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M. Saka Abeiasa
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Jurnal Medisains Kesehatan
Published by Universitas Sumatera Barat
ISSN : -     EISSN : 30260957     DOI : https://doi.org/10.59963/msbb
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Public Health
Jurnal Medisains Kesehatan adalah publikasi ilmiah yang memuat hasil penelitian dan kajian pemikiran dalam bidang Kedokteran, Ilmu Kebidanan, Ilmu Farmasi, Ilmu Gizi, Biomedik, Molekuler serta kegiatan lainya yang relevan. Jurnal Medisains Kesehatan diterbitkan oleh Universitas Sumatera Barat Pariaman dua kali setahun pada bulan Maret dan Oktober. format terbitan mulai mengikuti standar dasar e-journal direktorat penelitian dan pengabdian kepada masyarakat Ditjen Dikti.
Arjuna Subject : Biokimia, Genetika dan Biologi Molekuler - Biokimia, Genetika dan Biologi Molekuler (Lain-Lain)
Articles 54 Documents
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Formulasi Sediaan Obat Kumur (Gargarisma) Kombinasi Ekstrak Daun Jambu Biji dan Biji Pinang Gebbrina, Frank Sisca; Putra, Fajrian Aulia; Syafputri, Try Maya
Jurnal Medisains Kesehatan Vol. 6 No. 1 (2025): Jurnal Medisains Kesehatan
Publisher : Universitas Sumatera Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59963/jmk.v6i1.521

Abstract

Mouthwash is a liquid dosage form used to prevent and treat oral health problems. However, many commercial mouthwashes contain alcohol, which may cause side effects in certain individuals. This study aimed to formulate and evaluate a mouthwash (gargle) preparation made from a combination of guava leaf extract (Psidium guajava L.) and areca nut seed extract (Areca catechu L.). The extracts were obtained by maceration using 70% ethanol. Three formulations were prepared: F1 containing 3% guava leaf extract and 2.5% areca nut extract, F2 containing 3.5% guava leaf extract and 2.5% areca nut extract, and F3 containing 4% guava leaf extract and 2.5% areca nut extract. Physical evaluations included organoleptic tests, pH, viscosity, clarity, homogeneity, and hedonic (preference) tests. Results showed that all formulations met the required physical quality standards. Based on the preference test, formulation F3 received the highest score (26.2), surpassing F1 and F2. The combination of guava leaf and areca nut extracts shows potential as a natural, effective, safe, and alcohol-free mouthwash formulation.
Perbandingan Aktivitas Antidiare Ekstrak Etanol Daun Seledri Dan Biji Pinang Pada Mencit Terinduksi Minyak Jarak Putri, Sami Mardiah; Yansen, Fatridha; Humaira, Vilma
Jurnal Medisains Kesehatan Vol. 6 No. 1 (2025): Jurnal Medisains Kesehatan
Publisher : Universitas Sumatera Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59963/jmk.v6i1.522

Abstract

Diarrhea remains a significant health problem in Indonesia, especially among children. The use of medicinal plants as alternative therapy continues to grow due to their milder side effects compared to synthetic drugs. This study aimed to compare the antidiarrheal activity of ethanol extracts of celery leaves (Apium graveolens L.) and areca nuts (Areca catechu L.) on mice (Mus musculus L.) induced with castor oil. The experiment was conducted in a laboratory using a post-test only control group design involving 27 male mice divided into three groups: control, celery leaf extract (20 mg/kgBW), and areca nut extract (350 mg/kgBW). One Way ANOVA showed significant differences among groups in defecation frequency and diarrhea onset (p < 0.05; p = 0.000). The mean defecation frequency was 16 times in the control group, 13 in the celery extract group, and 8 in the areca extract group. Diarrhea onset occurred at 69.25 minutes, 51.75 minutes, and 37.5 minutes, respectively. The areca nut extract at 350 mg/kgBW was the most effective antidiarrheal agent, reducing defecation frequency and delaying diarrhea onset. This effect is attributed to secondary metabolites such as flavonoids, tannins, saponins, and alkaloids, which which act as natural antidiarrheals
Uji Aktifitas Daya Hambat Ekstrak Daun Jambu Biji (Psidium Guajava) Terhadap Pertumbuhan Bakteri Streptococcus Mutans Ramadhan, Willy Syahrina; Elfia, Linda; Iisniawati, Iisniawati
Jurnal Medisains Kesehatan Vol. 6 No. 1 (2025): Jurnal Medisains Kesehatan
Publisher : Universitas Sumatera Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59963/jmk.v6i1.523

Abstract

Dental caries is a common oral health problem caused by Streptococcus mutans, a bacterium that ferments carbohydrates into acid and damages tooth enamel. The high prevalence of dental caries in Indonesia highlights the need for natural antibacterial alternatives. Guava (Psidium guajava) leaf contains flavonoids, tannins, and saponins that have antibacterial potential. This study aims to determine the inhibitory effect of ethanol extract of guava leaves on Streptococcus mutans at concentrations of 1.25%, 2.5%, and 5%. The research used a laboratory experimental method with a Completely Randomized Design (CRD). Extraction was performed using maceration with 96% ethanol, while antibacterial testing used the disc diffusion method. The results showed inhibition zones at all concentrations, with the strongest inhibition at 5%. These findings indicate that guava leaf extract may serve as a natural antibacterial agent for preventing dental caries.
Perbandingan Efektivitas Antipiretik Ekstrak Etanol Daun Kapuk dan Daun Kembang Sepatu Pada Mencit Terinduksi Pepton Maharani, Silvia; Abeiasa, M. Saka; Yansen, Fatridha
Jurnal Medisains Kesehatan Vol. 6 No. 1 (2025): Jurnal Medisains Kesehatan
Publisher : Universitas Sumatera Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59963/jmk.v6i1.525

Abstract

Fever is a physiological response of the body to infection, characterized by an increase in temperature due to the activation of endogenous pyrogens. Herbal plants such as kapok (Ceiba pentandra) and hibiscus (Hibiscus rosa sinensis) are traditionally used as antipyretics due to their active compounds such as flavonoids, tannins, and saponins. This study aims to compare the antipyretic efficacy between ethanol extracts of kapok leaves and hibiscus in mice (Mus musculus) induced with fever using 10% peptone intravenously. The study design was a post-test only control group with 24 white male mice divided into three groups: P1 (negative control, only inducing peptone without treatment), P2 (induced by peptone and given kapok leaf extract 300 mg/kgBW), and P3 (induced by peptone and given hibiscus leaf extract 300 mg/kgBW). Body temperature was measured at 30 to 180 minutes after treatment. The results showed a decrease in average body temperature to 38.1°C at P2 and 36.7°C at P3, while P1's body temperature remained high above 39°C. One-Way ANOVA test showed significant differences between groups (p<0.05). Although both extracts showed significant antipyretic effects, hibiscus extract produced a greater decrease in temperature.

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