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Journal of Health Management and Pharmacy Exploration (JOHMPE)
Published by shm publisher
ISSN : 29854814     EISSN : 29855543     DOI : https://doi.org/10.52465/johmpe
Core Subject : Health,
Health Professions Medicine & Pharmacology Nursing Public Health Veterinary
Journal of Health Management and Pharmacy Exploration (JOHMPE) P-ISSN: 2985-4814 | e-ISSN: 2985-5543 is a journal that contains research material related to health management and pharmacy. Articles devoted to discussing any and all aspects of the most recent and noteworthy advancements in the fields of the development of health management science and pharmacy is possible to get the benefits of the application in life, especially from the perspective of the community, educational, and health institutions. The JOHMPE accepts manuscripts that are closely related to the health sector, including research articles, systematic reviews, and meta analyses. The Journal of Health Management and Pharmacy Exploration (JOHMPE) publishes contributions from a wide range of disciplines including: Health Policy Health Management Health Economics Health policy analysis Health policy ethics Politics of health Epidemiology Public health Phytochemistry social public policy Philosophy of health Clinical Pharmacy Community Pharmacy Pharmaceutics Pharmaceutical Chemistry Pharmacognosy
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 29 Documents
 1   2   3 
Antibacterial activity of active fraction of sweet corn hair extract (zea mays f saccharata kornicke & werner) against methicillin resistant staphylococcus aureus (MRSA) growth Juliani Khurfatul Jannah; Yuvianti Dwi Franyoto; Wulandari Wulandari; Jena Hayu Widyasti
Journal of Health Management and Pharmacy Exploration Vol. 1 No. 1 (2023): February 2023
Publisher : Surya Hijau Manfaat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52465/johmpe.v1i1.130

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) is a Staphylococcus aureus bacterium that is resistant to methicillin-type antibiotics. This study aims to determine the antibacterial activity of the active fraction of sweet corn hair extract on the growth of Methicillin-Resistant Staphylococcus aureus (MRSA) bacteria. Extraction was carried out by the remuneration method in 70% ethanol. In fractionation, liquid vacuum column chromatography with n-hexane, ethyl acetate, and methanol solvents was used. The fraction with the largest clear zone of methanol (100%) is with a clear zone diameter of 0.752 cm. Testing the antibacterial activity of ethanol extract at concentrations of 10%, 15%, and 20% obtained by clear zone with an average of 1,013; 1,073; 1,159 cm and in the active fraction with an average of 0,703; 0.903; 1,004 cm. Ciprofloxacin 0.005% was used as a positive control and DMSO as a negative control. The results showed that ethanol extract and an active fraction of sweet corn hair (Zea mays f saccharata Kornicke & Werner) had antibacterial activity against Methicillin-Resistant Staphylococcus aureus (MRSA). One-way ANAVA test results showed that there were significant differences in providing antibacterial activity (p> 0.05) between ethanol extract and active fractions at concentrations of 10%, 15%, and 20%. Flavonoid compounds, alkaloids, saponins, tannins, and triterpenoids in the active fraction of corn hair have antibacterial activity against MRSA bacteria.
W/O/W type lotion formulation of “arum manis” mango (Mangifera indica L.) pell as antioxidant Widya Rudiana; Wulandari Wulandari; Lilies Wahyu Ariyani
Journal of Health Management and Pharmacy Exploration Vol. 1 No. 2 (2023): August 2023
Publisher : Surya Hijau Manfaat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52465/johmpe.v1i2.132

Abstract

Arum manis mango peel contains compounds, namely flavonoids. Flavonoid compounds act as natural antioxidants. The weakness of flavonoid compounds is that they are not stable to the influence of high temperature and light intensity, so that the arum manis mango peel extract is made in the form of lotion type W/O/W. This study aims to determine the physical characteristics and stability of the W/O/W type emulsion form optimum formula in double emulsion preparations and lotion preparations, determine the stability of W/O/W type lotion preparations during storage using the cycling test method and determine the IC50 value in the optimum formula. lotion preparation type W/O/W. The optimum formula for double emulsion type W/O/W is found in formula 5 with a ratio of primary emulsion: secondary emulsion (80%:20%) with span 80 (10%) and tween 20 (5%) concentrations while the optimum formula for lotion preparations found in formula 3 with a ratio of double emulsion type W/O/W: lotion base (80%:20%) with a concentration of stearic acid (5%), cetyl alcohol (2.5%) and glycerin (10%). In the antioxidant activity of lotion preparations, the IC50 value was 136.543 ppm and the stability test on the cycling test method had an unstable form.
Antioxidant activity test of ethanol extract of red algae (Kappaphycus alvarezii) green variety from north coasts of Jepara district with DPPH method Wulandari Wulandari; Arifah Irna Nur Widyastuti; Ahmad Fuad Masduqi
Journal of Health Management and Pharmacy Exploration Vol. 1 No. 1 (2023): February 2023
Publisher : Surya Hijau Manfaat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52465/johmpe.v1i1.133

Abstract

Free radicals are unstable and highly reactive molecules that can cause cells damage. This cell damage can be inhibited by antioxidant compounds. One of the red algae, Kappaphycus alvarezii, is thought to contain phenolics and flavonoids compounds that can b used US antioxidants compounds. this study aims to determine the ethanol extract of red algae (Kappaphycus alvarezii) green variety has antioxidants activity using the DPPH method. this study also aims to determine the IC 50 value of the ethanolic extract of red algae (Kappaphycus alvarezii) green variety. The antioxidant activity test of red algae ethanol extract was carried out using the DPPH method. The results showed that the ethanolic extract of red algae (Kappaphycus alvarezii) green variety had antioxidant activity and the IC 50 value of the ethanolic extract of red algae was 242.28 ppm with a very weakcategory.
Antibacterial activity test of sweet arum mango peel extract gel preparation (Mangifera indica L.) against growth methicillin resistant staphylococcus aureus Wulandari Wulandari; Evira Refryliana
Journal of Health Management and Pharmacy Exploration Vol. 1 No. 1 (2023): February 2023
Publisher : Surya Hijau Manfaat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52465/johmpe.v1i1.134

Abstract

Inappropriate use of antibiotics can make bacteria’s reistance that cause skin diseases, the example is acne. Acne tretment usually uses synthethic drugs that causes side effects, so the alternative are used by plants that come from nature. On of the plats that has the potential as an antibacterial is the arum manis mango (Mangifera indica L.) because contains compounds that can inhibit the growth of Mathicillin Resistant Staphylococcus aureus. The research of this study was to determine the antibacterial activity of extract  gel’s arum manis mango peel to c. Extract of arum manis mango peel was obtained remaserated using 70% ethanol solvent. The extract obtined were phytochemicel screening and affirmation tests using the TLC (Thin Layer Chromatography) method to ensure the compounds contained. Arum manis mango peel is preparation of gel with a concentration of 5%, 10%, 15%, 20%, 25%. The results showed that extract of arum manis mango peel preparation gel with concentrations of 5%, 10%, 15%, 20%, 25%. The results showed that extract of arum manis peel preparation gel with concentration 5%, 10%, 15%, 20%, 25% showed significant difference in potential of antibacterial.
Effect of nephroprotectors of javanese bark extract (Lannea coromandelica) on aspirin-induced rat serum creatinine levels Jastria Pusmarani; Mus Ifaya; Risky Juliansyah Putri; Ade Safitri
Journal of Health Management and Pharmacy Exploration Vol. 1 No. 1 (2023): February 2023
Publisher : Surya Hijau Manfaat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52465/johmpe.v1i1.138

Abstract

Kidney disease is a global health problem based on the increase of incidence, prevalence, and morbidity rate. According to RISKESDAS 2018, the prevalence of chronic kidney disease (CKD) was increased significantly. Lannea coromandelica stem bark contains flavonoid was exhibited antioxidant that could be potential as nephroprotector. This study aimed to find out the nephroprotector effect of ethanolic extract of Lannea coromandelica stem bark by measurement serum creatinine levels at rats (Rattus novergicus). This study was used experimental laboratory method. In this study used 25 rats were divided into 5 groups. Group 1 was administered Na CMC 1 % as negative control group. Group 2 was administered aspirin 600 mg/kg body weight as induced control group. Group 3, 4, and 5 were administered Lannea coromandelica stem bark ethanolic extract with the doses 400 mg/kg body weight, 800 mg/kg body weight, and 1200 mg/kg body weight, respectively. The extract of lannea coromandelica stem bark groups were given for 4 days orally. Blood of rats were collected from the orbital sinus eye to be measured creatinine serum level at 5th day. The data was analyzed statistically with one way ANOVA and Paired samples test. The result of this study exhibited that there was a differences of creatinine levels between pre and post treatment with p-value=0.033< 0.05. In conclusion, this study presented that ethanolic extract of Lannea coromandelica stem bark was decreased serum creatinine levels at doses 800 and 1200 mg/kg body weight against the aspirin induced on rats.
Inhibitory test of binahong (Anredera cordifolia (Ten.) steenis) n-hexane fraction against bacillus subtillis bacteria by diffusion method Fitri Kurniasari; Puput Dwi Lestari
Journal of Health Management and Pharmacy Exploration Vol. 1 No. 1 (2023): February 2023
Publisher : Surya Hijau Manfaat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52465/johmpe.v1i1.140

Abstract

Binahong plants (Anredera cordifolia (Ten.) Steenis) contain alkaloids,flavonoids,saponins, and terpenoids, the chemical compounds of binahong leaves have many antibacterial properties. This study aims to determine the antibacterial inhibition of n-hexane (Anredera cofdifolia Ten.) Steenis) against Bacillus Subtillis. This type of research is experimental descriptive, binahong leaf n-hexane fraction was previously obtained by extraction using maceration method with 70% ethanol solvent obtained by using a 10% DMSO dissolved and tested for antibacterial inhibition with the method of solid well diffusion against Bacillus Subtillis in the series of concentrations of 20%,40%,60% dan 80% positive controls used were chloramphenicol 10% and negative control DMSO 20%. The results of the study showed that n-hexane fraction of binahong leaves (Anreders cordifolia (Ten.) Steenis) was able to inhibit the growth of the bacterium Bacillus subtillis. The greater the concentration used, the greater the results obtained.
Identification of bacterial morphology and catalase coagulation test on propionibacterium acnes bacteria M. Andi Chandra
Journal of Health Management and Pharmacy Exploration Vol. 1 No. 2 (2023): August 2023
Publisher : Surya Hijau Manfaat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52465/johmpe.v1i2.152

Abstract

Infection is a way for microorganisms such as bacteria, viruses and fungi to enter the skin which can cause skin problems such as acne. purpose of this study was to determine the morphology of p. acnes by gram staining method, then the catalase test was used to determine the ability of microorganisms to decompose hydrogen peroxide by producing catalase enzymes and coagulase test is a bacterial examination to detect the formation of coagulase enzymes that bind to the bacterial cell wall. The results obtained were that the morphology of the bacteria was in the form of salt and purple in color, the catalase test was positive and the coagulase test was positive. The conclusion obtained was that P. acnes ATCC 11827 was included in the group of gram-positive bacteria based on the results of gram staining and catalase and coagulase tests.
Combination of deep breathing relaxation techniques and aromatherapy to reduce pain in patient with thoracic myeloradiculopathy: a case report Isna Hanifah; Dyah Setyorini; Eka Afrima Sari
Journal of Health Management and Pharmacy Exploration Vol. 1 No. 2 (2023): August 2023
Publisher : Surya Hijau Manfaat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52465/johmpe.v1i2.154

Abstract

Thoracic myeloradiculopathy is a gradual loss of nerve function caused by spinal cord tumor metastases at the thoracic level resulting in pain and reduced sensation or paralysis. Mrs. N, 59 years old with thoracic myeloradiculopathy, has acute pain as the main nursing problem. The patient has been given pharmacological pain management by administering the analgesic paracetamol 3×500 mg. Acute pain in patients with thoracic myeloradiculopathy can occur in all phases of treatment which causes additional days of treatment so it is necessary to provide complementary therapy which can reduce the days of hospitalization. One of the nonpharmacological complementary therapies that have been proven effective in relieving pain in patients with thoracic myeloradiculopathy is a combination of deep breathing relaxation techniques using aromatherapy. Aromatherapy is given to the patient by dripping an essential oil containing Lavandula angustifolia (lavender), Citrus nobilis (mandarin orange), and Origanum majorana (marjoram) onto cotton and inhaled by the patient. Implementation is carried out once during a 7-day treatment period with a duration 0f 20-30 minutes after the patient performs personal hygiene or when going to rest. The evaluation results showed that the patient's pain scale decreased significantly from a score of 4 to a score of 2. Giving a combination of deep breathing relaxation techniques and aromatherapy is effective in reducing pain complaints in patients with thoracic myeloradiculopathy in addition to pharmacological therapy given by the medical team).
Antibacterial activity of flavonoid isolated from jamblang leaves (Syzigium Cumini (L.) Skeels) against Staphylococcus aureus Sania Nabila; Wulandari Wulandari; Endang Dwi Wulansari
Journal of Health Management and Pharmacy Exploration Vol. 1 No. 2 (2023): August 2023
Publisher : Surya Hijau Manfaat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52465/johmpe.v1i2.187

Abstract

Jamblang leaves (Syzigium cumini (L.) Skeels) is one type plants used as traditional medicine. Jamblang leaves contain several phytochemical compounds such as alkaloids, flavonoids, resins, tannins, and oils essential. Flavonoid compounds contained in jamblang leaves have as antibacterial ability. The identification of flavonoid compounds in jamblang leaves and the antibacterial activity of flavonoid compounds against Staphylococcus aureus have been carried out. This study was conducted from jamblang leaves (Syzigium cumini (L.) Skeels) at concentrations of 2%, 4% and 6% against the growth of Staphylococcus aureus bacteria and to determine the type and structure of flavonoid compounds that have antibacterial activity. The method used for the extraction is remaceration, the separation of compounds using preparative thin layer chromatography while the antibacterial activity test using the pitting method and identification of flavonoid compounds using UV-Vis spectrophotometry. Extraction of 500 g of jamblang leaf powder using 96% ethanol resulted in a yield of 22,08%. The results of the study tested the antibacterial activity of flavonoid compounds of jamblang leaves obtained an average of clear zones produced at concentrations of 2%, 4% and 6% consecutively amounting to 0.9540 cm; 1.0540 cm; 1.1583 cm and ciprofloxacin 0.005 % by 1.4077%. Based on statistical analysis of the SPSS program with anava test 1 way obtained the results of significant activity differences between concentrations. Identification of the structure in UV-Vis spectrophotometry shows that flavonoid compounds lead to 3,7,4' trihydroxy flavonol.
Strategy for improving pharmaceutical services based on SNARS edition 1 at the "X" hospital pharmacy installation in tomohon city Priska Juanita Pakingki; Opstaria Saptarini; Tri Wijayanti
Journal of Health Management and Pharmacy Exploration Vol. 1 No. 2 (2023): August 2023
Publisher : Surya Hijau Manfaat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52465/johmpe.v1i2.191

Abstract

Accreditation is a process of evaluating a hospital by KARS to improve patient safety and evaluate the quality of a hospital. This research was conducted at the "X" Hospital Pharmacy Installation in Tomohon City. To find out the level of conformity of the seven Pharmaceutical Services and Drug Use standards against the 1st Edition of 2018 National Hospital Accreditation Standards and problem solving strategies using a priority scale with the matrix method. The research design is a non-experimental research. analyzed descriptively quantitative and qualitative. The research data were processed in tabular form and repaired with a priority scale of problems using the matrix method. The conformity level of Pharmaceutical Services and Drug Use in the "X" Hospital Pharmacy Installation has not fully met the National Hospital Accreditation Standards. Improvement strategy based on priority scale of problems using the matrix method: Pharmaceutical Services and Drug Use Point 5 Preparation and delivery, Point 4 Prescription and copying, Point 3 Storage, Point 7 Monitoring drug effects, Point 6 Drug Administration, Point 1 Organizing and Point 2 Selection and procurement. Pharmaceutical services in the Pharmacy Installation as a whole are good but there are several points that have not met the standards and must be improved.

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