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Media Farmasi
Published by Poltekkes Kemenkes Makassar
ISSN : 02162083     EISSN : 26220962     DOI : https://doi.org/10.32382/mf.v19i2
Core Subject : Health, Science,
Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health
Media Farmasi beralih ke OJS 3 dengan alamat web yang abru namun Media Farmasi tetap Mempublikasikan review article dan original article diseluruh bidang Kefarmasian seperti Farmasetika dan Teknologi Farmasi, Farmasi Klinik, Farmakognosi, Kimia Farmasi yang tidak pernah dipublikasikan di jurnal lain atau tidak dalam sementara di review oleh jurnal lain
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 53 Documents
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Efek Anti Diabetes Ekstrak Daun Maja (Aegle marmelos L.) pada Zebrafish (Danio rerio) Syahrir, Putri Damayanti; Stevani, Hendra; Dewi, Sisilia Teresia Rosmala
Media Farmasi Vol 20 No 1 (2024): Media Farmasi Edisi April 2024
Publisher : Jurusan Farmasi Poltekkes kemenkes Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/mf.v20i1.567

Abstract

Anti Diabetes Effect Of Maja (Aegle marmelos L.) Leaf Extract On Zebrafish (Danio rerio) Several studies show the effectiveness of Maja leaves in Diabetes mellitus, however further proof is still needed to confirm the effectiveness of Maja leaves, one of which is by using experimental animals that are more similar to humans such as Zebrafish (Danio rerio). This research aims to determine the anti-diabetic effectiveness of maja leaf extract (Aegle marmelos L.) on Zebrafish (Danio rerio) after being induced by Aloxan. Maja leaves (Aegle marmelos L.) were extracted using the maceration method. This research was carried out using Aloxan and 0.1% glucose as inducers, and Metformin as a positive control, with extract doses of 200 mg/2L, 300 mg/2L, and 400 mg/2L. The results of the observations showed that the average decrease for each treatment group was that the negative control group given Aloxan and 0.1% glucose had an average decrease of 130 ± 15.6 mg/dL, the group given 200 mg maja leaf extract had an average decrease was 62.33 ± 15 mg/dL, for the group given 300 mg maja leaf extract had an average decrease of 68 ± 15 mg/dL, the group given 400 mg maja leaf extract had an average decrease of 67±11.5mg/dL and the positive control group given Metformin had an average reduction of 57.66±12.7mg/dL. So it can be concluded that maja leaf extract 200 mg, 300 mg, and 400 mg has been proven to significantly reduce blood glucose levels in zebrafish (p<0.05). Terdapat beberapa penelitian yang menunjukkan efektivitas Daun Maja pada Diabetes melitus, namun pembuktian lebih lanjut masih diperlukan untuk memastikan efektivitas daun Maja, salah satunya dengan menggunakan hewan coba yang lebih memiliki kemiripan dengan manusia seperti Zebrafish (Danio rerio). Tujuan dari Penelitian ini adalah untuk mengetahui efektivitas anti diabetes esktrak Daun maja (Aegle marmelos L.) pada Zebrafish (danio rerio) setelah diinduksi Aloxan. Daun maja (Aegle marmelos L.) diekstraksi dengan menggunakan metode maserasi. Penelitian ini dilakukan dengan menggunakan Aloxan dan glukosa 0,1% sebagai penginduksi, Metformin sebagai kontrol positif, dengan dosis ekstrak 200 mg/2L, 300 mg/2L, dan 400 mg/2L. Hasil pengamatan menunjukkan bahwa rata-rata penurunan untuk setiap kelompok perlakuan yaitu pada kelompok kontrol negatif yang diberi Aloxan dan glukosa 0,1% memiliki rata-rata penurunan sebesar 130 ±15,6 mg/dL, kelompok yang diberi ekstrak daun maja 200 mg memiliki rata-rata penurunan sebesar 62,33±15 mg/dL, untuk kelompok yang diberi ekstrak daun maja 300 mg memiliki rata-rata penurunan sebesar 68 ± 15 mg/dL, kelompok yang diberi ekstrak daun maja 400 mg memiliki rata-rata penurunan sebesar 67±11,5mg/dL dan untuk kelompok kontrol positif yang diberi Metformin memiliki rata-rata penurunan sebesar 57,66±12,7mg/dL. Sehingga dapat disimpulkan bahwa ekstrak daun maja 200 mg, 300 mg, dan 400 mg terbukti dapat menurunkan kadar glukosa darah pada Zebrafish secara signifikan (p<0,05).
Efektivitas Penggunaan Home Care Jamu Kombinasi Bawang Putih Terhadap Penurunan Kadar Kolesterol dan Tekanan Darah Pada Penderita Hiperkolesterol dan Hipertensi Anisyah, Luluk; Kurnia Andika, Venny
Media Farmasi Vol 19 No 2 (2023): Media Farmasi Edisi Oktober 2023
Publisher : Jurusan Farmasi Poltekkes kemenkes Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/mf.v19i2.115

Abstract

Effectiveness of Using Home Care Herbal Medicine Combination of Garlic in Reducing Cholesterol Levels and Blood Pressure in Hypercholesterol and Hypertension Sufferers This garlic combination herbal medicine contains antioxidants and alkaloids which are efficacious for lowering cholesterol levels and blood pressure. This research aims to determine the effectiveness of using a combination of garlic herbal medicine to reduce cholesterol levels and blood pressure. Cross-sectional research methodology with a one-group pre-test post-test design. The total number of respondents in the study was 42 sufferers, and these sufferers would have their cholesterol and blood pressure levels checked at weeks 1 and 4. The results of data analysis for the herbal medicine group using the Paired T-Test resulted in pre-systolic levels of 150.19 ± 22.37 mmHg; Post systolic 138.05±18.41mmHg; pre-diastolic level of 88.90±13.30 mmHg; Post diastolic 83.33±9.13 mmHg; pre cholesterol level 192.24 ± 47.27 mg/dL and post 179.90 ± 32.28 mg/dL; This means that there is a significant influence on the use of herbal medicine, while the systolic level in the pre-medication group was 148.33 ± 19.82 mmHg; pos 140.14±19.81 mph; means showing a significant influence on drug use; pre-diastolic level 84.29±12.83 mmHg; post 81.90±9.72 mmHg; pre-cholesterol level 189.95±51.36 mg/dL; post 183.19±35.10 mg/dL; This means that it shows a less significant influence between cholesterol and diastolic levels on drug use. The conclusion was that the use of herbal medicine therapy for systolic, diastolic, and cholesterol in the herbal medicine group was more effective therapy compared to the drug group.  ABSTRAK Jamu kombinasi bawang putih  mengandung antioksidan dan alkaloid yang berkhasiat untuk menurunkan kadar kolesterol dan tekanan darah. Tujuan penelitian ini untuk mengetahui efektivitas penggunaan jamu kombinasi bawang putih terhadap penurunan kadar kolesterol dan tekanan darah. Metode penelitian cross sectional dengan rancangan one group pre-test post-test design. Total responden dalam penelitian 42 penderita, dimana penderita tersebut akan di cek kadar kolesterol dan tekanan darahnya pada minggu ke 1, dan ke 4. Data tekanan darah rata kelompok menghasilkan nilai sistolik pre  150,19±22,37 mmHg ; Sistolik post 138,05±18,41mmHg ; kadar diastolik pre 88,90±13,30 mmHg ; Diastolik post 83,33±9,13 mmHg ; kadar kolesterol pre 192,24±47,27mg/dL dan post 179,90±32,28 mg/dL; Hal ini menunjukkan adanya pengaruh yang signifikan (p<0,05)  terhadap penggunaan jamu, sedangkan kadar sistolik pada kelompok obat pre 148,33±19,82 mmHg ; post 140,14±19,81 mmHg ; berarti menunjukkan adanya pengaruh yang signifikan terhadap penggunaan obat ; kadar diastolik pre 84,29±12,83 mmHg ; post 81,90±9,72 mmHg ; kadar kolesterol pre 189,95±51,36 mg/dL ; post 183,19±35,10 mg/dL ; berarti menunjukkan pengaruh yang kurang signifikan (p>0,05) antara kadar kolesterol dan diastolik pada penggunaan obat. Kesimpulan bahwa penggunaan terapi jamu pada sistolik, diastolik, dan kolesterol pada kelompok jamu merupakan terapi yang lebih efektif dibandingkan dengan kelompok obat.
Aktivitas Antihipertensi Ekstrak Etanol Daun Alpukat (Persea americana Mill.) Pada Tikus Putih (Rattus norvegicus) Fauziah Noer, Sitti; Alfiah Irfayanti, Nur; muna_rahmat, irpan_
Media Farmasi Vol 19 No 2 (2023): Media Farmasi Edisi Oktober 2023
Publisher : Jurusan Farmasi Poltekkes kemenkes Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/mf.v19i2.121

Abstract

The avocado leaf plant may lower blood pressure due to its content of flavonoid compounds. These compounds prevent the enzymatic conversion from angiotensin I to angiotensin II. This study aims to assess the antihypertensive activity of ethanol extract from avocado leaves (Persea americana Mill.) on white rats (Rattus norvegicus). The powder of avocado leaf simplicia was extracted by maceration using 70% ethanol. Fifteen white rats were divided into 5 groups, each consisting of 3 rats. Blood pressure measurements were taken before induction, and then the rats were induced with 2% NaCl and 11.07 mg/kgBB prednisone. Blood pressure was measured after induction using the tail-cuff auto-pickup method and a non-invasive device (CODA). The research results were statistically analyzed using a completely randomized design (CRD). The average reduction in systolic and diastolic blood pressure in the groups was as follows: dose 125 mg/kgBB (28.01/29.79%); dose 250 mg/kgBB (41.06/38.22%); dose 375 mg/kgBB (48.47/41.12%); positive control (40.97/28.65%), and negative control (5.76/2.8%). Ethanol extract from avocado leaves (Persea americana Mill.) at 250 mg/kgBB and 375 mg/kgBB of rat body weight showed antihypertensive activity that was not significantly different from the positive control, captopril. However, at a dose of 125 mg/kgBB, there was a significant difference from the positive control and a highly significant difference from the negative control CMC 1%. For diastolic blood pressure, the extract had antihypertensive activity that was not significantly different from the positive control captopril, but there was a significant difference from the negative control CMC 1%. Tanaman alpukat dapat memiliki efek menurunkan tekanan darah karena mengandung senyawa flavonoid. Senyawa ini bekerja dengan cara mencegah pengubahan enzimatis dari angiotensin I menjadi angiotensin II. Penelitian ini bertujuan untuk mengevaluasi aktivitas antihipertensi ekstrak etanol daun alpukat (Persea americana Mill.) pada tikus putih (Rattus novergicus). Serbuk simplisia daun alpukat diekstraksi secara maserasi dengan menggunakan etanol 70%. Sebanyak 15 ekor tikus putih dibagi menjadi 5 kelompok, dengan tiap kelompok terdiri atas 3 ekor tikus. Pengukuran tekanan darah dilakukan sebelum induksi, kemudian tikus diinduksi dengan NaCl 2% dan prednison 11,07 mg/kgBB. Tekanan darah diukur setelah induksi menggunakan metode tail-cuff auto-pickup dan alat non-invasive (CODA). Hasil penelitian dianalisis secara statistik dengan rancangan acak lengkap (RAL). Rata-rata penurunan tekanan darah sistolik dan diastolik pada kelompok dosis 125 mg/kgBB (28,01/29,79%); dosis 250 mg/kgBB (41,06/38,22%); dosis 375 mg/kgBB (48,47/41,12%); kontrol positif (40,97/28,65%), dan kontrol negatif (5,76/2,8%). Ekstrak etanol daun alpukat (Persea americana Mill.) pada dosis 250 mg/kgBB dan 375 mg/kg BB tikus menunjukkan aktivitas menurunkan tekanan darah sistolik yang tidak berbeda nyata dengan kontrol positif captopril. Sementara pada dosis 125 mg/kgBB, terdapat perbedaan nyata dengan kontrol positif dan perbedaan sangat nyata dengan kontrol negatif CMC 1%. Untuk tekanan darah diastolik, ekstrak ini memiliki aktivitas menurunkan tekanan darah yang tidak berbeda nyata dengan kontrol positif captopril, namun terdapat perbedaan nyata dengan kontrol negatif CMC 1%.
Aktivitas Vermisida Ekstrak Daun Miana Terhadap Ascaris Lumbricoides dengan Metode Real Time Pakadang, Sesilia Rante; Ratnah, St.; Salasa, Alfrida Monica; Karim, Djuniasti
Media Farmasi Vol 19 No 2 (2023): Media Farmasi Edisi Oktober 2023
Publisher : Jurusan Farmasi Poltekkes kemenkes Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/mf.v19i2.168

Abstract

Soiled Transmitted Helminth (STH) is an infectious disease caused by earthworms. The type of worm identified as the cause of STH is dominated by Ascaris lumbricoides and 3 other types. Many studies have been carried out to monitor the results of worm death. This study aimed to determine the profile of vermicides including onset of action, duration, and effectiveness of miana leaf extract compared to the drug pyrantel pamoat. The research method is to gradually start preparing miana leaf extract using a maceration process with continuous stirring, preparing the extract, and treating worms. The worms are placed in a sterile cup, then the test material is added and observed every hour. Worm death profiles such as paralysis, death, and life were observed for each worm subject. The results showed the death profile of worms after administration of miana leaf extract concentrations of 10, 20, and 40 mg/ml and pyrantel pamoat 2.5 mg/ml gave onset of action data for 4, 3, 2, and 1 hour respectively. The working duration of the test material is 5, 5, 3, and 1 hour respectively.  The effective dose is generated by a concentration of 40 mg/ml which can kill worms starting 2 hours after administration of the test material, with a duration of 1 hour  Soiled Transmitted Helminth (STH) adalah salah satu penyakit infeksi akibat cacing tanah. Jenis cacing yang teridentifikasi sebagai penyebab STH didominasi oleh Ascaris lumbricoides dan 3 jenis lainnya, penelitian telah banyak dilakukan dengan memantau hasil akhir kematian cacing. Tujuan penelitian ini mengetahui profil vermisida meliputi onset of action, durasi dan efektivitas ekstrak daun miana yang dibandingkan dengan obat pyrantel pamoat. Metode penelitian secara bertahap mulai penyiapan ekstrak daun miana dengan proses maserasi dengan pengadukan kontinu, penyiapan ekstrak dan perlakuan terhadap cacing. Cacing dimasukkan dalam cawan steril, kemudian ditambahkan bahan uji dan diamati setiap jam. Profil kematian cacing seperti paralisis, mati dan hidup diamati setiap subyek cacing. Hasil penelitian menunjukkan profil kematian cacing setelah pemberian ekstrak daun miana konsentrasi 10, 20 dan 40 mg/ml dan pyrantel pamoat 2,5 mg/ml memberikan data onset of action berturut 4, 3, 2 dan 1 jam. Durasi kerja bahan uji berturut 5, 5, 3 dan 1 jam. Dosis efektif dihasilkan oleh konsentrasi 40 mg/ml yang dapat mematikan cacing mulai 2 jam setelah pemberian bahan uji, durasi 1 jam.
Isolasi Dan Identifikasi Kitosan Dari Cangkang Kerang Bulu (Anadara antiquata) Rizki, Dewi; Ridwanto; Rani, Zulmai
Media Farmasi Vol 19 No 2 (2023): Media Farmasi Edisi Oktober 2023
Publisher : Jurusan Farmasi Poltekkes kemenkes Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/mf.v19i2.174

Abstract

Chitosan is a polysaccharide formed via deacetylation of chitin. In general, chitosan is made from waste products from the fishing industry, such as shrimp, crabs, shells of feather clams, snails, and so on. The chitosan comes from the head, skin, and carapace. The development of chitosan applications has great potential because the production of shrimp, crab, and feather clam shells continues to increase. Chitosan is a bioactive substance with use in the fishing industry. This research aims to isolate and characterize chitosan from feather clam shells (Anadara antiquata) to convert feather clam shells into chitin and deacetylate it into chitosan then to determine the functional groups and characteristics of chitosan using Fourier infrared (FTIR). The isolation methods used were deproteination using 4% NaOH solvent, demineralization with a 1:5 ratio of 2N HCl solvent, depigmentation with a 1:10 ratio of 4% NaOCl solvent and deacetylation with a 1:20 ratio of 50% NaOH solvent. and chitosan characterization. According to the study's findings, the degree of deacetylation obtained in the form of a white powder was 75%, odorless fine powder. Chitosan dissolves in acetic acid, according to the solubility test. The obtained water content was 3.81% and the ash content obtained was 0.7%. Feather clam shell waste is declared to be well isolated and meets the requirements by SNI with a degree of deacetylation value of 75%. Kitosan merupakan polisakarida dari deasetilasi kitin; biasanya dibuat dari limbah produk industri perikanan seperti bekicot, kepiting, udang, bulu kerang, dan cangkang kerang. Kitosan berasal dari kulit, karapas, dan bagian kepala. Karena produksi udang, kepiting, dan cangkang kerang bulu yang terus meningkat, pengembangan aplikasi kitosan sangat potensial. Kitosan merupakan bahan bioaktif memiliki manfaat untuk industri perikanan. Tujuan studi ini adalah untuk mengidentifikasi, menggambarkan kitosan yang ditemukan dalam cangkang kerang bulu (Anadara antiquata) agar merubah cangkang kerang bulu menjadi kitin dan di deasetilasi menjadi kitosan kemudian untuk mengetahui gugus fungsi dan karakteristik kitosan menggunakan fourier infrared (FTIR). Metode isolasi yang dilakukan yaitu  deproteinasi menggunakan pelarut NaOH 4%, demineralisasi menggunakan pelarut HCl 2N dengan perbandingan 1:5, depigmentasi menggunakan pelarut NaOCl 4% (1:10), deasetilasi dengan pelarut NaOH 50% (1:20) dan karakterisasi kitosan. Hasil penelitian menunjukkan derajat deasetilasi yang di peroleh yaitu 75% berbentuk serbuk halus berwarna putih dan  tidak berbau. Menurut uji kelarutan, kitosan larut dalam asam asetat. Kadar air yang diperoleh 3,81% dan kadar abu yang diperoleh 0,7%. Limbah cangkang kerang bulu dinyatakan terisolasi dengan baik dan telah memenuhi syarat sesuai dengan SNI dengan nilai derajat deasetilasi sebesar 75%.
Potensi Peningkatan Daya Ingat Pada Tikus Putih (Rattus norvegicus) Menggunakan Ekstrak Daun Kelor (Moringa oleifera) Dengan Metode Labirin Y Maze Indrisari, Maulita; Nurkhairi, Nurkhairi; Dewingsky, Lyevy; Muslimin, Lukman; Rumata, Rahma
Media Farmasi Vol 19 No 2 (2023): Media Farmasi Edisi Oktober 2023
Publisher : Jurusan Farmasi Poltekkes kemenkes Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/mf.v19i2.208

Abstract

Potential for Improving Memory in White Rats (Rattus norvegicus) Using Moringa Leaf Extract (Moringa oleifera) Using the Y Maze Method Memory decline is a disease of impaired brain function and cognitive decline characterized by changes in behavior, decreased memory, and difficulty in communicating. One of the causative factors is oxidative stress where the imbalance between the production of Reactive Oxygen Species (ROS) and the body's antioxidant defense system, causes lipid peroxidation, protein oxidation, and changes in ROS that cause the death of brain neurons. Moringa leaf (Moringa oleifera) is a plant that contains high antioxidants, namely flavonoids. These compounds provide neuroprotective effects on the brain due to oxidative stress that causes memory decline. The purpose of this study was to determine the activity of Moringa leaf extract on memory improvement in white rats (Rattus norvegicus) using the Y-Maze Labyrinth method. Experimental animals were divided into 5 groups, namely negative control (Na-CMC), Gingko Biloba, and treatment groups given moringa leaf extract at a dose of 50 mg / kgBB, 100 mg / kgBB and 200 mg / kgBB. The rats were first induced with Hyosin-Butylbrimide at a dose of 1.5 mg/KgBB in ip for 10 days. The administration of the extract was carried out for 18 days with the observed parameters including the time required for rats to find food in the Y-maze maze tool.  The observation data obtained were then analyzed using the Mann Whitney test. The results showed that the ethanol extract of moringa leaves has a memory enhancing activity. Memory enhancing activity was shown at a dose of 200 mg/kgBB. ABSTRAK Penurunan daya ingat merupakan penyakit gangguan fungsi otak dan penurunan kognitif yang ditandai dengan perubahan perilaku, penurunan memori, serta kesulitan dalam berkomunikasi. Salah satu faktor penyebabnya adalah stress oksidatif dimana ketidakseimbangan antara produksi Reactive Oxygen Species (ROS) dengan sistem pertahanan antioksidan tubuh, sehingga menyebabkan peroksidasi lipid, oksidasi protein, perubahan ROS yang menyebabkan kematian neuron otak. Daun Kelor (Moringa oleifera) merupakan tanaman yang mengandung antioksidan tinggi yaitu flavonoid. Senyawa tersebut memberikan efek neuroprotektif pada otak akibat stres oksidatif yang menyebabkan penurunan daya ingat. Tujuan penelitian ini untuk mengetahui aktivitas ekstrak Daun Kelor terhadap peningkatan daya ingat pada tikus putih (Rattus norvegicus) menggunakan metode Labirin Y-Maze. Hewan coba dibagi menjadi 5 kelompok yaitu kontrol negatif (Na-CMC), Gingko Biloba, kelompok perlakuan yang diberikan ekstrak Daun Kelor dengan dosis 50 mg/KgBB, 100 mg/KgBB dan 200 mg/KgBB. Terlebih dahulu tikus diinduksi dengan Hyosin-Butylbrimide dengan dosis 1,5 mg/KgBB secara ip selama 10 hari. Pemberian ekstrak dilakukan selama 18 hari dengan parameter yang diamati meliputi waktu yang dibutuhkan tikus untuk menemukan makanan pada alat labirin Y-maze.  Data hasil pengamatan yang diperoleh kemudian dianalisis menggunakan uji Mann Whitney. Hasil penelitian menunjukkan bahwa ekstrak etanol Daun Kelor mempunyai aktivitas peningkat daya ingat. Aktivitas peningkat daya ingat ditunjukkan pada dosis 200 mg/kgBB.
Formulasi Kapsul Ekstrak Etanol Daun Sambung Nyawa (Gynurae procumbens (Lour) Merr) dengan Variasi konsentrasi Bahan Pengikat Polivinil Pirolidon (PVP) burhan, Asril; Ikbal; Zulham, Zulham; Aisyah , Andi Nur; Khairi, Nur; Ulfa, Maria
Media Farmasi Vol 20 No 2 (2024): Media Farmasi Edisi Oktober 2024
Publisher : Jurusan Farmasi Poltekkes kemenkes Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/mf.v20i2.522

Abstract

Formulation of Ethanol Extract Capsules of Sambung Nyawa Leaves (Gynurae procumbens (Lour) Merr) with Varying Concentrations of Polyvinyl Pyrrolidone (PVP) Sambungnyawa (Gynurae procumbens (Lour) Merr) is known to have several secondary metabolite compounds including alkaloids, flavonoids, anthraquinones, saponins, glycosides and essential oils. The aim of this research is to obtain a stable concentration of PVP binder if formulated in granule form for encapsulation in ethanol extract of sambungjiwa leaves. The variation in PVP concentration used was 0.5%; 1.5 %; 2.5 %; 3.5 %; and 4.5%. Granules are made using the wet granulation method then put into the capsule shell and continued with evaluation. Based on the evaluation results of the ethanol extract capsule formulations of sambungjiwa leaves, it can be concluded that variations in the concentration of PVP as a binder can affect the physical stability of the capsule preparation, where the five formulas with different concentration variations have different stability after hygroscopicity testing. The formula that has good physical stability is the FK4 formula with a PVP concentration of 3.5%. Sambung Nyawa (Gynurae procumbens (Lour) Merr) diketahui memiliki beberapa senyawa metabolit sekunder diantaranya alkaloid, flavonoid, antraquinon, saponin, glikosida dan minyak atsiri, Tujuan dari penelitian ini untuk mendapatkan konsentrasi bahan pengikat PVP yang stabil jika diformulasi dalam bentuk granul untuk dikapsulkan pada ekstrak etanol daun Sambung Nyawa. Variasi konsentrasi PVP yang digunakan adalah 0,5 %; 1,5 %; 2,5 %; 3,5 %; dan 4,5 %. Granul dibuat dengan metode granulasi basah kemudian dimasukkan ke dalam cangkang kapsul dan dilanjutkan dengan evaluasi. Berdasarkan hasil evaluasi dari formulasi kapsul ekstrak etanol daun Sambung Nyawa  dapat disimpulkan bahwa variasi konsentrasi PVP sebagai bahan pengikat dapat mempengaruhi kestabilan fisik sediaan kapsul, dimana kelima formula dengan variasi konsentrasi yang berbeda memiliki kestabilan yang berbeda-beda setelah pengujian higroskopisitas. Formula yang memiliki kestabilan fisik yang baik adalah formula FK4 dengan konsentrasi PVP 3.5%.
Potensi Ekstrak Jahe Gajah (Zingiber officinale var. Roscoe) Sebagai Bahan Aktif Sediaan Gargarisma dalam Mencegah Pertumbuhan Streptococcus mutans Penyebab Karies Gigi Asmawati; Gunawan, Muh. Arfandy; Setiawan Jumain, Muhammad Asman; Dewi, Ratnasari
Media Farmasi Vol 20 No 2 (2024): Media Farmasi Edisi Oktober 2024
Publisher : Jurusan Farmasi Poltekkes kemenkes Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/mf.v20i2.526

Abstract

Potential of Elephant Ginger Extract (Zingiber officinale var. Roscoe) as an active ingredient in Gargarisma preparation in inhibiting the growth of Strptococcus mutans which causes dental caries Ginger plants are known to contain chemical compounds in the form of phenols and flavonoids where these compounds have potential antibacterial power. This study aims to formulate elephant ginger extract into gargarisma preparations and determine the stability of the physical quality as well as to determine the antibacterial potential of gargarisma elephant ginger extract preparations optimally. Elephant ginger was extracted using the maceration method, then dried using a freeze-drying device. Then formulation into gargarisma preparations whit concentrations of 5%, 10%, and 20% elephant ginger extract followed by evaluation of the preparation including pH test, organoleptic test, and viscosity test as well as antibacterial power test. The results of each study have an average value before and after the Cycling test, namely the pH test with 5% concentration: 6.13 and 6.06; concentration 10%: 5.92 and 5.96; concentration 20%: 5.96 and 5.91, on the viscosity test 5% concentration: 1.86cps and 2.19cps; concentration 10%: 2.05cps and 2.45cps; concentration 20%: 2.55cps and 3.06cps, the organoleptic test did not change. From the results of the inhibition test, the average value was obtained at a concentration of 5%: 9mm; concentration 10%: 14.33mm; concentration 20%: 17.67mm. it can be concluded that 5%, 10%, and 20% concentrated ginger extract can be formulated into elephant ginger preparations with gargarisma constraint and fulfils the physical quality requirements of gargarisma preparations as well as for the antibacterial power test, the significance value (p<0,05) indicates a significant difference. Each concentration. At a concentration of 10%, it had an optimal effect in inhibiting the growth of Streptococcus mutans. Tanaman Jahe Gajah diketahui mengandung senyawa kimia berupa fenol, flavonoid dimana senyawa tersebut memiliki potensi daya antibakteri. Penelitian ini bertujuan untuk memformulasi ekstrak jahe gajah menjadi sediaan gargarisma dan mengetahui stabilitas mutu fisik serta untuk mengetahui potensi antibakteri dari sediaan gargarisma ekstrak jahe gajah secara optimal. Jahe gajah diekstraksi menggunakan metode maserasi, kemudian dikeringkan menggunakan alat freeze drying, lalu diformulasi menjadi sediaan gargarisma dengan konsentrasi ekstrak jahe gajah 5%, 10%, dan 20% dilanjutkan dengan evaluasi sediaan meliputi uji pH, uji organoleptik, dan uji viskositas serta uji daya antibakteri. Hasil penelitian masing-masing memiliki nilai rata-rata sebelum dan sesudah Cycling test yaitu pada uji pH konsentrasi 5%: 6,13 dan 6,06; konsentrasi 10%: 5,92 dan 5,96; konsentrasi 20%: 5,96 dan 5,91, pada uji viskositas konsentrasi 5%: 1,86cps dan 2,19cps; konsentrasi 10%: 2,05cps dan 2,45cps; konsentrasi 20%: 2,55cps dan 3,06cps, pada uji organoleptik tidak mengalami perubahan. Dari hasil pengujian daya hambat didapatkan nilai rata-rata pada konsentrasi 5%: 9mm, konsentrasi 10%: 14,33mm, konsentrasi 20%: 17,67mm. Dapat disimpulkan bahwa ekstrak jahe gajah dengan konsentrasi 5%, 10%, dan 20% dapat diformulasi menjadi sediaan gargarisma dan memenuhi syarat mutu fisik sediaan gargarisma serta untuk uj daya antibakteri diperoleh nilai Signifikansi (p<0,05) menunjukkan adanya perbedaan yang bermakna tiap konsentrasi. Pada konsentrasi 10% sudah memberikan efek yang optimal dalam menghambat pertumbuhan Streptococcus mutans.
Teknik Aplikasi Sampel Pada Pengujian Kuantitatif Kromatografi Lapis Tipis: Tinjauan Terhadap Area Dan Faktor Retensi Kusumawati, Idha; Primaharinastiti, Riesta; Rifqi Prasetyawan, Hanif
Media Farmasi Vol 20 No 2 (2024): Media Farmasi Edisi Oktober 2024
Publisher : Jurusan Farmasi Poltekkes kemenkes Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/mf.v20i2.655

Abstract

Thin Layer Chromatography (TLC) is one of the most commonly used chromatographic techniques to identify compounds in mixtures and determine the purity of a compound. However, the crucial factor that is difficult to control, which can affect the accuracy of the results, is the stage of sample application. This study focused on investigating the effect of different techniques of sample application (manual and semi-automatic) on the area and retention factor (Rf) of the compound spot. Curcuminoid was used as a sample in this study. The manual sample application techniques used a 2μL capillary tube. The semi-automatic sample application techniques used a Camag Linomat-5 instrument with 0, 7, and 8 mm band lengths. After the development of the TLC plate using toluene: acetic acid (4:1, v/v)., the curcuminoid was separated into three spots: curcumin, demethoxycurcumin, and bisdemethoxycurcumin. A one-way ANOVA was used to analyze the spot area and Rf of the three compounds, followed by a Duncan test. The difference in sample application techniques causes differences in the size and shape of the initial sample spot, which affects the compound spot produced after developing of TLC plate. This study showed that the differences in application techniques cause significant differences in the Rf of the compound spot, but do not show significant differences in the compound spot area. Based on this research, optimizing the application techniques of samples is a critical stage and it is essential to optimize how to apply the sample on TLC plate, including the concentration, volume, shape, and size of the spot on TLC.
Aktivitas Antioksidan Ekstrak Etanol, Etil Asetat, Dan n-Heksan Biji Mengkudu (Morinda Citrifolia L.) Dengan Metode DPPH Nurisyah, Nurisyah; Irawati, Irawati; Salasa, Alfrida Monica; Asyikin, Asyhari
Media Farmasi Vol 20 No 2 (2024): Media Farmasi Edisi Oktober 2024
Publisher : Jurusan Farmasi Poltekkes kemenkes Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/mf.v20i2.686

Abstract

Antioxidants are compounds that can reduce the negative impact of free radicals. Noni seeds (Morinda citrifolia L.) contain these compounds as secondary metabolites. This research is a laboratory observational study to determine and compare the antioxidant activity of ethanol extract, ethyl acetate extract, and n-hexane extract noni seeds (Morinda citrifolia L.) using the 1,1-diphenyl-2- picrylhydrazyl method using a UV-Vis Spectrophotometer at a wavelength of 516 nm. The results showed that the IC50 value of the ethanol extract of noni fruit seeds was 507.75 ppm and the IC50 value of the ethyl acetate extract of noni fruit seeds was 43.18 ppm, while the n-hexane extract of noni fruit seeds had inactive antioxidant activity. The antioxidant activity of the ethanol extract of noni seeds is in the weak category and the antioxidant activity of the ethyl acetate extract is in the very strong category. The extracting solution that produces noni seed extract with the highest antioxidant activity is ethyl acetate solvent

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