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Journal of Health Management and Pharmacy Exploration (JOHMPE)
Published by shm publisher
ISSN : 29854814     EISSN : 29855543     DOI : https://doi.org/10.52465/johmpe
Core Subject : Health,
Health Professions Medicine & Pharmacology Nursing Public Health Veterinary
Journal of Health Management and Pharmacy Exploration (JOHMPE) P-ISSN: 2985-4814 | e-ISSN: 2985-5543 is a journal that contains research material related to health management and pharmacy. Articles devoted to discussing any and all aspects of the most recent and noteworthy advancements in the fields of the development of health management science and pharmacy is possible to get the benefits of the application in life, especially from the perspective of the community, educational, and health institutions. The JOHMPE accepts manuscripts that are closely related to the health sector, including research articles, systematic reviews, and meta analyses. The Journal of Health Management and Pharmacy Exploration (JOHMPE) publishes contributions from a wide range of disciplines including: Health Policy Health Management Health Economics Health policy analysis Health policy ethics Politics of health Epidemiology Public health Phytochemistry social public policy Philosophy of health Clinical Pharmacy Community Pharmacy Pharmaceutics Pharmaceutical Chemistry Pharmacognosy
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 29 Documents
 1   2   3 
Potential of purple eggplant skin fraction (Solanum Melongena Var. Serpentinum L.) as an in vitro sunscreen Sari, Salza Laila; Wulandari, Wulandari; Mutiara, Erlita Verdia
Journal of Health Management and Pharmacy Exploration Vol. 2 No. 1 (2024): February 2024
Publisher : Surya Hijau Manfaat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52465/johmpe.v2i1.131

Abstract

Sunscreen is a product that is used as skin protection against sun exposure. The skin of purple eggplant is known to contain secondary metabolites which are used as sunscreens. This study aims to determine the activity of sunscreen fraction of the purple eggplant (Solanum melongena var. serpentinum L.) in vitro. Testing of sunscreen activity was carried out by calculating the value of SPF (Sun Protection Factor), %TE (Percent Transmission of Erythema) and %TP (Percent Transmission of Pigmentation) using the UV-Vis Spectrophotometry method. The purple eggplant skin fractionation method is by using LVC (Liquid Vacuum Chromatography). The results of the fractionation were identified using phytochemical screening and combined TLC. The fraction results were tested for SPF (Sun Protection Factor), %TE and %TP values. The results showed that the extract yield was 26.33%. The fractions used are fraction 9; 10; 11; and 12 which showed the same stain after being evaporated, which was a brownish yellow stain with a yield of 21,24%. The purple eggplant skin fraction (Solanum melongena var. serpentinum L.) has SPF, %TE and %TP values with optimal protection at a concentration of 400 ppm with each value obtained being 19; 1.35 and 9.79. The results of the statistical test of the purple eggplant skin fraction showed that the data were normally distributed but not homogeneous. The results of the homogeneity test for each concentration of results showed that the data were not significantly different.
Differences in drug availability levels before and during the covid19 pandemic in the pharmaceutical installation of NTB provincial hospital Wisnu, M. Ari; Herowati, Rina; Harsono, Samuel Budi
Journal of Health Management and Pharmacy Exploration Vol. 2 No. 1 (2024): February 2024
Publisher : Surya Hijau Manfaat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52465/johmpe.v2i1.192

Abstract

Health services are now increasingly needed during the COVID-19 pandemic which threatens public health. The need for public medicines that must be available such as flu, cough, vitamin c, antibiotics and antimalarials and antivirals for health services makes hospitals must try to fulfil and currently the COVID-19 pandemic situation is still continuing so hospitals must be ready to provide health services to patients.This study aims to determine the differences in drugs in the Pharmacy Installation of the NTB Provincial Hospital before the COVID-19 pandemic in 2019 and during the COVID-19 pandemic in 2020. This study is a descriptive-evaluative study with retrospective data collection in 2019 which represents the period before the COVID-19 pandemic and 2020 which represents the COVID-19 pandemic. The samples used in the study consisted of drug data from the Pharmacy Installation of the NTB Province Regional General Hospital (RSUD) and were analyzed using the Wilcoxon test. The results obtained are the level of drug availability in the pharmaceutical installation of the NTB Provincial Hospital obtained based on the results of observing data in 2019 and 2020, namely 19 and 37 months. There is a significant difference (Asymp. Sig (2-tailed) 0.000) the level of drug availability in the Pharmacy Installation of the NTB Provincial Hospital before and during the COVID-19 pandemic in 2020 with a difference of 18 months.
Phytochemical contents and diuretic activity of ethanolic extract of the red leaf lettuce (Lactuca Sativa l.) Lestari, Ratih Guswinda; Amin, Muhammad Saiful; Kusuma, Eka Wisnu
Journal of Health Management and Pharmacy Exploration Vol. 2 No. 1 (2024): February 2024
Publisher : Surya Hijau Manfaat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52465/johmpe.v2i1.201

Abstract

This study was conducted to evaluated of phytochemical content and diuretic activity of the red leaf lettuce. Red leaf lettuce were extracted by cold  maceration method using 70% ethanol for the 3 days and remaceration for 1 days. The phytocemical content  in ethanolic extract were evaluated by  qualitatif method. A total of 25 male rats were divided into 5 groups with CMC Na, a standard drug (furosemide 10 mg/kg), and three different doses (200, 300, and 400 mg/kg) of ethanol extract. Parameters used to determine diuresis activity include first urine latency, urine pH and cumulative urine volume. The ethanolic extract induced diuresis in a dose dependent manner as compared to the negative control. Extracts at doses of 200, 300, and 400 mg/kg produced significant diuresis effects (p<0.05) compared to negative controls with values of diuretic action 1.35; 1.43; and 1.53, respectively. In addition, there was a slightly change in the pH of urine samples of the extract-treated group compared with the negative control. Phytochemicals analysis revealed the presence of alkaloids, flavonoids, phenolics, and tannins.
Relationship between healthy house and smoking habits with afb (+) pulmonary tuberculosis cases at the singotrunan public health center, Banyuwangi district Fakhira, Amira Dhisa; Keman, Soedjajadi
Journal of Health Management and Pharmacy Exploration Vol. 2 No. 1 (2024): February 2024
Publisher : Surya Hijau Manfaat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52465/johmpe.v2i1.281

Abstract

Singotrunan Public Health Center has 65 cases of AFB (+) pulmonary TB, which means increased by 22.6% from the previous year. Healthy house and smoking habits are known to be some of the risk factors for pulmonary TB cases. This study aims to analyze the relationship between healthy house and smoking habits with AFB (+) Pulmonary Tuberculosis cases in the working area of the Singotrunan Public Health Center, Banyuwangi District. The method used is analytic research with a case-control type. This research was conducted on 28 samples, consist of 14 from the case group and 14 from the control group in the working area of the Singotrunan Health Center. Data were obtained from assessments using observation sheets and interviews using questionnaires. The data obtained were analyzed univariably using tabulation and bivariably using the Chi Square test using the Odds Ratio value to determine the dynamics of the independent and dependent variables. The results of the Chi Square test showed that there is a significant relationship between healthy houses (pvalue = 0.022) and smoking habits (pvalue = 0.002) with AFB pulmonary TB cases (+). The Odds Ratio value shows that unhealthy homes have a 6.6 times higher risk and smoking increases the risk 15 times higher for being diagnosed with AFB (+) Pulmonary TB. In conclusion, healthy homes and smoking habits have the potential to increase the risk of AFB (+) Pulmonary TB in the working area of the Singotrunan Public Health Center, Banyuwangi District.
Comparison of ethyl acetat fracination of ganitrie (Elaeocarpus sphearicus) seeds as anti bacterial of Staphylococcus aureus and determination of total flavonoid content Sari, Yunita Kurnia; Suharsanti, Ririn; Wulandari, Wulandari
Journal of Health Management and Pharmacy Exploration Vol. 2 No. 1 (2024): February 2024
Publisher : Surya Hijau Manfaat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52465/johmpe.v2i1.291

Abstract

Infectious disease is a disease coused by the presence pf pathogenic microbes. Stahpylococcus aureus is a gram positive aerobic bacterium that couses phyogenic infections on humans. Antibiotics are the best choise to treat an infections. The purpose of this study was to determine the antibacterial activity of ganitri seed (Elaeocarpus sphearicus) to determine the exstract ratio, the ethyl acetat fractination of ganitri seeds woth a concetration of 35% on the growth of staphylococcus aureus bacteria and to determine the total flavonoid content. Exctraction was carried out by maceration method for 3x24 hours with 96% ethanol as solvent. Exctraction fractination using 2 methods, the first method is using 30% ethanol, cloroform, and ethyl acetat as solvent. The second fractination method uses hot destiled water and ethyl acetat as solvents. The test result of total flavonoid content in ganitri (Elaeocarpus sphearicus) seeds in ethanol exstract were 38.009 mgEQ / g, fraction 1 of 99.512 mgEQ / g, fraction 2 of 68.235 mgEQ / g. From the result of the determinatoin of the ethyl acrtat fraction 1 had highest yield with an average value of 99,512 mgEQ/g. The antibacterial activity test was 35% in each sample ang using a positive control of ciprofloxcacin and a negative control of DMSO. Based on the result of the clear zone of the ethanol extract was 1.118 cm, the ethyl acetate 1 fraction was 1.170 cm, and the ethyl acetat 2 fraction was 0,956 cm.
The relationship between mother's knowledge and the incidence of stunting in toddlers in polindes, mundar village, south labuan amas district, hulu sungai tengah regency in 2024 Qomah, Isti; Tazkiah, Misna; Rahmayanti, Rizka
Journal of Health Management and Pharmacy Exploration Vol. 2 No. 2 (2024): August 2024
Publisher : Surya Hijau Manfaat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52465/johmpe.v2i2.383

Abstract

Stunting is stunted growth caused by a lack of nutritional intake due to a diet that does not meet long-term needs. South Kalimantan Province is in the top 3 provinces with the highest reduction in stunting (-5.4%) in 2022 based on the SSGI results released by the Indonesian Ministry of Health. Initially in 2021 stunting in South Kalimantan reached 30.0% and in 2022 it decreased by 24.6%. With a figure of 24.6%, reducing stunting is still a priority for South Kalimantan to achieve the target of 14% in 2024. Based on data from the Hulu Sungai Tengah district health service in 2020, the figure was 10%, experiencing a decrease in 2021 with a figure of 9.44%, and in in 2022 there will be an increase of 31.10%. This research is analytical research. With a Cross Sectional approach. The research results showed that the majority of mothers had sufficient knowledge and 21 children were not stunted (33.9%), 9 children were stunted (14.5%), and there was insufficient knowledge with the incidence of stunted children being 13 people (21.0%). and there were 2 children (3.2%) who were not stunted, while there were 0 people (0%) with good knowledge and stunted babies, and 17 people (27.4%) who were not stunted. Based on the results of the chi square test, it was found that there was a relationship between maternal knowledge and the incidence of stunting at the Mundar Village Polindes with a P value = 0.000. It is recommended that the Mundar Village Polindes, South Labuan Amas District, Hulu Sungai Tengah Regency further increase health education activities related to health and education for mothers with babies and toddlers about preventing stunting through improving child nutrition.
Antipyretic activity test of papaya leaf extract (Carica papaya L.) against peptone-induced male white mice Mayqhuellia, Marsyanda Happy; Hayu Widyasti, Jena
Journal of Health Management and Pharmacy Exploration Vol. 2 No. 2 (2024): August 2024
Publisher : Surya Hijau Manfaat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52465/johmpe.v2i2.437

Abstract

Fever increases body temperature above normal (98.6°F/ 37°C). To treat complaints of fever, antipyretic drugs are given. Papaya leaves are believed to have antipyretic effects. The purpose of this study was to test the antipyretic activity and effective dose of ethanol extract of papaya leaves (Carica papaya L.) against peptone-induced mice. The test animals were grouped into 5 groups consisting of group I (negative control) CMC Na 0.5%, group II (positive control) paracetamol drug 65 mg/KgBB mice, group III papaya leaf ethanol extract 140 mg/KgBW mice, group IV papaya leaf ethanol extract 280 mg/KgBW mice, and group V papaya leaf ethanol extract 560 mg/KgBW mice, with peptone fever inducer 10 mL/kgBW subcutaneously. The body temperature of the test animals was observed every 30 minutes for 240 minutes after peroral administration of the preparation, then obtained data on T0, Tdemam and body temperature measurements at each time. The data was then used to calculate the AUC and the average AUC calculation data was analyzed by Shapiro wilk test and One way Anova test. The results of the study of ethanol extract of papaya leaves have antipyretic effects, namely due to the presence of flavonoids, alkaloids, tannins, steroids, and saponins. Papaya leaf ethanol extract has the most effective antipyretic activity, namely a dose of 560 mg/kg BW, which is comparable to the positive control of paracetamol.
Identification of chemical compounds of 70% ethanol extract of chinese betel leaves (Peperomia pellucida) from blora regency Kenanga, Gigih
Journal of Health Management and Pharmacy Exploration Vol. 2 No. 2 (2024): August 2024
Publisher : Surya Hijau Manfaat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52465/johmpe.v2i2.441

Abstract

Indonesia is rich in various plants, one of which is the Chinese Betel (Peperomia pellucida). This study aims to identify the chemical compounds of 70% ethanol extract from Chinese betel leaves in Blora Regency. The identification method is by laboratory observation with Thin Layer Chromatography (TLC). The results of the TLC test with the highest or best values are saponins, tannins, triterpenoids which can be seen by looking at the difference between the high points of the stains on the sample and the comparator. The active content in saponins, tannins and triterpenoids functions as a source of antibacterials, increasing the immune system. Flavonoids also have anti-inflammatory content (anti-inflammatory on the skin), as antioxidants and as histamine. Saponins as antibacterials with a mechanism that reacts with porins (transmembrane proteins) on the outer membrane of the bacterial cell wall, forming strong polymer bonds that damage the porins and can inhibit the growth of antibacterials.
Comparison of phenolic total ethanol extract of 70% and 96% carrot leaves and antibacterial activity test against Staphylococcus aureus Lathifah, Jihan Najla; Wulandari, Wulandari
Journal of Health Management and Pharmacy Exploration Vol. 2 No. 2 (2024): August 2024
Publisher : Surya Hijau Manfaat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52465/johmpe.v2i2.443

Abstract

Carrots (Daucus carota L.) are a plant that is widely used by the community, especially the tubers, while the leaves are not widely used and are only used as waste or animal feed. Carrot leaves contain secondary metabolites such as phenols, flavonoids, tannins, saponins, alkaloids, and steroids. Phenolic compounds are secondary metabolite compounds that are most abundant in nature. This compound can be used in the pharmaceutical world as an alternative treatment from natural ingredients, one of which is as an antibacterial. Staphylococcus aureus bacteria can cause skin infections such as boils. If it enters the bloodstream, it can cause meningitis or lung infections. This study aims to determine the total phenolic content in carrot leaves extracted with 70% and 96% ethanol solvents and to determine their antibacterial activity against Staphylococcus aureus. Carrot leaf extract is obtained by the maceration method. Total phenolic content was calculated using the Follin-Ciocalteau method. The antibacterial activity test was carried out using an excellent method. The research results showed that the yield of 70% ethanol extract was 17.235% and 96% ethanol extract was 16.053%. The results of testing the phenolic content of 70% ethanol extract of carrot leaves were 44.586 mgGAE/g and the phenolic content of 96% ethanol extract was 34.939 mgGAE/g. The results of the antibacterial activity test of 70% ethanol extract of carrot leaves had an average measurement of the inhibition zone at concentrations of 20%, 30% and 40%, namely 0.175 cm, 0.226 cm and 0.274 cm.
Test on the effectiveness of the utilization of binahong leaf extract (Anredera cordifolia (Ten.) Steenis) as an anti-aging cream Theedens, Maria Theodora; Widodo, Gunawan Pamudji; Astuti, Santi Dwi
Journal of Health Management and Pharmacy Exploration Vol. 2 No. 2 (2024): August 2024
Publisher : Surya Hijau Manfaat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52465/johmpe.v2i2.445

Abstract

Binahong leaves (Anredera cordifolia (Ten.) Steenis) contain flavonoids, essential oils, saponins, alkaloids and steroids/terpenoids. Antioxidant compounds derived from flavonoid function as protection for the skin from direct exposure to sunlight. This research was conducted to determine the stability and physical quality characteristics of the binahong leaf extract cream preparation and the effectiveness of binahong leaf extract as an anti-aging agent. Binahong leaf powder was extracted using the maceration method using 96% ethanol solvent. Formulations of binahong leaf ethanol extract is based on a concentration ratio of 3% (F1), 5% (F2) and 10% (F3). The resulting cream is of the vanishing cream (O/A) type. The irritation test was carried out on the back of a rabbit test animal which had first been shaved. Testing the effectiveness of anti-aging cream on the skin was experimental, by inducing UV-A light using light from the Exoterra® daylight basking spot and followed by skin analysis of anti-aging parameters (moisture, skin elasticity and percentage (%) of collagen) using the Skin tool Analyzer EH-900U. Analysis used the paired t-Test, one way ANOVA and Tukey test methods to examine the comparative effectiveness of treatments F1, F2 and F3 as anti-aging creams. The results of the research show that the average stability and physical quality of all anti-aging cream preparations of binahong leaf extract (Anredera cordifolia (Ten.) Steenis) have good results and fall within the established standard requirements. The concentration of binahong leaf extract which has the greatest influence on anti-aging effectiveness of F3 (10%), has the best effect compared to other formulas which is characterized by an increase in the parameters of moisture is 19,05%, elasticity is 27,17% and percent (%) collagen is 20,77%.

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