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Jurnal Farmasi dan Farmakoinformatika
Published by Universitas Gunadarma
ISSN : 29874718     EISSN : 29879914     DOI : https://doi.org/10.35760/jff
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology
Jurnal Farmasi dan Farmakoinformatika adalah jurnal yang melalui proses peninjauan. Jurnal Farmasi dan Farmakoinformatika ditujukan bagi para akademisi dan peneliti untuk mempublikasikan artikelnya yang merupakan teks asli dan belum pernah dipublikasikan di jurnal lain. Bidang yang tercakup dalam jurnal farmasi dan farmakoinformatika meliputi Farmasi Klinis dan Komunitas, Farmakologi, Teknologi Farmasi, Kimia Farmasi, Farmasi Bahan Alam, Manajemen Farmasi, dan Teknologi Informatika dibidang farmasi seperti Farmakoinformatika serta Bioinformatika dan Genetika.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 41 Documents
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Formulation And Determination Of The SPF Value Of Sunscreen Cream Spirulina platensis Microalgae Extract Ramdhiany, Nova Azizah; Tsurayya, Nadya
Jurnal Farmasi dan Farmakoinformatika Vol 3, No 1 (2025)
Publisher : Universitas Gunadarma

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35760/jff.2025.v3i1.12640

Abstract

Paparan sinar ultraviolet (UV) dari matahari yang berlebihan akan meningkatkan produksi Reactive Oxygen Species (ROS) dan mengaktifkan makrofag untuk melepaskan enzim matriks metalloproteinase (MMP) yang terlibat dalam degradasi matriks ekstraseluler kulit, seperti pelepasan kolagen dan elastin. Dalam mengatasi hal tersebut, lapisan epidermis kulit menyediakan berbagai senyawa penyerap sinar UV salah satunya yaitu melanin. Tetapi produksi pigmen melanin yang berlebihan dapat menyebabkan hiperpigmentasi yang menyebabkan tanda-tanda penuaan kulit. Sehingga, untuk mencegah hiperpigmentasi diperlukan tabir surya. Mikroalga Spirulina platensis menjadi salah satu bahan alam yang berpotensi sebagai bahan aktif tabir surya karena mengandung flavonoid dan senyawa fenolik yang melimpah. Kandungan tersebut bermanfaat untuk menyerap sinar UV. Penelitian ini bertujuan untuk mengetahui pengaruh variasi konsentrasi ekstrak etanol 90% Spirulina platensis yaitu 6%, 7%, dan 8% terhadap nilai SPF krim tabir surya dengan krim yang tidak diberi ekstrak, karakteristik fisik dan stabilitas sediaan krim tabir surya. Hasil pengujian SPF tertinggi secara in vitro dari krim dengan konsentrasi ekstrak 8% yaitu sebesar 22,05 dengan kategori proteksi ultra, dan krim yang tidak diberi ekstrak nilai SPFnya sebesar 0,5. Hasil evaluasi krim tabir surya berekstrak yaitu berwarna hijau pekat kecoklatan, bau khas wangi spirulina kuat, konsistensinya lembut, homogen, pH 6, tipe emulsi M/A, daya lekat 2-7 detik, dan daya sebar 5 – 6 cm. Uji stabilitas dengan cycling test menunjukkan hasil semua krim tabir surya stabil.
Efek Antihiperglikemik Kombinasi Daun Afrika (Vernonia Amygdalina) dan Daun Suruhan (Peperomia pellucida L. Kunth) pada Tikus Sprague-Dawley yang Diinduksi Aloksan Mandagi, Novita; Nainggolan, Hotlina
Jurnal Farmasi dan Farmakoinformatika Vol 3, No 1 (2025)
Publisher : Universitas Gunadarma

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35760/jff.2025.v3i1.12497

Abstract

Diabetes Melitus merupakan penyakit dengan gejala hiperglikemia kronis. Indonesia memiliki kekayaan hayati melimpah, dengan beragam tumbuhan yang memiliki potensi sebagai obat alternatif untuk antihiperglikemi, diantaranya daun suruhan (Peperomia pellucida L. Kunth) dan daun afrika (Vernonia amygdalina). Kedua tumbuhan ini dilaporkan mempunyai efektivitas menurunkan kadar glukosa darah. Oleh karena itu pada penelitian ini dilakukan uji kombinasi daun suruhan (Peperomia pellucida L.Kunth) dan daun afrika (Vernonia amygdalina) serta  dengan membandingkan efek antihiperglikeminya dengan obat antidiabetik oral. Sebanyak 30 ekor tikus jantan galur Sprague-Dawley digunakan. Tikus di induksi diabetes dengan menggunakan aloksan dosis 150 mg/kgBB. Tikus dikelompokkan menjadi 4 kelompok antara lain kelompok tikus normal tanpa induksi, kelompok tikus diabetes, kelompok tikus diabetes dengan ekstrak kombinasi daun afrika dosis 40 mg/kgBB dan daun suruhan dosis 200 mg/kgBB serta kelompok tikus diabetes dengan obat pembanding glibenklamid dosis 0.18 mg/kgBB. Pemberian ekstrak dan obat dilakukan setiap hari selama 28 hari. Kadar glukosa darah diukur diukur setiap 7 hari. Berdasarkan analisis data, diperoleh bahwa kelompok tikus diabetes dengan pemberian ekstrak kombinasi mengalami penurunan kadar glukosa darah yang signifikan nilai p = 0.027 (p < 0.050) dengan rerata 149,33 mg/dL. Dapat disimpulkan bahwa ekstrak kombinasi daun afrika dan daun suruhan memiliki penurunan kadar glukosa darah yang lebih besar dibanding dengan obat antidiabetik oral.
Front Matter Jurnal Farmasi dan Farmakoinformatika Vol. 3 No. 1 Jurnal Farmasi dan Farmakoinformatika, Editorial
Jurnal Farmasi dan Farmakoinformatika Vol 3, No 1 (2025)
Publisher : Universitas Gunadarma

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Evaluasi Penggunaan Antidiabetes Pada Pasien Diabetes Melitus Tipe 2 Rawat Inap Di Rumah Sakit Bhayangkara Brimob Ninia, Kriselda Evelyin; Oktavilantika, Dina Melia; Wijayanti, Rahayu
Jurnal Farmasi dan Farmakoinformatika Vol 3, No 1 (2025)
Publisher : Universitas Gunadarma

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35760/jff.2025.v3i1.12943

Abstract

Diabetes Melitus Tipe 2 (DMT2) merupakan penyakit gangguan metabolik akibat penurunan sekresi insulin oleh sel ᵦ pankreas atau gangguan fungsi insulin. Penyakit DM ini menjadi penyebab utama kebutaan, penyakit jantung dan kerusakan ginjal, International Diabetes Federation (IDF) memperkirakan 463 juta orang usia 20 sampai 79 tahun di dunia menderita DM pada tahun 2019, dan hasil survei World Health Organization (WHO) Indonesia adalah negara ranking 4 penyandang DM terbanyak. Sehingga penulisan penelitian ini bertujuan untuk evaluasi penggunaan terapi antidiabetes yaitu yang terdiri dari golongan metformin, , sulfonilurea, penghambat enzim sodium glucose co-transporter 2 (SGLT-2 inhibitor), penghambat alpha glukosidase, Thiazolidinedione, glucagon-like peptide-1 analog, penghambat dipeptidyl peptidase-4 (DPP-4) dan insulin. Tujuan penelitian ini yaitu menganalisis pola penggunaan dan rasionalitas antidiabetes pasien DMT2 di Rumah Sakit Bhayangkara Brimob. Penelitian ini merupakan penelitian non eksperimental dengan metode pengambilan sampel menggunakan metode purposive sampling, pengambilan sampel secara retrospektif. Metode analisis data menggunakan metode deskriptif. Hasil penelitian menunjukkan pada analisis pola penggunaan diperoleh golongan antidiabetes yang paling banyak digunakan yaitu insulin , pola penggunaan obat tunggal paling banyak yaitu monoterapi insulin ditahun 2023, dan pola penggunaan obat kombinasi paling banyak yaitu kombinasi insulin. Kemudian pada analisis rasionalitas diperoleh tepat obat sebanyak 62%, tepat pasien 97,6%, tepat dosis 97,6% dan tepat interval waktu pemberian 97,6%.
Formulasi Krim Ekstrak Daun Johar (Cassia siamea Lamk.) Dengan Perbandingan Trietanolamin Dan Setil Alkohol Sebagai Antibakteri Staphylococcus aureus Puspitasary, Kiki; Murti, Rita Widiyasari; Novitasari, Meliana; Yulianto, Dwi Joko
Jurnal Farmasi dan Farmakoinformatika Vol 3, No 1 (2025)
Publisher : Universitas Gunadarma

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35760/jff.2025.v3i1.11342

Abstract

Daun johar mengandung senyawa metabolit sekunder berupa alkaloid, flavonoid, saponin, dan tanin. Senyawa metabolit tersebut mempunyai aktivitas antibakteri terhadap Staphylococcus aureus. Senyawa-senyawa tersebut diambil dengan cara maserasi. Maserasi menggunakan pelarut etanol 96% selama 5 hari. Esktrak yang didapat kemudian dibuat menjadi sediaan krim. Penelitian ini dilakukan untuk mengetahui pengaruh perbedaan konsentrasi emulgator terhadap sifat fisik sediaan dan nilai daya hambat pertumbuhan bakteri setelah dibuat menjadi krim. Konsentrasi ekstrak daun johar disetiap formula adalah 8%. Berdasarkan penelitian yang telah dilakukan sebelumnya, ekstrak etanol daun johar dengan konsentrasi 8% dapat menghambat pertumbuhan bakteri Staphylococcus aureus sebesar 14,9 mm. Krim yang dibuat menggunakan emulgator trietanolamin dan setil alkohol. Konsentrasi trietanolamin pada Formula I (2,5%), Formula II (3,0%), Formula III (4,0%). Konsentrasi setil alkohol pada Formula I (2,0%), Formula II (2,5%), Formula III (3,0%). Evaluasi fisik yang dilakukan yaitu organoleptis, homogenitas, viskositas, pH, daya sebar dan daya lekat, serta dilakukan uji aktivitas antibakteri. Hasil data diolah secara statistik menggunakan One Way Anova. Hasil penelitian menunjukkan bahwa Formula III memiliki stabilitas yang paling baik. Hal ini dikarenakan kombinasi 2 emulgator yang mempunyai sifat saling mendukung, yaitu mampu meningkatkan konsistensi sediaan dan memiliki bentuk yang stabil. Formula I memberikan hasil daya hambat yang paling tinggi yaitu 16,8 mm. Berdasarkan hasil penelitian dapat disimpulkan bahwa ekstrak daun johar dapat dibuat sediaan krim dan adanya perbedaan konsentrasi emulgator dapat mempengaruhi stabilitas dan aktivitas antibakteri sediaan krim.
Analisis Kadar Octyl Methoxycinnamate (OMC) Dalam Sediaan Gel Tabir Surya dengan Metode Spektrofotometri UV-Vis Noviandari, Teta Astri; Aditya
Jurnal Farmasi dan Farmakoinformatika Vol. 3 No. 2 (2025)
Publisher : Universitas Gunadarma

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35760/jff.2025.v3i2.135

Abstract

Indonesia is one of the countries with a tropical climate with temperatures around 18-38°C. Indonesia is experiencing an increase in temperature so it is recommended to use sunscreen. One of the ingredients in sunscreen preparations is an octyl methoxycinnamate compound that can protect the skin from UVB rays. Badan Pengawas Obat dan Makanan (BPOM) stipulates that the maximum concentration of octyl methoxycinnamate allowed in sunscreen cosmetic preparations is 10%. The purpose of this study was to determine the levels of octyl methoxycinnamate contained in sunscreen gel samples circulating in Cibinong Market by UV-Vis spectrophotometric method. This study used the UV-Vis spectrophotometric method that has been validated for the analysis of octyl methoxycinnamate levels in sunscreen gel preparations. Based on the optimization results, it was found that the optimal solvent to attract OMC was isopropanol as shown by the linear equation y = 0.1003x + 0.0111 (R2 = 0.9998). Validation of the analytical method includes specificity showing OMC standard at λmax 308.5 nm; linearity with concentrations of 2, 3, 4, 5, 6, and 7 μg/mL with a value of y = 0.1006x+0.0102 (R2 = 0.9999); accuracy is shown from the percent of recovery is 127.88%; 113.67%; 108.44%; precision is also shown with %RSD with measurements are 0.4283%; 0.1255%; 0.122%, respectively; BD value = 0.679 μg/mL, and BK value = 2.058 μg/mL. This study using three sunscreen gel samples obtained from shops in Cibinong market showed that all gel samples containing octyl methoxycinnamate did not exceed the specified concentration, where sample A was 2.81%; sample B was 0.96%; and sample C was 0.37%.
Analisis Potensi Kejadian Medication Errors pada Fase Prescribing dalam Pelayanan Resep Pasien Rawat Jalan di Rumah Sakit Bhayangkara Brimob: Analysis of the Potential Incidence of Medication Errors in the Prescribing Phases in Outpatient Prescription Services at Bhayangkara Brimob Hospital Astuti, Septi Tri; Hartianty, Eka Pebi; Wijayanti, Rahayu
Jurnal Farmasi dan Farmakoinformatika Vol. 3 No. 2 (2025)
Publisher : Universitas Gunadarma

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35760/jff.2025.v3i2.136

Abstract

Prescription assessment is an activity that plays an important role in ensuring appropriate drug use and preventing medication errors. Medication errors most often occur in the prescribing phases, which is medication errors that occur during drug prescribing. This study aims to determine the implementation of prescription assessment and the potential incidence of medication errors in the prescribing phase in the assessment of outpatient prescriptions at Hospital Bhayangkara Brimob. The type of research used in this study is non-experimental research using descriptive research methods with retrospective data collection for the period October – December 2023. Sampling was the techniques of purposive sampling and calculated using the slovin formula so as to get minimum sample of 395 prescriptions and the number of samples used in this study was 450 prescriptions. The results showed that there was a potential for medication errors in the prescribing phase based on pharmaceutical and clinical requirements. In pharmaceutical requirements, it was found that the name, form or dosage strength of the drug was no listed by 14% (63 prescriptions), inapproopriate drug dosage by 25,33% (114 prescriptions), and inappropriate use rules by 20% (90 prescriptions). In clinical requirements, duplication of drugs was found at 1,11% (5 prescriptions) and drug interactions at 20,22% (91 prescriptions). Meanwhile, administrative requirements did not identify any potential medication errors. The conclusion of this study is that outpatient prescriptions at Bhayangkara Brimob Hospital still have the potential for medication errors in the prescribing phase based on pharmaceutical and clinical requirements.
Pengaruh Variasi Konsentrasi Asam Stearat Terhadap Stabilitas Fisik Sediaan Krim Tabir Surya Ekstrak Daun Sirih Hijau (Piper betle L.): The Effect Of Stearic Acid Concentration Variations On The Physical Stability Of Green Betel Leaf (Piper betle L.) Sunscreen Cream Preparations Sartiman; Masyithah, Lathvi
Jurnal Farmasi dan Farmakoinformatika Vol. 3 No. 2 (2025)
Publisher : Universitas Gunadarma

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35760/jff.2025.v3i2.137

Abstract

Exposure to ultraviolet rays at a certain level cannot be accepted by human skin. Objective: This study aims to see the potential value of the Sun Protection Factor (SPF) of green betel leaves (Piper betle L.) by finding good stability using stearic acid. Methods: This study was conducted with a qualitative approach with a laboratory experimental method. Data collection directly from the laboratory to determine whether there is sunscreen activity in green betel leaf extract (Piper betle L.) to see if there is a difference in the effect of stearic acid concentration on the stability of green betel leaf extract sunscreen cream (Piper betle L.). Results: The results obtained are that green betel leaf extract (Piper betle L.) has sunscreen activity with the higher the concentration of the extract, the higher the Sun Protection Factor (SPF) value. This can be proven by the results of data processing obtained, every 1% increase in concentration value. Then the SPF value increases by 0.21. The results of the stability test showed stable results with organoleptic consistency, pH, and homogeneity, and spreadability. After being formulated, the sunscreen cream has a Sun Protection Factor (SPF) value, the higher the concentration of stearic acid, the lower the SPF value, this can be proven by the results of data processing with the addition of 1% concentration value. Conclusion: The Sun Protection Factor (SPF) value decreases by -0.900 but the stability of the preparation shows good results. This study suggests that it is necessary to test the antioxidant levels in green betel leaf extract (Piper betle L.).
Formulasi dan Uji Stabilitas Krim Tabir Surya Mengandung Titanium Dioksida (TiO2) dengan Variasi Emulgator: Formulation and Stability Test Sunscreen Cream Containing Titanium Dioxide (TiO2) With Emulgator Variations Yulianti, Rizky Dwi; Mardiyanti, Siti
Jurnal Farmasi dan Farmakoinformatika Vol. 3 No. 2 (2025)
Publisher : Universitas Gunadarma

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35760/jff.2025.v3i2.138

Abstract

The use of sunscreen creams can protect the function of human skin structures from the negative effects of UV rays. This study aims to formulate sunscreen cream preparations with variations of polysorbate and sorbitan emulgators to determine the physical characteristics of cream preparations and determine the stability of sunscreen cream preparations containing titanium dioxide (TiO2) to SPF (Sun Protection Factor) values. This research uses laboratory experimental methods. The active ingredient used is TiO2, which is a physical blocker by reflecting UV radiation. Polysorbate and sorbitan are the emulgator combinations used in this study. Sunscreen cream preparations were formulated into four formulas by combining and varying the concentration of polysorbate and sorbitan emulgators. FI contained polysorbate 60 (3%) and sorbitan 60 (2%), FII polysorbate 80 (2.5%) and sorbitan 80 (2.5%), FIII polysorbate 60 (2.75%) and sorbitan 80 (2.25%), and FIV polysorbate 80 (3.25%) and sorbitan 60 (1.75%). Furthermore, the preparations were evaluated and tested for stability (cycling test,) as well as effectiveness determination tests (SPF, and %TE). The results showed that different combinations and variations in the concentration of polysorbate and sorbitan emulgators in the four formulas had an influence on the physical characteristics and stability of the preparation. And the results of the determination of the effectiveness of sunscreen cream have an influence of UV exposure on the in vitro effectiveness of sunscreen cream (SPF, and %TE).
Optimasi Formula Serum Wajah Menggunakan Ekstrak Etanol Daun Kelor (Moringa oleifera L.) sebagai Pelembap Kulit: Optimization of Face Serum Formula Using Ethanol Extract from Kelor Leaves (Moringa oleifera L.) as a Skin Moisturizer Rahayu, Elinda; Priyono, Saraswati Ramadhani
Jurnal Farmasi dan Farmakoinformatika Vol. 3 No. 2 (2025)
Publisher : Universitas Gunadarma

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35760/jff.2025.v3i2.139

Abstract

Moringa (Moringa oleifera L.) is a member of the Moringaceae family that is rich in flavonoids and phenolics, especially in the leaves, with potential as an antioxidant and skin moisturizer. Serum is a preparation made with low viscosity so that it can deliver a thin film of active substances to the skin surface and has a high water content so that it can hydrate the skin. This study aims to optimize the formula of a face serum based on ethanol extract of moringa leaves. The extract was obtained using the maceration method and tested at concentrations of 2%, 4%, and 6%. The highest antioxidant activity was shown at a concentration of 6%, which was used as the optimal concentration in formulations with variations of 5%, 10%, and 15% glycerin. Antioxidant activity was tested in vitro using the DPPH method with UV-Vis spectrophotometry, while skin moisture was tested using a moisture skin analyzer. The results showed that all formulations met physical quality standards and had moderate to strong antioxidant activity with IC₅₀ values of F0 (36,772 ppm), F1 (26,966 ppm), F2 (25,300 ppm), and F3 (23,591 ppm). Increased concentrations of extract and glycerin were associated with decreased IC₅₀ values and increased moisturizing effects, with formula 4 producing the most optimal performance.

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