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Journal of Food and Pharmaceutical Sciences
Published by Universitas Gadjah Mada
ISSN : 20897200     EISSN : 23390948     DOI : https://doi.org/10.22146/jfps.8237
Core Subject : Health, Science, Engineering,
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience
Journal of Food and Pharmaceutical Sciences offers scientists, researchers, and other professionals to share knowledge of scientific advancements. The journal will publish original research articles, review articles, short communication, and letter to editor. The area of focus should cover all aspects of food and pharmaceutical sciences. The range of topics covered in the journal include: New Horizons in Food Research; Food Chemistry; Integrated Food Science; Health, Nutrition, and Food; Food Engineering, Materials Science, and Nanotechnology; Toxicology and Chemical Food Safety; Food Microbiology and Safety; Drug Discovery; Computational Chemistry and Molecular Modeling; Pharmaceutical Biotechnology and Protein-Peptide Chemistry; Pharmaceutics, Biopharmaceutics, Drug Delivery, and Pharmaceutical Technology; Pharmaceutical Nanotechnology; Pharmacokinetics, Pharmacodynamics, and Drug Transport Metabolism; Analytical and Bioanalytical Chemistry; Pharmaceutical Chemistry; Natural Medicine and Nutraceutical; Chemical Processing of Pharmaceuticals including Crystallization, Lyophilization, and Chemical Stability of Drugs; Immunology, Biochemistry, and Cell and Molecular Biology
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 6 Documents
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Search results for , issue "Article In Press 2026" : 6 Documents clear
Development of Self-Nano Emulsifying Drug Delivery System (SNEEDS) Containing Hibiscus sabdariffa L. extract, an Anticancer Against T47D Cells, as a co-chemotherapy of cisplatin Efiana, Nuri Ari; Nurani, Laela Hayu; Wahyuningtyas, Nurma; Edityaningrum, Citra Ariani; Indratmoko, Septiana; Guntarti, Any; Ma’ruf, Muhammad
Journal of Food and Pharmaceutical Sciences Article In Press 2026
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.21378

Abstract

Background: The first-line chemotherapy drug for breast cancer is cisplatin. However, it shows a high incidence of resistance. Therefore, Hibiscus Sabdariffa L (HS), containing strong anticancer compounds, was developed using a self-nano-emulsifying drug delivery system (SNEDDS), potentially as cisplatin co-chemotherapy. This study aimed to develop the HS SNEDDS providing anticancer activity against T47D breast cancer cells. Methods: Development of HS SNEDDS (F1-F7) with various surfactant and co-surfactant concentrations was carried out, followed by characterization of HS SNEDDS. The selected formulation was performed regarding the cytotoxicity on T47D cells and selectivity on Vero cells. Results: F7 as a selected formulation indicated a transmittance, globule size, PI, zeta potential, and emulsification time of 97.80%, 15.68 ± 0.19 nm, 0.12 ± 0.01, -8.05 ± 1.88 mV, and 24.76 ± 0.29 seconds, respectively. Furthermore, the IC50 of HS extract, HS SNEDDS, and Cisplatin on T47D cells were 0.37 ± 0.02, 0.24 ± 0.02, and 0.01 ± 0.001 mg/mL The selectivity index (SI) of HS SNEDDS and cisplatin were 108101.25 and 8351.84, respectively. Conclusion: HS SNEDDS providing the required characteristics could be obtained, and potentially be used as a co-chemotherapy of cisplatin, showing the cytotoxic effect on T47D breast cancer cells.
Anti-Inflammatory Effects of Eicosapentaenoic Acid and Docosahexaenoic Acid Derived from Patin Fish Oil on Diabetic Nephropathy: A Bioinformatics Study Doddy Aditya Purnomo; Awidarta, Kevin; Nugroho, Agung Endro; Rohman, Abdul
Journal of Food and Pharmaceutical Sciences Article In Press 2026
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.22899

Abstract

Diabetic nephropathy is a severe complication of diabetes mellitus with a significant global impact on end-stage renal disease. Fish-derived fatty acids show promise in inflammatory disorders, but their mechanisms in diabetic nephropathy remain unclear. This study used network pharmacology and molecular docking to investigate the therapeutic targets of EPA and DHA from Patin fish oils. Potential targets of EPA and DHA were retrieved from the Swiss Target Prediction, SEA, and SuperPRED databases, identifying 160 and 185 targets, respectively. Notably, 37 and 62 of these targets overlapped with DN-related targets from GeneCards, DisGeNET, and OMIM. Protein-protein interaction (PPI) network analysis revealed hub genes, including PPARG, TLR4, and TP53, as critical mediators. Gene Ontology (GO) enrichment analysis revealed involvement in biological processes such as collagen metabolic process for EPA and regulation of inflammatory response for DHA, while KEGG pathway analysis highlighted the modulation of PPAR signaling, the renin-angiotensin system, and the AGE-RAGE signaling pathway. Molecular docking confirmed favorable binding affinities of EPA and DHA to key targets such as PPARG (-8.04 kcal/mol for DHA) and PPARD (-8.11 kcal/mol for EPA). These findings suggest that EPA and DHA may mitigate DN-associated inflammation through multi-target and multi-pathway interactions, positioning them as potential supplementary therapeutic agents.
Ethnopharmacology Analysis of Antidiabetic Medicinal Plants from Menoreh Hills: Linking Local Knowledge to Pharmacological Evidence Kintoko, Kintoko; Faisal Nur Arib; Nanik Sulistyani; Akrom
Journal of Food and Pharmaceutical Sciences Article In Press 2026
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.24603

Abstract

Abstract: The prevalence of type 2 diabetes mellitus (T2DM) has been increasing worldwide and in Indonesia. Documenting locally utilized antidiabetic plants may inform evidence-based phytotherapy. This study mapped antidiabetic medicinal plants in Samigaluh (Menoreh Hills) and prioritized candidates by linking community knowledge with pharmacological data. Semi-structured interviews and observation were conducted between July and August 2025, and involved ten informants selected through purposive and snowball sampling. Quantitative ethnobotanical indices (Use Value, Relative Frequency of Citation, Fidelity Level, Plant Part Value) were calculated, followed by a PubMed-based narrative review. The Zingiberaceae family was predominant (seven species); rhizomes were the most utilized (39.58%), followed by stems (25.00%) and leaves (22.92%). Vernonia amygdalina was prioritized for diabetes-specific consensus (Fidelity Level 100%, Relative Frequency of Citation 0.7), and Curcuma mangga for its high usage and popularity (Use Value 1.3, Relative Frequency of Citation 0.6). Pharmacological evidence indicates that V. amygdalina exhibits antidiabetic effects through the inhibition of α-amylase and α-glucosidase, enhancement of GLUT4, and suppression of gluconeogenesis, supported by its antioxidant and anti-inflammatory properties, while C. mangga demonstrates hypoglycemic activities and β-cell protection, along with anti-inflammatory, antioxidant, and immunostimulant activities as supportive mechanisms. Local knowledge thus aligns with mechanistic findings, supporting a complementary pairing of V. amygdalina and C. mangga for future antidiabetic combinations; further validation through in vitro and in vivo studies is recommended. Keywords: Curcuma mangga; indigenous knowledge; pharmacological evidence; phytotherapy; Vernonia amygdalina
Evaluation Antibacterial Activity of Rosary Pea (Abrus precatorius L.) Leaf Extract against the Growth of Staphylococcus aureus and Shigella sonnei Shari, Amalia; Syahfitri, Alda Bunga
Journal of Food and Pharmaceutical Sciences Article In Press 2026
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.24861

Abstract

Bacteria are major contributors to infectious diseases, including Staphylococcus aureus and Shigella sonnei. Although antibiotics remain the primary treatment, prolonged use can lead to antimicrobial resistance, highlighting the need for alternative agents capable of inhibiting pathogenic bacteria. Scientific validation of medicinal plants is crucial for complementing traditional knowledge in bioprospecting efforts. The Rosary pea (Abrus precatorius L.) is one such plant with potential antibacterial properties. This study evaluates the inhibitory activity of Abrus precatorius L. leaf ethanol extract against S. aureus and S. sonnei at concentrations of 3.125%, 6.25%, 12.5%, 25%, 50%, and 100%. The extract demonstrated optimal activity at 100%, exhibiting moderate inhibition against S. aureus and weak inhibition against S. sonnei. These findings underscore the potential of Abrus precatorius L as a source of antibacterial compounds and provide a foundation for developing improved formulations with enhanced antibacterial efficacy.
Integration of Molecular Docking in the Identification of Natural Antioxidants: Interaction Study of Jackfruit Leaf Flavonoids with NADPH:FMN Oxidoreductase Muhammad Andre Reynaldi; Meri Ropiqa
Journal of Food and Pharmaceutical Sciences Article In Press 2026
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.26236

Abstract

Oxidative stress plays a critical role in the progression of various degenerative diseases through increased production of reactive oxygen species (ROS), driven in spart by the activity of redox related enzymes such as NADPH:FMN oxidoreductase. Bioactive compounds from jackfruit leaves are known to possess antioxidant potential, yet their molecular mechanisms against specific enzymatic targets remain insufficiently elucidated. This study aimed to evaluate the potential interaction of jackfruit leaf flavonoids morin, oxyresveratrol, and artocarpin with NADPH:FMN oxidoreductase using molecular docking analysis. The 1BKJ protein structure was prepared following standard protocols, and all ligands were optimized prior to performing redocking for method validation. AutoDock Vina 1.2.7 was employed with a 20×20×20 Å grid box area. Redocking produced an RMSD of 0.1469 Å, confirming the reliability of the docking parameters. Docking results revealed that morin (–7.848 kcal/mol) and oxyresveratrol (–7.577 kcal/mol) exhibited stronger binding affinities compared with vitamin C (–5.713 kcal/mol) and artocarpin (–5.577 kcal/mol). The dominant interactions involved Arg15, Arg169, Tyr128, Tyr199, and Tyr200, residues that contribute to the stabilization of ligand protein complexes in silico and may be located near functionally relevant regions associated with redox activity. These findings suggest that jackfruit leaf flavonoids may serve as promising candidates for further investigation as potential modulators of redox related enzymes based on predictive in silico evidence.
Formulation of Theophylline Sustained-Release Tablets with a Combination of Eudragit RS 100 and Lactose Trisnaningtyas, Meysiska; Ikasari, Endang Diyah; Intan Martha Cahyani
Journal of Food and Pharmaceutical Sciences Article In Press 2026
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.26837

Abstract

Sustained-release (SR) delivery of Theophylline is pharmaceutically essential due to its narrow therapeutic index and the need to maintain controlled plasma exposure. This study aims to investigate the release kinetics and matrix-modifying roles of Eudragit RS 100 and lactose in three SR tablet formulations of Theophylline. Tablets were produced with the wet granulation method and evaluated for physicochemical properties, dissolution behavior according to USP specifications, and kinetic model fitting. The physicochemical evaluation revealed clear differences among formulations. F-1 exhibited the highest hardness (10.48 ± 0.10 kg/cm²) but excessive friability (2.40 ± 0.01%), whereas F-2 and F-3 showed lower hardness values (8.25 ± 0.03 and 8.03 ± 0.02 kg/cm²) with acceptable friability (0.32 ± 0.03% and 0.34 ± 0.03%). Granule flow properties improved progressively from F-1 to F-3, as indicated by reduced Carr’s Index (16.17 ± 0.16 to 11.58 ± 0.32%) and Hausner Ratio (1.193 to 1.131), accompanied by increased flow rates (12.12 ± 0.03 to 14.48 ± 0.53 g/s) (p < 0.05). These physicochemical differences were reflected in dissolution behavior and drug-release kinetics, confirming the matrix-modifying effects of Eudragit RS 100 and lactose. Kinetic modeling demonstrated formulation-dependent release mechanisms: F-1 showed the highest correlation with the zero-order model (R² = 0.9858), suggesting a near constant drug-release rate, whereas F-2 exhibited the best fit to a second-order model (R² = 0.9635), indicating concentration-dependent release. In contrast, F-3 was optimally described by the Korsmeyer–Peppas model (R² = 0.9545), consistent with anomalous transport governed by combined diffusion and polymer relaxation.

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