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Jurusan Farmasi Politeknik Kesehatan kemenkes Makassar Jl Baji gau No 10 Makassar
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Media Farmasi
Published by Poltekkes Kemenkes Makassar
ISSN : 02162083     EISSN : 26220962     DOI : https://doi.org/10.32382/mf.v19i2
Core Subject : Health, Science,
Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health
Media Farmasi beralih ke OJS 3 dengan alamat web yang abru namun Media Farmasi tetap Mempublikasikan review article dan original article diseluruh bidang Kefarmasian seperti Farmasetika dan Teknologi Farmasi, Farmasi Klinik, Farmakognosi, Kimia Farmasi yang tidak pernah dipublikasikan di jurnal lain atau tidak dalam sementara di review oleh jurnal lain
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 53 Documents
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Isolasi, Identifikasi, Dan Aktivitas Antibakteri Fungi Endofit Daun Pegagan (Centella asiatica L.) Terhadap Staphylococcus epidermidis Dan Propionibacterium acnes: Isolation, Identification and Antibacterial Activity Of Fungi Endophyte Of Pegagan Leaves (Centella asiatica L.) against Staphylococcus epidermidis and Propionibacterium acnes Pakadang, Sesilia Rante; Ayuasrini, Ayuasrini; Ratnah, St.; Salasa, Alfrida Monica
Media Farmasi Vol 21 No 1 (2025): Media Farmasi Edisi April 2025
Publisher : Jurusan Farmasi Poltekkes kemenkes Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/mf.v20i2.600

Abstract

Pegagan (Centella asiatica L.) is widely known as a traditional medicine with various properties, including as an antibacterial. This study aims to isolate endophytic fungi from Pegagan leaves that have the potential to produce antibacterial secondary metabolites against Staphylococcus epidermidis and Propionibacterium acnes. Isolation was carried out by leaf sterilization and inoculation on SDA media, followed by fermentation and extraction using ethyl acetate. Antibacterial activity tests were carried out using the agar diffusion method. Five isolates were obtained: PTH (Cylindrocladium), HJ (Aspergillus flavus), CRM (Aspergillus terreus), ABAB (Colletotrichum sp.), and CKT (Aspergillus niger). All isolates were bactericidal against S. epidermidis. Three isolates (HJ, CRM, and CKT) were bactericidal against P. acnes, while PTH and ABAB isolates were bacteriostatic. Tanaman Pegagan (Centella asiatica L.) dikenal luas sebagai obat tradisional dengan berbagai khasiat, termasuk sebagai antibakteri. Penelitian ini bertujuan mengisolasi fungi endofit dari daun Pegagan yang berpotensi menghasilkan metabolit sekunder antibakteri terhadap Staphylococcus epidermidis dan Propionibacterium acnes. Isolasi dilakukan melalui sterilisasi daun dan inokulasi pada media SDA, dilanjutkan fermentasi dan ekstraksi menggunakan etil asetat. Uji aktivitas antibakteri dilakukan dengan metode difusi agar. Diperoleh lima isolat: PTH (Cylindrocladium), HJ (Aspergillus flavus), CRM (Aspergillus terreus), ABAB (Colletotrichum sp.), dan CKT (Aspergillus niger). Seluruh isolat bersifat bakteriosida terhadap S. epidermidis. Tiga isolat (HJ, CRM, dan CKT) bersifat bakteriosida terhadap P. acnes, sedangkan isolat PTH dan ABAB bersifat bakteriostatik.
Analisis Profil Senyawa Metabolit Sekunder Ekstrak Daun Cempedak (Artocarpus integer) Dengan Metode Spektrofotometer UV-Vis dan LC-MS: Analysis Of Secondary Metabolites Compound Profile Of Cempedak Leaf Extract (Artocarpus integer) Using Uv-Vis Spectrophotometer And LC-MS Methods Hariri Putri, Maudina Artha; Tilarso, Dara; Sari, Tri Anita
Media Farmasi Vol 21 No 1 (2025): Media Farmasi Edisi April 2025
Publisher : Jurusan Farmasi Poltekkes kemenkes Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/mf.v21i1.975

Abstract

Cempedak (Artocarpus integer) leaves contain secondary metabolite compounds including flavonoids, saponins, phenolics, terpenoids, and tannins that act as natural antioxidants for anti-aging. The purpose of this study is to determine the metabolite compounds in ethanol extract of cempedak leaves analyzed using the LC-MS method. The results of analysis using the LC-MS method on cempedak leaf extract were 103 compounds consisting of flavonoids 92.44543%, phenols 3,66556%, saponins 1.50683%, alkaloids 1.22696%, terpenoids 0.98201%, tannins 0.41495% and steroids 0.22850%. The results on the chromatogram of the liquid chromatogram at the highest peak with the identified compound composition of 1.88812% called serotonin D belongs to the flavonoid group having a molecular weight (m/z) of 676,2308 with the chemical formula C40H36O10. These results show that cempedak leaves using the LC-MS method contain flavonoids, phenols, saponins, alkaloids, terpenoids, tannins, and steroids.
Evaluasi Keamanan Sirup Batuk Anak Melalui Deteksi Dietilen Glikol: Safety Evaluation of Children's Cough Syrup Through Detection of Diethylene Glycol Andi Ardiansyah Arifin; Megawati; Nurjannah; Nur, Syamsu
Media Farmasi Vol 21 No 1 (2025): Media Farmasi Edisi April 2025
Publisher : Jurusan Farmasi Poltekkes kemenkes Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/mf.v21i1.1255

Abstract

A recent report highlighted cases of contamination in children's cough syrup containing diethylene glycol, which poses potential health risks for children. This study aims to identify the presence of diethylene glycol in various children's cough syrups sold in Makassar City using Thin Layer Chromatography (TLC) and FT-IR Spectroscopy methods. A total of 9 samples of children's cough syrup from three different brands, each originating from three batches, were analyzed in this study. The TLC analysis results showed significant differences between the samples and the standard. The Rf values of the samples ranged from 0.72 to 0.85, while the Rf value of the diethylene glycol standard was recorded at 0.41. Additionally, FT-IR analysis, based on the wave numbers and intensity of the spectra, indicated that the sample spectra did not match those of the diethylene glycol standard. Based on the evaluation of all children's cough syrup samples using these two methods, no profiles consistent with the characteristics of diethylene glycol were detected.
Aktivitas Antioksidan Granul Instan Ekstrak Bunga Telang (Clitoria ternatea L) Sebagai Antidiabetes: Antioxidant Activity Of Instant Granules Of Telang Flower Extract (Clitoria ternatea L) As Antidiabetes Fani Temarwut, Farid; Arif, Mutmaina; Rahmatia
Media Farmasi Vol 21 No 1 (2025): Media Farmasi Edisi April 2025
Publisher : Jurusan Farmasi Poltekkes kemenkes Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/mf.v21i1.1265

Abstract

Diabetes mellitus (DM) is a group of metabolic diseases characterized by hyperglycemia that occurs due to abnormalities in insulin secretion, insulin action, or both. DM can be classified into several types, namely, type 1 DM, type 2 DM, existing type DM. Type 2 DM is one of the most common types, which is more than 90-95%. The purpose of this study was to formulate instant granules of Telang Flower extract (Clitoria ternatea L) and determine antioxidant activity and antidiabetic activity. This research is a laboratory experiment involving instant granule formulations that are tested for physical characteristics, then tested for antioxidant activity using DPPH and Pretest-Postest Control Group Design antidiabetic activity test on White Rats. The results of observations of instant granule characteristics testing which include organoleptical tests, flow speed, angle of repose, moisture content, dissolving time and pH meet the granule requirements. the results of the antioxidant activity test IC50 value F1 155.39, F2 115.73, F4 143.93 and F5 148.25 where the four formulas show moderate antioxidant characteristics, while the IC50 nlai F5 262.86 is included in the weak antioxidant category. The measurement of blood glucose levels before alloxan induction (pree) and after alloxan induction (mid) increased where in FI 9. 63>267.33 mg/dL, F2 105.66>248.00, mg/dL F3 99.00>217.66 mg/dL F4 99.00>263.33 mg/dL and F5 104.00>247.33 mg/dL, while in healthy control (without treatment) no increase occurred 97.66 mg/dL, while the decrease in glucose levels after alloxan induction (mid) and after being given instant granule preparations (post) on the 11th day decreased where for F1 267.33 <132.67 mg/dL, F2 248.00 <147.00, mg/dL F3 217.66 <119.33 mg/dL F4 263.33 <132.67 mg/dL and F5 247.33 <114.00 mg/dL. So it can be concluded that the instant granule preparation formulation of Telang Flower extract (Clitoria ternatea L) with a dose of 450 mg/KgBB with a concentration of PVP 3.5% as a binder meets the requirements of instant granule characteristics, also has moderate antioxidant activity and has the lowest blood glucose lowering effect compared to other formulas.
Review artikel: Potensi Tanaman Nilam (Pogostemon cablin Benth.) Sebagai Agen Antikanker: Article review : Potential of the Patchouli (Pogostemon cablin Benth.) as an Anticancer Agent Wulandari, Ayu; Fristiohady, Adryan; Wahyuni, Wahyuni; Sahidin, Sahidin; Arba, Muhammad; Irnawati, Irnawati
Media Farmasi Vol 21 No 1 (2025): Media Farmasi Edisi April 2025
Publisher : Jurusan Farmasi Poltekkes kemenkes Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/mf.v21i1.1270

Abstract

Globally, cancer remains one of the leading causes of death, and the number of cases continues to increase along with world population growth, population aging and modern lifestyles. The prevalence of cancer in 2024 will still be influenced by many factors, including lifestyle, diet, environmental exposure, and advances in cancer detection and treatment. Currently, a lot of research related to alternative cancer therapy focuses on the use of natural product as anticancer agents that are more selective, effective, and with lower side effects. This article review aims to provide information regarding the patchouli plant (Pogostemon cablin) and its potential as an anticancer agent. This review was carried out by collecting literature from various databases published in the last 10 years (2014 – 2024). Based on literature searches, P. cablin is known to have anticancer activity against endometrial, ovarian, liver, skin, nasopharyngeal, prostate, blood, colorectal and lung cancer.
Scoping Review: Profil Pengobatan Pasien Stroke Iskemik Di Indonesia Setelah Dikeluarkannya Panduan Nasional Pelayanan Kedokteran Stroke Tahun 2019: Scoping Review: The Drug Therapy Profile of Ischemic Stroke Patients in Indonesia Following of the 2019 National Guidelines for Stroke Medical Service Lisnawati, Retno; Panduwiguna, Ivans; Saepudin
Media Farmasi Vol 21 No 1 (2025): Media Farmasi Edisi April 2025
Publisher : Jurusan Farmasi Poltekkes kemenkes Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/mf.v21i1.1309

Abstract

In Indonesia, stroke is one of the leading causes of morbidity and mortality. The National Guidelines for Medical Services Stroke (PNPK) which was established in 2019, provides guidance for raising the bar for stroke treatment. The purpose of this scoping study is to understand the profile of stroke patients in Indonesia following the PNPK 2019 with an emphasis on drug therapy, evaluation, and rationality. This study used a scoping review design with article searches using the PubMed and Google Scholar databases from 2020 to 2024. Criteria for inclusion include articles about stroke prevention in Indonesia, which can be accessed and used after PNPK 2019. From 1288 articles in PubMed and 80 articles in Google Scholar, 11 articles were selected that met the criteria. The most commonly used treatment combinations for stroke patients are neuroprotectants, antiplatelet, antihypertensive, and anti dislipidemia. Neuroprotectants, such as Citicoline, are the most commonly used drugs. The most effective antihypertensive treatment is a combination of CCB and ARBs. The majority of articles demonstrate high drug rationality, with accurate indication, patient, medication, and dosage reaching 100%. There are advantages to using rtPA for thrombolysis treatment, particularly in terms of onset time, access, and systemic benefits. While the profile of drug therapy among ischemic stroke patients in Indonesia demonstrates high rationality, the 2019 PNPK Stroke places more emphasis on therapy for ischemic stroke patients in the hyperacute phase, However, research on the application of therapy in hyperacute phase ischemic stroke patients has not been extensively conducted.
A Systematic Narrative Review : Kajian Farmakologi dan Toksikologi Meniran (Phyllanthus niruri L.): A Systematic Narrative Review : Pharmacology and Toxicology Study of Meniran (Phyllanthus niruri L.) Pandapotan, Herianto; Fitriani, Hannie; Hayati, Farida; Syukri, Yandi
Media Farmasi Vol 21 No 1 (2025): Media Farmasi Edisi April 2025
Publisher : Jurusan Farmasi Poltekkes kemenkes Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/mf.v21i1.1317

Abstract

Background: Meniran (Phyllanthus niruri L.) is a traditional medicinal plant widely utilized in various countries due to its pharmacological potential. Objective: This study aims to explore the biological activity by summarizing scientific findings regarding the pharmacological effects and toxicological profile of meniran, as well as highlighting the understanding related to safe therapeutic doses. Methods: This review was conducted using a systematic narrative approach, utilizing literature from journal articles, scientific reports, reference books, and publication data from databases such as PubMed, Scopus, and Google Scholar. Inclusion criteria comprised peer-reviewed studies published in the last 10 years, while exclusion criteria eliminated non-scientific articles and those not relevant to pharmacology or toxicology. Results: A total of 200 articles were identified, resulting in 34 articles selected for review after applying inclusion and exclusion criteria. From the four journals/studies reviewed, it was found that bioactive compounds in meniran, such as flavonoids and lignans, play a crucial role in therapeutic effects including antioxidant activity, hepatoprotection, antimicrobial effects, and anti-inflammatory properties. Additionally, two journals/studies indicated that long-term use of meniran may have toxic effects. Conclusion: Meniran exhibits pharmacological activities such as antioxidant effects, hepatoprotection, antimicrobial effects, and anti-inflammatory effects; however, it may have toxic effects on the kidneys and liver when used in high doses. Further research is necessary to ensure the safety and effectiveness of its use in medical therapy.
Isolasi, Identifikasi, dan Uji Aktivitas Antibakteri Fungi Endofit Daun Bidara Arab (Ziziphus spina-christi L.) Terhadap Propionibacterium acnes Dan Staphylococcus epidermidis Salasa, Alfrida Monica; Layuksugi, Defline Apriliana; Pakadang, Sesilia Rante; Ratnah, St.; Asmawati
Media Farmasi Vol 21 No 2 (2025): Media Farmasi Edisi Oktober 2025
Publisher : Jurusan Farmasi Poltekkes kemenkes Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/mf.v21i2.605

Abstract

Isolation, Identification, and Antibacterial Activity of Endophytic Fungi from Ziziphus spina-christi Leaves Against Propionibacterium acnes and Staphylococcus epidermidis Ziziphus spina-christi L. (Arabian bidara) has long been used in traditional medicine for preventing acne and enhancing skin health. Acne pathogenesis is closely associated with the proliferation of Propionibacterium acnes and Staphylococcus epidermidis. This study aimed to isolate endophytic fungi from bidara leaves and assess their ability to produce antibacterial secondary metabolites. Endophytes were isolated through surface sterilization and successive purification on Sabouraud Dextrose Agar, followed by fermentation on Potato Dextrose Agar and ethyl acetate extraction. Phytochemical profiling and antibacterial activity were evaluated using standard qualitative assays and the agar diffusion method on Mueller Hinton Agar, respectively.Six pure isolates were obtained: brown (Aspergillus niger), grey (Colletotrichum sp.), cream (Aspergillus terreus), green (Aspergillus flavus), turquoise (Aspergillus fumigatus), and white (Cylindrocladium sp.). Phytochemical screening revealed the presence of alkaloids, flavonoids, polyphenols, and tannins in varying combinations across isolates. Antibacterial testing showed that all isolates inhibited P. acnes and S. epidermidis, except the green isolate, which exhibited no bactericidal activity. These findings indicate that bidara leaf endophytes represent a promising source of antibacterial compounds with potential applications in acne management. Tanaman Bidara Arab (Ziziphus spina-christi L.) adalah tanaman tradisional yang diyakini secara empiris mencegah pertumbuhan jerawat dan menghaluskan kulit. Propionibacterium acnes dan Staphylococcus epidermidis merupakan jenis bakteri yang dapat menimbulkan jerawat. Penelitian ini bertujuan untuk memperoleh isolat fungi endofit Daun Bidara Arab yang berpotensi menghasilkan metabolit sekunder sebagai antibakteri Propinobacterum acnes dan Staphylococcus epidermidis. Fungi endofit diisolasi dengan cara sterilisasi Daun Bidara Arab, selanjutnya diinokulasi berulang pada media Sabouraud Dextrose Agar hingga diperoleh isolat murni. Dilakukan fermentasi pada media Potato Dextrose Agar diekstraksi dengan etil asetat. Skrining fitokimia ekstrak etil asetat dilakukan untuk mendapatkan metabolit sekunder digunakan untuk pengujian antibakteri dengan metode difusi agar pada media Mueller Hinton Agar. Hasil penelitian didapatkan 6 isolat murni, yaitu isolat coklat diduga Aspergillus niger, isolat abu-abu diduga Colletotrichum sp, isolat crem diduga Aspergillus terreus, isolat hijau diduga Aspergillus flavus, isolat toska diduga Aspergillus fumigatus, serta isolat putih diduga Cylindrocladium. Hasil skrining fitokimia menunjukkan isolat coklat mengandung alkaloid, polifenol, tannin, isolat crem mengandung alkaloid, flavonoid, polifenol dan tannin, isolat abu-abu mengandung polifenol dan tannin, isolat putih mengandung flavonoid, polifenol, tannin. Pengujian antibakteri didapatkan semua isolat pada Daun Bidara Arab berpotensi menghambat serta membunuh Propionibacterium acnes dan Staphylococcus epidermidis sedangkan isolat hijau tidak berpotensi dalam membunuh Propionibacterium acnes dan Staphylococcus epidermidis
Tingkat Kepuasan Pasien Diabetes Mellitus Tipe 2 Terhadap Pelayanan Tenaga Kefarmasian Di Puskesmas Moncongloe Kabupaten Maros Amoer, Andi Dian Fitri; Tangdilintin, Frederika; Saud, Anshar; Bahar, Muh. Akbar
Media Farmasi Vol 21 No 2 (2025): Media Farmasi Edisi Oktober 2025
Publisher : Jurusan Farmasi Poltekkes kemenkes Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/mf.v21i2.1384

Abstract

ABSTRACT Diabetes mellitus (DM) is one of the serious health problems and the biggest cause of death in the world. One of the districts that has the largest number of people with diabetes mellitus in South Sulawesi Province is Maros Regency. Pharmacists play a very important role in the therapeutic process of DM patients to improve the quality of life of patients. Objective. This study aims to determine the level of patient satisfaction based on perceptions of pharmaceutical services at the Moncongloe Health Center, Maros Regency. Methods. This study is a quantitative study with cross sectional method. This research instrument is a questionnaire adopted from previous studies that have been proven valid and reliable. This research was conducted at the Moncongloe Health Center, Maros Regency, South Sulawesi Province in January 2024. Results. This study shows that respondents gave a satisfied perception of the overall service of pharmaceutical personnel with a total percentage of 86%. In the aspect of prescription screening, the dominant patient was satisfied with a percentage of 43%; the aspect of drug preparation 66%; the aspect of drug information communication and education 46.6%; drug monitoring 42.8% of each patient was satisfied. Conclusion. The overall level of patient satisfaction with the perception of pharmaceutical personnel services at the Moncongloe Health Center, Maros Regency is 86% which is included in the satisfied category.
Penerapan Pelayanan Informasi Obat Di Beberapa Puskesmas Kabupaten Gowa Usman, St. Atifah Ananda; Achmad, Alghifary Anas; Anggriani, Andi; Bahar, Muh. Akbar
Media Farmasi Vol 21 No 2 (2025): Media Farmasi Edisi Oktober 2025
Publisher : Jurusan Farmasi Poltekkes kemenkes Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/mf.v21i2.1413

Abstract

Drug information services (DIS) are activities carried out by pharmaceutical personnel to provide accurate, clear, and up-to-date information about drugs to patients, doctors, nurses, and other health professionals. This research aims to determine the implementation of drug information services in several Community Health Centers in the Gowa Regency area. This research uses a cross-sectional study method. Research subjects who met the inclusion criteria were 18 years of age or older, able to read and write, had received treatment at least three times, and were willing to participate in the research. This research was conducted at four health centers in four regions of Gowa Regency: Parangloe Health Center representing the North region, Tamaona Health Center representing the East region, Batumalonro Health Center representing the South region, and Bontonompo Health Center representing the West region. This research was carried out from December 2023 to January 2024. The application of drug information services, in the form of providing information on drug doses, was 90.3%; drug names, 76.5%; how to use, 72.8%; indications, 72.5%; dosage forms, 70.5%; storage, 35.8%; interactions, 32.8%; side effects, 27.5%; contraindications, 27.5%; and stability, 25.8%. It can be concluded that the implementation of drug information services in several health centers in the Gowa Regency area has not been carried out optimally. Keywords: DIS, Patient, Pharmacist, Gowa Regency, Drug

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