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Astri Desmayanti
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Journal of Food and Pharmaceutical Sciences
Published by Universitas Gadjah Mada
ISSN : 20897200     EISSN : 23390948     DOI : https://doi.org/10.22146/jfps.8237
Core Subject : Health, Science, Engineering,
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience
Journal of Food and Pharmaceutical Sciences offers scientists, researchers, and other professionals to share knowledge of scientific advancements. The journal will publish original research articles, review articles, short communication, and letter to editor. The area of focus should cover all aspects of food and pharmaceutical sciences. The range of topics covered in the journal include: New Horizons in Food Research; Food Chemistry; Integrated Food Science; Health, Nutrition, and Food; Food Engineering, Materials Science, and Nanotechnology; Toxicology and Chemical Food Safety; Food Microbiology and Safety; Drug Discovery; Computational Chemistry and Molecular Modeling; Pharmaceutical Biotechnology and Protein-Peptide Chemistry; Pharmaceutics, Biopharmaceutics, Drug Delivery, and Pharmaceutical Technology; Pharmaceutical Nanotechnology; Pharmacokinetics, Pharmacodynamics, and Drug Transport Metabolism; Analytical and Bioanalytical Chemistry; Pharmaceutical Chemistry; Natural Medicine and Nutraceutical; Chemical Processing of Pharmaceuticals including Crystallization, Lyophilization, and Chemical Stability of Drugs; Immunology, Biochemistry, and Cell and Molecular Biology
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 173 Documents
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Analysis of Physicochemical Properties and Quality Testing of Beef Tallow and Lard Oil Along with Identification using FTIR and GC-MS Mukti Utomo, Adhitya Ilham; Salamah, Nina; Guntarti, Any; Ahda, Mustofa
Journal of Food and Pharmaceutical Sciences Vol 13, No 3 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.21973

Abstract

The halal industry is rapidly growing worldwide, especially in Indonesia, which has the largest Muslim population and abundant natural resources. This study aims to analyze the physicochemical properties and quality of beef tallow and lard oil, as well as to identify differences in FTIR and GC-MS spectra to distinguish between these two animal fats.The results show that lard oil has a higher extraction yield (30%) compared to beef tallow (17%). Lard oil also has a higher iodine value (53 g), indicating a greater proportion of unsaturated fatty acids, making it suitable for culinary applications. Conversely, beef tallow has a lower peroxide value (5 meq O₂/kg), indicating better resistance to oxidation.FTIR analysis reveals differences in functional groups, with lard oil showing a higher degree of unsaturation. GC-MS analysis identifies important compounds such as 9-octadecenoic acid methyl ester in lard oil, while beef tallow is dominated by tetradecanoic acid methyl ester.This study emphasizes the need for the development of Indonesian National Standards (SNI) to ensure product quality and halal compliance. These findings provide important insights for the halal industry and food safety in Indonesia, as well as encouraging further research on the composition of animal fats.
Unlocking the Therapeutic Potential of Avocado Peel Waste: A Comprehensive Review of Phytochemicals and Pharmacological Activities Awidarta, Kevin; Rohman, Abdul; Nugroho, Agung Endro
Journal of Food and Pharmaceutical Sciences Vol 13, No 3 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.22376

Abstract

Avocado peel waste, a significant byproduct of the global avocado industry, represents an underutilized resource rich in bioactive compounds, prompting growing interest in its potential pharmacological applications. This review addresses the need to explore these compounds within the context of sustainable waste management and natural therapeutic development, aiming to evaluate their chemical composition and biological activities. A comprehensive analysis was conducted by synthesizing data from peer-reviewed studies, focusing on phytochemical identification using advanced techniques such as UHPLC-QTOF-MS, HPLC-DAD, and LC-DAD-ESI-MS, alongside pharmacological assessments via methods like DPPH, TBARS, and in vitro assays. The findings reveal that avocado peels, particularly from the Hass cultivar, contain diverse phytochemicals including phenolics, flavonoids, and organic acids, exhibiting antioxidant, neuroprotective, antibacterial, antifungal, antiplatelet, antiaging, anti-inflammatory, and anticancer properties. These activities are attributed to mechanisms such as radical scavenging, enzyme inhibition, and apoptosis induction, with specific studies highlighting neuroprotective effects in Parkinson’s disease models. The review concludes that avocado peel waste holds substantial promise as a sustainable source of bioactive compounds for food and pharmaceutical applications, though challenges like bioavailability and cultivar variability necessitate further research. Innovative extraction and formulation strategies could unlock its full therapeutic potential, contributing to a circular economy and health innovation.
A Study of Drug Interaction with Nifedipine and Magnesium Sulfate in the Management of Preeclampsia: An Observational Study Awaluddin, Nurhikma; Aadilah, Aadilah; Mahasakti, M Tri Budi
Journal of Food and Pharmaceutical Sciences Vol 13, No 3 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.22532

Abstract

Maternal mortality rate (MMR) remains a major priority in global health. The World Health Organization (WHO) estimates that MMR will decrease to 70 per 100,000 live births by 2030. However, in 2015, MMR in Indonesia reached 305 per 100,000 live births. Drug Related Problems (DRPs) are undesirable events that occur due to drug therapy and can hinder the recovery process of patients. Identifying drug-related issues during treatment is crucial for reducing morbidity, mortality, and therapy costs, as well as enhancing the effectiveness of pharmacological therapy.vThis study aims to identify DRPs caused by the use of the combination of Nifedipine and Magnesium Sulfate in preeclamptic patients at RSIA Sitti Khadijah 1 Makassar. The research method employed is non-experimental (observational) with a descriptive (qualitative) approach. The results indicate that among 32 preeclamptic patients who consumed the combination of Nifedipine and Magnesium Sulfate, there were no reported DRPs or adverse effects that jeopardized the patients' lives. These findings suggest that the combination therapy is in accordance with the management guidelines for preeclampsia in pregnant women based on national medical service protocols.
Examination of Borax in Meatballs: Qualitative Analysis Yunitasari, Norainny; Dalmayanti, Fanny; Ratnasari, Diah
Journal of Food and Pharmaceutical Sciences Vol 13, No 3 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.22713

Abstract

Borax is a chemical that is hazardous to health and is often misused as a food additive. The addition of this chemical is to make food chewier and more durable. It is important to test the presence of borax in snacks around us. The purpose of this study was to test the presence of borax in meatballs sold in the town square in one of the cities in East Java. The test method was carried out qualitatively, namely organoleptic test, AgNO3 test, turmeric extract test, and borax test kit. The results showed that all meatball samples tested positive for borax. Organoleptically, meatballs containing preservatives do not easily become soft (remain chewy), do not give off a bad smell for longer, and do not grow mold easily. This kind of research is important to anticipate the emergence of diseases due to borax abuse.
Test for Determination of Tannin Characteristics of Oolong Tea Leaf Extract (Camellia sinensis (L.) Kuntze) from Kemuning Tea Plant Karanganyar Styawan, Anita Agustina; Khairiyah, Fatikhatun Nissa’
Journal of Food and Pharmaceutical Sciences Vol 13, No 4 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.19303

Abstract

The oolong tea plant protects the body's cells from the damaging effects of free radicals by acting as an antioxidant. The content of oolong tea leaves contains tannin compounds which have a good effect on the body and the more tannin content in the tea, the greater it is its antioxidant activity. The purpose of this study is to use UV-visible spectrophotometry to ascertain the tannin content of the oolong tea leaf extract from the Kemuning tea plantation. The observational research method is being used. A sample of dried oolong tea leaves is used in this investigation. 1% FeCl3 was used to assess the sample qualitatively, and UV-Vis spectrophotometry was used to analyze the sample quantitatively. The solvent used was ethanol 96%%. The study's conclusions show that the sample contains tannins, which are qualitatively distinguished by a shift in color to a greenish-black tint. The oolong tea leaf extract has a quantifiable tannin concentration of 12.26% mg TE/g. Indicates that tannins can give a bitter and astringent taste, and can give a pleasant flavor to tea.
Review article: Flavonoid Extraction Method of Parsley Leaf Extract (Petroselinum crispum) Yogi Maha Putra, I Made Artadinatha; Kusuma Dewi, Luh Putu Mirah
Journal of Food and Pharmaceutical Sciences Vol 13, No 4 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.21156

Abstract

Flavonoids are bioactive polyphenolic compounds known for their antioxidant, anti-inflammatory, and antimicrobial properties. Although widely distributed in plants, parsley (Petroselinum crispum) is highlighted for its high flavonoid content, which is recognized as the dominant class of secondary metabolites compared to other constituents such as essential oils and pigments, making it a strong candidate for pharmaceutical applications. This review aimed to evaluate and compare various extraction methods used to isolate flavonoids from parsley leaves. A systematic literature search was conducted through Google Scholar, Scopus, and PubMed for articles published between 2014 and 2024 using keywords “flavonoid,” “parsley leaves,” and “extraction method.” Inclusion criteria comprised full-text original articles in English or Indonesian reporting extraction methods and total flavonoid content; reviews and incomplete studies were excluded. Among the methods reviewed, Ultrasonic-Assisted Extraction (UAE) proved most effective. When normalized to 1 g/minute, UAE yielded 0.312 mg/g of total flavonoids, demonstrating higher efficiency in terms of extraction yield and time. UAE utilizes acoustic cavitation to enhance solvent penetration and mass transfer, improving yield while preserving compound integrity. Ethanol was identified as the optimal solvent due to its polarity and compatibility with flavonoid structures. In conclusion, UAE with ethanol presents a promising strategy for efficient flavonoid extraction from parsley in pharmaceutical and nutraceutical applications.
Development of Self-Nano Emulsifying Drug Delivery System (SNEEDS) Containing Hibiscus sabdariffa L. extract, an Anticancer Against T47D Cells, as a co-chemotherapy of cisplatin Efiana, Nuri Ari; Nurani, Laela Hayu; Wahyuningtyas, Nurma; Edityaningrum, Citra Ariani; Indratmoko, Septiana; Guntarti, Any; Ma’ruf, Muhammad
Journal of Food and Pharmaceutical Sciences Article In Press 2026
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.21378

Abstract

Background: The first-line chemotherapy drug for breast cancer is cisplatin. However, it shows a high incidence of resistance. Therefore, Hibiscus Sabdariffa L (HS), containing strong anticancer compounds, was developed using a self-nano-emulsifying drug delivery system (SNEDDS), potentially as cisplatin co-chemotherapy. This study aimed to develop the HS SNEDDS providing anticancer activity against T47D breast cancer cells. Methods: Development of HS SNEDDS (F1-F7) with various surfactant and co-surfactant concentrations was carried out, followed by characterization of HS SNEDDS. The selected formulation was performed regarding the cytotoxicity on T47D cells and selectivity on Vero cells. Results: F7 as a selected formulation indicated a transmittance, globule size, PI, zeta potential, and emulsification time of 97.80%, 15.68 ± 0.19 nm, 0.12 ± 0.01, -8.05 ± 1.88 mV, and 24.76 ± 0.29 seconds, respectively. Furthermore, the IC50 of HS extract, HS SNEDDS, and Cisplatin on T47D cells were 0.37 ± 0.02, 0.24 ± 0.02, and 0.01 ± 0.001 mg/mL The selectivity index (SI) of HS SNEDDS and cisplatin were 108101.25 and 8351.84, respectively. Conclusion: HS SNEDDS providing the required characteristics could be obtained, and potentially be used as a co-chemotherapy of cisplatin, showing the cytotoxic effect on T47D breast cancer cells.
Nutrition Labelling’s Impact on Consumption Patterns and Nutrition Awareness in Community: A Literature Review Wahyuni, Tri; Flora, Rostika; Rahmiwati, Anita
Journal of Food and Pharmaceutical Sciences Vol 13, No 4 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.21874

Abstract

Background: Nutrition labelling on food packaging has become an essential tool for assisting consumers in making healthier food choices. Various label styles are used in different nations, but their usefulness varies according to the design and ease of understanding by customers, the aim of this study is to determine the impact of nutrition labels on consumption pattern and nutrition awareness; Methods: This study used a descriptive literature review with 2 data sources, namely PubMed and Google Scholar. The keywords used are "Nutrition Labelling" OR "Food Labels" AND "Healthy Food Choices" AND “Nutrition Awareness” with predetermined inclusion and exclusion criteria, then article analysis was carried out to achieve the objectives; Results: A total of 5 articles met the criteria and objectives of the study, the study's findings indicate show that front-of-pack nutrition labeling (FoPL) is essential for directing better food choices and increasing consumer nutrition awareness; and Conclusions: Nutrition labelling has been found to play a significant effect in raising nutritional knowledge and affecting people's consumption habits. Labels like Multiple Traffic Lights (MTL), Traffic Light Food Labels (TLF), and Nutri-Score regularly encourage healthy food choices by offering information that is simple to understand and visually appealing.
Nutritional and Microbiological Evaluation of Market-Sourced Ready-to-Eat Snail Meat in Delta, Edo, and Ondo States, Nigeria I Ogu, Gideon; Ereziwosa, Beatrice O.
Journal of Food and Pharmaceutical Sciences Vol 13, No 4 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.22221

Abstract

Snail meat is a popular delicacy in Nigeria, cherished for its taste, nutritional composition, and culinary versatility. However, the safety and quality of ready-to-eat snail meat (RTESM) have not been extensively studied. This research aimed to evaluate the chemical and microbiological quality of ready-to-eat snail meat in three southern Nigerian states: Delta, Edo, and Ondo. A total of 60 samples were collected from open markets in these regions and analyzed for proximate, trace metals and microbiological properties using standard techniques. The proximate analysis revealed non-significant (p˂0.05) variations in moisture, fat, protein, ash, crude fiber, and carbohydrate contents among the samples from different locations. Akure and Benin City RTESM samples showed higher moisture content (51.34 - 52.28), while Warri samples had higher fat (13.56 %) and protein (24.22 %) contents. Akure samples exhibited higher ash (10.48 %) and carbohydrate (9.86 %) contents. Appreciable amountof essential metals in the RTESM were observed and highlight its potential as a valuable dietary component. Potential foodborne bacteria, including Listeria spp. (6.7 %), Salmonella spp., (15.0 %), Escherichia coli (25.0 %), and Staphylococcus aureus (53.3 %) were detected and pose some public health concerns. Findings from this study provide valuable insights into the chemical and microbiological quality of RTESM in southern Nigeria. The variations observed in chemical composition and the presence of potentially harmful microorganisms emphasize the need for implementation of good hygiene practices throughout the production and processing chain to ensure the safety and nutritional value of snail meat products.
Bioactive Pigments of Monascus purpureus: Identification and Characterization Shaleha, Resha Resmawati; Yuliana, Anna; Rahmiyani, Ira; Pebiansyah, Anisa; Indriyanti, Indriyanti
Journal of Food and Pharmaceutical Sciences Vol 13, No 4 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.22574

Abstract

Monascus purpureus is a filamentous fungus that has long been recognized as one of the main producers of natural pigments. These pigments, including yellow (ankaflavin, monascin), orange (rubropunctatin, monascorubrin), and red (rubropunctamine, monascorubramine), are widely used as natural coloring agents. Compared to synthetic dyes, Monascus pigments are considered safer and possess additional biological activities, making them attractive for applications in the food, pharmaceutical, and cosmetic industries. Therefore, accurate identification of the pigments in Monascus purpureus is essential to ensure their safety, functionality, and potential industrial applications. The aim of this research is to determine the results of pigment identification Monascus purpureus using UV-Vis Spectrophotometry, Fourier Transform Infra-Red (FTIR), Thin Layer Chromatography (TLC), Preparative Thin Layer Chromatography (Preparative TLC), and Liquid Chromatography- Mass Spectrometry (LC-MS). The method used is method laboratory experiments. Samples are tested using several instruments. The extraction results show that the % yield value meets the requirements, namely >10%, then the fractionation results show that the water fraction gets more thick extract, the TLC results for the water fraction show a spot height of 4.7 cm with a value of Rf 0.78, the results of Preparative TLC on the water fraction show the presence of a single fluorescent band at wavelengths of 254 nm and 366 nm. The UV-Vis spectrophotometry results were identified at a wavelength of 477 nm with an absorbance of 0.364, then the FTIR results on Preparative TLC scrapings from the water fraction showed the presence of functional groups from the orange pigment structure and the LC-MS results showed that the sample was a compound. Monascorubrin (C23H28O5) with a molecular weight of 384.99 g/mol and compound rubropunctatin (C21H22O5) with a molecular weight of 354.74 g/mol. These results provide information that the sample is an orange pigment from Monascus purpureus with two compounds monascorubrin and rubropunctatin.

Page 16 of 18 | Total Record : 173

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