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Journal of Pharmaceutical and Sciences.
Published by Universitas Tjut Nyak Dhien
ISSN : -     EISSN : 26563088     DOI : https://doi.org/10.36490/journal-jps.com
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 21 Documents
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Search results for , issue "JPS Volume 9 Nomor 1 (2026)" : 21 Documents clear
The Literature review: Investigasi Perbandingan Antioksidan pada Tanaman Obat Herbal di Pulau Jawa dengan Spektrofotometri UV-Vis dan Metode DPPH (2,2-difenil-1-pikrilhidrazil) Sebayang , Madame Marselly; Mierza , Vriezka
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.554

Abstract

Due to environmental changes and pollution due to free radicals, interest in alternative medicine is increasing, especially on the island of Java. Natural health solutions are increasingly needed, which is what prompted this research. We measured the concentration of antioxidant compounds using the UV-Vis spectrophotometric method and the free radical scavenging capacity of plant extracts using the DPPH method. Using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) and UV-Vis spectrophotometric methods with IC50 value determination, this article aims to investigate and compare potential herbal plants found on the island of Java. This research was carried out using a literature review method by considering inclusion and exclusion criteria with keywords such as antioxidants, herbal medicinal plants, UV-Vis spectrophotometry, and DPPH method. The results showed that the plant species studied had different antioxidant activities. Some herbs have high levels of antioxidants, so they may be used as natural health supplements. Additionally, this study emphasizes how important it is to use accurate analytical methods to evaluate antioxidant content. To provide a comprehensive picture of the antioxidant potential of each plant, UV-Vis spectrophotometry and DPPH methods work together. The results show that this study identified several herbal plants on the island of Java that have high levels of antioxidants. These plants can be used to develop herbal-based health products. To carry out a comparative evaluation of antioxidant content, the UV-Vis and DPPH spectrophotometric methods were proven to be effective. This discovery can be the basis for further research and development of more effective and useful herbal health products.
Studi Pemberian Diuretik Pada Pasien Sirosis Hepatik Dengan Komplikasi Asites di RSUD dr. Iskak Tulungagung. Annastasya P.D. , Agies; Puspitasari, Alvina Arum; Hasmono , Didik; Muzayyanah , Binti
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.741

Abstract

According to the World Health Organization (WHO), cirrhosis is a structural change of the liver from normal to abnormal, characterized by fibrosis. Ascites is the most common complication in liver cirrhosis patients with the primary trigger (75%) is portal hypertension. The treatment focuses on removing the fluid from the peritoneal cavity. This study aim to understanding the pattern of diuretic use as ascites therapy in patients with cirrhosis hepatic. An observational study with a retrospective and descriptive approach using total sampling method in patients diagnosed with cirrhosis and ascites who received diuretics at Dr Iskak Tulungagung general hospital during January-December 2022 were conducted. The tools used in this study include medical records, data collection sheets, clinical data sheets, and laboratory data. Among 62 patients, 16 (26%) received spironolactone monotherapy, 9 (14%) furosemide monotherapy, 21 (34%) combination therapy, and 16 (26%) underwent switching between regimens. Spironolactone, particularly at 100 mg orally once daily, either alone or in combination with furosemide (40 mg intravenously once daily), was the most frequently prescribed diuretic regimen. These findings indicate that the therapeutic approach applied in clinical practice has generally followed the AASLD guideline recommendations.
Identifikasi Senyawa Aktif dalam Daun Dadap Serep (Erythrina subumbrans (Hassk.) Merr) dan Potensinya sebagai Antioksidan Nauval, Lailatul Azizah Okta; Wijayatri , Ratna; Oktaviyani , Tiwi
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1164

Abstract

Background: Erythrina subumbrans (Hassk.) Merr, locally known as dadap serep, is a medicinal plant traditionally used to treat various ailments, suggesting the presence of bioactive compounds. Scientific exploration of its phytochemical profile and antioxidant potential, however, remains limited compared to other species in the genus. Objective: This study aimed to (1) identify the bioactive compound groups in the 70% ethanol extract of Erythrina subumbrans leaves through phytochemical screening and Thin Layer Chromatography (TLC), and (2) evaluate its antioxidant activity quantitatively using the DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging method. Methods: The leaves were extracted via maceration using 70% ethanol. The extract was subjected to standard phytochemical screening tests for flavonoids, alkaloids, saponins, and tannins. Flavonoid profiling was performed using TLC with a quercetin standard. Antioxidant activity was assessed by the DPPH method, with vitamin C as a reference standard, and the IC₅₀ value was determined. Results: Phytochemical screening confirmed the presence of flavonoids, alkaloids, saponins, and tannins. TLC analysis indicated the presence of flavonoid compounds, with one major spot showing an Rf value similar to the quercetin standard. The DPPH assay revealed that the extract possesses strong antioxidant activity, with an IC₅₀ value of 49.94 ppm. According to established antioxidant strength criteria, this IC₅₀ value is categorized as very strong.Conclusion: The 70% ethanol extract of Erythrina subumbrans leaves contains diverse bioactive compounds, particularly flavonoids, and exhibits very strong antioxidant activity. These findings scientifically support its traditional use and highlight its potential as a promising source of natural antioxidants for further pharmaceutical or nutraceutical development.
Formulasi Dan Uji Aktivitas Antibakteri Gel Ekstrak Etanol Daun Brotowali (Tinospora cordifolia (Willd.) Miers) Terhadap Bakteri Pada Ulkus Diabetikum Meutia , Rena; Valerie , Monica; Safriani , Riri; Aiman , Hanifa Rifdah; Fachrunniza , Yunda; Fadhilah , Dhea Nur; Ratmelya , Dara Sukma; Sabrina , Nur Irhamni; Meila , Okpri
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1167

Abstract

Diabetic ulcers are a chronic complication of Diabetes Mellitus, which occurs due to uncontrolled blood glucose levels. Patients with a history of Diabetes Mellitus are susceptible to wounds, especially on the feet, and are difficult to heal, leading to infection. Bacteria identified as causing infection in diabetic ulcers include gram-positive bacteria such as Staphylococcus aureus and Staphylococcus epidermidis. The purpose of this study was to determine the antibacterial activity of Tinospora cordifolia (Willd.) Miers leaf gel against Staphylococcus aureus bacteria, which are the bacteria that cause infections in diabetic ulcers. The method used was to measure the area of ​​the inhibition zone formed on NA media that had grown bacteria, using the well method, then added the gel preparation of Tinospora cordifolia leaf extract with each concentration of 10%, 20% and 30%. Previously, the gel preparation had been evaluated by several tests such as organoleptic tests, homogeneity, adhesiveness, spreadability and pH. The results of the study obtained antibacterial activity testing at each concentration have antibacterial activity with each category being moderate and very strong. The very strong category was obtained at a concentration of 30% with an average inhibition zone obtained 15,64 mm, while at a concentration of 10%, 20% were included in the moderate category with a concentration obtained 9,75, and 10,28 mm. The conclusion of this study is that the gel of brotowali leaf extract (Tinospora cordifolia (Willd.) has antibacterial activity against one of the bacteria that causes diabetic ulcer infections, namely Staphylococcus epidermidis.
Efek protektif ekstrak etanol Bidens pilosa L. terhadap sistem imun tubuh berdasarkan histologis limpa Rattus norvegicus yang diinduksi alkohol Marpaung, Mieky Grasiaella; Silitonga, Melva
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1183

Abstract

This study aims to determine the protective activity of Bidens pilosa L. leaf ethanol extract (EEDK) on the immune system based on the white pulp diameter, and histopathology of the spleen of white rats given alcohol. The study was conducted experimentally using a completely randomized design (CRD), with treatments divided into 5 groups: negative control (K-) without EEDK or alcohol administration, positive control (K+) administered 10 ml/kg body weight of alcohol, treatment 1 (P1) administered 250 mg/kg body weight of EEDK and 10 ml/kg body weight of alcohol, treatment 2 (P2) given 500 mg/kgbb EEDK and 10 ml/kgbb alcohol, and treatment 3 (P3) given 750 mg/kgbb EEDK and 10 ml/kgbb alcohol. EEDK was administered 1 hour after alcohol administration and was given orally every day for 43 days. The parameters observed in this study were diameter of the white pulp, and histopathology of the white rat spleen. The observation data were analyzed using one-way ANOVA and followed by a post hoc test with the DMRT test to see the differences between treatments. The results showed that the ethanol extract Bidens pilosa L. potential as an immunomodulator by increasing the diameter of the white pulp of the spleen, and had a significant effect on spleen histology by showing protective activity with a decrease in the level of spleen tissue damage due to alcohol, particularly tissue fibrosis, lymphocyte apoptosis, and necrosis (p£0.05).
Eksplorasi Efek Hidrasi Lotion Yang Diperkaya Dengan Ekstrak Clitoria Ternatea Pada Kulit Mus Musculus Yang Terpapar Sinar UV Prabowo, Cheryl; Pribadi , Florence; Mellyanawati, Mellyanawati
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1218

Abstract

This study aimed to evaluate the effectiveness of a lotion enriched with butterfly pea flower extract (Clitoria ternatea) in improving skin hydration in mice (Mus musculus) exposed to ultraviolet (UV) light. Butterfly pea flower extract is known to contain anthocyanins and phenolic compounds, which act as antioxidants and are thought to maintain skin moisture. The study design used an experimental method. Mice were randomly allocated into five groups (n = 6 per group), consisting of a negative control group, a positive control group, and three treatment groups receiving butterfly pea flower extract lotion at concentrations of 0.5%, 1%, and 2%.  Skin hydration levels were measured using a Scalar Moisture Checker after five minutes of UV exposure. The results showed a significant difference in hydration levels between groups. The 1% butterfly pea flower extract lotion showed a significant increase in skin hydration compared to the negative control (p < 0.05), indicating its optimal moisturizing efficacy among the tested formulations. These findings indicate that butterfly pea flower extract has potential as an active ingredient in lotion formulations to improve hydration in skin damaged by UV light exposure. This study provides a scientific basis for the use of butterfly pea flower extract as a natural moisturizing agent.
Formulasi Tablet Effervescent Ekstrak Daun Kelor (Moringa oleifera L.) sebagai Pemenuhan Nutrisi untuk Pencegahan Stunting Zola, Elpa Giovana; Syafitri , Eka; Rahmadevi , Rahmadevi; Agustina , Dea Ayu
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1239

Abstract

Stunting remains a significant nutritional problem in Indonesia, requiring practical and acceptable nutritional interventions. Moringa oleifera L. leaves are known to contain essential minerals such as zinc, iron, and iodine, which play an important role in supporting optimal growth. This study aimed to formulate effervescent tablets of Moringa leaf extract and evaluate their physical quality as an alternative nutritional supplement for stunting prevention. Moringa leaf extract was obtained through maceration and formulated into four effervescent tablet formulas with varying extract concentrations. The evaluations included granule flow properties, angle of repose, pH, size uniformity, weight uniformity, dispersion time, FTIR analysis, and hedonic testing. The results showed that all formulas met the physical quality requirements of effervescent tablets. The granules exhibited good flow characteristics with an angle of repose below 40°, while the tablet pH values ranged from 4,4 -5,8, indicating suitability for oral administration. All formulas complied with the standards for size and weight uniformity, and the dispersion time ranged from 1 to 2 minutes. FTIR analysis confirmed the presence of hydroxyl, carbonyl, nitroso, and benzene functional groups associated with flavonoids, saponins, and tannins, which contribute beneficial mineral content. Based on physical and organoleptic evaluations, Formula 2 showed the best combination of extract content and granule flow properties, while Formula 1 was the most preferred in terms of taste.
Aktivitas Antimikobakteri serta Penentuan MIC–MBC Ekstrak Etanol Daun Clerodendrum minahassae terhadap Mycobacterium smegmatis Palandi, Reky Royke; Lengkey , Yessie K.; Maarisit , Wilmar; Sumangando , Adolfina; Potalangi , Nerny A.; Karauwan , Ferdy A.; Tulandi , Selvana S.; Untu , Sonny D.; Pareta , Douglas N
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1242

Abstract

Tuberculosis remains a major global health challenge, particularly due to the increasing emergence of drug-resistant strains, highlighting the need for new antimycobacterial agents from natural sources. Clerodendrum minahassae, a medicinal plant traditionally used in North Sulawesi, has demonstrated antibacterial activity; however, its antimycobacterial potential has not been previously explored. This study aimed to evaluate the antimycobacterial activity of the ethanolic leaf extract of C. minahassae against Mycobacterium smegmatis as a surrogate model and to estimate its minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). The extract was tested at concentrations of 5, 7.5, and 10 µg/disc using the disc diffusion method. Inhibition zone diameters increased in a concentration-dependent manner, ranging from 9.40 ± 0.52 mm to 10.60 ± 0.92 mm. Quantitative analysis using Bloomfield-based linear regression revealed a strong dose–response relationship (R² = 0.9926), from which MIC and MBC values of 0.63 µg/disc and 2.52 µg/disc were estimated, respectively. These findings indicate that the ethanolic extract of C. minahassae exhibits measurable inhibitory and bactericidal activity against M. smegmatis at relatively low concentrations. While this study represents an exploratory screening, the results support the potential of C. minahassae as a source of bioactive compounds with antimycobacterial relevance. Further investigations involving fractionation, compound identification, toxicity assessment, and validation against pathogenic Mycobacterium tuberculosis strains are warranted.  
Analisis Efektivitas Nanocurcumin Terhadap Ekspresi TNF-α Dan Diameter Lesi Pada Mencit (Mus musculus) Yang Diinduksi Endometriosis Dharma, Komang Ayu Vanessa; Pribadi , Florence; Kusumah , Irwin Priyatna
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1249

Abstract

Endometriosis is a chronic gynecological disease characterized by the growth of endometrial-like tissue outside the uterus, which triggers local inflammation and lesion progression. The pathological process involves increased proinflammatory cytokines, including TNF-α, and activation of proliferative and angiogenic pathways. Nanocurcumin, with higher bioavailability compared to conventional curcumin, is known to have the potential to modulate inflammation and inhibit ectopic tissue growth. This study aimed to analyze the effect of nanocurcumin at a dose of 10 mg/kgBW on TNF-α expression and endometriosis lesion diameter in endometriosis-induced mice. The laboratory experimental study used a post-test only control group design with three treatment groups (control, nanocurcumin after induction, and nanocurcumin before induction), each consisting of 10 mice. TNF-α expression was measured using the ELISA method, while lesion diameter was assessed macroscopically. Data analysis was performed using the Shapiro–Wilk normality test, Levene's homogeneity test, ANOVA, and Tukey's extended test. The results showed no significant difference in TNF-α levels between groups (p = 0.933). However, there was a significant difference in endometriosis lesion diameter (p < 0.001), with the nanocurcumin group showing the greatest lesion shrinkage compared to the control and other treatment groups. Nanocurcumin significantly reduced the diameter of endometriosis lesions in mice, although it did not significantly reduce serum TNF-α levels. These findings suggest that the therapeutic effects of nanocurcumin may be mediated through local mechanisms that are not fully reflected in serum biomarkers.
Aktivitas Antibakteri Ekstrak Etanol dan Dekokta Daun Jambu Kristal (Psidium guajava L. Cultivar Kristal) Terhadap Bakteri Escherichia coli dan Shigella sonnei Wardhani, Agviolisa Kusuma; Munawaroh , Rima
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1253

Abstract

Crystal guava leaves (Psidium guajava L. Cultivar Kristal) are plants that have potential as antibacterial agents against bacteria that cause diarrhea because they belong to the Psidium guajava L. species, which is widely reported to contain bioactive compounds such as flavonoids, tannins, and alkaloids. This study was conducted to determine the antibacterial activity of crystal guava leaves and the group of compounds that act as antibacterial agents. The study design was experimental, using ethanol extracts and decoctions of crystal guava leaves made at concentrations of 40% w/v, 20% w/v, 10% w/v, and 5% w/v and tested on bacteria that cause diarrhea, namely Escherichia coli and Shigella sonnei, using the well diffusion method. Then, TLC-Bioautography was performed to detect the compound components. Statistical data analysis using SPSS began with normality, homogeneity, Kruskal-Wallis, and Mann-Whitney tests. The results showed that the 40% w/v concentration had the largest inhibition zone in both extracts. The compounds contained in the ethanol extract and crystal guava leaf decoction were flavonoids, alkaloids, and tannins. Meanwhile, the specific compound that acts as an antibacterial agent in ethanol extracts and crystal guava leaf decoction is the flavonoid group, specifically quercetin. The Kruskal-Wallis test with a p-value of 0,001 < 0,005 showed that there was a significant difference between concentrations. Further analysis using the Mann-Whitney test showed that the 40% concentration group was significantly different from the 5% concentration group.

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