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Muhammad Iqhrammullah
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Narra X
Published by PT Narra Sains Indonesia
ISSN : -     EISSN : 29882990     DOI : DOI: https://doi.org/10.52225/narrax
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health
Narra X is a multidisciplinary journal, published three times in a year (April, August, and December). The journal aims to act as a platform for rapid scientific communication while upholding the highest integrity. Articles are published in a form of Original articles, Short Report, Case Reports, Methods articles, Review articles, and Letters to the Editor. All submitted articles are subjected to peer-review prior to their publication. As a multidisciplinary journal, Narra X welcomes articles from any subject field, depending on the editorial capacity. At the moment, Narra X is handled by section editors in the following fields: Health and medicine Chemistry Biology Mathematics Physics Narra X is online only journal and all articles do not have page numbers; instead, they are given a unique article number.
Arjuna Subject : -
Articles 94 Documents
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Random forest-based QSAR modeling for predicting the potency of neprilysin inhibitors using Mordred molecular descriptors Albar, Nizam; Rampengan, Derren DCH.; Azhari, Saiful; Mahmudi, Mahmudi; Fahdhienie, Farrah; Susilawati, Anggi; Habiburrahman, Muhammad
Narra X Vol. 4 No. 1 (2026): April 2026 (In Press)
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narrax.v4i1.242

Abstract

Neprilysin (NEP) is a zinc-dependent metallopeptidase, considered a key therapeutic target in heart failure management. Efficient identification of potent NEP inhibitors remains a challenge in drug discovery. The aim of this study was to develop a quantitative structure–activity relationship (QSAR) model using 2D Mordred molecular descriptors and Random Forest algorithms to predict the inhibitory potency (pIC50) of drug candidates. A curated dataset of compounds with experimentally determined IC₅₀ values (in nM) against NEP was preprocessed and converted to pIC50. Mordred was used to calculate 2D molecular descriptors, and descriptors with missing values were excluded. The dataset was split into training, internal validation, and external test sets. A Random Forest regression model was trained using 500 estimators, and model performance was evaluated using R2, root mean square error (RMSE), mean absolute error (MAE), and concordance correlation coefficient (CCC), while a binary classification model was also constructed. Feature importance, residual analysis, and chemical space visualization were conducted to assess model interpretability and reliability. The regression model demonstrated moderate to strong predictive performance, with R2 of 0.286, RMSE of 0.949, MAE of 0.723, and CCC of 0.532 in the internal validation. External validation showed improved generalization, with R2=0.659, RMSE=0.858, MAE=0.630, and CCC=0.763. Binary classification revealed an accuracy of 0.953, precision of 1.000, recall of 0.943, and an F1-score of 0.971, indicating strong discriminative ability in classifying inhibitory versus non-inhibitory compounds. Top contributing descriptors included ATSC2p (feature importance=0.0505), GATS2p (0.0408), and SaasC (0.0317). Principal component analysis (PCA) and Williams plots confirmed that test compounds lie within the model’s applicability domain, with no major outliers in leverage or residual distribution. The developed Random Forest-based QSAR model demonstrates strong predictive power and interpretability for identifying NEP inhibitors. This study provides a valuable tool for virtual screening and highlights the relevance of 2D structural features in governing NEP inhibitory activity. It is the first dedicated QSAR analysis of neprilysin inhibition using Mordred descriptors with rigorous internal and external validation.
Technology-based contraceptive decision aids and the role of healthcare providers: A scoping review Wisdayanti, Syah R.; Prawitasari, Shinta
Narra X Vol. 4 No. 1 (2026): April 2026 (In Press)
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narrax.v4i1.254

Abstract

Technology-based decision aids are increasingly integrated into contraceptive counseling to enhance informed decision-making and promote patient-centered care. However, evidence regarding their effectiveness on clinical outcomes and the evolving role of healthcare providers remains limited. The aim of this study was to map existing evidence on technology-based contraceptive decision aids and to examine the role of healthcare providers in supporting decision-making processes. The study was conducted in accordance with the PRISMA-ScR framework. A systematic search was performed across PubMed/MEDLINE, Cochrane Library, ProQuest, ScienceDirect, and Scopus for studies published between January 1, 2000, and March 1, 2025. Study selection and data extraction were performed independently by two reviewers, with discrepancies resolved through discussion. A total of five studies were included, encompassing web-based platforms, mobile applications, and tablet-based tools. The findings suggest that technology-based decision aids improve patient knowledge and satisfaction. However, the assisting technology does not improve contraceptive uptake and continuation rates. Across studies, healthcare providers remained essential in facilitating shared decision-making by contextualizing information, addressing patient concerns, and supporting individualized choices. In conclusion, current evidence suggests that the use of technology to support contraceptive decision-making improves subjective outcomes, but not clinical outcomes. Healthcare providers remain essential in complementing these tools, ensuring that decisions are informed and tailored to individual contexts. Further high-quality studies are needed to strengthen the evidence base and evaluate long-term effectiveness.
Effect of Mindfulness-Based Stress Reduction on burnout among nurses: A systematic review and meta-analysis of randomized controlled trials Talia, Ani; Abidin, Raniindra KS.; Jayanagara, Oscar
Narra X Vol. 4 No. 1 (2026): April 2026 (In Press)
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narrax.v4i1.259

Abstract

Burnout is highly prevalent among nurses, characterized by emotional exhaustion, depersonalization, and reduced personal accomplishment, and is associated with adverse impacts on mental health, professional performance, and quality of patient care. Mindfulness-Based Stress Reduction (MBSR) has been proposed as a potential intervention; however, evidence regarding its effectiveness across burnout dimensions remains inconsistent. The aim of this study was to systematically evaluate and quantify the effects of MBSR on burnout among nurses across the three Maslach Burnout Inventory (MBI) dimensions. A systematic search of PubMed, ScienceDirect, and the Cochrane Library was conducted up to October 2025. Eligible studies evaluated MBSR among nurses, with burnout outcomes measured using the MBI subscales: emotional exhaustion, depersonalization, and personal accomplishment. Meta-analyses were performed using inverse-variance random-effects model, with heterogeneity assessed using the I² statistic. Outcomes were categorized by follow-up duration: short-term (0–4 weeks), medium-term (>1–6 months), and long-term (>6 months). A total of seven RCTs were included in the meta-analysis. MBSR was associated with a significant reduction in emotional exhaustion overall (mean difference (MD): −5.80, 95% confidence interval (95%CI): −7.77 to −3.84; I²=26%), with the strongest effects observed in the short term (MD: −7.00), which attenuated in the medium term (MD: −5.03) and were not sustained at long-term follow-up. Depersonalization showed a modest overall reduction (MD: −2.71, 95%CI: −4.25 to −1.16), although heterogeneity was substantial (I²=70%) and effects were not maintained over time. No significant improvement was observed for personal accomplishment (MD: −0.53, 95%CI: −2.95 to 1.88; I²=88%). Risk of bias across studies was generally low to moderate, and no evidence of publication bias was identified. MBSR appears to provide short-term reductions in emotional exhaustion and may offer transient benefits for depersonalization; however, these effects diminish over time and no significant improvement is observed in personal accomplishment. These findings suggest that MBSR may function primarily as a short-term supportive intervention, and sustained reductions in burnout likely require integration with organizational strategies and ongoing support.
Association of reactive hyperglycemia, D-dimer, and asymmetric dimethylarginine (ADMA) with outcomes in acute ischemic stroke Imran, Imran; Syahrul, Syahrul; Musadir, Nasrul
Narra X Vol. 4 No. 1 (2026): April 2026 (In Press)
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narrax.v4i1.261

Abstract

Acute ischemic stroke is frequently accompanied by stress-related (reactive) hyperglycemia and may involve coagulation activation and endothelial dysfunction, reflected by D-dimer and asymmetric dimethylarginine (ADMA) levels, respectively. These factors may influence clinical outcomes. The aim of this study was to evaluate the associations of reactive hyperglycemia, D-dimer, and plasma ADMA with stroke outcomes in patients with acute ischemic stroke. A cross-sectional study was conducted among patients with acute ischemic stroke admitted to the neurology ward and stroke unit of Dr. Zainoel Abidin Hospital, Banda Aceh, Indonesia, between May and September 2024. Functional stroke outcome (FSO) was assessed using the Barthel Index, and disability stroke outcome (DSO) was assessed using the modified Rankin Scale (mRS). A total of 123 patients were included. The findings indicate that mean admission blood glucose was significantly higher in the improved FSO group than in the unchanged-worsened group (p=0.004), whereas mean blood glucose did not differ significantly across DSO categories (p=0.194). Mean D-dimer was significantly higher in the unchanged-worsened FSO group than in the improved group (538.6±249.4 vs 398.4±128.5 ng/mL; p<0.001). Across DSO categories, D-dimer showed a significant difference only between the no-disability and moderate-disability groups (p=0.044), without a consistent graded pattern. Mean ADMA levels were not significantly different between FSO groups (p=0.136), but it was statistically significant between DSO categories (slight vs moderate disability), p=0.045. The present analysis indicated that elevated D-dimer, dyslipidemia, heart disease, and GCS were significantly associated with FSO. Systolic blood pressure, diastolic blood pressure, reactive hyperglycemia, and hypertension were significantly associated with DSO severity. Overall, elevated D-dimer was more strongly associated with Barthel Index-based functional outcome, whereas reactive hyperglycemia was associated with mRS-based disability outcome.

Page 10 of 10 | Total Record : 94

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