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DEVELOPMENT OF STANDARDIZED OLFACTORY TEST AS A COGNITIVE IMPAIRMENT SCREENING TOOL IN INDONESIAN ELDERLY: A PRELIMINARY STUDY Kristian, Kevin; Handajani, Yvonne Suzy; Widjaja, Nelly Tina; Suswanti, Ika; Turana, Yuda
Berkala Ilmiah Kedokteran Duta Wacana Vol. 9 No. 1 (2024): BERKALA ILMIAH KEDOKTERAN DUTA WACANA
Publisher : Faculty of Medicine Universitas Kristen Duta Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21460/bikdw.v9i1.631

Abstract

The decline of olfactory function is an early indicator of neurodegenerative diseases, such as Alzheimer’s and Parkinson’s disease. An olfactory function assessment instrument using ten familiar scents with multiple-choice answers has been developed, but several items were inapplicable and had not been standardized. This study aimed to identify various scents that have not been standardized for the aging population with normal cognitive function. This research was a preliminary study with a descriptive cross-sectional approach conducted in Kalianyar village, Jakarta, involving 23 elderly participants with normal cognitive function. An instrument consisting of a list of scents was employed in two steps, with or without assistance. Initially, participants had one chance to smell and try to guess the type of scent given. If the scent was not guessed correctly, participants were then provided with multiple-choice options as a hint. Based on the assessment of twelve scents from the existing research, only nine scents were recognizable. Among them, coffee, lemongrass, oranges, eucalyptus, and menthol were the scents with the most correct answers without assistance. Additionally, there were four scents recognized with or without assistance, such as jasmine, lemon, aromatic ginger, and lime. This study found that only nine scents were familiar and had the potential to be utilized in the future as a screening tool for cognitive impairment.
Lingkar Pinggang Sebagai Faktor Risiko Utama Osteoartritis Lutut dan Peran Penting Depresi Felicia, Tesya; Kristian, Kevin; Handajani, Yvonne Suzy; Barus, Jimmy Fransisco Abadinta
Jurnal Kedokteran Meditek Vol 31 No 3 (2025): MEI
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jkdoktmeditek.v31i3.3496

Abstract

Background: As the elderly population increases, the incidence of osteoarthritis (OA) also rises. In Indonesia, the prevalence of OA is 15.5% in men and 12.7% in women. Research on OA in Indonesia remains limited, particularly regarding population-based studies. Purpose: This study aimed to provide an overview of knee OA and its risk factors among older adults living in Pusaka Kebon Jeruk, West Jakarta. Methods: This cross-sectional study involved 100 respondents. Data were collected through interviews using questionnaires. Bivariate analysis was conducted using chi-square tests, and multivariate analysis was performed using multiple logistic regression (p<0.05). Results: The study found that 28% of the elderly had knee OA, with the majority aged 60-74 years (75%), female (71%), unemployed (82%), educated for 12 years or more (90%), and married (55%). Bivariate analysis identified waist circumference (p<0.001) and depression (p=0.032) as variables significantly associated with knee OA. Multivariate analysis indicated that waist circumference was the most significant factor affecting knee OA, with an odds ratio (OR) of 24.239. The prevalence of knee OA requires serious attention from the government and healthcare providers. Conclusion: Knee OA is significantly related to waist circumference and depression, with waist circumference being the most critical factor. Central obesity is associated with a higher risk of knee OA. Therefore, it is essential to prevent central obesity through a balanced diet and regular exercise.
Evaluating The CURB-65 Score for Prognostic Assessment in COVID-19 Patients: A Systematic Review Astiarani, Yunisa; Sari, Gabriella Aninda Puspita; Kristian, Kevin
Journal of Urban Health Research Vol. 3 No. 2 (2025): Journal of Urban Health Research
Publisher : School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/juhr.v3i2.6640

Abstract

Introduction: Several instruments and biomarkers have been used to assess the severity and predict outcomes in COVID-19 patients, each with varying sensitivity levels. One such tool is the CURB-65 score—an acronym for Confusion, Urea nitrogen, Respiratory rate, Blood pressure, and age ≥65 years—which has traditionally been used to evaluate the severity of community-acquired pneumonia. Its application in COVID-19 patients aims to identify clinical deterioration and assist in risk stratification. Accurate prognosis is essential to guide clinical management and reduce mortality. However, the utility of the CURB-65 score in predicting outcomes in COVID-19 patients remains a subject of debate. This study aims to evaluate the performance of the CURB-65 score in determining the prognosis of patients with COVID-19. Methods:This systematic review was conducted in accordance with PRISMA guidelines. Relevant studies published between 2020 and 2022 were identified through searches using predefined keywords in PubMed, ScienceDirect, and EBSCO databases. Studies of all designs that assessed the CURB-65 score concerning COVID-19 outcomes were considered for inclusion. Results: Ten studies were included in this review, evaluating the CURB-65 score's effectiveness in predicting various outcomes in COVID-19 patients, including overall mortality, 30-day mortality, adverse outcomes, need for organ support, ICU admission and intervention, critical illness, mechanical ventilation, and 72-hour mortality. Seven out of ten studies demonstrated good prognostic performance of the CURB-65 score, with sensitivity greater than 80% or an Area Under the Curve (AUC) exceeding 0.80 for predicting mortality. Conclusion: The CURB-65 score shows promising utility in predicting mortality among COVID-19 patients and may perform better than several other prognostic tools. Its simplicity and accessibility make it a valuable aid in clinical decision-making, although further validation in different populations may be warranted.
THE ROLE OF OLFACTORY FUNCTION AND MULTIMORBIDITY IN COGNITIVE IMPAIRMENT: Peranan Fungsi Penghidu dan Multimorbiditas Terhadap Fungsi Kognitif Kristian, Kevin; Vebriana, Gennesia; Hardi, Nicholas; Turana, Yuda; Handajani, Yvonne Suzy
Jurnal Berkala Epidemiologi Vol. 13 No. 2 (2025): Jurnal Berkala Epidemiologi (Periodic Epidemiology Journal)
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbe.V13I22025.193-200

Abstract

Background: As the population ages, the issue of cognitive impairment is becoming increasingly worrisome, especially with the rise in conditions like multiple chronic diseases and loss of smell among the elderly. Purpose: The goal of this research is to explore how multiple chronic diseases, sense of smell, and cognitive impairment are linked among the senior population. Methods: This study involved 128 individuals at a senior community in Jakarta with an average age of 68.34 years. The presence of multiple chronic diseases was determined by looking for highest prevalence of disease pairs, and the sense of smell was tested with an 8-smell test. Cognitive function was measured with the CERAD questionnaire, with a score below 52 indicating cognitive impairment. The analysis included Chi-square tests at a 95% confidence level. Results: The findings suggest a clear link between lower levels of education and cognitive impairment (p=0.018; OR=3.214), as well as between loss of smell and cognitive deterioration (p=0.049; OR=2.565). However, having more than three chronic diseases was found to significantly increase the risk of cognitive impairment (p=0.018; OR=2.678), but there was no significance to support that certain disease pairs were more likely to lead to cognitive impairment. Conclusion: This research underscores the significance of sense of smell and the presence of multiple chronic diseases, especially in greater numbers, as major risk factors for cognitive impairment in the elderly.
PEKERJAAN SEBAGAI FAKTOR PROTEKTIF MEMORI PADA LANSIA Suwito, Michelle Margaretha; Handajani, Yvonne Suzy; Turana, Yuda; Kristian, Kevin
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 40 No 2 (2024): Vol 40 No 2 (2024): Volume 40, No 2 - Maret 2024
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v40i2.586

Abstract

Introduction: The risk of memory impairment increases with age, with a global prevalence of 20% of elderly experiencing difficulties in memory related activities.Aim: The aim of this study is to understand memory impairment and its associated factors in a community- dwelling setting in Kebon Jeruk, West Jakarta.Method: This cross-sectional study involved 98 participants aged over ≥60 years. Data was collected by interview using validated instruments. Statistical analysis was done using chi-square method for bivariate analysis and multiple logistic regression for multivariate analysis.Result: Majority of participants were women (71%), with ages of ≥65 years (81%), an education of >12 years (90%) and were unemployed (87%). Memory impairment was found in 82% of participants. Chi- square analysis showed that factors significant to memory impairment were age (p: 0.021; OR: 0.734; 95%CI: 0.515 – 1.046), occupation (p: 0.045; OR: 0.727; 95%CI: 0.486 – 1.127), and physical activity (p: 0.013; OR: 1.338; 95%CI: 0.998 – 1.794). Multiple logistic regression analysis showed that the most significant factor affecting memory impairment was age (OR: 3.766).Discussion: Memory impairment in the elderly is associated with age, occupation, and physical activity. Of these factors, age is the most significant factor, with a risk increase of 3.766 times in impairing memory of the elderly.Keywords: Age, elderly, memory impairment, occupation, physical activity.
Aktivitas Fisik Sebagai Penentu Frailty: Melampaui Indeks Massa Tubuh, Lingkar Pinggang, dan Body Fat Percentage. Sejati, Fabian; Turana, Yuda; Handajani, Yvonne Suzy; Kristian, Kevin
Bahasa Indonesia Vol 24 No 2 (2025): Damianus Journal of Medicine
Publisher : Atma Jaya Catholic University of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/djm.v24i2.6138

Abstract

Pendahuluan: Proses penuaan meningkatkan risiko seseorang untuk mengalami masalah kesehatan, salah satunya adalah frailty. Sebuah penelitian studi potong lintang oleh Setiati, et al. di Indonesia pada tahun 2020, didapatkan prevalensi sebesar 66,20% pre-frail dan 18,70% frail. Tujuan: Mendapatkan gambaran mengenai frailty pada lansia dan faktor risikonya di Pusaka Kebon Jeruk, Jakarta Barat. Metode: Penelitian ini menggunakan metode potong lintang dan terdiri dari 100 subjek dengan usia ≥60 tahun yang telah memenuhi kriteria penelitian. Pengambilan data dilakukan melalui wawancara menggunakan instrumen yang sudah divalidasi. Hasil: Dari 100 responden, sebagian besar berusia 60-74 tahun (75%), perempuan (71%), pendidikan ≥12 tahun (90%). Terdapat 18% lansia yang mengalami frailty. Analisis bivariat menunjukkan faktor yang memiliki hubungan bermakna adalah usia (p<0,001; RO=7,633; 95%CI=2,519–23,127) dan aktivitas fisik (p=0,011; RO=3,857; 95%CI=1,308–11,370). Simpulan: Frailty memiliki hubungan bermakna dengan usia dan aktivitas fisik. Usia menjadi faktor yang paling memengaruhi dan meningkatkan risiko frailty pada lansia.
PERAN ANALISIS SUARA DALAM DETEKSI DINI KOGNITIF PADA LANSIA: STUDI PENDAHULUAN Kristian, Kevin; Adhitya, Paskalis; Tirta Wening, Andrea; Indrawan, Novelya; Indrajaya, Feryandinata; Yauw, Michael
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 41 No 4 (2025): Volume 41 Nomor 4, September 2025
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v41i4.615

Abstract

ABSTRACT Introduction: The increase in life expectancy makes the cognitive abilities of the elderly important. The need for a rapid diagnosis of cognitive impairment renders the currently available instruments inadequate. Standardization of the use of voice analysis for cognitive assessment is required for quick diagnosis. Aim: To determine the relationship between voice components and cognitive impairment in the elderly. Methods: A descriptive and analytical cross-sectional study was conducted on elderly individuals over 60 years old who did not have visual or hearing impairments. Cognitive assessment using MoCA-INA was performed on 107 elderly individuals who met the inclusion criteria and were categorized into normal and cognitively impaired groups. Results: The majority of the study respondents were aged 61-70 years (57.9%), not frail (93.5%), had multimorbidity (60.74%), had a habit of exercising (66.4%), and had a formant frequency 1 (F1) of the vowel /e/ <500.9 Hz (50.5%). Univariate analysis showed that F1 of the vowel /e/ had very high variability (107041.294), and the compare means analysis showed a significant relationship (p=0.034). Discussion: Most of the elderly in this study did not have cognitive impairment. There was a relationship between F1 of the vowel /e/ and cognitive impairment at a MoCA-INA cut-off score of 22. There was no relationship between age, exercise habits, multimorbidity, fundamental frequency of the vowels /a/ and /e/, amplitude of the vowels /a/ and /e/, F1 and F2 of the vowel /a/, and F2 of the vowel /e/. Keywords: cognitive impairment, elderly, formant 1 (F1), voice analysis
Gangguan Fungsi Bahasa Meningkatkan Risiko Kualitas Hidup Buruk pada Lansia Piustan, Mas Eaufrat; Turana, Yuda; Handajani, Yvonne Suzy; Kristian, Kevin
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 41 No 4 (2025): Volume 41 Nomor 4, September 2025
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v41i4.673

Abstract

Introduction: The quality of life of the elderly requires attention. Language function is closely related to identifying individuals who are vulnerable to a decline in quality of life. Aim: This study aims to examine the relationship between sociodemographic factors, language function, social engagement, and frailty with elderly’s quality of life. Methods: This study employed a cross-sectional method with 100 respondents aged ≥60 years. Quality of life was measured using the WHOQOL-BREF, language function was assessed using the CERAD Verbal Fluency Test, social engagement was evaluated using the Social Disengagement Index, frailty was measured using the Fried Frailty Index, and sociodemographic factors were assessed through interviews using validated instruments. Results: Chi-square analysis showed a significant relationship between language function and the psychological, social, and environmental domains (p<0.05). Gender was only significantly associated with the environmental domain. Frailty was associated with psychological, social, overall quality of life, and health satisfaction. Multiple logistic regression analysis shows that impaired language function is a risk factor for impairments in the psychological (OR=3.335; 95%CI=1.376-8.082), social (OR=3.473; 95%CI=1.376-8.763), and environmental domain (OR=4.649; 95%CI=1.057-20.442). Frailty was identified as risk factor for impairments in psychological domain (OR=3.274; 95%CI=1.069-10.022) and health satisfaction (OR=3.378; 95%CI=1.105-10.328). Being female served as protective factor against impairments in the environmental domain (OR=0.159; 95%CI=0.036-0.694). Discussion: Impaired language function increase the risk of psychological, social, and environmental impairments. Being female serves as protective factor against environmental domain impairment. Frailty increases the risk of psychological impairments and poor health satisfaction. Keywords: Age, elderly, frailty, language, quality of life
Association Between Smoking and Central Obesity in Individuals Aged ≥40 Years Based on the Indonesian Family Life Survey-5 Hendri, Gabriel Anetta; Kurniawan, Felicia; Astiarani, Yunisa; Santi, Bryany Titi; Kristian, Kevin
Althea Medical Journal Vol 12, No 3 (2025)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v12n3.4272

Abstract

Background: Obesity and smoking are major public health concerns and leading causes of preventable morbidity and mortality. Smoking may contribute to central obesity through multiple mechanisms, and individuals aged ≥40 years are at higher risk. This study aimed to examine the association between smoking and central obesity, considering sociodemographic factors, using data from the Indonesian Family Life Survey-5 (IFLS-5).Methods: A cross-sectional study was conducted using secondary data from IFLS-5. Participants included Indonesians aged ≥40 years with complete data on smoking and waist circumference. Smoking status was assessed using the Brinkman Index (BI) and classified as light (0–199), moderate (200–599), or heavy (>600). Central obesity was defined as waist circumference ≥90 cm for male and ≥80 cm for female. Associations were analyzed using Chi-square tests at 95% confidence interval.Results: Of 3,391 participants, the majority were male (95.4%) with a mean age of 52.76±9.78 years (range 40–101). The prevalence of central obesity was 22.3% (n=790), and the largest group of participants were moderate smokers (54.9%). Central obesity was significantly associated with smoking status (p=0.003), age (p<0.001), gender (p<0.001), and education level (p<0.001). No significant associations were found with marital status (p=0.826), occupation (p=0.374), or residence (p=0.750).Conclusions: Smoking, age, gender, and education level are significantly associated with central obesity among Indonesians aged ≥40 years. Preventive measures, including smoking cessation and lifestyle interventions, are essential to reduce central obesity and the risk of cardiovascular disease.
EVALUASI KELAYAKAN MEDIA KESEHATAN ELEKTRONIK DAN DISTRIBUSINYA DALAM MENGADAPTASI KEBIASAAN BARU DI ERA PANDEMI COVID-19 Astiarani, Yunisa; Putri, Giovani Indah Giantoro; Santi, Bryany Titi; Wiraharja, Regina Satya; Hadiyanto; Kristian, Kevin
Mitramas: Jurnal Pengabdian dan Pemberdayaan Masyarakat Vol. 1 No. 2 (2023)
Publisher : Universitas Katolik Indonesia Atma Jaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/mitramas.v1i2.4459

Abstract

Informasi yang salah selama pandemi COVID-19 dapat menyebabkan ketidak pedulian bahkan perilaku berbahaya di masyarakat. Informasi yang valid dan benar, khususnya tentang adaptasi kebiasaan baru di era new normal, dibutuhkan untuk mengurangi penyebaran penyakit yang kian meningkat. Kegiatan evaluasi kelayakan media promosi kesehatan eletronik bertujuan agar informasi lebih mudah dimengerti dan diaplikasikan. Distribusi media promosi kesehatan yang melibatkan tokoh masyarakat, kader, dan wakil warga diharapkan dapat mengurangi resistensi warga setempat terhadap informasi pencegahan. Evaluasi dan distribusi media kesehatan elektronik dilakukan di sebuah rukun warga (RW) di Kecamatan Penjaringan, Jakarta Utara. Perwakilan warga setempat mengevaluasi e-poster dan video edukasi melalui formulir online tentang kejelasan informasi, bahasa, dan desain. Kedua media tersebut kemudian disebarkan ke seluruh kepala keluarga di RW setempat. Sebanyak 54 wakil warga mengevaluasi media promosi kesehatan elektronik tersebut, dengan rata-rata 97% setuju bahwa e-poster mudah dibaca, menarik untuk dibaca lebih lanjut, dan membantu pemahaman yang lebih baik. Video edukasi juga diterima dengan baik, dengan rata-rata 98% peserta setuju bahwa video tersebut mudah dipahami, memiliki artikulasi yang jelas, dan membantu pemahaman yang lebih baik. Selain itu, 94.5% peserta tidak setuju video tersebut dijelaskan terlalu cepat. Distribusi media mencapai 87,6% dari seluruh rumah tangga di rukun warga setempat dan diterima dengan baik. Evaluasi media promosi kesehatan yang dilakukan oleh perwakilan warga membantu kelancaran distribusi media elektronik pada warga sekitar.