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Neurona
Published by Perhimpunan Dokter Spesialis Neurologi Indonesia
ISSN : 02166402     EISSN : 25023748     DOI : https://doi.org/10.52386/neurona
Core Subject : Health, Science,
Health Professions Medicine & Pharmacology Neuroscience
Neurona merupakan satu-satunya jurnal yang memuat perkembangan penelitian dan kasus terbaru bidang neurosains oleh Perhimpunan Dokter Spesialis Saraf (PERDOSSI) Pusat di Indonesia. Jurnal ini diterbitkan bulan Maret, Juni, September dan Desember. Bidang studi cakupan NEURONA meliputi: Stroke dan Pembuluh darah Neurotrauma Neuroonkologi Neuro Infeksi Neuro Behavior Neurorestorasi Neuropediatri Gangguan Tidur Nyeri Kepala Neurootologi Neuro Intervensi Neuro Intensif Neurogeriatri Gangguan Gerak Epilepsi Neuro Epidemiologi
Arjuna Subject : Kedokteran - Neurologi Klinis
Articles 299 Documents
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PERAN SARKOPENIA SEBAGAI FAKTOR RISKO GANGGUAN VISUOSPASIAL PADA LANSIA Wong, Brian
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 40 No 2 (2024): Vol 40 No 2 (2024): Volume 40, No 2 - Maret 2024
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v40i2.569

Abstract

Introduction: Visuospatial impairment, as a form of cognitive impairment, could serve as an early indication of dementia in the elderly. Sarcopenia, a progressive and generalized skeletal muscle disorder, can be associated with the risk of visuospatial impairment in the elderly. Aim: This study aims to get an overview of visuospatial impairment with its associated risk factors in the elderly at Pusaka Kebon Jeruk, West Jakarta. Methods: This study uses a cross-sectional involving 100 respondents aged 60 years and above. Visuospatial impairment is measured using constructional praxis. An elder is considered to has visuospatial impairment if scoring < 11. Sarcopenia is assessed according to European Working Group on Sarcopenia in Older People 2 (EWGSOP2). Frailty status is evaluated using the Fried frailty phenotype. Blood glucose and serum cholesterol levels are measured through laboratory tests. Results: This study included 100 respondents, with 50 respondents having visuospatial impairment. Bivariate analysis found a significant association between sarcopenia and visuospatial impairment (P: 0.016, OR: 2.667, 95% CI: 1.188 – 5.985). Multivariate analysis found a similar result, that is a significant association between sarcopenia and visuospatial impairment (P: 0.017, OR: 2.752, 95% CI: 1.203 – 6.296). Bivariate analysis was done by using χ2 test, while multivariate analysis was done by using binary logistic regression using backward analysis. Discussion: Sarcopenia is significantly associated with visuospatial impairment, increasing the risk of visuospatial impairment by 2.752-fold. Keywords: Elderly, Sarcopenia, Visuospatial impairment,
Gambaran Quantitative Electroencephalography Pada Penderita Gangguan Kognitif Pascastroke di RSUP Dr. Mohammad Hoesin Palembang Febrianto, Yohanes; Nindela, Rini; Harun, Yusril; Handayani, Sri; Legiran, Legiran
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 40 No 3 (2024): Volume 40, No 3 - Juni 2024
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v40i3.573

Abstract

Post-stroke cognitive impairment (PSCI) is one of the post-stroke complications that is often overlooked. Quantitative electroencephalography (QEEG) is an alternative examination in patients with PSCI. QEEG results of PSCI patients shows abnormalities in spectral power, coherence, power ratio, and peak alpha frequency (PAF). Aim: Knowing the QEEG characteristic in PSCI patients and the characteristic differences between the post stroke dementia (PSD) and post stroke cognitive impairment no dementia (PSCI-ND). This research is a descriptive study of PSCI patients at the RSMH Palembang from September-November 2023, followed by a QEEG examination. There were 31 patients who completed the research. There is higher median absolute and relative power delta and theta both per region and globally, decreased interhemsiferous coherence at F3-F4, P3-P4, O1-O2, T5-T6, C3-C4, increased delta alpha ratio and delta theta alpha beta ratio in the frontal region, as well as a decrease in peak alpha frequency in all regions. Patients with post-stroke dementia have more abnormality in relative global power, frontal DAR and DTABR, and PAF than patients with PSCI-ND Stroke can cause slowed conduction along the cortical-subcortical pathways, disruption of cholinergic pathways and impaired communication in various parts of the brain. This condition can cause a decrease in alpha power as an important wave in cognitive function and an increase in delta power in various brain regions. A decrease in the fast wave spectrum and an increase in the slow wave spectrum may lead to decreased cognitive function as seen in patients with PSCI Post stroke cognitive impairement, Power ratio, Quantitative electroencephalography, spectral power.
DIAGNOSIS DAN TATA LAKSANA NEUROMYELITIS OPTICA SPECTRUM DISORDER (NMOSD) Estiasari, Riwanti; Chandra, Fitria; Remana Sitinjak, Monalisa; Susanto, Arief; Maharani, Kartika; Imran, Darma
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 41 No 1 (2024): Vol 41 No 1 (2024): Volume 41, No 1 - Desember 2024
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v41i1.576

Abstract

Neuromyelitis optica spectrum disorders (NMOSD) is an autoantibody mediated chronic inflammatory disease that predominantly affects optic nerves and spinal cord. NMOSD patients could experience visual disturbances, sensorimotor disorders, or autonomic disorders aligned with the pathological lesion involvement. Diagnostic criteria of the International Panel for NMO Diagnosis (IPND) 2015 are utilized to establish NMOSD diagnosis. Management of NMOSD encompasses initial and maintenance treatments that aim to prevent disease progression.
KARAKTERISTIK SOSIODEMOGRAFI REMAJA DAN DEWASA MUDA DENGAN IDE BUNUH DIRI SERIUS PADA MASA PANDEMI Pandia, Veranita; Danasasmita, Febrianti
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 41 No 3 (2025): Vol 41 No 3 (2024): Volume 41, No 3 - Juni 2025
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Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

ABSTRACT Introduction: The incidence of suicide among adolescents and young adults is on the rise, including in Indonesia. COVID-19 pandemic has created a global crisis situation, increasing the risk of individuals contemplating ending their lives. Sociodemographic characteristics of adolescents and young adults are important factors to consider in relation to their vulnerability to suicidal ideation. Aim: This study aims to examine the correlation between sociodemographic characteristics and serious suicidal ideation among adolescents and young adults. Methods: This research employed a cross-sectional study involving 1,508 high school students and 526 university students in Bandung and its surrounding areas. Participants completed a questionnaire on sociodemographic characteristics and the Suicide Ideation Scale (SIS) through online guidance (Zoom meeting). The research findings were analyzed using t-Test on variables consisting of 2 groups and ANOVA test for variables consisting of more than 2 groups followed by Tukey's HSD post-hoc test. Results: The study found that female (p<0.001), respondents' education as a student (p<0.05), parental education as a diploma and bachelor’s degree (p<0.05), and parental separation (p<0.001) were correlated with the presence of serious suicidal ideation among both adolescents and young adults. Discussion: Sociodemographic characteristics correlating with serious suicidal ideation were gender, respondents' education level, parental education level, and parental marital status. Further research is needed to understand various suicide risk factors in adolescents and young adults in Indonesia, including biological, psychosocial, and cultural factors. Keywords: adolescents, sociodemographic, suicidal ideation, young adults
POLIFARMASI DAN PENGOBATAN YANG KURANG TEPAT DALAM FARMAKOTERAPI STROKE, BAGAIMANA SPESIALIS NEUROLOGI MENSIKAPINYA: POLYPHARMACY AND INAPPROPIATE MEDICATION IN STROKE PATIENT: WHAT NEUROLOGIST SHOULD AWARE? Pambudi, Pagan; Steven
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 41 No 3 (2025): Vol 41 No 3 (2024): Volume 41, No 3 - Juni 2025
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v41i3.585

Abstract

Polypharmacy and inappropriate medication use are often found in elderly stroke patients and have negative consequences such as less than optimal functional outcomes, increased incidence of drug side effects, increased treatment time and costs. However, polypharmacy seems difficult to avoid in stroke patients where there are many underlying comorbidities that require pharmacotherapy. Neurology specialist doctors as doctors responsible for patients need to manage polypharmacy and inappropriate use of drugs in order to achieve treatment goals, namely optimal functional outcomes and patient safety at an efficient cost.
PEKERJAAN SEBAGAI FAKTOR PROTEKTIF MEMORI PADA LANSIA Suwito, Michelle Margaretha; Handajani, Yvonne Suzy; Turana, Yuda; Kristian, Kevin
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 40 No 2 (2024): Vol 40 No 2 (2024): Volume 40, No 2 - Maret 2024
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v40i2.586

Abstract

Introduction: The risk of memory impairment increases with age, with a global prevalence of 20% of elderly experiencing difficulties in memory related activities.Aim: The aim of this study is to understand memory impairment and its associated factors in a community- dwelling setting in Kebon Jeruk, West Jakarta.Method: This cross-sectional study involved 98 participants aged over ≥60 years. Data was collected by interview using validated instruments. Statistical analysis was done using chi-square method for bivariate analysis and multiple logistic regression for multivariate analysis.Result: Majority of participants were women (71%), with ages of ≥65 years (81%), an education of >12 years (90%) and were unemployed (87%). Memory impairment was found in 82% of participants. Chi- square analysis showed that factors significant to memory impairment were age (p: 0.021; OR: 0.734; 95%CI: 0.515 – 1.046), occupation (p: 0.045; OR: 0.727; 95%CI: 0.486 – 1.127), and physical activity (p: 0.013; OR: 1.338; 95%CI: 0.998 – 1.794). Multiple logistic regression analysis showed that the most significant factor affecting memory impairment was age (OR: 3.766).Discussion: Memory impairment in the elderly is associated with age, occupation, and physical activity. Of these factors, age is the most significant factor, with a risk increase of 3.766 times in impairing memory of the elderly.Keywords: Age, elderly, memory impairment, occupation, physical activity.
Karakteristik Gambaran Elektroensefalografi Pada Pasien Kejang Pascastroke : Sebuah Studi Retrospektif Nafiah, Risqon
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 41 No 1 (2024): Vol 41 No 1 (2024): Volume 41, No 1 - Desember 2024
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v41i1.588

Abstract

Introduction: Stroke is the second leading cause of death in the world with many complications, including seizures and epilepsy. Post-stroke epileptic seizures can occur either in the acute phase or in the late phase of stroke. Electroencephalography (EEG) examination, a non-invasive diagnostic method, plays an important role for the diagnosis of post-stroke seizures. Aim: This retrospective study aims to investigate the characteristic of EEG in post-stroke seizures patients. Methods: This study analyzed EEG data of post-stroke seizure patients between 2019-2023. Inclusion criteria was history of motor seizures, while exclusion criteria were history of previous seizures or epilepsy and having severe metabolic disorders. Results: Seventy six post-stroke seizure patients were analyzed in this study. 78.9% were post ischemic stroke, while 21.1% were hemorrhage stroke. There were 23.7% normal EEG, while the remaining 72.3% showed abnormal EEG, consist of 19.7% abnormal EEG II and 56.6% abnormal EEG III. Discussion: There were no significant differences found in the characteristics of post-stroke seizures (such as age, gender, EEG classification, and EEG abnormalities). However, there is a significant difference in the presence of sharp-spike waves between post-ischemic stroke seizures and post-hemorrhagic stroke seizures, while sharp-spike waves are identified as one of the risk factors for recurrent post-stroke seizures. Keywords: Stroke, electroencephalography, post stroke seizure
MALFORMASI KAVERNOSA FRONTAL PADA WANITA BERUSIA 36 TAHUN: SEBUAH LAPORAN KASUS Hardika, Made Sebastian Dwi Putra; Ekasari, Ni Wayan Nurlina; Indrayani, Ida Ayu Sri
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 41 No 1 (2024): Vol 41 No 1 (2024): Volume 41, No 1 - Desember 2024
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v41i1.589

Abstract

Background: Cerebral cavernous malformation (CCM) is a low-flow neurovascular disease caused by dilatation of capillaries in thin-walled cerebral blood vessels, causing extravasation of blood cells, which is the second highest neurovascular disease. It is a dynamic lesion that can develop over time and the current literature until now still discusses ideal management and effective therapeutic interventions. Case Report: A 36-year-old woman, with no previous medical history, experienced her first ever seizure with pattern of focal to generalized motor onset tonic clonic seizure. Initial head computer tomography (CT) imaging results showed a hyperdense lesion with minimal perifocal edema in the left frontal lobe. Digital subtraction angiography (DSA) showed no evidence of arteriovenous malformation or developmental venous anomaly (DVA). She was diagnosed with CCM type I according to the Zabramski classification based on head magnetic resonance imaging (MRI) result. She was given anti-seizure medications and planned for CCM resection as definitive treatment. Discussion: Diagnosis of CCM is quite more difficult than other neurovascular disease. Head MRI imaging serves as the gold standard modality for diagnostic purposes. Treatment for CCM include conservative treatment, surgery, or radiosurgery. Hemorrhagic in multiple lesions, worse initial neurological findings after hemorrhagic episode, brainstem lesion, and concomitant of other vascular malformations are associated with higher morbidity rates. Conclusion: Early detection of CCM can determine the appropriate treatment for patients. Identification of patients at higher risk can optimize the timing of intervention taken so as to reduce morbidity and mortality rates. Keywords: CCM, cavernous, seizure, malformation
ANALISA TARIF INDONESIAN-CASE BASED GROUPS (INA-CBGs) STROKE ISKEMIK SEBELUM DAN SETELAH IMPLEMENTASI PERATURAN MENTERI KESEHATAN NOMOR 3 TAHUN 2023 Berlin, Opel; Merryn, Kenny; Susan, Dewie
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 41 No 1 (2024): Vol 41 No 1 (2024): Volume 41, No 1 - Desember 2024
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Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Introduction: Stroke is a catastrophic disease with the third highest cost burden in Indonesia. The national health insurance scheme implemented until now is Indonesian-Case Based Groups (INA-CBGs). In response to inflation and the mismatch between hospital costs and INA-CBGs rates, the government has adjusted the INA-CBGs rates through Minister of Health (MOH) Regulation number 3 of 2023.Aim: This study aims to compare hospital costs with INA-CBGs rates before and after the implementation of Minister of Health Regulation number 3 of 2023 in hospitalized ischemic stroke patients.Methods: This analytical observational study was conducted on ischemic stroke patients with the INA-CBGs code G-4-14-x who were hospitalized in a type D private hospital in South Sumatra. Data was collected retrospectively from October 2020 to January 2024.Results: The most significant independent variable for hospital costs’ variation was length of stay (p = 0.000). There was an insignificant negative difference between hospital costs and INA-CBGs rates before and after the implementation of MOH Regulation number 3 of 2023 (- Rp. 1,013,529.17 vs. - Rp. 921,871.43; p = 0.113). The Class III – mild group was the only group that had significantly reduced the negative difference after the implementation of MOH Regulation number 3 of 2023 (- Rp 1.523.590,00 vs. – Rp 606.087,50; p = 0.026), but there was still a negative difference both before and after implementation.Discussion: The INA-CBGs rate adjustment is insufficient to cover ischemic stroke patients hospitalized in Type D private hospitals. Further research is needed with a larger sample size and conducted in hospitals of various types and regions.Keywords: Hospital costs, INA-CBGs rates, Ischemic stroke
PROFIL KLINIS DAN NEUROIMAGING PASIEN CAROTID CAVERNOUS FISTULA DI RUMAH SAKIT WAHIDIN SUDIROHUSODO MAKASSAR Ardhany, Andri; GOYSAL, YUDY
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 41 No 1 (2024): Vol 41 No 1 (2024): Volume 41, No 1 - Desember 2024
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v41i1.596

Abstract

Introduction: Carotid cavernous fistula (CCF) is a rare abnormal connection between the carotid artery and the cavernous sinus. Based on its etiology, CCF is divided into traumatic and spontaneous types. CCF presents with varied clinical findings and neuroimaging features. Diagnosis is established based on clinical findings and neuroimaging characteristics. Objective: This study aims to provide a descriptive overview of clinical profile and neuroimaging of CCF patients at Wahidin Sudirohusodo Hospital, Makassar. Method: This descriptive study retrospectively collected data from medical records of Wahidin Sudirohusodo Hospital, Makassar, from January 2023 to March 2024, using total sampling method. Results: A total of 25 subjects meeting the criteria were obtained. The mean age was 33.08±15.37 years, predominantly male (76%). The duration of symptoms was mostly >1 month (88%). Trauma was the most common etiology (76%). Unilateral lateralization was most frequent (84%). The most common symptoms and signs were proptosis (80%), conjunctival injection (60%), and headache (52%). Cranial nerve VI involvement was most frequent (52%). All subjects had direct CCF anatomical characteristics. Imaging features included dilated superior ophthalmic vein (92%), proptosis (76%), and cavernous sinus enlargement (36%). Discussion: Traumatic etiology was more common than spontaneous in CCF, consistent with other studies finding traumatic etiology most prevalent in direct CCF patients. Symptoms and signs such as proptosis, conjunctival injection, headache, and imaging features like dilated superior ophthalmic vein, proptosis, and cavernous sinus enlargement on CT scan or MRI suggest CCF. Keywords: Carotid-Cavernous Fistula, Proptosis, Cavernous Sinus

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