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Media Farmasi
Published by Poltekkes Kemenkes Makassar
ISSN : 02162083     EISSN : 26220962     DOI : https://doi.org/10.32382/mf.v19i2
Core Subject : Health, Science,
Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health
Media Farmasi beralih ke OJS 3 dengan alamat web yang abru namun Media Farmasi tetap Mempublikasikan review article dan original article diseluruh bidang Kefarmasian seperti Farmasetika dan Teknologi Farmasi, Farmasi Klinik, Farmakognosi, Kimia Farmasi yang tidak pernah dipublikasikan di jurnal lain atau tidak dalam sementara di review oleh jurnal lain
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 64 Documents
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Studi Bioinformatika Tanaman Genus Nigella terhadap Kanker Payudara Tipe Basal Berbasis Transkriptomik dan Farmakologi Jaringan Saipul Maulana; Muhammad Sulaiman Zubair; Muhammad Azwar AR
Media Farmasi Vol 22 No 1 (2026): Media Farmasi Edisi April 2026
Publisher : Jurusan Farmasi Poltekkes kemenkes Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/mf.v22i1.2038

Abstract

Basal-type breast cancer (Triple-Negative Breast Cancer, TNBC) is an aggressive subtype characterized by poor prognosis and limited conventional therapeutic options due to the absence of hormone receptor and HER2 expression. To address this challenge, this study aims to elucidate the molecular mechanisms of compounds derived from the Nigella genus against basal-type breast cancer using a Network Pharmacology approach integrated with transcriptomic data. This in silico experimental study began with the identification of 433 bioactive compounds from the Nigella genus retrieved from databases, which were predicted to target a total of 2,227 potential proteins. Transcriptomic analysis was performed using the GSE7904 dataset, comparing 18 basal-type breast cancer samples with 7 normal control samples. Statistical analysis identified 9,666 significantly Differentially Expressed Genes (DEGs). Venn diagram intersection analysis between the compound targets and DEGs revealed 996 overlapping genes, which were designated as potential candidate targets. Protein–Protein Interaction (PPI) network topology analysis identified EGFR (Epidermal Growth Factor Receptor) as the top hub protein with a degree value of 110, followed by SRC (108) and PIK3CA (70). Functional enrichment analysis (KEGG) validated EGFR as a critical receptor in TNBC, initiating oncogenic signaling pathways such as MAPK and PI3K–Akt that drive basal-type cancer cell proliferation. Bioactive compounds from Nigella were predicted to exert their effects by interacting with membrane receptors and inhibiting tyrosine kinase activity. Therapeutic intervention targeting EGFR using bioactive compounds from the Nigella genus therefore represents a promising strategy to overcome resistance and aggressiveness in basal-type breast cancer.
Evaluasi In Silico Interaksi Senyawa Bioaktif Daun Serai Cymbopogon citratus Terhadap Protein Sortase A Streptococcus mutans Sebagai Target Potensial Pencegahan Karies Gigi Asmawati; Alfrida Monica Salasa; St. Ratnah; Sesilia Rante Pakadang; Muhammad Asman Setiawan Jumain; A. Moh. Whisnu Surya Dinata; Rizky Alfiana; Muh. Arfandy Gunawan
Media Farmasi Vol 22 No 1 (2026): Media Farmasi Edisi April 2026
Publisher : Jurusan Farmasi Poltekkes kemenkes Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/mf.v22i1.2076

Abstract

Dental caries remains a major oral health problem with high prevalence and is primarily caused by the activity of Streptococcus mutans. One of the key virulence factors of this bacterium is Sortase A protein, which plays an essential role in bacterial adhesion and biofilm formation. This study aimed to evaluate the potential of bioactive compounds from Cymbopogon citratus as inhibitors of Sortase A from Streptococcus mutans using an in silico approach. The research method involved preparation of the Sortase A protein structure (PDB ID: 4TQX) and bioactive compounds of C. citratus, followed by molecular docking analysis using AutoDock Vina integrated with UCSF Chimera. Ligand–protein interaction analysis was performed to determine binding affinity and identify key amino acid residues involved, and the results were compared with a standard ligand (1QON). In addition, ADMET prediction was conducted to evaluate the absorption, distribution, metabolism, excretion, and toxicity profiles of the major compounds. The molecular docking results showed that luteolin and rutin exhibited strong binding affinities toward Sortase A, with binding energy values of -7.3 kcal/mol, comparable to the standard ligand (-7.2 kcal/mol). Luteolin demonstrated a similar interaction pattern with the standard ligand through the key residue Phe237, while rutin formed multiple hydrogen bonds around the active site. ADMET prediction indicated that luteolin possessed better oral absorption and a more favorable safety profile than rutin. In conclusion, luteolin is the most promising bioactive compound from Cymbopogon citratus for dental caries prevention through inhibition of Sortase A of Streptococcus mutans
Aktivitas Radical Scavenging Melalui Penghambatan Nitric Oxide Madu Hutan Asal Kolaka Timur Pada Sel Makrofag Raw 264.7 Hariana; Wahyuni; Lidya Agriningsih Haruna; La Ode Muh. Julian Purnama; Adryan Fristiohady
Media Farmasi Vol 22 No 1 (2026): Media Farmasi Edisi April 2026
Publisher : Jurusan Farmasi Poltekkes kemenkes Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/mf.v22i1.2105

Abstract

Forest honey is a natural product rich in bioactive compounds, particularly phenolics and flavonoids, which contribute to its antioxidant and anti-inflammatory properties. East Kolaka, Southeast Sulawesi, is recognized as a potential source of forest honey; however, scientific data regarding its biological activity remain limited. This study aimed to evaluate the antioxidant and anti-inflammatory activities of forest honey from East Kolaka using in vitro and in vivo approaches. Antioxidant activity was assessed using DPPH, ABTS, and β-carotene bleaching assays, while anti-inflammatory activity was evaluated through inhibition of nitric oxide production in LPS-induced RAW 264.7 macrophage cells and a xylene-induced mouse ear edema model. The results demonstrated notable antioxidant activity, with IC₅₀ values of 68.16 ± 1.18 mg/L (DPPH), 56.36 ± 3.72 mg/L (ABTS), and 4.11 ± 0.66 mg/L (BCB). Additionally, the honey significantly suppressed nitric oxide production in vitro and reduced ear edema in vivo, with the highest dose showing comparable effectiveness to sodium diclofenac. These findings indicate that East Kolaka forest honey has promising potential for development as a functional food or nutraceutical derived from local natural resources.
Evaluasi Masker Peel Off Ekstrak Kulit Pisang Cavendish (Musa acuminata L.) dengan Variasi Konsentrasi PVA Besse Yuliana; Husnul Khotimah Aris; Habiburrahim`
Media Farmasi Vol 22 No 1 (2026): Media Farmasi Edisi April 2026
Publisher : Jurusan Farmasi Poltekkes kemenkes Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/mf.v22i1.1631

Abstract

Cavendish banana peel (Musa acuminata L.) contains antioxidant compounds such as flavonoids and phenolics, which have potential as active ingredients in cosmetic formulations, particularly peel-off masks. This study aimed to evaluate the stability of peel-off gel mask formulations containing Cavendish banana peel extract with varying concentrations of polyvinyl alcohol (PVA). The research was conducted experimentally in the laboratory using three different formulations (PVA 10%, 13%, and 16%). The banana peel extract was obtained through maceration using 70% ethanol, followed by the formulation of gel-based peel-off masks. The formulations were evaluated for organoleptic properties, homogeneity, viscosity, pH, spreadability, drying time, irritation potential, and stability using cycling tests. The results showed that all formulations met the requirements for organoleptic properties and homogeneity and did not cause skin irritation. The formulation containing 13% PVA (F2) demonstrated the most optimal physical stability, with consistent viscosity, ideal spreadability (5.3–5.6 cm), appropriate pH range (5.82–5.75), and drying time within acceptable limits (17.29–18.17 minutes). The F1 formulation had excessive spreadability and lower viscosity, while F3 showed the fastest drying time but less stable pH values. In conclusion, the 13% PVA formulation exhibited the best physical stability for peel-off gel masks containing Cavendish banana peel extract.

Page 7 of 7 | Total Record : 64

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