiveness of ethyl acetate extract derived from Dragon's Scales Leaf (Pyrrosia piloselloides (L)) against Staphylococcus aureus. The employed method entailed the use of the diffusion technique with paper discs. The ethyl acetate extract of Dragon's Scales Leaf was formulated in three distinct concentrations, namely 40%, 60%, and 80%. In addition, Gentamicin at a 1% concentration served as the positive control. The measurements yielded inhibitory zone diameters of 14.05 mm, 15.49 mm, 14.90 mm, and 14.81 mm for the ethyl acetate extract and Gentamicin, respectively. This investigation's observed inhibitory zone diameters fall within the 'weak' category, with the highest extract concentration displaying a strength equivalent to Gentamicin as the positive control. In light of these findings, it can be concluded that the ethyl acetate extract of Dragon's Scales Leaf (Pyrrosia piloselloides (L)) can impede the growth of Staphylococcus aureus bacteria.
Uji sitotoksisitas ekstrak etanol daun sirih cina (Peperomia pellucida [L.] Kunth) dengan metode brine Shrimp lethality test Fadhlah Al-Uyun Nasution; Ridwanto Ridwanto; Zulmai Rani
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.260

Abstract

The degree of harm a drug inflicts on cells, for instance, cancer cells, is known as its cytotoxicity. Cytotoxic substances can stop cancer cell proliferation, making anticancer medications possible. Plant extracts or active chemicals derived from plants can be used as herbal plants' anticancer agents. Among these is Chinese betel, a plant with numerous health benefits despite being frequently regarded as a weed. This study looked at the LC50 value using the BSLT method to identify the type of secondary metabolite chemicals and the cytotoxicity of Chinese betel leaf ethanol extract. This study looks at the number of Artemia salina deaths to characterise, screen for phytochemicals, and determine the cytotoxicity of Chinese betel leaves using the BSLT method- leaf larvae with LC50 values expressed. In the phytochemical screening test, Chinese betel leaves exhibited positive results for saponin, flavonoid, alkaloid, tannins, and steroids. The findings of the cytotoxicity test utilising probit analysis demonstrated that the ethanol extract of Chinese betel leaves is poisonous and may have anticancer properties, with an LC50 value of 335.7376 µg/mL.

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