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Journal of Pharmaceutical and Sciences.
Published by Universitas Tjut Nyak Dhien
ISSN : -     EISSN : 26563088     DOI : https://doi.org/10.36490/journal-jps.com
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 26 Documents
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Search results for , issue "JPS Volume 9 Nomor 2 (2026)" : 26 Documents clear
Efek Nefroprotektif Ekstrak Bunga Telang (Clitoria ternatea L.) Pada Tikus Model Nefrotoksisitas: Analisis Biokimia, Histopatologi, Antioksidan, dan Sitokin Lubis, Asyrun Alkhairi; Sembiring, Novitaria Br; Razoki, Razoki; Siregar, Citra Alvia Nazmi; Kaban, Ade Yasmin; Pandiangan, Qori Tari Jelitta; Sitanggang, Kristia Andini
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1444

Abstract

Background: Butterfly pea flower (Clitoria ternatea L.) is rich in antioxidants and bioactive compounds that may protect the kidney from nephrotoxic injury. Objective: This study aimed to evaluate the nephroprotective effect of ethanolic extract of butterfly pea flower in gentamicin-induced rats. Methods: This in vivo experimental study used 30 male Wistar rats divided into five groups: normal control, negative control, and three treatment groups receiving butterfly pea flower extract at doses of 100, 200, and 400 mg/kgBW. The extract was administered orally, while gentamicin 100 mg/kgBW was given intraperitoneally. Parameters observed included BUN, urea, IL-6, TNF-α, renal morphology, kidney weight, and histopathology. Results: Gentamicin increased BUN, urea, IL-6, and TNF-α levels and caused histopathological damage and morphological changes in the kidney. Administration of butterfly pea flower extract reduced inflammatory response, improved histopathology, and restored renal morphology and kidney weight toward normal. The best histopathological improvement was observed at 200 mg/kgBW, whereas the strongest anti-inflammatory effect was found at 400 mg/kgBW. Conclusion: Ethanolic extract of butterfly pea flower has potential as a nephroprotective agent against gentamicin-induced nephrotoxicity.  
Studi In Vitro : Aktivitas Antijamur Kulit Buah dan Daun Coffea canephora Terhadap Candida albicans Widianingsih , Mastuti; Aini , Yesi Afrida
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1456

Abstract

Candida albicans is a major cause of invasive candidiasis with high morbidity and mortality rates, and it has shown increasing resistance to antifungal agents. The objective of this research to evaluate the antifungal activity of Coffea canephora peel and leaf extract against Candida albicans in vitro by determining the Minimum Inhibitory Concentration (MIC). Robusta coffee peel and leaves were extracted using maceration with 96% ethanol, followed by phytochemical screening and antifungal activity testing using the broth dilution method. Phytochemical screening revealed the presence of alkaloids, phenolic-tannins, flavonoids, saponins, and terpenoids, while steroid were not detected. Based on the antifungal activity test conducted separately, both extracts had the same MIC value at a concentration of 12,5%. Statistical analysis using One Way ANOVA demonstrated a significant difference among treatment groups (p<0,05). The antifungal activity of the extract is presumed to be associated with phenolic compounds, such as chlorogenic acid and caffeine, which may act through disruption of cell membrane integrity and inhibition of ergosterol synthesis. These finding suggest that Coffea canephora peel and leaf extract has the potential to be further developed as an antifungal agent, especially in topical formulations, but further toxicity tests and in vivo tests are required.
Analisis Kadar Albumin dan Profil Protein Ikan Toman (Channa Micropeltes) dari Kalimantan Selatan Kusumadewi, Nia; Warasky, Nafach Olya; Padjrin , M. Awaluddin; Andika, Andika
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1482

Abstract

Toman fish (Channa micropeltes) is a freshwater fish widely found in Kalimantan and known for its high nutritional value, particularly its albumin and omega-3 fatty acid content. However, studies regarding the metabolite profile and albumin levels of this species are still limited compared with other snakehead fish species. This study aimed to analyze the protein profile and determine the albumin levels of toman fish collected from three regions in South Kalimantan, namely Barito Kuala, Banjarmasin, and Banjarbaru. Albumin extraction was carried out using the Ultrasonic-Assisted Extraction (UAE) method. Qualitative characterization of protein functional groups was performed using ATR-FTIR spectroscopy in the range of 4000–400 cm⁻¹, while quantitative determination of albumin levels was conducted using UV–Vis spectrophotometry at a wavelength of 642 nm with bromocresol green (BCG) reagent. The results showed that the highest albumin level was obtained from Banjarmasin samples (0.560 ± 0.0343 %w/w), followed by Barito Kuala (0.542 ± 0.0416 %w/w), whereas the lowest level was observed in Banjarbaru samples (0.431 ± 0.0261 %w/w). ATR-FTIR analysis confirmed the presence of albumin in all samples through the identification of characteristic amide I (~1650 cm⁻¹) and amide II (~1550 cm⁻¹) absorption bands. Statistical analysis indicated that differences in albumin levels among sampling locations were not statistically significant (p > 0.05), although numerical variations were observed and may be associated with environmental and habitat conditions. Overall, the combination of UV–Vis spectrophotometry and ATR-FTIR proved effective for the characterization and determination of albumin in Channa micropeltes.
Determinan Perilaku Kepatuhan Minum Obat pada Pasien Hipertensi Usia Produktif di Pelayanan Kesehatan Primer: Scoping Review Kusniawati, Kusniawati; Herawati, Herawati; Sanyoto, Didik Dwi; Illiandri, Oski; Arifin, Syamsul
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1483

Abstract

Background: Hypertension is a major global health problem and a leading risk factor for cardiovascular disease. Although effective antihypertensive medications are widely available, poor medication adherence remains a significant challenge in achieving optimal blood pressure control, particularly among productive-age patients. Objective: This scoping review aimed to identify and synthesize evidence on the determinants of medication adherence among productive-age hypertensive patients (aged 18–59 years) in primary care settings. Methods: The review followed the Joanna Briggs Institute (JBI) framework and the PRISMA Extension for Scoping Reviews (PRISMA-ScR) guidelines. A comprehensive literature search was conducted in PubMed, Scopus, ScienceDirect, and Google Scholar for articles published between 2016 and 2026. Studies involving productive-age participants (18–59 years) that examined determinants of adherence to antihypertensive medication were included. Results: A total of 14 studies met the inclusion criteria. The findings revealed that medication adherence among productive-age hypertensive patients was influenced by multiple factors, including sociodemographic characteristics (age, education, economic status), self-efficacy, health literacy, treatment-related factors (regimen complexity, side effects), healthcare system support (effective communication, counseling), social support, and digital health interventions (mobile applications, electronic reminders). Conclusion: Medication adherence among productive-age hypertensive patients is a multidimensional behavior. Comprehensive, integrated strategies are required, including patient education, enhancing self-efficacy and health literacy, simplifying treatment regimens, strengthening communication with healthcare providers, and using technology-based interventions to improve long-term adherence and blood pressure control.
Fitokimia Rosemari (Rosmarinus officinalis) untuk Mencegah Degradasi Kolagen dan Pembentukan Kerutan: sebuah Tinjauan Pustaka Parimartha , Nyoman Ledy Trisna; Laksemi , Dewa Ayu Agus Sri
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1486

Abstract

of the most visible manifestations. Aging disrupt the balance between collagen synthesis and degradation, leading to fragmentation of collagen fibers and loss of skin elasticity. Natural phytochemicals have gained increasing attention as potential agents for preventing or delaying skin aging due to their antioxidant and anti-inflammatory properties. Rosemary (Rosmarinus officinalis) contains a variety of bioactive compounds with potential dermatological benefits. Major phytochemicals identified in rosemary include phenolic acids such as rosmarinic acid, diterpenes such as carnosic acid and carnosol, as well as flavonoids and volatile terpenoids. These compounds have demonstrated strong antioxidant activity and the ability to modulate molecular pathways associated with skin aging. Evidence from in vitro studies suggests that rosemary phytochemicals can reduce reactive oxygen species (ROS) production, suppress inflammatory signaling pathways, and inhibit the expression of MMPs involved in collagen degradation. Emerging clinical evidence, particularly from oral supplementation studies, also suggests improvements in skin elasticity, wrinkle depth, and oxidative stress biomarkers, supporting the translational potential of rosemary phytochemicals in human skin. Available evidence supports the potential application of rosemary-derived compounds in dermatological and cosmeceutical formulations aimed at preventing collagen degradation and wrinkle formation. This literature review summarizes current evidence on the phytochemical composition of rosemary and the molecular mechanisms through which its bioactive compounds may contribute to the prevention of skin aging.
Formulasi Dan Aktivitas Antioksidan Sirup Air Kelapa Tua (Cocos nucifera L) Dan Ekstrak Buah Merah (Pandanus conoideus L) Dengan Metode DPPH Ahmad, Siti Mun Muhliza; Astuti, Ratih Arum; Muslihin, A.M.
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1496

Abstract

Background: Mature coconut water (Cocos nucifera L.) has the potential as a health drink but is often discarded as waste. Red fruit (Pandanus conoideus L.) is an endemic plant of Papua that is rich in antioxidants. The combination of both is expected to produce a beneficial herbal syrup preparation. Objective: To formulate a combination syrup of mature coconut water and red fruit extract and to determine its antioxidant activity using the DPPH method. Methods: Red fruit extract was obtained by maceration using 96% ethanol. Phytochemical screening was performed on both ingredients. The syrup was prepared with the addition of sugar, citric acid, vanilla, and CMC. Physical evaluation included organoleptic, homogeneity, pH, viscosity, and clarity tests. Antioxidant activity was tested using the DPPH method at a wavelength of 517 nm using a UV-Vis spectrophotometer. Results: Phytochemical screening showed that mature coconut water contains alkaloids, while red fruit extract contains flavonoids, tannins, saponins, and alkaloids. The syrup evaluation met SNI requirements: organoleptic (reddish-orange color, characteristic odor, sweet taste), homogeneous, pH 5–6, viscosity 250 mPa·s, and clear. The IC50 values of the syrup in three consecutive replicates were 550.34 μg/mL, 2282.3 μg/mL, and 2863.4 μg/mL, which are classified as weak antioxidant activity (IC50 > 200 ppm). Conclusion: The combination syrup of mature coconut water and red fruit extract exhibits weak antioxidant activity but meets the physical quality standards of the preparation. This preparation has the potential to be developed as a herbal health drink.
Efek Terapi Adjuvan Gel Kolagen terhadap Kadar Matriks Metaloproteinase-8 Saliva pada Gingivitis Pasca Scaling Root Planing Fitri, Haria; Kasuma , Nila; Hardisman, Hardisman; Ali , Hirowati
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1500

Abstract

Gingivitis is a reversible inflammatory condition of the gingival tissue without attachment loss, primarily caused by plaque accumulation, which can trigger an immune response. Matrix metalloproteinase-8 (MMP-8) is an enzyme that contributes to collagen degradation. Scaling and root planing (SRP) is the standard therapy; however, it may induce a transient inflammatory response and result in suboptimal tissue regeneration, thereby necessitating adjunctive therapy. This study aimed to evaluate the effect of adjunctive collagen gel therapy on salivary matrix metalloproteinase-8 levels in gingivitis. This experimental study employed a pre- and post-test control group design involving 50 subjects divided into five groups: healthy control, gingivitis treated with SRP, and gingivitis treated with SRP combined with 1%, 2%, and 4% collagen gel. Salivary MMP-8 levels were measured to assess the inflammatory response. Statistical analysis revealed that collagen gel at concentrations of 1% and 2% had a significant effect on MMP-8 levels. In conclusion, Collagen gel at 1% and 2% concentrations significantly modulated salivary MMP-8 levels, suggesting a potential role in the tissue remodeling phase following SRP.
Pengetahuan, Sikap, dan Perilaku Pengguna Metode Kontrasepsi Jangka Panjang dan Pendek di Daerah Terpencil Indonesia Fitriani , Hani Sri; Wikaningtyas , Pratiwi; Zazuli , Zulfan
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1507

Abstract

The use of long-acting contraceptive methods (LACMs) in Indonesia remains relatively low despite government efforts to increase their adoption to reduce maternal and child mortality. This study aims to examine differences in knowledge, attitudes, and practices (KAP) between LACM users and non-LACM users, as well as to identify factors influencing contraceptive method selection among women of reproductive age in a rural area of Indonesia. A cross-sectional design was employed involving 394 respondents selected through Cluster Random Sampling, all of whom completed validated and reliable questionnaires. Data were analyzed descriptively. The Mann–Whitney test was used to compare KAP between LACM and non-LACM users. Chi-square tests and logistic regression analysis were conducted to identify factors associated with contraceptive method selection. The results showed significant differences between the two groups. LACM users demonstrated higher levels of knowledge, more positive attitudes, and better contraceptive practices compared with non-LACM users. Factors associated with LACM use included high knowledge (OR = 2.415; p = 0.001), education above primary school level (OR = 7.03; p = 0.003), exposure to print media (OR = 28.331; p = 0.000), and obtaining contraceptives from community health centers (OR = 6.6; p = 0.009). In conclusion, short-acting contraceptive users exhibited lower knowledge, attitudes, and practices than LACM users. Therefore, individuals with low KAP levels should be prioritized in reproductive health education and promotion programs.
Formulasi Transdermal Patch Nanoemulgel Ekstrak Dadap Serep (Erythrina subumbrans (Hassk.) Merr.) dan Rimpang Kencur (Kaempferia galanga L.) sebagai Kandidat Laktagogum Herbal Berbasis Usadha Monika , Ni Luh Gde Mona; Yunita , Ella
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1510

Abstract

Traditional Usadha-based herbal lactagogues, such as Erythrina subumbrans and Kaempferia galanga, are used by lactating mothers; however, their delivery in practical, standardized forms is limited. This study aimed to formulate a nanoemulgel transdermal patch containing E. subumbrans extract and K. galanga extract, evaluate its physicochemical properties, and assess its safety for skin irritation as a potential herbal lactagogue. Extracts of E. subumbrans and K. galanga were added to the nanoemulsion base. The nanoemulsions were incorporated into HPMC/PVP-based transdermal patch matrices by solvent casting. The resulting patches were evaluated for physicochemical properties and tested for skin irritation. Phytochemical screening confirmed the presence of flavonoids, tannins, triterpenoids, saponins, and alkaloids in both extracts. The total flavonoid contents were 47.44 mg QE/g for E. subumbrans and 36.79 mg QE/g for K. galanga. The nanoemulsion exhibited greater than 90% transmittance, mean droplet size of 7.79 nm, and polydispersity index (PDI) of 0.193. The patches met acceptable physical criteria, including a thickness of 0.20 mm, weight variation with %CV less than 10%, and folding endurance over 300. pH values ranged from 6.00 to 6.58. In a human patch test, no erythema or edema was observed; only mild pruritus (mean = 0.2) was reported in two participants. The formulated nanoemulgel transdermal patches demonstrated favorable physicochemical properties and were non-irritating. These patches show potential as a herbal lactagogue delivery system; further studies on lactation  efficacy and long-term stability are recommended.
Aktivitas Sedatif Ekstrak Etanol Batang Tali Kuning (Anamirta cocculus (L.) Wight & Arn.) Terhadap Mencit (Mus musculus) Jantan Fitrianti, Wiwit Ayu; Muslihin, A.M.; Astuti, Ratih Arum
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1513

Abstract

Mental health is a state of well-being that includes where individuals recognize their personal potential, enabling them to manage life's pressures and be able to work productively. Treatment of mental health disorders usually involves the use of sedative drugs such as benzodiazepines, barbiturates, and several other drugs. This study aims to evaluate the sedative activity of the ethanol extract of tali kuning (A. cocculus (L.) Wight & Arn.) stem in male mice as an alternative therapy requiring sedative effects. The study was conducted using a quantitative experimental approach with a pretest–posttest control group design and the rotarod method. The experimental animals were divided into five groups: positive control, negative control, and three extract dose groups treated with the ethanol extract of tali kuning stem at 19.25 mg/kgBW, 38.5 mg/kgBW, and 77 mg/kgBW. The results indicated that the ethanol extract of tali kuning stem at all three doses produced sedative activity, as validated by a paired sample t‑test that revealed significant differences condition between pre‑ and post‑treatment measurements. The ethanol extract of tali kuning stem at doses of 19.25 mg/kgBW, 38.5 mg/kgBW, and 77 mg/kgBW demonstrated sedative activity, although statistical comparison with the positive control showed variable results depending on dose and observation time.

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