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Journal of Food and Pharmaceutical Sciences
Published by Universitas Gadjah Mada
ISSN : 20897200     EISSN : 23390948     DOI : https://doi.org/10.22146/jfps.8237
Core Subject : Health, Science, Engineering,
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience
Journal of Food and Pharmaceutical Sciences offers scientists, researchers, and other professionals to share knowledge of scientific advancements. The journal will publish original research articles, review articles, short communication, and letter to editor. The area of focus should cover all aspects of food and pharmaceutical sciences. The range of topics covered in the journal include: New Horizons in Food Research; Food Chemistry; Integrated Food Science; Health, Nutrition, and Food; Food Engineering, Materials Science, and Nanotechnology; Toxicology and Chemical Food Safety; Food Microbiology and Safety; Drug Discovery; Computational Chemistry and Molecular Modeling; Pharmaceutical Biotechnology and Protein-Peptide Chemistry; Pharmaceutics, Biopharmaceutics, Drug Delivery, and Pharmaceutical Technology; Pharmaceutical Nanotechnology; Pharmacokinetics, Pharmacodynamics, and Drug Transport Metabolism; Analytical and Bioanalytical Chemistry; Pharmaceutical Chemistry; Natural Medicine and Nutraceutical; Chemical Processing of Pharmaceuticals including Crystallization, Lyophilization, and Chemical Stability of Drugs; Immunology, Biochemistry, and Cell and Molecular Biology
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 173 Documents
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Anti-Inflammatory Effects of Eicosapentaenoic Acid and Docosahexaenoic Acid Derived from Patin Fish Oil on Diabetic Nephropathy: A Bioinformatics Study Doddy Aditya Purnomo; Awidarta, Kevin; Nugroho, Agung Endro; Rohman, Abdul
Journal of Food and Pharmaceutical Sciences Article In Press 2026
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.22899

Abstract

Diabetic nephropathy is a severe complication of diabetes mellitus with a significant global impact on end-stage renal disease. Fish-derived fatty acids show promise in inflammatory disorders, but their mechanisms in diabetic nephropathy remain unclear. This study used network pharmacology and molecular docking to investigate the therapeutic targets of EPA and DHA from Patin fish oils. Potential targets of EPA and DHA were retrieved from the Swiss Target Prediction, SEA, and SuperPRED databases, identifying 160 and 185 targets, respectively. Notably, 37 and 62 of these targets overlapped with DN-related targets from GeneCards, DisGeNET, and OMIM. Protein-protein interaction (PPI) network analysis revealed hub genes, including PPARG, TLR4, and TP53, as critical mediators. Gene Ontology (GO) enrichment analysis revealed involvement in biological processes such as collagen metabolic process for EPA and regulation of inflammatory response for DHA, while KEGG pathway analysis highlighted the modulation of PPAR signaling, the renin-angiotensin system, and the AGE-RAGE signaling pathway. Molecular docking confirmed favorable binding affinities of EPA and DHA to key targets such as PPARG (-8.04 kcal/mol for DHA) and PPARD (-8.11 kcal/mol for EPA). These findings suggest that EPA and DHA may mitigate DN-associated inflammation through multi-target and multi-pathway interactions, positioning them as potential supplementary therapeutic agents.
Detection of Mefenamic Acid in Hyperuricemia Herbal Medicine using UV-Vis Spectrophotometry and FTIR Spectroscopy Combined with Chemometrics Putri, Anggita Rosiana; Kalima, Nanda; Ihsan, Bachtiar Rifai Pratita; Hardaniani, Prisma Trida
Journal of Food and Pharmaceutical Sciences Vol 13, No 4 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.23558

Abstract

The adulteration of herbal medicines with synthetic drugs poses a serious risk to public health. Mefenamic acid, a non-steroidal anti-inflammatory drug (NSAID), is sometimes illicitly added to herbal products marketed for hyperuricemia to enhance their therapeutic effect. This study aims to detect the presence of mefenamic acid in herbal medicines for hyperuricemia using a combination of UV-Vis spectrophotometry and Fourier Transform Infrared (FTIR) spectroscopy coupled with chemometric. approaches, specifically Orthogonal Partial Least Squares Discriminant Analysis (OPLS-DA) and Partial Least Squares (PLS). The UV-Vis method was validated and showed good linearity with an R² value of 0.999. Accuracy testing revealed recovery rates ranging from 98.75% to 101.92%, while precision testing produced %RSD values between 0.86% and 1.05%. The limit of detection (LOD) and limit of quantification (LOQ) were found to be 0.235 ppm and 0.711 ppm, respectively. FTIR spectral data were processed using OPLS-DA and PLS to classify and predict adulterated samples. The validated OPLS-DA model demonstrated strong classification performance, effectively distinguishing between adulterated and non-adulterated samples. Furthermore, the detection results from UV-Vis, OPLS-DA, and PLS methods were consistent, confirming the reliability of the integrated approach.
Identification of Rationality and Potential Drug Interactions in Preeclampsia Patients with Comorbidities Awaluddin, Nurhikma; Zafira Dedy, Nadya Aliyah; Dwi Rantisari, Andi Meinar; Murtiadi, Nadya Nur Aulia
Journal of Food and Pharmaceutical Sciences Vol 13, No 4 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.23764

Abstract

Preeclampsia is one of the pregnancy complications that constitutes a major cause of maternal and fetal morbidity and mortality. Its management requires the rational and safe use of medications, as there is a potential for drug interactions that may affect therapeutic outcomes. This study aimed to evaluate the rationality of drug use and potential drug interactions in preeclampsia patients in the inpatient ward of Pertiwi Mother and Child Hospital, Makassar. This research employed a descriptive method with a retrospective approach, utilizing medical records of preeclampsia patients from January 2024 to January 2025. The evaluation of rationality was based on the “four rights” principle: right indication, right drug, right dose, and right time of administration. The results of this study showed that the majority of patients received rational pharmacotherapy, with nifedipine being the most commonly used antihypertensive drug. The potential drug interactions identified were predominantly of moderate severity. The findings indicate that, overall, drug use among preeclampsia patients in this hospital has not yet been fully rational, and the presence of potential drug interactions requires careful consideration in clinical practice.
Ultra-High Performance Liquid Chromatography Method Validation for Micro-dissolution Analysis of Ketoconazole in Alginate-Acacia Gum Composite Capsules Lumakso, Fajar Aji; Annisa, Viviane; Cermenda, Riska; Chabib, Lutfi
Journal of Food and Pharmaceutical Sciences Vol 13, No 4 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.24078

Abstract

Ketoconazole, a BCS Class 2 antifungal drug, has good absorption but suffers from low solubility and poor bioavailability. To address this, a natural polymer-based matrix of alginate and acacia gum was formulated to enhance dissolution. This study aimed to validate a Ultra High Performance Liquid Chromatography method for analyzing ketoconazole content in micro-dissolution testing of capsule formulations. The method employed a C18 column with a mobile phase of acetonitrile:WFI (0.15% TEA, pH 3.5; 50:50) at 1 mL/min and detection at 265 nm. Validation demonstrated compliance with selectivity, linearity (r = 0.9996), sensitivity (LoD 6.51 µg/mL; LoQ 19.74 µg/mL), accuracy (99.6–101.3%), and precision (<2%, except one interday result at 2.08%). Micro-dissolution testing showed sustained ketoconazole release, exceeding 100% within 240 minutes. Data modeling (performed using DDSolver) indicated comparable fit for the Higuchi (R²_adj = 0.96) and Korsmeyer (R²_adj = 0.93) models, suggesting diffusion-controlled release of ketokonazole. The validated UHPLC method is suitable for micro-dissolution studies, and the alginate-acacia gum formulation effectively modulates drug release.
The Effect of Maltodextrin Concentration Variations on the Microencapsulation of Probiotics from Manonjaya Salak Fruit Juice (Salacca zalacca (Gaert.) Voss) Nofriyaldi, Ali; Fakhirah, Deani Sucia; Nurzaman, Mochamad Herdi
Journal of Food and Pharmaceutical Sciences Vol 13, No 4 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.24203

Abstract

Probiotic beverages have weaknesses in terms of shelf life related to stability. One way to maintain the stability of probiotic beverages is to encapsulate them into microcapsules using maltodextrin. The objective of this study is to determine the characteristics and effects of varying maltodextrin concentrations F1 (20%), F2 (40%), F3 (60%) on the physical properties of microcapsules from Manonjaya salak fruit (Salacca zalacca) probiotic beverages. This study was conducted experimentally in the production of microcapsules using the freeze-drying method. Data were analyzed descriptively, including organoleptic evaluation, measurement of total lactic acid, pH, lactic acid bacteria (LAB) count, moisture content, and morphological characterization using a Scanning Electron Microscope (SEM). The results of the characteristics of Manonjaya snake fruit juice microencapsulation can be concluded that variations in maltodextrin concentration affect the characteristics of microcapsules where all formulas meet the requirements, except for the results of the water content test between 10–10.33% which does not meet the requirements (≤ 3%). Thus, further research is needed in optimizing the microencapsulation formula of snake fruit juice, such as using a combination of coatings, longer freeze drying optimization time, and evaporation of snake fruit juice.
Ethnopharmacology Analysis of Antidiabetic Medicinal Plants from Menoreh Hills: Linking Local Knowledge to Pharmacological Evidence Kintoko, Kintoko; Faisal Nur Arib; Nanik Sulistyani; Akrom
Journal of Food and Pharmaceutical Sciences Article In Press 2026
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.24603

Abstract

Abstract: The prevalence of type 2 diabetes mellitus (T2DM) has been increasing worldwide and in Indonesia. Documenting locally utilized antidiabetic plants may inform evidence-based phytotherapy. This study mapped antidiabetic medicinal plants in Samigaluh (Menoreh Hills) and prioritized candidates by linking community knowledge with pharmacological data. Semi-structured interviews and observation were conducted between July and August 2025, and involved ten informants selected through purposive and snowball sampling. Quantitative ethnobotanical indices (Use Value, Relative Frequency of Citation, Fidelity Level, Plant Part Value) were calculated, followed by a PubMed-based narrative review. The Zingiberaceae family was predominant (seven species); rhizomes were the most utilized (39.58%), followed by stems (25.00%) and leaves (22.92%). Vernonia amygdalina was prioritized for diabetes-specific consensus (Fidelity Level 100%, Relative Frequency of Citation 0.7), and Curcuma mangga for its high usage and popularity (Use Value 1.3, Relative Frequency of Citation 0.6). Pharmacological evidence indicates that V. amygdalina exhibits antidiabetic effects through the inhibition of α-amylase and α-glucosidase, enhancement of GLUT4, and suppression of gluconeogenesis, supported by its antioxidant and anti-inflammatory properties, while C. mangga demonstrates hypoglycemic activities and β-cell protection, along with anti-inflammatory, antioxidant, and immunostimulant activities as supportive mechanisms. Local knowledge thus aligns with mechanistic findings, supporting a complementary pairing of V. amygdalina and C. mangga for future antidiabetic combinations; further validation through in vitro and in vivo studies is recommended. Keywords: Curcuma mangga; indigenous knowledge; pharmacological evidence; phytotherapy; Vernonia amygdalina
A Structure-Based Virtual Screening Protocol Utilizing PyPLIF HIPPOS and Vina for Targeting BACE-1 Primana, Mala Hikmawan; Oka, Mitsue; Istyastono, Enade Perdana; Riswanto, Florentinus Dika Octa
Journal of Food and Pharmaceutical Sciences Vol 13, No 4 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.24790

Abstract

Alzheimer’s Disease (AD) is a leading cause of dementia, characterized by progressive cognitive decline driven in part by amyloid-β (Aβ) accumulation. The β-site amyloid precursor protein cleaving enzyme 1 (BACE-1) is responsible for initiating Aβ generation, making it a central therapeutic target. Yet, developing effective BACE-1 inhibitors has proven difficult due to structural complexity and pharmacological limitation. This study aimed to construct and validate a structure-based virtual screening (SBVS) workflow combining Vina and PyPLIF HIPPOS to facilitate the identification of promising BACE-1 ligands. The protocol was validated through 100 independent redocking experiments of the native ligand (PDB ID: 3L5F), all reproducing the crystallographic pose with RMSD < 2.0 Å. Large-scale screening of the DUDE dataset (283 active ligands; 18,100 decoys) generated interaction fingerprint, which were subsequently analyzed using Recursive Partitioning and Regression Trees (RPART) under varying prior probabilities. At the optimal prior ratio of 0.82:0.18, the model achieved an enrichment factor (EF) of 10.03, surpassing the DUDE benchmark (EF = 8.1). analysis consistently highlighted ionic interactions with Asp289 and hydrophobic contacts with Trp137 as key determinants of ligand activity. From 283 active ligands, 32 were classified as true positives, narrowing the pool of candidates and interpretable SBVS protocol and proposing a dual anchoring strategy involving Asp289 and Trp137 as a rational design principle for novel BACE-1 inhibitors in AD therapy.
Evaluation Antibacterial Activity of Rosary Pea (Abrus precatorius L.) Leaf Extract against the Growth of Staphylococcus aureus and Shigella sonnei Shari, Amalia; Syahfitri, Alda Bunga
Journal of Food and Pharmaceutical Sciences Article In Press 2026
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.24861

Abstract

Bacteria are major contributors to infectious diseases, including Staphylococcus aureus and Shigella sonnei. Although antibiotics remain the primary treatment, prolonged use can lead to antimicrobial resistance, highlighting the need for alternative agents capable of inhibiting pathogenic bacteria. Scientific validation of medicinal plants is crucial for complementing traditional knowledge in bioprospecting efforts. The Rosary pea (Abrus precatorius L.) is one such plant with potential antibacterial properties. This study evaluates the inhibitory activity of Abrus precatorius L. leaf ethanol extract against S. aureus and S. sonnei at concentrations of 3.125%, 6.25%, 12.5%, 25%, 50%, and 100%. The extract demonstrated optimal activity at 100%, exhibiting moderate inhibition against S. aureus and weak inhibition against S. sonnei. These findings underscore the potential of Abrus precatorius L as a source of antibacterial compounds and provide a foundation for developing improved formulations with enhanced antibacterial efficacy.
Exploration of the Wound Healing Activity of Ethanol Extract-Based Ointment from Curry Leaves on the Wound Healing Process Andilala, Andilala; Sihombing, Juliana Sion
Journal of Food and Pharmaceutical Sciences Vol 13, No 4 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.25000

Abstract

Indonesian society widely utilizes traditional medicinal plants, including curry leaves (Murraya koenigii L.), which contain alkaloids, tannins, flavonoids, saponins, steroids, and triterpenoids known to possess antioxidant and anti-inflammatory properties. This study aims to formulate curry leaf ethanol extract ointments as wound healing agents and to determine the most effective concentration in accelerating incision wound recovery. Five treatments were prepared: ointment base (negative control), Betadine 10% (positive control), and curry leaf ethanol extract ointments at concentrations of 5%, 10%, and 15%. The ointments were assessed for physical properties and tested on male white rats. The results showed that all formulations met the organoleptic, stability, homogeneity, pH, adhesion, and spreadability requirements. Quantitative wound-healing analysis demonstrated that the 15% extract ointment produced the highest healing percentage, achieving 56.4% on day 5, 70.9% on day 8, and 100% by day 14, outperforming Betadine 10% (80% by day 14). One-way ANOVA revealed significant differences among treatment groups (p < 0.05), with the 15% formulation showing the most effective therapeutic response. These findings indicate that curry leaf ethanol extract ointment, particularly at a 15% concentration, has strong potential as a topical Wound Healing agent.
Thrombolytic Activity and Protein Characterization of Extract from White Oyster Mushroom (Pleurotus ostreatus) Alishlah, Tanfidz; Umayah Ulfa, Evi; Arimurti, Sattya; Eka Putri, Khilwiyah
Journal of Food and Pharmaceutical Sciences Vol 13, No 4 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.25015

Abstract

Venous thromboembolism (VTE) is a condition resulting from the presence of thrombi within blood vessels. Globally, these illnesses are the leading causes of death. In 2022, the WHO estimates that 19.8 million fatalities or 32% of worldwide deaths were a result of cardiovascular disease, which is initiated by thromboembolism. The use of thrombolytic medicines is one treatment option for thromboembolic illness. The exploration revealed that numerous mushrooms contain protease enzymes with a thrombolytic effect. A common edible mushroom in Indonesia is the white oyster mushroom (Pleurotus ostreatus). By assessing thrombolytic activity using the Blood Clot Lysis Assay method and characterizing proteins using SDS-PAGE electrophoresis, this study aims to determine the thrombolytic activity of the extract and crude protein from the white oyster mushroom. The findings demonstrated the thrombolytic activity of the extract and crude protein of oyster mushroom at 29.89% and 37.89%, respectively. The extracts with volumes of 500 µl and the crude protein with a concentration of 0.05 g/mL exhibited the highest thrombolytic activity. The thrombolytic activity results of the extract (500 µl) and crude proteins (0.02 g/mL and 0.05 g/mL) of the white oyster mushroom were significantly higher than the positive control (p<0.05). According to protein characterization, the white oyster mushroom extract and crude protein had protein molecular weights of 45.50 kDa, 32.51 kDa, 21.09 kDa, and 15.1 kDa, respectively. White oyster mushroom extracts and crude protein have the potential to be developed as thrombolytic agents, serving as a safe, natural, and cost-effective alternative for thromboembolism disorders. While the results offer an important foundation, further studies are necessary to confirm and extend these findings.

Page 17 of 18 | Total Record : 173

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