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Journal of Food and Pharmaceutical Sciences
Published by Universitas Gadjah Mada
ISSN : 20897200     EISSN : 23390948     DOI : https://doi.org/10.22146/jfps.8237
Core Subject : Health, Science, Engineering,
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience
Journal of Food and Pharmaceutical Sciences offers scientists, researchers, and other professionals to share knowledge of scientific advancements. The journal will publish original research articles, review articles, short communication, and letter to editor. The area of focus should cover all aspects of food and pharmaceutical sciences. The range of topics covered in the journal include: New Horizons in Food Research; Food Chemistry; Integrated Food Science; Health, Nutrition, and Food; Food Engineering, Materials Science, and Nanotechnology; Toxicology and Chemical Food Safety; Food Microbiology and Safety; Drug Discovery; Computational Chemistry and Molecular Modeling; Pharmaceutical Biotechnology and Protein-Peptide Chemistry; Pharmaceutics, Biopharmaceutics, Drug Delivery, and Pharmaceutical Technology; Pharmaceutical Nanotechnology; Pharmacokinetics, Pharmacodynamics, and Drug Transport Metabolism; Analytical and Bioanalytical Chemistry; Pharmaceutical Chemistry; Natural Medicine and Nutraceutical; Chemical Processing of Pharmaceuticals including Crystallization, Lyophilization, and Chemical Stability of Drugs; Immunology, Biochemistry, and Cell and Molecular Biology
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 173 Documents
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Influence of Stearic Acid and Triethanolamine on the Physical Properties and Antibacterial Efficacy of Ocimum basilicum L. Anti-acne Cream against Staphylococcus epidermidis Nurcahya, Salsabila; Pranata, Yovi; Pratamarta, Meliasi Nora; Hidayati, Nurul; Setiawansyah, Arif
Journal of Food and Pharmaceutical Sciences Vol 13, No 4 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.25043

Abstract

Acne vulgaris represents a significant dermatological concern, with Staphylococcus epidermidis identified as a key pathogenic contributor. While Ocimum basilicum L. (basil) leaves contain bioactive compounds including flavonoids, eugenol, and tannins that demonstrate promising antibacterial properties, the successful translation of these natural antimicrobials into effective topical formulations remains critically dependent on appropriate excipient selection. Despite the growing interest in botanical-based acne treatments, there exists a significant knowledge gap regarding how emulsifying agents, particularly stearic acid and triethanolamine (TEA), influence both the physical stability and therapeutic efficacy of herbal cream formulations. This study investigated the effects of varying concentrations of stearic acid and TEA on the physical characteristics, stability, and antibacterial activity of basil leaf extract cream formulations against S. epidermidis ATCC-12228. Extracts obtained via maceration in 96% ethanol were incorporated into cream formulations (F0–F4), which were subsequently evaluated for organoleptic properties, homogeneity, spreadability, adhesion, pH, stability using a thermal cycling test, and antibacterial activity via disc diffusion. Stability assessment revealed notable differences across formulations. Although all formulations maintained consistent pH values and exhibited uniform microscopic homogeneity after cycling, variations in spreadability and adhesion indicated differing degrees of structural stability. Formulations F3 and F4 showed minimal changes across cycles, demonstrating superior resistance to thermal stress, whereas F0 exhibited significant instability in both spreadability and adhesion. Antibacterial testing showed that the formulation containing 20% basil extract (F4) produced the largest inhibition zone (11.83 ± 0.77 mm). Beyond its higher extract content, F4’s superior antibacterial performance is attributed to its more stable structural matrix, which likely enhanced the release and bioavailability of active phytochemicals such as eugenol and flavonoids, thereby promoting more efficient diffusion into the agar medium. Overall, the findings demonstrate that stearic acid and TEA concentrations substantially influence both the physical stability and antibacterial efficacy of basil-based cream formulations. The optimal stability and enhanced antimicrobial activity observed in F3 underscore their potential as promising candidates for topical anti-acne product development.
Integration of Molecular Docking in the Identification of Natural Antioxidants: Interaction Study of Jackfruit Leaf Flavonoids with NADPH:FMN Oxidoreductase Muhammad Andre Reynaldi; Meri Ropiqa
Journal of Food and Pharmaceutical Sciences Article In Press 2026
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.26236

Abstract

Oxidative stress plays a critical role in the progression of various degenerative diseases through increased production of reactive oxygen species (ROS), driven in spart by the activity of redox related enzymes such as NADPH:FMN oxidoreductase. Bioactive compounds from jackfruit leaves are known to possess antioxidant potential, yet their molecular mechanisms against specific enzymatic targets remain insufficiently elucidated. This study aimed to evaluate the potential interaction of jackfruit leaf flavonoids morin, oxyresveratrol, and artocarpin with NADPH:FMN oxidoreductase using molecular docking analysis. The 1BKJ protein structure was prepared following standard protocols, and all ligands were optimized prior to performing redocking for method validation. AutoDock Vina 1.2.7 was employed with a 20×20×20 Å grid box area. Redocking produced an RMSD of 0.1469 Å, confirming the reliability of the docking parameters. Docking results revealed that morin (–7.848 kcal/mol) and oxyresveratrol (–7.577 kcal/mol) exhibited stronger binding affinities compared with vitamin C (–5.713 kcal/mol) and artocarpin (–5.577 kcal/mol). The dominant interactions involved Arg15, Arg169, Tyr128, Tyr199, and Tyr200, residues that contribute to the stabilization of ligand protein complexes in silico and may be located near functionally relevant regions associated with redox activity. These findings suggest that jackfruit leaf flavonoids may serve as promising candidates for further investigation as potential modulators of redox related enzymes based on predictive in silico evidence.
Formulation of Theophylline Sustained-Release Tablets with a Combination of Eudragit RS 100 and Lactose Trisnaningtyas, Meysiska; Ikasari, Endang Diyah; Intan Martha Cahyani
Journal of Food and Pharmaceutical Sciences Article In Press 2026
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.26837

Abstract

Sustained-release (SR) delivery of Theophylline is pharmaceutically essential due to its narrow therapeutic index and the need to maintain controlled plasma exposure. This study aims to investigate the release kinetics and matrix-modifying roles of Eudragit RS 100 and lactose in three SR tablet formulations of Theophylline. Tablets were produced with the wet granulation method and evaluated for physicochemical properties, dissolution behavior according to USP specifications, and kinetic model fitting. The physicochemical evaluation revealed clear differences among formulations. F-1 exhibited the highest hardness (10.48 ± 0.10 kg/cm²) but excessive friability (2.40 ± 0.01%), whereas F-2 and F-3 showed lower hardness values (8.25 ± 0.03 and 8.03 ± 0.02 kg/cm²) with acceptable friability (0.32 ± 0.03% and 0.34 ± 0.03%). Granule flow properties improved progressively from F-1 to F-3, as indicated by reduced Carr’s Index (16.17 ± 0.16 to 11.58 ± 0.32%) and Hausner Ratio (1.193 to 1.131), accompanied by increased flow rates (12.12 ± 0.03 to 14.48 ± 0.53 g/s) (p < 0.05). These physicochemical differences were reflected in dissolution behavior and drug-release kinetics, confirming the matrix-modifying effects of Eudragit RS 100 and lactose. Kinetic modeling demonstrated formulation-dependent release mechanisms: F-1 showed the highest correlation with the zero-order model (R² = 0.9858), suggesting a near constant drug-release rate, whereas F-2 exhibited the best fit to a second-order model (R² = 0.9635), indicating concentration-dependent release. In contrast, F-3 was optimally described by the Korsmeyer–Peppas model (R² = 0.9545), consistent with anomalous transport governed by combined diffusion and polymer relaxation.

Page 18 of 18 | Total Record : 173

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