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Grimsa Journal of Science Engineering and Technology
Published by PT. Graha Primera Saintifika
ISSN : -     EISSN : 30265118     DOI : https://doi.org/10.61975/gjset
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Chemical Engineering, Chemistry & Bioengineering Engineering Medicine & Pharmacology Physics
Grimsa Journal of Science Engineering and Technology aims to provide a platform for researchers, scholars, and professionals to share their innovative ideas, findings, and insights in the following areas: Science and Innovation, Engineering and Technology, Information Technology and Computer Science, Environmental Science and Sustainability, Biotechnology and Bioengineering, Materials Science and Engineering, Healthcare and Medical Technology, Interdisciplinary Studies
Arjuna Subject : Umum - Umum
Articles 40 Documents
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Efficacy of Purple Chrysanthemum Ethanol Extract in Inhibiting Staphylococcus aureus and Escherichia coli Growth Paukiran, Degol; Budiarso, Fona; Manampiring, Aaltje; Fatimawali, Fatimawali; Kepel, Billy Johnson; Bodhi , Widdhi
Grimsa Journal of Science Engineering and Technology Vol. 3 No. 1 (2025): April 2025
Publisher : Graha Primera Saintifika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61975/gjset.v3i1.63

Abstract

Staphylococcus aureus, a Gram-positive bacterium, and Escherichia coli, a Gram-negative bacterium, are known to cause both enteric and systemic infections in humans. The improper use of antibiotics has often been associated with the emergence of antibiotic resistance. Purple chrysanthemum (Chrysanthemum morifolium) has shown significant potential as an alternative treatment, owing to its strong antioxidant, anti-inflammatory, and antibacterial properties. These properties are attributed to the presence of bioactive compounds such as polyphenols, flavones, essential oils, and other phytochemicals. This study aimed to identify secondary metabolites and evaluate the antibacterial activity of ethanol extracts from purple chrysanthemum (Chrysanthemum morifolium). The extraction process was conducted using Ultrasonic-Assisted Extraction (UAE), and the antibacterial activity was assessed using the disc diffusion method at extract concentrations of 12.5%, 25%, and 50%, with ciprofloxacin serving as the positive control. Phytochemical screening revealed the presence of alkaloids, flavonoids, tannins, phenolics, and steroids in the ethanol extract of purple chrysanthemum. Importantly, all ethanol extracts demonstrated antibacterial activity. The highest inhibition zones were observed at a 50% concentration, with S. aureus showing an inhibition zone of 12.35 ± 0.4 mm, while E. coli exhibited an inhibition zone of 15.08 ± 0.22 mm.
Innovative Multi-Color LED HPL Lamps for Improved Efficiency in Floating Lift Net Fishing Jailani, Abdul Qadir; Suharyanto, Suharyanto; Ruchimat, Toni
Grimsa Journal of Science Engineering and Technology Vol. 3 No. 1 (2025): April 2025
Publisher : Graha Primera Saintifika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61975/gjset.v3i1.64

Abstract

This research focuses on the design and fabrication of a high-power LED (HPL) light that integrates red, green, and blue LEDs for underwater lighting, commonly known as "lacuda," used on floating fishing rafts. The lamp features an aluminum heatsink with integrated fins for efficient heat dissipation and is coated with a resin-catalyst mixture for durability. The study involved measuring, drafting, assembling, and wiring the LEDs, followed by field testing in Krueng Raya Bay, Aceh Province. The primary objective was to evaluate the performance of HPL LED lights compared to traditional tubular fluorescent lamps (TL) used on floating rafts. Results showed that the HPL LED lights met design specifications and were technically suitable for fishing operations. Notably, they proved more efficient than TLs by providing superior light penetration when submerged, addressing the limitations of surface-mounted lighting. These findings suggest that HPL LED lights are a viable alternative for underwater lighting in fishing operations.
In Vitro Analysis of Anti-Inflammatory Effects of Purple Chrysanthemum (Chrysanthemum morifolium) Leaf Extract Nastiti, Gemi; Fatimawali, Fatimawali; Budiarso, Fona Dwiana Hermina; Manampiring, Aaltje Ellen; Kepel, Billy Johnson; Bodhi, Widdhi
Grimsa Journal of Science Engineering and Technology Vol. 3 No. 1 (2025): April 2025
Publisher : Graha Primera Saintifika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61975/gjset.v3i1.70

Abstract

Chronic inflammatory diseases are the most significant cause of death in the world and pose the greatest threat to human health. Treatment of inflammation is usually done by taking anti-inflammatory drugs that have dangerous side effects in long-term use. Chrysanthemum is the largest horticultural commodity in North Sulawesi that also holds great potential in the world of health. Based on its phytochemical content, purple chrysanthemum leaves have potential as an anti-inflammatory agent. This study aimed to analyze the anti-inflammatory activity of ethanol extract of purple chrysanthemum leaves using the red blood cell membrane stabilization method. This study used an in vitro laboratory experimental method using rat blood. The anti-inflammatory activity of the extract was tested using the red blood cell membrane stabilization method at 4 concentration series, namely 50 ppm, 100 ppm, 200 ppm, and 400 ppm, then measured on a UV-Vis spectrophotometer. The results of phytochemical screening showed that the ethanol extract of purple chrysanthemum (Chrysanthemum morifolium) leaves contains active compounds such as flavonoids, alkaloids, tannins, steroids, and phenolics. The ethanol extract of purple chrysanthemum leaves exhibits anti-inflammatory activity, with higher extract concentrations demonstrating stronger anti-inflammatory effects. The stability percentage values obtained at 50, 100, 200, and 400 ppm were 28.87%, 41.85%, 47.41%, and 64.15% with an IC50 of 235.88 ppm and a correlation coefficient of 0.94.
Analyzing The Correlation of Uric Acid and Fasting Blood Sugar in Type 2 Diabetes Patients: A Study from ODSK Hospital, North Sulawesi, Indonesia Gafur, Fathin; Assa, Youla; Tiho, Murniati
Grimsa Journal of Science Engineering and Technology Vol. 3 No. 2 (2025): October 2025
Publisher : Graha Primera Saintifika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61975/gjset.v3i2.66

Abstract

Type 2 diabetes mellitus (T2DM) is a major non-communicable disease in Indonesia and is commonly diagnosed using fasting blood glucose (FBG) levels. Recent studies have suggested a potential association between fasting blood sugar (FBS) and uric acid, which plays a role in oxidative stress and glucose metabolism, although findings have been inconsistent. This study aimed to examine the association between blood uric acid levels and FBG levels in T2DM patients at ODSK Regional Hospital, North Sulawesi, Indonesia, given the rising prevalence of T2DM and related metabolic disorders in the region. A cross-sectional study was conducted using secondary data from medical records of T2DM patients between July 2023 and July 2024. Among male patients, 25 percent had uric acid levels between 3.0 and 7.4 mg/dL, while 28.8 percent had levels above 7.4 mg/dL. Among female patients, 32.7 percent had uric acid levels between 2.1 and 6.3 mg/dL, and 13.5 percent had levels above 6.3 mg/dL. Additionally, 84.6 percent of all patients had FBG levels of 126 mg/dL or higher. Statistical analysis showed no significant correlation between blood uric acid levels and FBG levels (ρ = 0.541; r = 0.541), suggesting that there is no significant association between these two variables in this population.
Investigating the Anti-Inflammatory Potential of Ethanol Extracts from Purple Chrysanthemum Flowers Sumakul, Gilbert Samuel; Fatimawali, Fatimawali; Bodhi, Widdhi; Budiarso, Fona Hermina Dwiana; Kepel, Billy Johnson; Manampiring, Aaltje
Grimsa Journal of Science Engineering and Technology Vol. 3 No. 2 (2025): October 2025
Publisher : Graha Primera Saintifika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61975/gjset.v3i2.69

Abstract

Indonesia has high biodiversity, with around 9,600 species of flora possessing medicinal properties. One such plant is the purple chrysanthemum (Chrysanthemum morifolium), which is rich in bioactive compounds with anti-inflammatory potential. The purple chrysanthemum is used in traditional medicine to treat various diseases and has demonstrated significant anti-inflammatory activity in vitro. Given the high prevalence of inflammatory diseases in Indonesia and the side effects associated with conventional drugs, this plant is considered a promising alternative therapy that may be safer and more effective. The aim of this study was to identify the phytochemical compounds and evaluate the anti-inflammatory activity of an ethanol extract from purple chrysanthemum flowers (Chrysanthemum morifolium) in vitro. The extract was prepared using 96% ethanol, and its anti-inflammatory activity was assessed using the red blood cell membrane stabilization method. Blood samples were collected from Wistar rats. The inhibitory concentration (IC50) values of the extract and Diclofenac Sodium were 203.08 ppm and 224.04 ppm, respectively. These findings indicate that the ethanol extract of purple chrysanthemums exhibits anti-inflammatory activity
Comparative Assessment of Microscopy and RDTs in Diagnosing Plasmodium vivax Mesaulawan, Septyarini; Sorisi, Angle Maria Hasthee; Tuda, Josef Sem Berth
Grimsa Journal of Science Engineering and Technology Vol. 3 No. 1 (2025): April 2025
Publisher : Graha Primera Saintifika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61975/gjset.v3i1.71

Abstract

Plasmodium vivax is the primary cause of malaria in Indonesia in 2023, particularly in areas with low to moderate endemicity. To reduce malaria transmission, rapid and accurate diagnostic tools are essential for early detection. Microscopic examination remains the gold standard, but the limited availability of trained microscopists and facilities hinders its effectiveness in endemic areas. The Rapid Diagnostic Test (RDT) based on pLDH, such as SD Bioline® Malaria Ag Pf/Pan®, offers rapid results and ease of use, which are beneficial in resource-limited settings. However, performance data for this RDT in Indonesia remains limited. This study evaluates the field performance of SD Bioline® compared to microscopic examination as the reference standard for P. vivax diagnosis. The study involved 62 EDTA blood samples from suspected malaria patients at the Parasitology Laboratory of the Faculty of Medicine, Sam Ratulangi University, from July 2022 to December 2024. Microscopic examination revealed 54 positive cases (87.1%), while SD Bioline® detected 50 positive cases (80.6%). The sensitivity and specificity of SD Bioline® were 92.6% and 100%, respectively, with a negative predictive value (NPV) of 66.6% and a positive predictive value (PPV) of 100%. The results suggest that SD Bioline® demonstrates good sensitivity and specificity for detecting P. vivax in endemic areas. However, false negatives require microscopic confirmation. Combining RDT with microscopy can improve diagnostic accuracy and support Indonesia's malaria elimination efforts by 2030.
Managing the Maze: Advanced Approaches to Pediatric Cataract Complications Imelda, Eva; Jannah, Siti Rain; Adev, Sarra Mutiara; Toshniwal, Nikhil
Grimsa Journal of Science Engineering and Technology Vol. 3 No. 1 (2025): April 2025
Publisher : Graha Primera Saintifika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61975/gjset.v3i1.80

Abstract

Complicated cataract is a condition characterized by opacification of the crystalline lens due to intraocular diseases, particularly inflammatory conditions and other abnormalities. It often affects younger age groups, leading to visual impairment that typically requires surgical intervention. A 3-year-old girl presented with complaints of white spots in both eyes for one week. Following a physical examination and ultrasonography, she was diagnosed with bilateral complicated cataracts. The patient was scheduled for procedures including synechiolysis and irrigation-aspiration. However, due to intraoperative complications, additional procedures were necessary. Postoperatively, the patient was treated with antibiotic and anti-inflammatory medications and underwent optical rehabilitation using spectacles. This case highlights the management of pediatric cataracts and the challenges involved, with particular focus on postoperative optical rehabilitation to prevent amblyopia. Prompt and appropriate treatment of cataracts in children is crucial to clear the visual axis and restore a clear retinal image, thereby preventing the development of amblyopia.
Integrated Risk Management for Energy Efficiency: A Case Study of Batam’s Manufacturing Sector Timba, Ayub; Yandri, Erkata; Ludji, Omrie; Sidharta, Rendy; Amaral, Clizardo; Ariati, Ratna
Grimsa Journal of Science Engineering and Technology Vol. 3 No. 2 (2025): October 2025
Publisher : Graha Primera Saintifika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61975/gjset.v3i2.87

Abstract

The manufacturing sector in Batam faces increasing pressure from rising energy costs and operational inefficiencies. This study investigates how integrating risk management frameworks, specifically ISO 31000 and FMEA, can enhance energy efficiency in manufacturing operations. A mixed-methods approach was employed, combining quantitative analysis of energy consumption data from selected firms with qualitative insights from interviews with key industrial stakeholders. Baseline energy performance was established, and operational risks were assessed and prioritized. Findings show that outdated machinery, poor maintenance, and unplanned downtimes significantly contributed to energy inefficiency. Implementation of risk-based interventions led to measurable improvements in energy use and cost reduction. Firms adopting the integrated approach reported that 15% energy saving in PT X results in operational cost savings of $ 29.994, and 10% energy saving in PT Y results in operational cost savings of $ 23.952. The Return on Investment (ROI) from implementing an integrated energy risk management strategy is estimated to reach 18 months to 20 months, based on reduced energy consumption and increased productivity. The study underscores the importance of tailored risk-energy frameworks in industrial settings and suggests avenues for future research in broader contexts.
Fine-Tuning ChemBERTa for Predicting Activity of AXL Kinase Inhibitors in Oncogenic Target Modeling Noviandy, Teuku Rizky; Idroes, Ghazi Mauer; Patwekar, Mohsina; Idroes, Rinaldi
Grimsa Journal of Science Engineering and Technology Vol. 3 No. 2 (2025): October 2025
Publisher : Graha Primera Saintifika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61975/gjset.v3i2.98

Abstract

The development of selective kinase inhibitors remains a key objective in cancer drug discovery, where predictive computational models can significantly accelerate the identification of leads. In this study, we investigate the fine-tuning strategies of the transformer-based ChemBERTa model for quantitative structure–activity relationship (QSAR) modeling of AXL receptor tyrosine kinase inhibitors, an important therapeutic target implicated in tumor progression and metastasis. A dataset of AXL inhibitors was curated from the ChEMBL database. Three fine-tuning configurations, namely baseline, full fine-tune, and aggressive, were implemented to examine the influence of learning rate, weight decay, and the number of frozen transformer layers on model performance. Models were evaluated using accuracy, precision, recall, F1-score, and calibration metrics. Results showed that both the full fine-tune and aggressive configurations outperformed the baseline model, achieving higher precision and F1-scores while maintaining robust recall. The aggressive configuration achieved the most balanced performance, with improved calibration and the lowest expected calibration error, indicating reliable probabilistic predictions. Overall, this study highlights that controlled fine-tuning of ChemBERTa significantly enhances predictive performance and confidence estimation in QSAR modeling, offering valuable insights for optimizing transformer-based chemical language models in kinase-targeted drug discovery.
Antioxidant Potential of Yellow Chrysanthemum (Chrysanthemum indicum) Leaves: In Vitro Analysis Using DPPH and FRAP Techniques Ley, Gabriella Therezia Ley; Kepel, Billy Johnson; Fatimawali, Fatimawali; Manampiring, Aaltje Ellen; Budiarso, Fona Dwiana Hermina; Bodhi, Widdhi
Grimsa Journal of Science Engineering and Technology Vol. 3 No. 2 (2025): October 2025
Publisher : Graha Primera Saintifika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61975/gjset.v3i2.68

Abstract

The shift from infectious diseases to non-communicable diseases (NCDs), driven by aging and unhealthy lifestyles, has led to an increase in degenerative diseases. The World Health Organization (WHO) reported that NCDs account for 74% of global deaths. An imbalance between free radicals and antioxidants contributes to the progression of these diseases, highlighting the need for research on plant-derived antioxidants. Secondary metabolites, particularly phenolic and flavonoid compounds, are abundant in Chrysanthemum indicum and are known for their potential antioxidant properties. This study aims to identify the secondary metabolites and evaluate the antioxidant activity of yellow chrysanthemum (Chrysanthemum indicum) leaves using two methods: Ferric Reducing Antioxidant Power (FRAP) and 2,2-diphenyl-1-picrylhydrazyl (DPPH). The extraction process was performed using the reflux method with 96% ethanol as the solvent. Antioxidant activity was assessed using the DPPH and FRAP methods, with absorbance measurements conducted via UV-Vis spectrophotometry. Phytochemical screening revealed the presence of phenols, flavonoids, tannins, steroids/triterpenoids, and alkaloids in the ethanol extract of yellow chrysanthemum leaves. The antioxidant activity assay using the DPPH method indicated a value of 64.34 ppm, signifying strong antioxidant activity. In contrast, the FRAP method showed weak antioxidant activity, with an IC50 value of 187.13 ppm.

Page 4 of 4 | Total Record : 40

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