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Journal of Health Management and Pharmacy Exploration (JOHMPE)
Published by shm publisher
ISSN : 29854814     EISSN : 29855543     DOI : https://doi.org/10.52465/johmpe
Core Subject : Health,
Health Professions Medicine & Pharmacology Nursing Public Health Veterinary
Journal of Health Management and Pharmacy Exploration (JOHMPE) P-ISSN: 2985-4814 | e-ISSN: 2985-5543 is a journal that contains research material related to health management and pharmacy. Articles devoted to discussing any and all aspects of the most recent and noteworthy advancements in the fields of the development of health management science and pharmacy is possible to get the benefits of the application in life, especially from the perspective of the community, educational, and health institutions. The JOHMPE accepts manuscripts that are closely related to the health sector, including research articles, systematic reviews, and meta analyses. The Journal of Health Management and Pharmacy Exploration (JOHMPE) publishes contributions from a wide range of disciplines including: Health Policy Health Management Health Economics Health policy analysis Health policy ethics Politics of health Epidemiology Public health Phytochemistry social public policy Philosophy of health Clinical Pharmacy Community Pharmacy Pharmaceutics Pharmaceutical Chemistry Pharmacognosy
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 29 Documents
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Effectiveness and safety of the monoclonal antibody drug lecanemab (Leqembi) in reducing beta-amyloid plaques in alzheimer's dementia: a literature review Meidina, Adinda Nezma; Ramadhanti, Nafilah; Istiqomah, Dyah Fatha; Putri, Yolanda Delia; Hasibuan, Nabila Az-zahra
Journal of Health Management and Pharmacy Exploration Vol. 3 No. 1 (2025): February 2025
Publisher : Surya Hijau Manfaat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52465/johmpe.v3i1.547

Abstract

Dementia is a syndrome characterized by cognitive decline, behavioral changes, and impaired self-care, with Alzheimer's disease (AD) being the most common cause. The global prevalence of AD is rising and is expected to reach 152 million cases by mid-century, imposing significant public health and economic burdens, particularly in low- and middle-income countries. AD is marked by synapse loss and neuronal atrophy, beginning in the hippocampus and spreading across the cerebral cortex due to β-amyloid plaque and neurofibrillary tangle accumulation, which disrupt neuronal communication and survival. Current treatments, such as memantine and cholinesterase inhibitors, provide only temporary symptom relief without stopping disease progression. Literature was searched using search engines such as Google Scholar, Science Direct, ResearchGate, and NCBI. Inclusion and exclusion criteria were applied, resulting in 27 relevant references that explored monoclonal antibody-based therapies and multidisciplinary interventions for AD management. Lecanemab has been shown to reduce amyloid accumulation effectively. However, its use is associated with risks such as amyloid-related imaging abnormalities with edema (ARIA-E) and hemorrhage ARIA-H, particularly in ApoE ε4 carriers. Despite these concerns, recent meta-analyses suggest that lecanemab is generally well-tolerated and offers potential as a cost-effective treatment for AD. Monoclonal antibody therapies, such as lecanemab, provide hope for slowing AD progression. Further research is crucial for developing more effective treatments. A multidisciplinary approach that integrates pharmacological therapies with advanced technologies may offer a more effective strategy for managing AD in the future.
Analysis of the musculoskeletal pain risk profile through observation of work posture in minimarket employees Laeto, Arwan Bin; Putri, Siti Sarahdeaz Fazzaura; Agustine, Vania; Hasbi, Alfian; Zulissetiana, Eka Febri
Journal of Health Management and Pharmacy Exploration Vol. 3 No. 1 (2025): February 2025
Publisher : Surya Hijau Manfaat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52465/johmpe.v3i1.549

Abstract

Musculoskeletal pain refers to the discomfort experienced in the musculoskeletal system as a result of various pain-inducing factors. Musculoskeletal pain is a leading cause of disability and absenteeism in the workplace. The primary causes of declining health among workers include occupational injuries (29.5%), overtime (25.9%), and ergonomic factors (13.7%), significantly influence occupational health and can adversely affect organ function. The study was conducted through observational approach with a cross-sectional design and primary data collected using the Nordic Body Map (NBM) questionnaire and the Rapid Entire Body Assessment (REBA). The study population is mini market employees and sample comprises were employees who fulfil inclusion and exclusion criteria as many as 50 respondents by using non-probability sampling technique. The results of study were obtained that the majority of workers belong to the age group of under 35 years, as many as 49 individuals (98%) and more than half of the respondents are predominantly female, accounting for 52% of the total. Furthermore, the study indicates that the dominant "Very Painful" predilection criterion is most frequently reported in the back and waist of the respondents, accounting for 40% of the total respondents. Next, the majority of minimarket workers exhibit a moderate level of risk in their work posture, with 21 individuals (42%) falling into this category. Based on the results, it is recommended that respondents engage more actively in physical exercise and massage therapy.
Optimization of chitosan and sodium tripolyphosphate as a carrier system for nanoparticles of ethanol extract of aloe vera (Aloe vera l.) as an antioxidant Efrilia, Erin; Sunarni, Titik; Kuncahyo, Ilham
Journal of Health Management and Pharmacy Exploration Vol. 3 No. 1 (2025): February 2025
Publisher : Surya Hijau Manfaat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52465/johmpe.v3i1.532

Abstract

Aloe Vera has phenolic active compounds that are proven to have potential antioxidant activity but are sensitive to light, easily oxidized and unstable at high temperatures. To overcome this, aloe vera is formulated into a chitosan and sodium tripolyphosphate carrier system. The interaction between chitosan and sodium tripolyphosphate for nanoparticle formation is strongly influenced by the ratio of both. The purpose of this study was to obtain the optimal formula of aloe vera extract nanoparticle preparation with chitosan and sodium tripolyphosphate carrier system with critical parameters including particle size, polydispersity index, zeta potential, sorption efficiency and antioxidant activity. Aloe vera was extracted with 96% ethanol using maceration method. Determination of chitosan and sodium tripolyphosphate concentration variation using simplex lattice design method. The results of the tests that have been carried out, the characteristics of aloe vera nanoparticle preparations with variations in the concentration of chitosan: sodium tripolyphosphate in runs 2 & 6 have the most optimal formula with the ratio of chitosan: sodium tripolyphosphate = (0.3: 0.1).
Antioxidant and trombolitic activity of etanol extract and fractions of carica culver (Carica pubescens) in vitro Pratiwi, Yunia; Mardiyono, Mardiyono; Indrayati, Ana
Journal of Health Management and Pharmacy Exploration Vol. 3 No. 1 (2025): February 2025
Publisher : Surya Hijau Manfaat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52465/johmpe.v3i1.533

Abstract

The prevalence of degenerative diseases arising from cell damage and free radicals continues to increase. The reactivity of oxidant compounds that exceed the limit can form a chain reaction capable of damaging parts of blood vessel cells that cause thrombolysis. Carica skin waste (Carica pubescens) has not been widely utilized, carica skin has the potential to have the ability as an antioxidant and thrombolytic. This study aims to determine the potential antioxidant and thrombolytic activity of carica peel. Carica peel samples were extracted by remaceration method using 70% ethanol and then fractionated with n-hexane, ethyl acetate, and water solvents. Antioxidant activity testing was carried out using the DPPH (2.2 Diphenyl-1-picrylhydrazyl) method and thrombolytic activity with the clot lysis method. The results showed that the ethyl acetate fraction had the highest antioxidant activity compared to ethanol extract and other fractions with an IC50 value of 37.04 ppm with an AAI value of 0.54. The thrombolytic activity test of ethyl acetate fraction is also the highest thrombolytic agent with clot lysis value reaching 46.06% close to the clot lysis value of nattokinase positive control of 52.39%.
Test of the activity of 96% ethanol extract gel of avocado seeds (Persea americana mill.) on burn wound healing in the back of new zealand rabbits Ulya, Fajar Putri Nuril; Sari, Gigih Kenanga; Saraswati, Maulita
Journal of Health Management and Pharmacy Exploration Vol. 3 No. 1 (2025): February 2025
Publisher : Surya Hijau Manfaat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52465/johmpe.v3i1.548

Abstract

Avocado seeds contain secondary metabolite compounds in the form of alkaloids, flavonoids, saponins, tannins, triterpenoids and steroids. The mechanism of flavonoids in inhibiting the inflammatory process in burns is through various methods, namely inhibiting capillary permeability, inhibiting the release of serotonin and histamine to the site of inflammation. In this study, avocado seed extract was obtained by maceration method and formulated into a gel preparation with a concentration of 5%, 10% and 15%. The gel base was used as a negative control, and the gel containing 10% placenta extract and 0.5% neomycin sulfate was used as a positive control, applied to burn wounds on the backs of New Zealand rabbits with a diameter of 2 cm. The activity test of avocado seed extract gel was conducted on 3 rabbits, with each formulation applied 3 times, and the wound diameter was measured daily. This test was conducted for ten days. Avocado seeds (Persea americana Mill.) contain alkaloids, flavonoids, tannins, saponins and titerpenoids. The results of observations of the healing and drying process of burns, avocado seed extract gel (Persea americana Mill.) on the 10th day were F1 (5%) wound diameter 0.2 cm, F2 (10%) wound diameter 0.1 cm, F3 (15%) wound diameter 0 cm. Avocado seed extract gel (Persea americana Mill.) with a concentration of 15% can provide the best effect on healing burns.
Activity test cream anti aging extract ethanol 70% star fruits leaves (Averrhoa bilimbi l.) on skin new zealand rabbit backs exposed to UV-A light Puspitasari, Iliananda; Saraswati, Maulita; Sari, Gigih Kenanga
Journal of Health Management and Pharmacy Exploration Vol. 3 No. 2 (2025): August 2025
Publisher : Surya Hijau Manfaat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52465/johmpe.v3i2.542

Abstract

Skin is an organ that protects humans from external influences. Damage to the skin can interfere with human health and appearance. One of the most feared things is premature aging, the main cause of skin aging and malignant melanoma is the entry of ultraviolet (UV) rays from the sun. One of the plants, namely starfruit leaves, has antioxidant content that can change or reduce free radicals and also as an anti-free radical such as flavonoids, saponins, alkaloids, and tannins. Cream can be used by applying it to the skin of the face to prevent anti aging. Objective: To determine the activity of anti-aging cream of 70% ethanol extract of starfruit leaves (Averrhoa bilimbi L.) on the back skin of New Zealand rabbits exposed to UV-A light. Methodology: Extract starfruit leaves using the maceration method with 70% solvent and make a cream preparation to test anti-aging activity with concentrations of 3%, 5%, and 7%. Results: Formulation 3 with a concentration of 7 % of starfruit leaf extract cream can provide optimal effects as an anti-aging agent when exposed to UV-A rays, seen from the average value which is almost the same as the positive control.
Preliminary identification of N-Acetyltransferase 2 (NAT2) gene polymorphisms in the dayak population Dewi, Lutfiana Aswindra; Peranginangin, Jason Merari; Dewi, Lucia Vita Inandha
Journal of Health Management and Pharmacy Exploration Vol. 3 No. 2 (2025): August 2025
Publisher : Surya Hijau Manfaat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52465/johmpe.v3i2.612

Abstract

Polymorphism is a change or mutation in a gene that does not cause a change in the protein structure. The N-Acetyltransferase NAT enzyme is encoded by the N-Acetyltransferase 2 (NAT2) gene, the N-Acetyltransferase 2 (NAT2) gene, several variations of DNA known as single nucleotide polymorphisms (SNPs) that alter the genotype, haplotype, and phenotype. The NAcetyltransferase 2 (NAT2) genotype was classified into three phenotypes, namely fast acetylators, intermediate acetylators, and slow acetylators. The purpose of this study was to determine the type of polymorphism and the type of polymorphism of the NAT2 gene of the Dayak tribe. In this study, blood samples from the Dayak tribe were isolated from the Wizard Genomic DNA Purification kit and then identified Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP). With stages 1. Denaturation 2. Anneling and 3. Extension using NAT2 N4 and N5 primers then RFLP with restriction enzymes KpnI, TaqI and BamHI then electrophoresed with 2% agarose gel. The results of the initial identification of the N-Acetyltransferase 2 (NAT2) gene polymorphism in the Dayak tribe obtained 5 types of genotypes NAT2*4/*5B (20%), NAT2*4/*6A (33.3%), NAT2*4/*7B (20%), NAT2*5B/5B (13.3%) and NAT2*7B/7B (13.3%). From the phenotype of the Dayak tribe, there are two medium acetylators (73.3%) and slow acetylators (26.3%).
Management physiotherapy for cervical root syndrome with ultrasound, nerve mobilization and exercise: a case report Salsabila, Dika Tiara; Pristanto, Arif; Fauzan, Muhammad
Journal of Health Management and Pharmacy Exploration Vol. 3 No. 2 (2025): August 2025
Publisher : Surya Hijau Manfaat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52465/johmpe.v3i2.552

Abstract

Cervical Root Syndrome (CRS) is an abnormal condition caused by irritation or compensation of the cervical nerve roots, which can occur due to trauma. Arthritis, or compression of the intervertebral discs in the neck area. This research is to determine the benefits of providing ultrasound (US) modalities, nerve mobilization, isometric exercises, and stretching in CRS cases. The measurements used are pain measurement using the Numerical Rating Scale (NRS), Range of Motion (ROM) measurement using a goniometer, muscle strength measurement using Manual Muscle Testing (MMT), and functional activity measurement using the Neck Disability Index (NDI). The research was carried out directly on a patient with CRS condition by administering therapy in three meetings with physiotherapy intervention.  After 3 therapy meetings carried out by the physiotherapy program for Cervical Root Syndrome with physiotherapy modalities in the form of US, nerve mobilization, isometric exercises and stretching, significant changes were seen in reducing pain, increasing joint range of motion, muscle strength and functional ability.
Counselling on the correct use of antibiotics to prevent antibiotic resistance and the use of family medicinal plants (toga) for health Astuty, Meilinda Windy; Solehah, Santi; Ambarwati, Suci; Rahman, Zihni Mahira; Silpia, Rena; Ramdani, Qisti Cahya Putri; Ramdhani, Salma Fitria
Journal of Health Management and Pharmacy Exploration Vol. 3 No. 2 (2025): August 2025
Publisher : Surya Hijau Manfaat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52465/johmpe.v3i2.558

Abstract

A significant increase in the use of antibiotics in the community is often not matched by a proper understanding of their use, potentially leading to antibiotic resistance. This research aims to educate the community about the importance of proper antibiotic use and the utilization of Family Medicinal Plants (TOGA) as alternative medicine. Community service activities were carried out on November 24, 2024 in Salam Mulya Village, Pondok Salam District, Purwakarta Regency, in collaboration with Holistic Purwakarta Hospital. The methods used included education and discussion, with the distribution of brochures containing information on the use of antibiotics and TOGA. The results of the activity showed that the community showed high enthusiasm for the education provided, with 50 participants attending and actively participating in the discussion. The positive response from the community showed an increased understanding of the importance of the correct use of antibiotics and the utilization of herbal medicines. It is hoped that this activity can be continued and developed to increase public awareness about health.

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