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Neurona
Published by Perhimpunan Dokter Spesialis Neurologi Indonesia
ISSN : 02166402     EISSN : 25023748     DOI : https://doi.org/10.52386/neurona
Core Subject : Health, Science,
Health Professions Medicine & Pharmacology Neuroscience
Neurona merupakan satu-satunya jurnal yang memuat perkembangan penelitian dan kasus terbaru bidang neurosains oleh Perhimpunan Dokter Spesialis Saraf (PERDOSSI) Pusat di Indonesia. Jurnal ini diterbitkan bulan Maret, Juni, September dan Desember. Bidang studi cakupan NEURONA meliputi: Stroke dan Pembuluh darah Neurotrauma Neuroonkologi Neuro Infeksi Neuro Behavior Neurorestorasi Neuropediatri Gangguan Tidur Nyeri Kepala Neurootologi Neuro Intervensi Neuro Intensif Neurogeriatri Gangguan Gerak Epilepsi Neuro Epidemiologi
Arjuna Subject : Kedokteran - Neurologi Klinis
Articles 10 Documents
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Search results for , issue "Vol 37 No 3 (2020)" : 10 Documents clear
PENGETAHUAN PESERTA PROGRAM PENDIDIKAN DOKTER SPESIALIS NEUROLOGI INDONESIA TENTANG SEMIOLOGI BANGKITAN EPILEPSI Suryani Gunadharma; Yovita Stevina; Anam Ong; Siti Aminah; Lisda Amalia; Uni Gamayani
NEURONA Vol 37 No 3 (2020)
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v37i3.159

Abstract

Introduction: Seizure semiology is an effective method for syndrome diagnosis, especially when electroencephalogram (EEG) and brain magnetic resonance imaging (MRI) cannot provide sufficient information. Diagnosis of clinical epilepsy based on semiology required a comprehensive knowledge especially for neurology residentsandidate of neurology specialist. Aim: To assess the knowledge of Indonesian neurology resident about seizure semiology. Methods: This observational descriptive study was conducted from 4 choosen university in Indonesia from February to September 2019. Participants were neurology residents from 1st semester to 8th semester. Participants were asked to fill in that quetionnaire consist of 6 questions about the teaching of seizure semiology in their university. Five ictal videos were presented to be analyzed for semiology, lateralization, and localization. These videos were chosen by 3 epilepsy consultants from different universities. Results: The participants consist of 135 residents, 16 in the 1st semester, 21 in the 2nd, 18 in the 3rd, 14 in the 4th, 14 in the 5th, 15 in the 6th, 19 in the 7th, 18 in the 8th semester. Video semiology were already lectured from the 3rd semester in 66.7%-83%. Only 30.3% of semiology features from 5 videos can be recognized by the participants, semiology knowledge was improved from 2nd semester. An average of 55.6% participants could answer lateralization and 52% localization. Discussion: Neurology resident knowledge about seizure semiology is still insufficient, improvement and uniformity in teaching methodology of semiology is needed. Keywords: Indonesian neurology resident, knowledge, seizure semiology
PREVALENSI NYERI NEUROPATIK PADA PASIEN DENGAN NYERI KANKER DI RSUPN DR CIPTO MANGUNKUSUMO DAN PKN RS DHARMAIS Henry Riyanto Sofyan; Tiara Aninditha; Louis Kwandou; Jonathan Odilo; Rini Andriani
NEURONA Vol 37 No 3 (2020)
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v37i3.160

Abstract

Introduction: Cancer pain is one of the most common complications in cancer. As much as 30-50% of cancer patients experienced pain. Cancer pain patients have reported complaints of pain with a neuropathic component. Early diagnosis of neuropathic cancer pain has a clinical implication for patient management. However, the proportion of neuropathic cancer pain has not been studied in Indonesian population. Aim: The study was to get an overview of neuropathic pain prevalence among cancer pain patients in Cipto Mangunkusumo General Hospital and National Cancer Referral Dharmais Hospital. Methods: The design of this research was cross-sectional. The study was done in Cipto Mangunkusumo General Hospital and National Cancer Referral Dharmais Hospital in July-September 2019. The subjects in this research were adult cancer patients who consulted with the Department of Neurology. The data acquired were patient’s demography, cancer history, imaging, and pain assessment. PainDETECT questionnaire was employed to assess neuropathic pain. The data were processed and presented descriptively and analytically. Results: There were 57 subjects obtained in this research with average age of 45.91. As much as 31.6% subjects had neuropathic cancer pain. Breast cancer identified in 38.6% subjects. There were no differences of gender, age, cancer type, and pain intensity between subjects with and without neuropathic cancer pain. Radiating pain and subject with metastasis experienced neuropathic cancer pain more frequently. Discussion: The prevalence of neuropathic cancer pain in the Indonesian population is 31.6%. Radiating pain and patients with metastasis cancer tend to experienced neuropathic pain more frequently. Keywords: Cancer, Indonesia, neuropathic pain, prevalence
PASCAOPERASI ADENOMA HIPOFISIS: HUBUNGAN ANTARA DURASI AWITAN DENGAN LUARAN KLINIS VISUS DAN LAPANG PANDANG Renindra Ananda Aman; Reki Setiawan; Retno Asti Werdhani; Samsul Ashari; David Tandian; Syaiful Ichwan; Affan Priyambodo; Setyo Widi Nugroho
NEURONA Vol 37 No 3 (2020)
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v37i3.161

Abstract

Introduction: Pituitary adenomas can cause decrease of visual acuity (VA), narrowing visual field (VF). Several studies have showed that the duration of complaints were related significantly with clinical outcomes. As a national referral center hospital, all pituitary adenoma patients who came to our institution were referred from ophthalmologists, neurologists, and neurosurgeons from other institutions. Aim: In this study, we investigated the relationship between duration, which is calculated from the time of symptoms first appeared to the time of surgery, and outcome (VA and VF) in pituitary adenoma patients who underwent transsphenoidal surgery. Methods: A retrospective design was used on pituitary adenoma patients that underwent transsphenoidal surgery between 2015-2017 in Cipto Mangunkusumo Hospital. The duration between symptoms’ onset and surgery was calculated in months. VA and VF examinations were performed 1 day before surgery and within 1 to 2 months postoperatively. Results: There were 71 patients (36 male, 35 female) with decreased VA and narrowed VF, with a median age of 42 years (20-77 years). The median length of duration of onset for both symptoms was 12 months (1-108 months). 40.5% patients had improved VA postoperatively, with median duration of onset of 11 months. Improvement in VF was experienced in 67.6% patients, with median duration of onset of 12 months. Discussion: There was a statistically significant relationship between the duration of onset and the VF outcomes. Improvements in the VF were found in patients who underwent surgery up to 12 months after the time of onset. Keywords: Pituitary adenoma, transsphenoidal surgery, visual acuity, visual field
HUBUNGAN KADAR MAGNESIUM DENGAN VOLUME HEMATOMA DAN DERAJAT KLINIS PASIEN PERDARAHAN INTRASEREBRAL Bhetaria Santoso; Amiruddin Aliah; Susi Aulina
NEURONA Vol 37 No 3 (2020)
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v37i3.162

Abstract

Introduction: High serum magnesium levels at hospital admission are associated with a small volume of incoming hematoma with a lower National Institutes of Health Stroke Scale (NIHSS) score. Aim: To assess the correlation between the serum magnesium levels, the hematoma volume, and the clinical degree in patients with acute supratentorial intracerebral hemorrhagic stroke. Methods: The study used a cross-sectional design of acute supratentorial intracerebral hemorrhagic stroke patients whose the levels of serum magnesium and clinical stroke degrees were examined using the NIHSS from January 2018 through April 2019 at Wahidin Sudirohusodo Hospital, Makassar. Results: There were 32 subjects (18 male, 14 female) obtained in this research with average age of 55.81+0.496 and average level of serum magnesium 1.9244+0.49657mg/dL. The results indicated that there was a significant correlation between serum magnesium levels and the hematoma volume and clinical degree in patients with acute supratentorial intracerebral hemorrhagic stroke. Through the Spearman correlation test, it was found that serum magnesium levels were correlated negatively and linearly with hematoma volume and NIHSS acute supratentorial intracerebral hemorrhagic stroke patients. Discussion: There was a significant correlation between serum magnesium levels, hematoma volume and clinical degree in patients with acute supratentorial intracerebral hemorrhagic stroke. Keywords: Acute intracerebral hemorrhage stroke, clinical degree of stroke (NIHSS), hematoma volume, serum magnesium level
HUBUNGAN KOLESTEROL NON-HDL TERHADAP FUNGSI KOGNITIF PADA PASIEN STROKE ISKEMIK DENGAN DEFISIT NEUROLOGIS RINGAN Aylenia Lysandra; Budi Riyanto Wreksoatmodjo; Josephine Retno Widayanti
NEURONA Vol 37 No 3 (2020)
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v37i3.163

Abstract

Introduction: Ischemic stroke patients have higher risk of cognitive decline. Severity of cognitive impairment depends on the severity of neurological deficit. The severity of cognitive impairment is also affected by abnormal non-HDL cholesterol level which includes atherogenic lipid that causes atherosclerosis. Aim: Understanding the association of non-HDL cholesterol and cognitive function in mild stroke patients at Atma Jaya Hospital in 2014-2018. Methods: A cross-sectional study by analyzing stroke registry patients (115 subjects). Data is analyzed by using Chi-square test and Fisher exact test. Results: Total sample of this research is 115 respondents. Mean age was 58±11,286 years old and 30,4% graduated from senior high school. 38,3% have cognitive impairment measured by Mini Mental State Examination (MMSE), of which 79.5% have abnormal non-HDL cholesterol. Meanwhile, 70,4% have cognitive impairment measured by Montreal Cognitive Assessment Indonesian Version (MoCA-Ina), of which 76.5% have abnormal non-HDL cholesterol. Cognitive function measured by MMSE and MoCA-Ina has no significant association with non-HDL cholesterol (respectively). Discussion: This research contradicted the previous research. It is suspected that there is no direct relationship between non-HDL cholesterol and cognitive function. Besides, cholesterol acts as antioxidant, has a role in neurotransmission and has a protective effect. Discussion: Cognitive function in patients with mild stroke, measured by MMSE and MoCA-Ina, is not associated with non-HDL Cholesterol. Keywords: Cognitive function, ischemic stroke, mild stroke, non-HDL cholesterol
HUBUNGAN KADAR ANTIBODI RESEPTOR ASETILKOLIN DENGAN DERAJAT KEPARAHAN PENYAKIT MIASTENIA GRAVIS DI RS CIPTO MANGUNKUSUMO Manfaluthy Hakim; Fika Tiara; Ahmad Yanuar; Winnugroho Wiratman; Luh Ari Indriawati; Astri Budikayanti; Fitri Octaviana
NEURONA Vol 37 No 3 (2020)
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v37i3.164

Abstract

Introduction: Acetylcholine receptor (AChR) antibody is main antibody in pathogenesis of myasthenia gravis (MG). AChR antibody is an important diagnostic tests. Myasthenia gravis clinical features can be divided into ocular, generalized and bulbar MG. Severity of MG can be assessed based on MG composite score (MG-cs). Aim: To evaluate association between level of AChR antibody and MG severity based on MG severity in Cipto Mangunkusumo Hospital. Methods: This was a descriptive-analytic cross-sectional study which were done at Cipto Mangunkusumo Hospital during January to November 2017. Inclusion criteria were MG patients aged 18-75 years old. Assessment of MG composite score and blood withdrawal were performed at the same time. The level of AChR antibody was measured by ELISA method. Results: There were 72 subjects met inclusion criteria. Mean age was 43 years old (SD 12.56) with proportion higher in women (2.5:1). Ocular MG was the most initial symptom (79.2%) and early onset was the most common(77.8%). There were 59.7% subject who had seropositive AChR antibody. There was no significant association between seropositive AChR antibody and gender, age of onset, MG type, MGFa classification, immunotherapy. There was no association between level of AChR antibody and MG-cs(p=0.727). Discussion: There wasn’t any association between level of AChR antibody and MG severity based on MG-cs. Keywords: AChR antibody, MG composite score, MG severity
MEMBANGUN SISTEM CODE STROKE PADA DUA RUMAH SAKIT PENDIDIKAN DI INDONESIA Rakhmad Hidayat; Hirari Fattah Yasfi; Dinda Diafiri; Reyhan Eddy Yunus; Andi Ade Wijaya Ramlan; Taufik Mesiano; Mohammad Kurniawan; Al Rasyid; Salim Harris
NEURONA Vol 37 No 3 (2020)
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v37i3.165

Abstract

Code stroke system is rapid respond system for ischemic stroke patient’s care to have immediate therapy in order to increase effectiveness and achieve maximum outcome. Cipto Mangunkusumo Hospital and Universitas Indonesia Hospital are educational hospitals with different background, resources, facilities, and conditions in code stroke system implementation. This paper compares the code stroke system between both hospitals from some aspects, such as emergency unit health care providers, cost and facility, diagnostic imaging, initiator of code stroke system, observation room, availability of catherization lab, and communication within code stroke team. Code stroke system can be implemented in many hospitals correspondingly adjusting each of hospital conditions by maximizing advantages to cover the hospital’s shortcomings. Keywords: Code stroke, hospital, ischemic stroke, thrombectomy, thrombolysis
MULTIPEL SKLEROSIS PROGRESIF SEKUNDER, GEJALA KLINIS, DIAGNOSIS, DAN TATA LAKSANA Riwanti Estiasari; Nadia Devianca; Kartika Maharani; Darma Imran
NEURONA Vol 37 No 3 (2020)
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v37i3.166

Abstract

Multiple sclerosis (MS) is a chronic inflammatory autoimmune disorder of the central nervous system (CNS) affecting the myelin. MS is very detrimental which causes disability and will reduce the productivity and quality of life of the patients, especially if it progressed to secondary progressive multiple sclerosis (SPMS) which there will be a continuous worsening of neurological deficits. Early detection of symptom progression can be done to overcome the problems that may occur in SPMS. By early detection, immediate therapy of SPMS can be given thus preventing the progression. It is therefore important for us to know the definition of SPMS, how to detect progression, and the treatment options for SPMS that will be explained in this literature review. Keywords: Progression, therapy, SPMS
TUBERKULOMA SEREBRAL PADA PENDERITA ACQUIRED IMMUNE DEFICIENCY SYNDROME Vincent Ongko Wijaya; Dony Ardianto; Gama Sita Setya Pratiwi; Anton Mahendra; Glennis Widra Shintyalola; Rasi Irfan Asany
NEURONA Vol 37 No 3 (2020)
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v37i3.167

Abstract

Cerebral tuberculoma is a central nervous system complication which rare and jeopardize due to tuberculosis (TB) infection. The authors reports a case of a 23 years old female with history of human immunodeficiency virus infection and acquired immunodeficiency syndrome (HIV/AIDS) and under treatment for active TB, presented with headache and dizziness since 1 week before admission. Neurological examination in normal range. Lab value showed decrease level in CD4 absolute and continue with contrast head CT scan. The patient has been given main therapy with dexamethasone, cotrimoxazole, and anti-tuberculosis drugs Keywords: HIV/AIDS, tuberculoma, tuberculosis
METASTASIS OTAK TIPE MILIER PADA KASUS ADENOKARSINOMA PARU DENGAN MUTASI EGFR T790M I Made Oka Adnyana; Ni Luh Putu Eka Arisanti
NEURONA Vol 37 No 3 (2020)
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v37i3.168

Abstract

Brain metastasis is the most common intracranial tumor with the number of events exceeding primary brain tumors. It still holds high mortality and morbidity rate to date. Most of the metastases are macroscopic parenchymal mass lesions with surrounding edema and occurred in the gray-white matter junction. Miliary brain metastasis is a rare condition with generally poor prognosis. A male patient, 51 years old, Balinese, was admitted with decreasing consciousness since 1 week ago. The patient was diagnosed with lung adenocarcinoma with positive EGFR mutation in March 2019 and since April 2019 was started taking gefitinib 200mg every 24 hours. The patient also had intermittent headaches accompanied by vomiting, the head MRI with contrast showed multiple-miliary punctate lesions on almost every brain tissue, suggesting miliary type metastases. Further investigation revealed a positive EGFR T790M mutation. Miliary type brain metastases is a rare condition with poor prognosis. Chemotherapy and radiotherapy do not provide a satisfactory result. Miliary metastases pattern should be considered in differential diagnoses of patients with progressive dementia and multiple lesions as numerous diseases have similar head CT scan appearances. To this date, there is no standard therapy regimen for miliary brain metastases but some studies showed that the combination of whole-brain radiotherapy and EGFR tyrosine kinase inhibitor was deemed as having beneficial effects. The survival rate on these cases range from 14 days to 24 months. Keywords: Adenocarcinoma, brain, lung, metastases, miliary type

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