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INDONESIA
International Journal of Cell and Biomedical Science
Published by Stem Cell and Cancer Research Indonesia
ISSN : -     EISSN : 28296621     DOI : https://doi.org/10.59278/
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology
International Journal of Cell and Biomedical Science, formerly CBS Int. Journal is an open-access, peer-reviewed journal published by Stem Cell and Cancer Research (SCCR), Indonesia. The journal publishes papers describing original findings and reviews articles in all aspects of cell, molecular biology, and biomedical research. Received manuscripts are accepted for publication only after rigorously being reviewed by independent experts in the respective fields determining the originality, validity, and conclusions.
Arjuna Subject : Biokimia, Genetika dan Biologi Molekuler - Biokimia, Genetika dan Biologi Molekuler (Lain-Lain)
Articles 5 Documents
 1 
Search results for , issue "Vol 3 No 8 (2024)" : 5 Documents clear
Cytotoxic and Antiproliferative Effects of Gynura divaricata Ethanolic Extract on HCT-116 Colorectal Cancer Cells In Vitro Putri Rifai, Fauziah Novita; Hidayah, Nurul; Sakinah, Feby Nur; Adityani, Resanti
International Journal of Cell and Biomedical Science Vol 3 No 8 (2024)
Publisher : Stem Cell and Cancer Research (SCCR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59278/cbs.v3i8.50

Abstract

Background: Colorectal cancer is a major cause of cancer-related morbidity and mortality worldwide. The limitations of conventional treatments such as chemotherapy and radiotherapy have driven the search for alternative therapies with fewer side effects. Objective: This study aimed to investigate the cytotoxic effects of Gynura divaricata extract on HCT-116 colorectal cancer cells and evaluate its potential as a complementary anticancer agent. Methods: Gynura divaricata was extracted using ethanol through a maceration process. HCT-116 cells were cultured and treated with various concentrations of the extract. Cell viability was measured using the MTT assay, and the IC50 value was calculated through linear regression analysis. Results: Treatment with Gynura divaricata extract resulted in a dose-dependent decrease in cell viability. The IC50 value was determined to be 62.09 µg/mL, indicating significant cytotoxic activity against HCT-116 cells. Conclusion: Gynura divaricata exhibits potential as an alternative or adjunctive therapy for colorectal cancer due to its ability to reduce cancer cell viability.
Generation of M2c Macrophages Using IL-10 Exposure In Vitro Alif, Iffan; Kurniawan, Dicky Zulfa F; Wilaksono, Bhirau; Susanto, Indra
International Journal of Cell and Biomedical Science Vol 3 No 8 (2024)
Publisher : Stem Cell and Cancer Research (SCCR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59278/cbs.v3i8.52

Abstract

Background : Macrophages are essential cells of the innate immune system that highly adaptable and play vital roles in tissue homeostasis, immune regulation, and development. Among their various phenotypes, the M2c subtype—induced by IL-10 and TGF-β—is known for its regulatory functions, high phagocytic capacity, and pro-angiogenic potential. This study aimed to investigate whether M2c polarization via IL-10 stimulation occurs in a dose-dependent manner by differentiating human monocyte-derived macrophages using IL-10 at concentrations of 5, 10, and 20 ng/mL. Methods : IL-10 expression levels were assessed by ELISA and qPCR. The results demonstrated a clear dose-dependent increase in IL-10 expression across both methods. Results : ELISA measurements showed IL-10 levels increasing from a mean of 3.2±0.7 pg/mL in untreated controls to 19.34±2.3 pg/mL (5 ng/mL), 35.5±7 pg/mL (10 ng/mL), and 67.2±5.8 pg/mL (20 ng/mL). Similarly, qPCR analysis revealed a corresponding increase in IL-10 gene expression, with relative fold changes from 1±0 (untreated control) to 3.1±0.4, 6±1.3, and 10.1±1.6, respectively. Conclusions : These findings indicate that IL-10 induces M2c macrophage polarization in a dose-dependent manner, providing insight into optimized conditions for generating regulatory macrophage populations for potential therapeutic applications.
A 36-Year-Old Male with Snake Bite Grade I Manus Dextra Case Report Dewi, Ratna; Pranandari, Ayun; Ardani, Yanuar
International Journal of Cell and Biomedical Science Vol 3 No 8 (2024)
Publisher : Stem Cell and Cancer Research (SCCR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59278/cbs.v3i8.54

Abstract

Background: Snakebite remains a major global public health concern, particularly in tropical regions like Indonesia. Snake envenomation may lead to local and systemic manifestations including erythema, swelling, pain, hypotension, respiratory distress, and even death. Case: A 34-year-old male presented to the Emergency Department of Esensia Main Clinic with the chief complaint of a traumatic wound on the right hand resembling a snakebite, accompanied by hand swelling, pain, nausea, and dizziness. The patient had applied a cloth bandage prior to arrival. Results: The patient was diagnosed with a grade I snakebite of the right hand (manus dextra) based on clinical history and physical examination. Management included administration of anti-snake venom serum (ASVS). Conclusion: Venomous snakebites can result in severe outcomes, including death; thus, early and appropriate management is crucial. In this case, medical treatment included administration of ASVS.
Therapeutic Potential of Mesenchymal Stem Cells and Their Secretome in Ameliorating Renal Fibrosis: A Comprehensive Narrative Review Amansyah, Fajar; Amalina, Nur Dina
International Journal of Cell and Biomedical Science Vol 3 No 8 (2024)
Publisher : Stem Cell and Cancer Research (SCCR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59278/cbs.v3i8.55

Abstract

Chronic kidney disease (CKD) represents a global health challenge with limited therapeutic options, often progressing to end-stage renal disease requiring dialysis or transplantation. Renal fibrosis, characterized by excessive extracellular matrix deposition and loss of functional nephrons, constitutes the final common pathway for most progressive kidney diseases. Conventional therapies primarily target symptoms rather than underlying pathological mechanisms. Mesenchymal stem cells (MSCs) have emerged as promising candidates for regenerative therapy due to their multipotent differentiation capabilities, immunomodulatory properties, and paracrine effects. Growing evidence suggests that the therapeutic benefits of MSCs are predominantly mediated through their secretome—a complex mixture of soluble factors, extracellular vesicles, and exosomes. This narrative review comprehensively examines the current understanding of MSC-based therapies for renal fibrosis, with particular emphasis on their secretome. We explore the mechanisms of action, preclinical evidence, ongoing clinical trials, and challenges in translating MSC secretome-based therapies to clinical applications. Recent advances in secretome characterization, bioengineering approaches to enhance therapeutic efficacy, and targeted delivery strategies are also discussed. Despite promising results, several hurdles remain, including standardization of preparation protocols, identification of key therapeutic components, and optimization of delivery methods. This review highlights the transformative potential of MSC secretome in renal fibrosis treatment while acknowledging the need for further research to realize its full clinical potential.
Strategies for Controlling Diabetes Mellitus in Adolescents through a Family Approach at Puskesmas after the COVID-19 Pandemic Sira, Amaze Grace; Priskila, Loury; Wicaksono, Hendi; Simanjuntak, Mario Hendrian; Nappoe, Angela Aletha Biatrix; Julianto, Dayceline Helena
International Journal of Cell and Biomedical Science Vol 3 No 8 (2024)
Publisher : Stem Cell and Cancer Research (SCCR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59278/cbs.v3i8.56

Abstract

Background Non-communicable diseases (NCDs) have become a burden on the health system in Indonesia in recent years. The increasing prevalence of diseases such as heart disease, diabetes mellitus, and cancer has an impact on national health financing, and people's quality of life. This study is a literature review that aims to evaluate the relationship between NCD risk factors, the impact of the COVID-19 pandemic on early detection of chronic diseases, and the role of primary health facilities and family approaches in controlling NCDs. Methods Secondary data were obtained from various scientific journals and official reports through systematic searches in Clinical Key, Google Scholar, and PubMed. Discussion The review showed that risk factors such as body mass index (BMI), unhealthy diet, low physical activity, and family history significantly contributed to the increase in NCD cases. The COVID-19 pandemic has also caused serious disruptions to preventive health services, including decreased access to early detection of Type 2 Diabetes Mellitus Programs such as Posbindu PTM and PIS-PK conducted by Puskesmas have an important role in promotive and preventive efforts, although they are still faced with various obstacles. The family approach in implementing healthy living behaviors and early detection has proven crucial in supporting the success of NCD control. Conclusion: The integration of the family approach in the national NCD control strategy needs to be strengthened to improve the effectiveness of interventions and the quality of life of the community.

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