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Al Makki Health Informatics Journal
Published by Al-Makki Publisher
ISSN : 30256518     EISSN : 30250501     DOI : -
Core Subject : Health,
Dentistry Health Professions Nursing Public Health Veterinary
l Makki Health Informatics Journal is an open-access scientific peer-review journal publishing. The Al Makki Health Informatics Journal focuses on exchanging information relating to intelligent computing and health informatics applied in industry, hospitals, government, and universities. All articles should include a validation of the idea presented, e.g. through case studies, experiments, or systematic comparisons with other approaches already in practice. Two types of papers are accepted: (1) A short paper that discusses a single contribution to a specific new trend or a new idea, and; (2) A long paper that provides a survey of a specific research trend using a systematic literature review (SLR) method, as well as a traditional review method. Topics of interest include, but are not limited to: Electronic health record E-Health Information Medical Image Processing & Techniques Data Mining in Healthcare Bioinformatics & Biostatistics Mobile applications for patient care Medical Image Processing & Techniques Hospital information systems Document handling systems Electronic medical record systems Standardization, and systems integration ICT in health promotion programmes e-health Guidelines and protocols E-learning & education in healthcare Telemedicine Software- Portals-Devices & Telehealth Public health & consumer informatics Data Mining & Knowledge Discovery in Medicine ICT for Patient empowerment ICT for Patient safety Medical Databanks-Databases & Knowledge Bases Healthcare Quality assurance Nursing Informatics Evaluation & Technology Assessment Home-based eHealth Health Management Issues Health Research Health Economics Issues Statistical Method for Computer Medical Decision Support Systems Medical Informatics or medicine in general Organizational, economic, social, clinical impact, ethical and cost-benefit aspects of IT applications in health care.
Arjuna Subject : Profesi Kesehatan - Terminologi Medis
Articles 56 Documents
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Diagnostic Approach to Patients with Hepatic Abscess: A Case Report Pradnyani, Made Ayu Agustia; Made Dwija Suarjana, I
Al Makki Health Informatics Journal Vol. 3 No. 1 (2025): Al Makki Health Informatics Journal
Publisher : Al Makki Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57185/hij.v3i1.44

Abstract

Hepatic abscess is a severe infection characterized by pus accumulation within the liver, often caused by bacterial or amoebic pathogens. This case report discusses the diagnostic challenges and management of bilateral hepatic abscesses in a resource-limited setting. A 43-year-old male presented with right upper quadrant abdominal pain, jaundice, and systemic symptoms. Diagnostic investigations, including ultrasonography and contrast-enhanced CT scan, revealed abscesses in the right and left hepatic lobes. Laboratory findings showed leukocytosis, hypoalbuminemia, and elevated liver enzymes. The patient was treated with empiric antibiotics and underwent laparotomy for abscess drainage, yielding 1700 cc of pus. Postoperative recovery was uneventful, with significant clinical improvement. This study highlights the importance of a combined medical and surgical approach in managing complex hepatic abscess cases, particularly in settings with limited diagnostic resources. The findings emphasize early diagnosis, multidisciplinary care, and tailored treatment strategies to improve outcomes for patients with hepatic abscesses, especially in underserved regions.
Harnessing Artificial Intelligence in Generic Formulation Development and Life Cycle Management - A Comprehensive Review Babu, Murali Mohan; Luh Putu Nurshanti, Ni; Martha Wijaya, Harry; R. Tjandrawinata, Raymond
Al Makki Health Informatics Journal Vol. 3 No. 1 (2025): Al Makki Health Informatics Journal
Publisher : Al Makki Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57185/hij.v3i1.45

Abstract

Artificial intelligence (AI) is revolutionizing the pharmaceutical industry by enhancing efficiency, precision, and cost-effectiveness in drug development. This study explores the application of AI in the lifecycle management of generic drugs, focusing on key stages such as active pharmaceutical ingredient (API) synthesis, excipient selection, pre-formulation studies, bioequivalence testing, and regulatory compliance. By leveraging machine learning algorithms, AI facilitates predictive modeling, risk assessment, and optimization of drug formulation processes, reducing time-to-market and improving scalability. Despite significant advancements, challenges such as data quality, algorithm transparency, and infrastructure limitations persist, particularly in resource-constrained settings. This review highlights case studies and emerging technologies that address these challenges, providing actionable insights for pharmaceutical stakeholders. The study also discusses AI's potential to streamline supply chain logistics, enhance accessibility, and ensure regulatory adherence. By integrating AI across all stages of generic drug development, this research underscores its transformative potential in improving drug affordability, accessibility, and patient outcomes globally.
Poor Outcome in an Elderly Patient with Generalized Tetanus During Hospitalization: Identifying Contributing Factors - A Case Report Prakoso, Iqbal Adi; Septiana Maria Kathrine, Anita; Satri Delta Wijaya, Muhammad
Al Makki Health Informatics Journal Vol. 3 No. 1 (2025): Al Makki Health Informatics Journal
Publisher : Al Makki Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57185/hij.v3i1.46

Abstract

Tetanus, caused by Clostridium tetani, remains a significant global health challenge despite the availability of vaccines. This case report discusses a 64-year-old male farmer diagnosed with Grade IV generalized tetanus following a puncture wound caused by a fish bone. The patient presented with stiffness, trismus, risus sardonicus, and opisthotonus, with symptoms progressively worsening. The diagnosis was established using Ablett's classification, and treatment included tetanus antitoxin, antibiotics, diazepam, and nutritional support. However, limited healthcare resources, inadequate isolation facilities, and a lack of essential medications contributed to a poor prognosis, culminating in the patient's death. This case emphasizes the critical need for improved healthcare infrastructure, early diagnosis, comprehensive management, and public health initiatives to prevent tetanus through vaccination and education. The findings highlight the importance of addressing systemic healthcare barriers to enhance outcomes in severe tetanus cases.
Effectiveness of the Nutrition Education Program in Increasing Awareness of Balanced Eating Patterns in Elementary Schools Fransisca, Vika
Al Makki Health Informatics Journal Vol. 2 No. 6 (2024): Al Makki Health Informatics Journal
Publisher : Al Makki Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57185/hij.v2i6.47

Abstract

The increasing prevalence of malnutrition and diet-related health issues among children emphasizes the urgent need for effective nutrition education. This study evaluates the effectiveness of a tailored nutrition education program in increasing awareness of balanced eating patterns among elementary school students in Indonesia. Using a qualitative research design, data were collected through semi-structured interviews, focus group discussions, and observations involving 20 students and their teachers. The findings reveal significant improvements in students' knowledge and attitudes toward balanced eating, highlighting the effectiveness of interactive learning methods and culturally relevant content. Parental involvement emerged as a critical factor in reinforcing the program's lessons. Challenges such as financial constraints and varying levels of parental support were noted, suggesting the need for community-level interventions. The results align with social cognitive theory, emphasizing observational learning and environmental influences. This study underscores the importance of integrating nutrition education into school curriculums and provides a replicable model for similar interventions. Future research should explore the long-term impacts and scalability of such programs.
Analysis of Reproductive Health Education Program for Adolescents in Secondary Schools Astuti, Aurelia Widya
Al Makki Health Informatics Journal Vol. 2 No. 6 (2024): Al Makki Health Informatics Journal
Publisher : Al Makki Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57185/hij.v2i6.48

Abstract

Reproductive health education in secondary schools is very important considering the increasing rate of teenage pregnancy and the low knowledge of reproductive health among adolescents. This study aims to explore the effectiveness of reproductive health education programs implemented in these schools. This study aims to identify the materials taught, teaching methods used, as well as students' responses and perceptions of the reproductive health education program. The methods used in this study include in-depth interviews and focus group discussions (FGDs) with 60 students from three secondary schools in X city. Data were collected over two months and analyzed to find relevant patterns and themes. Findings showed that the education program improved students' knowledge of reproductive health, but there were challenges such as social stigma and variations in the quality of teaching. Students reported increased confidence and better understanding of reproductive health topics. Reproductive health education programs in secondary schools have significant potential to improve adolescent understanding, but improvements in materials, teaching methods, and social environmental support are needed to achieve optimal results.
The Role of the Four Pillars in Heart Failure with Reduced Ejection Fraction (HFrEF) and Heart Failure with Preserved Ejection Fraction (HFpEF): How Different? Wili Mahendra, Dentino
Al Makki Health Informatics Journal Vol. 3 No. 2 (2025): Al Makki Health Informatics Journal
Publisher : Al Makki Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57185/hij.v3i2.49

Abstract

Heart failure (HF) remains a major clinical challenge, with two main phenotypes: heart failure with reduced ejection fraction (HFrEF) and heart failure with preserved ejection fraction (HFpEF). These conditions exhibit distinct pathophysiology, clinical manifestations, and therapeutic responses, requiring distinct management approaches. The four pillars of HFrEF therapy—renin-angiotensin system (RAS) inhibitors, β-blockers, mineralocorticoid receptor antagonists (MRAs), and sodium-glucose cotransporter-2 (SGLT2) inhibitors—have been shown to reduce mortality and morbidity. In contrast, HFpEF management focuses more on risk factor control and symptom-based therapy, with SGLT2 inhibitors being the only treatment that has shown significant clinical benefit. This literature review aims to evaluate the different roles of the four pillars of therapy in both phenotypes of heart failure and their implications for clinical practice. Although HFrEF treatment has made significant progress with strong clinical trial evidence, HFpEF management still requires further exploration to identify more effective strategies. Therefore, a deeper understanding of each phenotype's pathophysiology and therapeutic response is essential to improve patient outcomes and optimize heart failure management.
Antibacteria Susceptibility Test of Garlic (Allium sativum L.) Against Enterococcus faecalis As Root Canal Medicament Syaidah Ageng Kuswandi, Nabilla; Tarigan, Gita; Yuliadewi Rahmawati, Dicha
Al Makki Health Informatics Journal Vol. 3 No. 2 (2025): Al Makki Health Informatics Journal
Publisher : Al Makki Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57185/hij.v3i2.50

Abstract

This study aims to investigate the effect of garlic extract (GE) on the inhibition of Enterococcus faecalis (EF) bacterial growth. This study is a laboratory experimental research with a true experimental post-test only control group design, conducted in vitro using the well diffusion method. The experimental group consists of EF bacteria treated with different concentrations of GE, while the control group consists of EF bacteria treated with 0.2% chlorhexidine (CHX) as the positive control (PC) and 10% dimethyl sulfoxide (DMSO) as the negative control (NC). This study aims to observe the inhibition zone diameter (IZD) of bacterial growth after treatment with different concentrations of GE or control agents, measured in millimeters using a caliper. Phytochemical test revealed that the GE used in this study contains secondary metabolite compounds such as phenolics, flavonoids, saponins, and steroids, resulting in an IZD of 5.85 ± 0.26 at 100% GE and 3.25 ± 0.27 at 75% GE. The IZD formed on PC was 17.34 ± 0.33, and no IZD was formed on 50% GE or NC. The effect of GE in inhibiting the growth of EF was observed by the presence of inhibition zones at 100% and 75% concentrations, although it was not yet able to match the effectiveness of 0.2% CHX.
A Pharmacogenomic Study to Predict Reverse Remodeling Afies, Mohammad
Al Makki Health Informatics Journal Vol. 3 No. 3 (2025): Al Makki Health Informatics Journal
Publisher : Al Makki Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57185/hij.v3i3.51

Abstract

Cardiac remodeling refers to structural, functional, and molecular changes in the heart in response to stress or injury. These alterations, involving both cellular and interstitial changes, contribute to the progression of heart disease. Long-term activation of the autonomic nervous system (ANS) exacerbates these changes, leading to systemic vasoconstriction, sodium and water retention, and ventricular remodeling, which accelerates disease progression. Neurohormonal activation is essential in compensating for falling cardiac output in heart failure (HF), but it also plays a major role in the progression of the disease. This study explores the role of the renin-angiotensin-aldosterone system (RAA) and the sympathetic nervous system in cardiac remodeling, particularly in heart failure, and the influence of genetic factors on drug response. The research focuses on the ß2-Adrenergic Gln/Gln Receptor genotype, a key genetic variant relevant to pharmacogenomics in left ventricular hypertrophy (LVH) treatment. Using a comprehensive review of clinical and experimental data, this study highlights how genetic polymorphisms affect the pharmacokinetics and pharmacodynamics of drugs such as beta-blockers, ACE inhibitors, and ARBs. The findings indicate that while the ß2-Adrenergic Gln/Gln Receptor genotype significantly influences drug efficacy, the challenges in applying personalized treatments based on genetic data require significant time and cost investments. The study's implications emphasize the need for personalized therapies and enhanced pharmacogenomic research to improve treatment outcomes in heart failure management, particularly in drug response and disease progression.
The Effect of The Application of Head Coaching on The Work Motivation and Job Satisfaction of The Implementing Nurse at The Bandar Lampung Advent Hospital Gulo, Magdalena; Hastono, Sutanto Priyo; Wijayanti, Catharina Dwiana
Al Makki Health Informatics Journal Vol. 3 No. 3 (2025): Al Makki Health Informatics Journal
Publisher : Al Makki Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57185/hij.v3i3.52

Abstract

Nursing human resources today are experiencing a change in the generation of workers. The need for the role of the head nurse in carrying out coaching to support, collaborate, and facilitate nursing human resources of different generations in order to build effective working relationships, increase motivation, self-potential, and staff job satisfaction. The purpose of the study was to assess the impact of coaching training on nurses' motivation and job satisfaction. Quasi-experimental research design with one group pre-posttest design. Respondents in the research were implementing nurses, using questionnaire measuring tools. The results were obtained by the majority of respondents aged 20-30 years (42.9%), PK 2 career path (37.5%), nurse education (50.0%), and length of work 1-5 years (44.6%). Before the coaching training, the average motivation was 25.13 and job satisfaction was 23.73, while after the coaching training, the average motivation increased to 43 and job satisfaction increased to 35.98. The Paired Samples Test showed a significant effect of coaching training on motivation and job satisfaction with a p-value of 0.000, as well as an R square result of 0.838.  The need for the implementation of coaching by the head of the room to increase the motivation and work of nurses which will have an impact on the quality and effectiveness of nursing services.
Literature Review: Analysis and Validation of the Effectiveness of Antidiabetic Drugs in the Biological Matrix Using the HPLC (High Performance Liquid Chromatography) Method Aulia Fernanda, Syahwa; Tirsta Az-zahra, Naila; Savitri Setyoasih, Teresa; Najwa Akmila, Ghefira; Bekti Pertiwi, Sekar; Maharani, Sabrina
Al Makki Health Informatics Journal Vol. 3 No. 2 (2025): Al Makki Health Informatics Journal
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Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

High-Performance Liquid Chromatography (HPLC) is a widely used analytical method for the separation, identification, and quantification of compounds in complex biological matrices, such as plasma, serum, and urine. This article discusses the analysis and validation of the effectiveness of antidiabetic drugs using HPLC, focusing on sample preparation, column selection, mobile phase, and detectors used. Method validation is performed to ensure parameters such as specificity, linearity, precision, accuracy, limit of detection (LOD), and limit of quantification (LOQ) are met. Literature study from 18 journals showed that HPLC is a sensitive, specific, and efficient method for antidiabetic drug analysis. Preparation techniques such as protein precipitation and solid-phase extraction provide optimal results in minimizing biological matrix interferences. In addition, the Photodiode Array (PDA) detector proved superior in terms of sensitivity and analyzability at low concentrations compared to other detectors. By fulfilling all validation parameters, HPLC can be relied upon as a primary method for the analysis of antidiabetic drugs in biological matrices.

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