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Media Farmasi
Published by Poltekkes Kemenkes Makassar
ISSN : 02162083     EISSN : 26220962     DOI : https://doi.org/10.32382/mf.v19i2
Core Subject : Health, Science,
Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health
Media Farmasi beralih ke OJS 3 dengan alamat web yang abru namun Media Farmasi tetap Mempublikasikan review article dan original article diseluruh bidang Kefarmasian seperti Farmasetika dan Teknologi Farmasi, Farmasi Klinik, Farmakognosi, Kimia Farmasi yang tidak pernah dipublikasikan di jurnal lain atau tidak dalam sementara di review oleh jurnal lain
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 53 Documents
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Tinjauan Literatur Sistematis; Pemanfaatan Teknologi CRISPR-CAS9 Untuk Pengobatan Penyakit Huntington’s Sari, Meliana; Kasasiah, Ahsanal
Media Farmasi Vol 20 No 2 (2024): Media Farmasi Edisi Oktober 2024
Publisher : Jurusan Farmasi Poltekkes kemenkes Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/mf.v20i2.704

Abstract

Huntington's Disease (HD) is a neurodegenerative disorder caused by a CAG triple expansion (>36) in the first exon of the HTT gene encoding the huntingtin protein. Advances in gene editing technologies, such as CRISPR-Cas9, provide new hope for correcting the genetic mutations underlying HD. This review article aims to review the potential and effectiveness of CRISPR-Cas9 technology as a therapeutic tool for HD. The writing method used was Systematic Literature Review, with literature searches conducted using three databases: PubMed, ScienceDirect, and SpringerLink. This study reviewed several studies that used in vivo and in vitro models to evaluate the impact of HTT gene editing on mutant huntingtin protein expression and HD symptoms. Results showed that CRISPR-Cas9 can effectively reduce mutant huntingtin protein expression, reduce neuronal toxicity, and improve motor symptoms in mouse models of HD. Although these results are promising, further studies are needed to optimize the safety and effectiveness of using CRISPR-Cas9 in genetic therapy for HD.
Potensi Ekstrak Air Kayu Manis (Cinnamomum burmanii) Sebagai Agen Neuroprotektif Pada Penyakit Parkinson Dengan Model Mencit Jantan (Mus musculus) Yang Diinduksi Haloperidol Mentari, Ika Ayu; Azmi, Rizky Nur; Astriani, Nur Atika; Kamilah, Lila Zulfa
Media Farmasi Vol 20 No 2 (2024): Media Farmasi Edisi Oktober 2024
Publisher : Jurusan Farmasi Poltekkes kemenkes Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/mf.v20i2.735

Abstract

Parkinson's disease (PP) is a neurodegenerative disease, Parkinson's occurs due to mitochondrial dysfunction caused by oxidative stress. Compounds that can prevent the formation of oxidative stress are antioxidants. One plant that has a role or activity as a high antioxidant is cinnamon (Cinnamomum burmani). This study aims to determine the antioxidant activity, total phenols and total flavonoids of cinnamon water extract and the effect of the dose concentration of cinnamon water extract on reducing the symptoms of Parkinson's disease in mice that have been induced by Haloperidol. Total phenols used the Follin-Ciocalteu method, total flavonoids used the colorimetric method with AlCl3 reagent. The antiparkinson test used 30 male mice divided into 5 test groups such as group I healthy, group II levodopa, group III Haloperidol, groups IV, V, and VI given cinnamon water extract at successive doses of 200; 400;800 mg/KgBW. Groups II-VI were given Haloperidol induction at 45 minutes after treatment. The tests were carried out on the pole test, rotarod test and sense of smell observations were carried out for 14 days with data collected every day 0, 4, 7, 11 and 14. The results showed that cinnamon water extract had a total phenol content of 617.2 mg GAE/g and total flavonoids 565 mg GAE/g, and has an antioxidant activity IC50 of 4.124 μg/mL. ANOVA analysis with Tukey's follow-up test in the rotaroad test showed significantly different in dose 200,400 and 800 mg/kgBW with the haloperidol group (P <0.05), as well as the ability of the sense of smell when compared with Haloperidol giving 800 mg/KgBW extract significantly different (P<0.05). Cinnamon extract can reduce the symptoms of parkinsonis in mice induced by haloperidol in effective dose 800 mg/kgBW and has strong antioxidant activity.
SNEDDS Sebagai Sistem Penghantaran Baru Berbasis Sediaan Gel Tea Tree Oil Untuk Anti Jerawat Firdani, Alnessia; Pratiwi, Mutia Dian; Pramitasari, Kharisma; Suryani, Putri Jian; Pratiwi, Elasari Dwi
Media Farmasi Vol 20 No 2 (2024): Media Farmasi Edisi Oktober 2024
Publisher : Jurusan Farmasi Poltekkes kemenkes Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/mf.v20i2.796

Abstract

Acne is a skin condition that is often discussed, especially among teenagers, because of its potential to damage self-confidence. The use of cosmetics that contain anti-acne active compounds from natural ingredients, such as tea tree oil, is one of the effective acne treatments. Tea tree oil is an essential oil that has hydrophobic and lipophilic properties. So, a good conveyor system such as SNEDDS is needed. The SNEDDS tea tree oil gel preparation in this study aims to assess the potential inhibition of the preparation against staphylococcus epidermidis, a type of acne-causing bacteria. The data analysis in this study uses descriptive methods, such as homogeneity test, organoleptic test, pH test, dispersion test, viscosity test, stability test, and antibacterial test. Antibacterial activity data is data obtained in the form of the diameter of the obstacle area and measured using a caliper. The results of the antibacterial activity test against staphylococcus epidermidis bacteria are as follows: positive control (Clindamycin) has an inhibition of 32.26 mm, F1 (SNEDDS tea tree oil 0% gel) does not inhibit, and F2 (SNEDDS tea tree oil 20% gel) has an inhibition of 24.44 mm. Thus, it can be concluded that SNEDDS tea tree oil gel has the ability to inhibit bacteria in the very strong category (>10mm).
Sinergitas Efek Kombinasi Ekstrak Daun SirsaK (Annona muricata Linn) Dengan Doksorubisin Pada Sel Kanker Payudara MCF-7 Lukman; Aswad, Hijral; Lestari, Desy Ayu; Paluseri, Andi
Media Farmasi Vol 20 No 2 (2024): Media Farmasi Edisi Oktober 2024
Publisher : Jurusan Farmasi Poltekkes kemenkes Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/mf.v20i2.832

Abstract

Doxorubicin is the first line of cancer treatment but has very serious side effects such as hair loss, kidney damage and liver function abnormalities. One strategy to reduce these side effects is to combine doxorubicin with medicinal plants with anti-cancer properties such as soursop leaves (Annona muricata Linn). The aim of this research is to determine the synergistic effect of the combination of soursop leaf extract with doxorubicin to inhibit the growth of MCF-5 breast cancer cells. Soursop leaves were extracted with 96% ethanol while the anti-cancer test used the MTT method. The results of the study showed that soursop leaf extract had anti-cancer properties with IC25 and IC50 respectively being 29.36 ± 1.16 and 58.75 ± 2.35 µg/mL while doxorubicin was 1.34 ± 0.04 and 2. 76 ± 0.03 µg/mL. The combination of soursop leaf extract and doxorubicin showed a value of 0.8-1.0 (moderate synergistic). In conclusion, the combination of soursop leaf extract and doxorubicin shows a synergistic effect.
Efektivitas Ekstrak Daun Andong Terhadap Kesembuhan Luka Bakar Pada Kelinci (Oryctolagus cuniculus) Prayitno, Suprapto; Edikamal, Sainal; Izza, Nurul
Media Farmasi Vol 20 No 2 (2024): Media Farmasi Edisi Oktober 2024
Publisher : Jurusan Farmasi Poltekkes kemenkes Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/mf.v20i2.881

Abstract

The Andong plant (Cordyline fruticosa L.) is an ornamental plant that is often planted in people's yards in Indonesia. This plant is believed to be able to treat burns by using plant parts in the form of leaves which are processed by crushing them and then applying them to the wound area. In previous research, it was reported that andong leaves (Cordyline fruticosa L.) contain compounds, phenols, flavonoids, tannins and saponins. This plant plays a role in the process of closing wounds, due to its chemical content in the form of tannins which act as adstringents which can increase granulation in wounds and stop light bleeding. This research will test the effects of andong leaves as a medicine for burns using rabbit test animals. This research was carried out in the phytochemical and pharmacological toxicology laboratory at Pancasakti University, Makassar experimentally by testing the treatment of burn wounds on male rabbits using andong leaf extract (Cordyline fruticosa L.) containing flavonoids, saponins and tannins which have potential as a burn wound treatment. The diameter of the burn wound is indicated by the presence of burn wound healing activity. When giving andong leaf extract with a concentration of 5%, 10%, 15%. Giving the extract with a concentration of 15% had the best concentration with a healing percentage value of 95%, but at this concentration giving the positive control had a higher healing effect on burn wounds with a healing percentage value of 99.5%. So from the results of this research it can be concluded that andong leaf extract has effectiveness in healing burns in male rabbits and a 15% concentration of andong leaf extract has the highest effectiveness in healing burns, but this concentration does not exceed the effectiveness of healing when given the positive control given by bioplacenton.
Preservation Potential and Microbial Growth Inhibitory Effect Of Galangal (Alpinia galanga (L.) Willd.) And Lemongrass (Cymbopogon citratus (DC.) Stapf) Oils And Extracts On Chicken (Gallus domesticus) Fillets Hartanti, Dwi; Pradani, Dea Yulinestria; Nurlaeli, Eli; Fadlilah, Intan Nur; Syah Putri, Tina; Djalil, Asmiyenti Djaliasrin; Hamad, Alwani
Media Farmasi Vol 20 No 2 (2024): Media Farmasi Edisi Oktober 2024
Publisher : Jurusan Farmasi Poltekkes kemenkes Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/mf.v20i2.993

Abstract

Galangal (Alpinia galanga (L.) Willd.) and lemongrass (Cymbopogon citratus (DC.) Stapf) are spices known for their antimicrobial activity and potentially developed into a natural food preservative. This study evaluated the potential development of galangal and lemongrass oils and extracts for natural food preservatives. The essential oils and water extracts of galangal and lemongrass were obtained by water and steam distillation and infusion methods, respectively. Chicken fillets were immersed in three concentrations of galangal and lemongrass oils and extracts, with sterile water as the control. The fillets were tightly closed, kept in the refrigerator for 15 days, and evaluated for their preservation potential and microbial inhibitory activity on days 3, 6, 9, 12, and 15. The chicken fillet preservation potential was evaluated by comparing the time spoilage signs started to be observable in the control and treatment groups. The percent of microbial growth inhibition (%MI) was calculated from optical density (OD) and was used as the antimicrobial activity parameter. The %MI was analyzed by two-way ANOVA at α=0.05. Treatment and storage time significantly affected %MI. Galangal extracts at 10 and 20% delayed rancid odor, off-texture, and slime formation for nine days. Microbial growth inhibitory activity was shown by galangal oil at 0.25, 1.25, and 6.25 mg/ml and galangal extract at 20%. In conclusion, galangal extract at 20% was the most promising sample potentially developed into a natural chicken fillet preservative.
Antihypertensive Activity Profile of Bangkirai Leaves (Shorea laevis Ridl.) Ethanol Extract on Angiotensin II (4ZUD) and β-Adrenergic (6PS5) Receptors Agus, Adhe; Siswandono, Siswandono; Butar-Butar, Maria; Fernandes, Andrian; Maharani, Rizki
Media Farmasi Vol 20 No 2 (2024): Media Farmasi Edisi Oktober 2024
Publisher : Jurusan Farmasi Poltekkes kemenkes Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/mf.v20i2.994

Abstract

Hypertensive is a cardiovascular system disorder characterized by systolic pressure ≥ 140mmHg and diastolic ≥ 90mmHg. The increase in blod pressure is due to the mechanism of angiotensin II and β-adrenergic receptors, so in developing medicine for hypertension, compounds are needed to inhibit the activation of angiotensin II to angiotensin II, as well as β-adrenergic. Kalimantan, Indonesia has a biodiversity that has the potential as medicine such as Bangkirai (Shorea laevis Ridl.). Based on previous research on secondary metabolites, various compounds have been identified that have potential as new drug candidates, for example as antihypertensive. This study aims to determine the pharmacological profile and mechanism of angiotensin I inhibition at the 4ZUD and β-adrenergic receptors inhibition at the 6PS5 receptor, from ethanol extract of bangkirai leaves by carrying out molecular docking which begins with several stages including preparation and optimization of the structure of the test compound and structure preparation of 3D receptors 4ZUD and 6PS5. To find out the correctness of the method, validation was carried out on the Olmesartan ligand compound for 4ZUD and the propranolol ligand for 6PS5. Based on research carried out on both receptors, results were obtained for the test compounds in the form of MolDockScore, the pharmacological profile of absorption, distribution, metabolism, excretion, and toxicity. MolDockScore results show that the compound Colchicine, N-desacetyl-N-[4-hydroxy-3,5-dimethoxycinnamoyl] has the lowest values, namely -146.503 at the 4ZUD receptor dan -129.718 at the 6PS5 receptor, which is close to the natural ligand value compared to other metabolite compounds. Apart from that, it also provides good results based on the pharmacological profile of the 4ZUD and 6PS5 receptors including HIA (95.73%), Caco2 (35.14nm/second), and PPB (87.67%). Negative test results are also shown in the mutagenic toxicity profile (Ames Test Method), non-mutagenic, and carcinogenic tests which include genotoxic and nongenotoxic.
In-Silico Analysis of Momordica charantia L. As Antidiabetic Agents Through Activation of Human UDP-Galactose 4-Epimerase Receptors Pramesthi, Asri Dwi Endah Dewi; Suwarno, Kafka Navisa; Pratama, Aldo; Rasyidah, Jamiatur; I Wayan Surya Rahadi; Rasida, Rima
Media Farmasi Vol 20 No 2 (2024): Media Farmasi Edisi Oktober 2024
Publisher : Jurusan Farmasi Poltekkes kemenkes Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/mf.v20i2.1002

Abstract

This study investigates the antidiabetic potential of compounds found in Momordica charantia L., commonly known as bitter melon, through molecular docking and ADME (Absorption, Distribution, Metabolism, and Excretion) analysis. Utilizing in silico methods, several bioactive compounds from bitter melon, such as charantin, vicine, momordenol, momordicilin, and momordicoside, were evaluated for their ability to interact with the human UDP-Galactose 4-Epimerase receptor, a key enzyme involved in glucose metabolism. The docking results indicate that these compounds exhibit strong binding affinities, suggesting their role in glucose regulation. Further ADME analysis revealed that the compounds generally comply with the Lipinski Rule of Five, indicating favorable drug-like properties, though some compounds exhibited potential toxicities requiring further investigation. These findings highlight the potential of Momordica charantia as a source of antidiabetic agents, warranting additional in vivo and clinical studies to confirm their efficacy and safety in managing diabetes mellitus.
Peningkatan Kelarutan Ketoprofen Dalam Bentuk Mikropartikel Dengan Metode Emulsification-Ionic-Gelation Menggunakan Polyvinylprrolidone (PVP) Dan Tripolifosfat(TPP) Dirgahayu Yahya, Nurul Fitri; Sinala, Santi; Stevani, Hendra
Media Farmasi Vol 20 No 2 (2024): Media Farmasi Edisi Oktober 2024
Publisher : Jurusan Farmasi Poltekkes kemenkes Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/mf.v20i2.1006

Abstract

A nonsteroidal anti-inflammatory drug called ketoprofen is used to treat musculoskeletal and joint disorders, including osteoarthritis. Ketoprofen has a low solubility in water, which is a major obstacle to the absorption of the drug into the body.However, by using emulsification ion gelation technology, it is possible to create microparticles, which can improve the solubility of ketoprofen. . The aim of this study was to use emulsification and ion gelation to produce ketoprofen microparticles with higher solubility. SEM was used to characterize the structure of the ketoprofen particles. Subsequently, ketoprofen solubility and content tests were performed. When the properties were evaluated using SEM microparticles, the particle size gradually decreased from pH2, pH4, and pH6, and the water solubility of the drug increased due to the small particle size of the generated microparticles. After the emulsification-ionic gelation process, the solubility of ketoprofen increased two-fold and the pH of water increased two-fold compared to untreated ketoprofen. From this, it can be concluded that polyvinylpyrrolidone (PVP) and tripolyphosphoric acid (TPP) effectively improved the solubility of sparingly water-soluble ketoprofen in the emulsification ion gelation process of ketoprofen production.
Inkorporasi Ekstrak Daun Jarak Pagar (Jatropha Curcas L) dalam Patch Transdermal Sebagai Anti Hiperglikemi; Formulasi Dan Pankreatik Histopatologi Sukmawati, Muli; Arisanty; Daswi, Dwi Rachmawaty; Stevani, Hendra; Daton, Dicky Alexander
Media Farmasi Vol 20 No 2 (2024): Media Farmasi Edisi Oktober 2024
Publisher : Jurusan Farmasi Poltekkes kemenkes Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/mf.v20i2.1060

Abstract

Incorporation Of Jarak Pagar Leaves Extract (Jatropha Curcas L) In Transdermal Patch As Antihyperglycemic ; Formulation And Pancreatic Histopathology Transdermal patches are known to have a more immediate therapeutic effect and could avoid the risk of side effects that may arise compared to oral. This study aimed to produce Jarak Pagar leaves ethanolic extract transdermal patch (JPL-EETP) to enhance the penetration of Jarak Pagar leaves extract (JPL-EE) to maximize the systemic therapeutic effect of antidiabetics. In addition, easy and enjoyable medication could improve patient compliance. Transdermal patch was prepared by making the formula of JPL-EETP with different concentrations of extract with solvent-evaporated methods. JPL-EETP optimization was carried out by determining the pH, aeration, folding resistance, and organoleptic. Furthermore, the optimal JPL-EETP formulas were followed by the in vivo assay, ex vivo assay, and pancreatic histopathology assay. The JPL-EETP physicall determination were carried out the appropriate of transdermal patch measurements.  F3 with an JPL-EE concentration of 1.75 g can provide an antidiabetic effect on in vivo asay that is as good as oral antihyperglycemic drugs (p>0.05). Ex vivo study confirmed that the gallate acid permeation across the porcine skin of F2 showed higher percentage of permeation of 94,2% respectively after 24 h. The histophatology assay presence no significant difference between the surface area of ​​the islets of Langerhans and the histopathological after administration of metformin or Jarak Pagar leaves extract transdermal patch. The results suggest that Jarak Pagar leaves ethanolic extract transdermal patch is a potential candidate of antidiabetics drug from natural source and can provide a higher patient compliance along with effectiveness in the management and treatment of diabetes which can be easily applied to the skin. Sediaan patch transdermal diketahui memiliki efek terapi yang lebih cepat dan dapat amenghindari resiko efek samping yang mungkin timbul dibanding sediaan oral. Penelitian ini bertujuan untuk membuat ekstrak etanol daun Jarak Pagar (PT-EJPL) yang diformulasikan dalam bentuk patch transdermal untuk meningkatkan efektifitasnya sebagai antihiperglikemi. Patch transdermal dibuat dalam beberapa konsentrasi EJPL dengan metode solvent-evaporated. Karakteristik PT-EJPL ditentukan dengan pengukuran pH, daya lipat, dan uji organoleptik. Penentuan efek antihiperglikemi dilakukan secara in vivo menggunakan tikus wistar putih. Persentase pelepasan fenolik dilakukan secara ex vivo menggunakan kulit babi selama 24 jam. Analisis pakreas histopatologi dilakukan dengan melihat luar area pulau langerhans sebelum dan sesudah perlakuan. Hasil pengujian menunjukkan karateristik patch yang sesuai persyaratan. Formula 3 dengan konsentrasi EEJPL 1.75 g menunjukkan efek antihiperglikemi pakling baik (p<0.05) sejalan dengan hasil uji pelepasan asam gallat pada F3 mencapai 94,2% pada jam ke 24. Analisis histopatologi luas permukaan sel langerhans menunjukkan tidak perbedaan signifikan antara kelompok kontrol dan perlakuan (p>0.05). Penelitian ini berhasil memformulasikan EJPL kedalam sistem penghantaran transdermal dan dapat dipertimbangkan sebagai kandidat antidiabetik herbal.

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