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Journal of Food and Pharmaceutical Sciences
Published by Universitas Gadjah Mada
ISSN : 20897200     EISSN : 23390948     DOI : https://doi.org/10.22146/jfps.8237
Core Subject : Health, Science, Engineering,
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience
Journal of Food and Pharmaceutical Sciences offers scientists, researchers, and other professionals to share knowledge of scientific advancements. The journal will publish original research articles, review articles, short communication, and letter to editor. The area of focus should cover all aspects of food and pharmaceutical sciences. The range of topics covered in the journal include: New Horizons in Food Research; Food Chemistry; Integrated Food Science; Health, Nutrition, and Food; Food Engineering, Materials Science, and Nanotechnology; Toxicology and Chemical Food Safety; Food Microbiology and Safety; Drug Discovery; Computational Chemistry and Molecular Modeling; Pharmaceutical Biotechnology and Protein-Peptide Chemistry; Pharmaceutics, Biopharmaceutics, Drug Delivery, and Pharmaceutical Technology; Pharmaceutical Nanotechnology; Pharmacokinetics, Pharmacodynamics, and Drug Transport Metabolism; Analytical and Bioanalytical Chemistry; Pharmaceutical Chemistry; Natural Medicine and Nutraceutical; Chemical Processing of Pharmaceuticals including Crystallization, Lyophilization, and Chemical Stability of Drugs; Immunology, Biochemistry, and Cell and Molecular Biology
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 139 Documents
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Impaired Liver Function in the Use of Clozapine as an Antipsychotic Aziz, Abdul; Herawati, Fauna; Pratama, Jainuri Erik; Gondokesumo, Marisca Evalina
Journal of Food and Pharmaceutical Sciences Vol 13, No 2 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.20811

Abstract

Clozapine is an atypical antipsychotic used to treat psychosis, mainly as a second choice for patients with refractory schizophrenia and recommended to manage schizophrenia that does not respond to other therapies. Clozapine is also often associated with elevated transaminase levels without clinical symptoms. In this case, a 45-year-old man, who had been diagnosed with schizophrenia since October 2020, was undergoing treatment with various antipsychotic drugs, including clozapine. About a week before hospitalization, there was a change in the patient's behavior. Due to this condition, the patient was brought to the outpatient psychiatric clinic at Airlangga University Hospital Surabaya, the patient was given clozapine 25 mg therapy at night, but the symptoms experienced were getting worse. The patient was finally taken for hospitalization at Dr. Soetomo Hospital Surabaya. While undergoing treatment at the hospital, the patient was given clozapine 10 mg therapy in the morning and at night, in addition, Olanzapine 10 mg was given intramuscularly if needed. However, on the third day after starting treatment, the patient began complaining of low-grade fever (37.8°C), nausea, and fatigue. Laboratory tests showed an increase in liver enzyme levels. However, several cases of severe liver toxicity due to clozapine use have been reported, and there are no specific guidelines for physicians to prevent or treat this condition. Close monitoring of liver function test (LFT) results is crucial in clozapine therapy, especially in considering the decision to stop treatment early if necessary.
Collagen Deposition Effect of Superoxide Dismutase Corn Kernel Extract (Zea mays L.) as Skin Photoaging Treatment Pratiwi, Mustika Endah; Barus, Andre Anusta; Boli Tobi, Claudius Hendraman
Journal of Food and Pharmaceutical Sciences Vol 13, No 2 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.21048

Abstract

Intensive exposure to UV-A rays can develop photoaging in human skin. To aid this condition, several potential anti-photoaging mechanisms that have been investigated can be implemented, including collagen promotion. Collagen production in the skin has been studied promoted by an enzymatic antioxidant, superoxide dismutase (SOD). Here, we found out the collagen deposition effect from SOD crude extract of corn kernel in 3T3 fibroblast cells as alternative ingredients of anti-photoaging. Soluble protein content and SOD activity assay were executed first to prop up the main test. Collagen deposition effect was measured using staining method with picric acid solution. The result showed the highest Soluble protein and SOD activity was in 100% precipitation of corn kernel SOD extract (20.91 mg/ml and 65.50% respectively). The highest collagen deposition percentage obtained was 106.7% in 100 mg/ml corn kernel SOD extract. The collagen deposition percentage obtained was not significantly different from 2.5 mg/ml ascorbic acid. Based on viewing collagen condition under a microscope, there was an improvement in collagen, which was indicated by the interconnected collagen fibers when the extract and ascorbic acid were given. The research that has been conducted concludes that corn kernel SOD extract has anti-photoaging activity through collagen deposition effect.
Effect of Soyghurt Fortification with Syzygium myrtifolium Walp. Leaves Extract on Antioxidant Activity Susanti, Susanti; Rizkuloh, Lina Rahmawati; Mardianingrum, Richa
Journal of Food and Pharmaceutical Sciences Vol 13, No 2 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.21223

Abstract

Soyghurt contains antioxidant compounds such as isoflavones which is derived from soybeans as main ingredient for making soyghurt. To increase antioxidant activity, it is necessary to add other antioxidant compounds such as anthocyanins which is found in Syzygium myrtifolium Walp. which also acts as a red pigment. The aim of this study was to determine the effect of adding Syzygium myrtifolium leaf extract to the antioxidant activity of soyghurt. It began with the making of soy milk then fermented with Lactobacillus bulgaricus into soyghurt. Plants were extracted by maceration in ethanol and made a dry extract. The addition of dried extract to soyghurt was carried out in 3 concentrations, 1%, 3% and 5%. The results of antioxidant activity assay using the free radical DPPH scavenging method showed that there was a decrease in the IC50 in soyghurt fortified with extract compared to soyghurt without extract. The higher concentration of extract, the smaller IC50 value. Soyghurt with 5% extract had the smallest IC50 (694.14 g/mL) while the IC50 of soyghurt without extract was 2823.17 g/mL. The conclusion is that fortification of Syzygium myrtifolium leaf extract has an effect on the antioxidant activity of soyghurt.
A Synergistic Approach: Enhanced Apoptotic and Proliferative Inhibition of Cisplatin by Nanocurcumin in HeLa Cells Subandi, Subandi; Gizta, Aura Bella; Balindra, Fredlina Rossa; Handono, Kusworini; Khotimah, Husnul
Journal of Food and Pharmaceutical Sciences Vol 13, No 2 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.21389

Abstract

Cisplatin is a widely used chemotherapeutic agent for cervical cancer, but its effectiveness is often limited by cellular resistance and severe side effects. Curcumin has demonstrated potential to enhance cisplatin's anticancer effects by inducing apoptosis and inhibiting cell proliferation; however, its clinical use is constrained by poor solubility and low bioavailability. To overcome these limitations, liposomal nanocurcumin was developed. This study aimed to evaluate the synergistic effects of cisplatin and nanocurcumin on Bax and BrdU expression as markers of apoptosis and proliferation in HeLa cervical cancer cells. A true experimental post-test only design was employed with five groups: HeLa cell control (no treatment), positive control (cisplatin 5 µg/mL), and three treatment groups receiving cisplatin 2.5 µg/mL combined with nanocurcumin at 25, 50, and 100 µg/mL. Cells were incubated for 48 hours and analyzedusing flow cytometry. The combination treatment significantly increased Bax expression and reduced BrdU expression compared to cisplatin alone, with the strongest effect observed at 100 µg/mL nanocurcumin. These findings suggest that nanocurcumin may serve as a promising adjuvant to enhance the therapeutic efficacy of cisplatin by promoting apoptosis and suppressing proliferation in cervical cancer cells.
Monoclonal Antibodies Aggregation during Administration to Patients and the Role of Pharmaceutical Excipients Almira, Deta; Nurcahya, Bekti Meilani; Rahmawati, Fita; Laksitorini, Marlyn Dian
Journal of Food and Pharmaceutical Sciences Vol 13, No 2 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.21391

Abstract

Monoclonal antibodies (mAbs) are powerful therapeutic agents known for their high specificity and effectiveness in treating complex diseases. Yet, one of their major challenges is their tendency to aggregate, which can reduce treatment efficacy and even trigger unwanted immune responses. This review focuses on how pharmaceutical excipients can help prevent antibody aggregation, particularly during the drug administration process, a phase often overlooked. We conducted a systematic literature search using Scopus, PubMed, and ScienceDirect, targeting studies on excipients and aggregation in therapeutic proteins. After applying the selection criteria, six original research articles were analyzed. The findings reveal that several excipients—such as L-arginine, polysorbates, trehalose derivatives, proline analogs, and cyclodextrins—can effectively stabilize mAbs. They work by reducing interfacial stress, minimizing protein–protein interactions, and preserving antibody structure during stress conditions like infusion or inhalation. These insights highlight the importance of choosing the right excipient based on the administration route to ensure antibody stability and therapeutic impact. By shifting the focus from formulation to administration, this review provides a practical perspective that can support the development of safer and more effective mAb therapies.
Pharmaceutical Grade Microcrystalline Cellulose from Corn Husk (Zea mays L.): Fabrication and Characterization Cahyani, Intan Martha; Ikasari, Endang Diyah; Tadlkirotulladlat, Novi; Anggraini, Novita Sindy
Journal of Food and Pharmaceutical Sciences Vol 13, No 2 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.21516

Abstract

Corn is a plant that grows easily in tropical climates. Corn production in Indonesia reaches 25.18 tons, the use of which in society is still limited to corn kernels as food, while other parts of the corn plant are waste. Corn husks are an abundant natural waste and contain 44.08% cellulose, so they can potentially be a source of pharmaceutical excipients, namely microcrystalline cellulose (MCC). This research aims to isolate and characterize MCC from pharmaceutical grade corn husks with commercial MCC as a comparator. The two methods of making MCC are delignification using 2% NaOH at 80-90°C 4 h. Hydrolysis using variations in HCl concentrations, namely 2 N, 4 N, and 6 N, at a temperature of 80°C 4 h. The research results obtained cellulose content in α-cellulose and MCC of corn husks with 3 consecutive treatments of 74.02%, 84.48%, 86.55%, and 84.44%. The result of the analysis test of FTIR, SEM, XRD, and PSA instruments indicate that corn husk MCC has characteristics of commercial MCC as a standard. The resulting corn husk MCC has physicochemical characteristics according to standards that can be used as a pharmaceutical excipient.
Application of Clustering Analysis with Unsupervised Technique on Fish Oil Samples Miftahul Jannah, Nadia; Primatyas Ningrum, Karina; Anggriani Syafrie, Firhani
Journal of Food and Pharmaceutical Sciences Vol 13, No 2 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.21517

Abstract

Fish oil contains many fatty acids (FAs) important for human health. Each fish oil tends to have a different fatty acid content. This study aims to group the fish oil content profile in several samples, such as keting fish oil (KFO), catfish oil (CFO), and pomfret fish oil (PFO), based on GC-MS analysis data with unsupervised techniques. GC-MS is a method that can be used to identify the fatty acid content in fish oil. Fish oil is extracted using the dry rendering method combined with a hydraulic press to obtain the oil, then derivatised before being analysed on the GC-MS instrument. Due to the multivariate data from GC-MS, multivariate statistical techniques are required to effectively group the fish oil samples based on their Fatty Acid profiles. Principal Component Analysis (PCA) and Cluster Analysis (CA) chemometrics are unsupervised techniques that can group multivariate data by displaying plot scores and dendrograms of sample analysis results. The fatty acid content of keting fish, catfish, and pomfret fish oil has three dominant compounds in sequence, namely oleic acid, palmitic acid, and stearic acid, with different percentages. Thegrouping profile of fish oil was successfully determined by PCA, total variance explained by the first four components (PC4) of 99.4%, and CA, which produced three groups based on the fatty acid content of fish oil.
In Silico Study of Compounds Identified in Curcuma aeruginosa Roxb Rhizome as BRAF V600E Inhibitors in Melanoma Cancer Suharsanti, Ririn; Ryan Radix Rahardhian, Muhammad; Kusmita, Lia
Journal of Food and Pharmaceutical Sciences Vol 13, No 2 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.21589

Abstract

Curcuma aeruginosa Roxb rhizome contains secondary metabolite compounds and plays a role in various activities such as antioxidant, antibacterial, anthelmintic, antiandrogenic, antinociceptive, and anticancer. Anticancer activity that has been reported in Curcuma aeruginosa Roxb rhizome is limited to breast and cervical cancer. The purpose of this study was to explore the potential of Curcuma aeruginosa Roxb rhizome in melanoma cancer through the mechanism of inhibiting the BRAF V600E. The 96% ethanol extract of Curcuma aeruginosa Roxb rhizome was separated to produce n-hexane (HF), ethyl acetate (EAF), and ethanol (EF) fractions. The GC-MS results showed that there were 31 compounds from the three fractions. The docking validation process was carried out on the native ligand N-(3-{[5-(4-chlorophenyl) -1H-pyrrolo [2,3b]pyridin3yl] carbonyl}2,4difluorophenyl) propane-1-sulfonamide. All compounds were prepared as ligands for molecular docking with the BRAF V600E receptor (PDB ID: 3OG7). Docking validation on native ligand showed RMSD 1.03Å. The smallest binding affinity are 4,4a,5,6,7,8-Hexahydronaphthalen-2(3H)-one (-6,89 kcal/mol); 1Cyclohexyl-2-propen-1-one (-6,68 kcal/mol); Cyclooctenone (-6,23 kcal/mol); and vemuravnib is still better as K+ (-11.11 kcal/mol). All three compounds do not bind to key amino acid residues of BRAF V600E such as vemuravenib at GLN A:530, CYS A:532; ASP A:594. These results indicate that further structural development is needed for better activity.
Optimization And Characterization of Silver Nanoparticle Biosynthesis Using Parijoto Fruit (Medinilla speciosa) Water Extract With Box-Behnken Design Nurjana, Qinta Laily; Amin, Azizah; Annisa, Viviane; Munawiroh, Siti Zahliyatul
Journal of Food and Pharmaceutical Sciences Vol 13, No 2 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.21683

Abstract

Silver nanoparticles in the medical field are used as additives in vaccines, anti-diabetic agents, wound and bone healing, biosensors and anticancer therapy in medical applications. One of the plants that can act as a reducing agent in the biosynthesis of silver nanoparticles is the parijoto fruit (Medinilla speciosa). This study aims to optimize and characterize the biosynthesis of silver nanoparticles from the water extract of parijoto fruit (M. speciosa) with a box-behnken design. The method used in this study starts from the manufacture of water extract of parijoto fruit (M. speciosa) then continued with the biosynthesis of silver nanoparticles. The formula for the biosynthesis of silver nanoparticles will be optimized with a box-behnken design and characterized by Particle Size Analyzer (PSA), Fourier Transform Infrared (FTIR), and Transmission Electron Microscopy (TEM). The results obtained in this study will be analyzed using descriptive techniques. The optimization results with the Behnken box design showed an optimal formula with an extract concentration of 1%, a sonication time of 6 minutes, and a sonicator pulser of 30. The particle size obtained was 85 ± 0.1 nm with a PI of 0.486 ± 0.006 and a zeta potential of -27.3 ± 1.5. The FTIR spectrum showed C=O, C-O and O-H groups indicating flavonoid compounds as bioreductant agents. The morphology of silver nanoparticles showed instability. (4) Conclusions:the optimization of silver nanoparticles from parijoto fruit water extract (M. speciosa) have been discovered used the Box-Behnken design and has good silver nanoparticle characteristics.

Page 14 of 14 | Total Record : 139

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