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Ophthalmologica Indonesiana
Published by Perhimpunan Dokter Spesialis Mata Indonesia
ISSN : 01261193     EISSN : 2460545X     DOI : 10.35749
Core Subject : Health,
Health Professions Medicine & Pharmacology Public Health
Ophthalmologica Indonesiana is an open accessed online journal and comprehensive peer-reviewed ophthalmologist journal published by the Indonesian Ophthalmologist Association / Perhimpunan Dokter Spesialis Mata (PERDAMI). Our main mission is to encourage the important science in the clinical area of the ophthalmology field. We welcome authors for original articles (research), review articles, interesting case reports, special articles, clinical practices, and medical illustrations that focus on the clinical area of ophthalmology medicine.
Arjuna Subject : Kedokteran - Ophthalmology
Articles 869 Documents
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Bevacizumab vs Ranibizumab in Macular Edema due to Retinal Vein Occlusion: Short-term Outcomes KURNIAWAN, CHALID
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/vvcfz739

Abstract

Introduction & ObjectivesBevacizumab or Ranibizumab was widely used as therapy for macular edema (ME) in retinal veinocclusion (RVO) and diabetic retinopathy. The purpose of this study was to comparing short-termoutcomes for patients who received intravitreal Bevacizumab (IVB) injection or Ranibizumab (IVR)for ME due to RVO MethodsThis was observational, cross sectional study comparing patients received IVB or IVR. Primaryoutcomes data (visual acuity and central macular thickness/CMT) and secondary outcomes data(number injection and intra ocular pressure/IOP) were collected at baseline and 3 months afterinjection ResultsThere were 4 eyes in each group. There were no significant difference in mean change of visualacuity (-0.275±0.25 vs -0.15±0.5 logMAR; p=0.676) and CMT (-171.50±129.08 vs -98.25±37.67 um;p=0.345) in IVB vs IVR groups. There were also no significant difference in mean change of IOP(2±2.16 vs 2±4.69 mmHg; p=1) and number of injection (2.25±0.50 vs 1.75±0.9; p=0.401 ) in bothgroups. ConclusionIn short-term both IVB and IVB have relative similar outcomes on increasing visual acuity anddecreasing CMT in ME due to RVO
Vitrectomy for the Management of Vitreous Hemorrhage : Clinical Characteristics and Surgical Outcomes Switania, Astriviani; Elvioza; Girsang, Waldensius; Soedarman, Soefiandi; Agustiawan, Referano
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/kd6h2266

Abstract

Purpose: Vitreous hemorrhage (VH) can cause sudden loss of vision. Conservative management is sometimes employed, yet potential risk due to delayed diagnosis and definitive treatment is concerning. Vitrectomy for VH can reduce such risk by confirming the etiology and providing surgical treatment. This study was conducted to evaluate the clinical characteristics and surgical outcomes of vitrectomy for VH in our center. Methods: A descriptive study was conducted. Data were collected retrospectively from patient’s medical records who underwent vitrectomy for VH from January to December 2020, including pre-operative clinical characteristics, surgical and adjunctive intervention, and postoperative findings. Statistical analysis was conducted. Comparison of final visual acuity to baseline visual acuity was analyzed. Results: There were 164 eyes from 164 subjects who underwent vitrectomy due to VH included in this study. The mean age of the subjects was 55,2 ± 9,8 years. Most of the subjects had severe VH pre-operatively (84,7%). Diabetic retinopathy was the most common etiology (45,1%), followed by breakthrough from submacular hemorrhage (29,9%) and retinal vein occlusion (10,3%). Most of the subjects (87,2%) underwent early vitrectomy. Final visual acuity in all subject groups improved significantly compared to baseline visual acuity (p = 0,00; p < 0,05). Final visual acuity in subjects with breakthrough from submacular hemorrhage was lower compared to other etiology. Complications after vitrectomy were recurrent VH (10,3%) and increased intraocular pressure associated with silicone oil (1,82%). Conclusion: Early vitrectomy appears to be beneficial for VH. Visual acuity varies regarding the etiology, nevertheless, was maintained or improved in most subjects.
Anti-RAGE (Receptor Advanced Glycation End products) Antibody Improves Diabetic Retinopathy in Rats via Hypoglycemic and Anti-inflammatory Mechanism Indiarsih, Tiara Bunga; Amin, Ramzi; Ansyori, A.K.
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/xny05743

Abstract

Background: Receptor advanced glycation end products (RAGE) activation plays an essential role in diabetic retinopathy (DR) progression. This study was aimed to explore the role of anti-RAGE antibodies (RAGE antagonists) in inhibiting DR progression through their hypoglycemic and anti- inflammatory mechanism in diabetic retinopathy induced rats. Methods: A total of 30 male Wistar rats were randomly divided into five group. The group was consisted of normal control group, DR group without treatment, DR group with anti-RAGE 1 g/kg BW, 10 g/kg BW, and 100 g/kg BW. To assess the diabetic retinopathy, fundus photographs were taken every week using a camera with 16x magnification placed in front of the rat's eyes. Blood glucose was checked by the glucose oxidase-peroxidase method. Retinal TNF-? levels and VEGF were examined using an enzyme-linked immunosorbent assay (ELISA) kit. Results: The finding of this study showed that anti-RAGE treatment at dose of 10 and 100 g/kg BW, HbA1c levels were significantly higher (p< 0.05) compared to the normal control group but significantly lower (p< 0.05) than in the diabetes group. The mean blood vessel diameter in the DR+anti-RAGE 10 and 100 g/kg BW groups was significantly lower than in the diabetic retinopathy group (p< 0.05). The administration of anti-RAGE 10 and 100 g/kg BW showed the ability to significantly reduce VEGF levels compared to the DR group (p< 0.05). Conclusions: This study revealed at doses of 10 and 100 g/kg BW, anti-RAGE antibodies improved diabetic retinopathy in Wistar rats through hypoglycemic effects and anti-inflammatory mechanisms.
Outcome of laser Treatment for Retinopathy of Prematurity Panggalo, Idayani; Muhidin, Habibah S; Ichsan, Andi Muhammad; Budu; Suryanita, Andi; Windy , Dyah Ayu
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/npeamz55

Abstract

Introduction & ObjectivesRetinopathy of prematurity is a proliferative disorder that requires urgent treatment. Proper casefinding and treatment will prevent permanent blindness in infants. Laser photocoagulation is anpreferred technique for the treatment of ROP. Aim of this study to describe the result of laserindirect Ophthalmoscopy in Makassar, South Sulawesi, Indonesia. MethodsThis is Observational retrospective study, from 1130 screening procedures during 2020 until 2022.This study found 41 ROP patients who had received therapy. ResultsFrom 43 patients who received therapy, most were ROP stage 3 (80%), APROP (19%) and the restwere Stage IV A . 40 infants received lasers photocoagulation, and one infant received both laserphotocoagulation and intravitreal anti-VEGF. Regression was found in all cases of stage 3 ROP.Patients with aggressive posterior ROP also were treated successfully, except one patientprogressed to stage 4 ROP. Conclusionwith screening and prompt treatment, good outcomes have been obtained for infants with ROP
DIAGNOSTIC TEST OF POSTERIOR SEGMENT OCULAR EXAMINATION ON THE SEVERITY OF PEDIATRIC ACUTE LYMPHOBLASTIC LEUKEMIA (ALL) AT DR. MOHAMMAD HOESIN GENERAL HOSPITAL PALEMBANG Putra, Chani Sinaro; Amin, Ramzi; Sari, Dian Puspita; Theodorus
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/axmc2035

Abstract

Background: Acute lymphoblastic leukemia (ALL) is one of the highest incidence of all cancers in children. Ocular involvement can diagnose the development of the disease. Patients with ALL often have ocular manifestations either resulting from direct infiltration or indirect causes of neoplastic cells. The aim of this study to diagnose from posterior segment findings on disease severity in pediatric patients with acute lymphoblastic leukemia (ALL) at Muhammad Hoesin Hospital Palembang Methods: A diagnostic test to determine the sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of posterior segment findings in disease severity diagnostic of pediatric patients with ALL from November 2021 to May 2022. Posterior segment findings that were evaluated included retinal hemorrhages, roth spots, exudate and papilledema. Disease severity of pediatric ALL is divided into high risk and standard risk. All data were analyzed using SPPS version 22.0 Results: There were 68 patients who selected by inclusion criteria. A total of 30 (44.1%) subjects with high risk and 38 (55.9%) with standard risk. in this study there is no patient have papilledema and only one patient (1.5%) has retinal hemorrhage, roth spot and exudate. From statistical analysis, it was found that the three posterior findings had a sensitivity of 0% and a specificity of 97.4%. Conclusion: The results of this study show that the findings of the posterior eye segment can be used as a screening tool for the severity of acute lymphoblastic leukemia, because only one component of sensitivity and specificity has a value of > 80%.
Reducing Treatment Burden for Age-Related Macular Degeneration Patients: A Systematic Review of Ranibizumab Port Delivery System Paramitha, Dewa Ayu Anggi; Putri, Ajeng Kartika Ayu; Ardhia, Seruni Hanna; Jutamulia, Jovita
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/zh73sh38

Abstract

Introduction & ObjectivesRanibizumab port delivery system (PDS) is a newly developed method that provides a continuous,long-term supply of ranibizumab into the vitreous, reducing the burden of monthly intravitrealinjection visits for neovascular age-related macular degeneration (nAMD) patients. This review aimsto evaluate the efficacy and safety of ranibizumab PDS in nAMD. MethodsAn extensive literature search was performed on 4 online databases: PubMed, Cochrane, ProQuest,and ScienceDirect. The inclusion criteria are human studies comparing ranibizumab port deliverysystem and intravitreal ranibizumab, English language, with full-text journal available. The mainoutcome measurements are best-corrected visual acuity (BCVA) in Early Treatment DiabeticRetinopathy Study (ETDRS) letters, central foveal thickness (CFT), and adverse events. ResultsTwo randomized controlled trials (RCTs) with a total of 638 adults were evaluated. At week 96,ranibizumab PDS reported observed mean BCVA changes from baseline (-1.0; +4.2; ETDRS letters)compared to monthly intravitreal ranibizumab (-1.1; +6.1; ETDRS letters). However, there was anincrease in mean CFT changes from baseline (+9.9; +22.3 vs ?1.3; ?35.8, ?m) and severe adverseevents frequency (22; 4 vs 4; 0) with ranibizumab PDS versus monthly intravitreal ranibizumab,respectively. ConclusionRanibizumab PDS showed comparable visual outcomes to intravitreal ranibizumab whiledemonstrating inferior anatomical outcomes and higher incidence of severe adverse effects. Despitethis, with fewer treatment visits required for up to 24 weeks, ranibizumab PDS can potentiallyreduce the treatment burden in nAMD patients with poor compliance. Further studies are needed toprovide better patient eligibility guidelines and recommendations for adverse event management ofranibizumab PDS.
EFFECT OF “PERMATA-KU” EXERCISE ON THE AMPLITUDE OF ACCOMMODATION AND COMPUTER VISION SYNDROME SCORE IN COMPUTER USERS Azkadina, Amira; Nugroho, Trilaksana; Astuti, Fatimah Dyah Nur; Reki, Winarto; Dharma, Andhika Guna
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/e07wgj60

Abstract

Background and Objective: Intense and long-term computer users are at risk of suffering health problems known as computer vision syndrome (CVS) which can have an impact on physical, mental, and economic health. One of the alternative therapies developed is "PERMATA-KU" exercise to reduce complaints related to CVS. The aim of the study was to reveal the effect of "PERMATA-KU" exercise on amplitude of accommodation (AA) and Computer Vision Syndrome scores on computer users. Method: The study of a quasi-experimental with pre-post control design was done. The research subjects were divided into the “PERMATA-KU” exercise group (21 people) and the control group (19 people) with treatment for 4 weeks. CVS scores were measured using the CVS-Questionnaire and monocular AA scores were measured using the push-up method using a Berrens ruler. Mann-Whitney difference test analysis was performed. Results: The exercise group experienced a significant increase in monocular AA value (p=0.010) while the control group experienced a significant decrease in AA (p=0.025). The mean delta of monocular AA values between groups was significantly different after the intervention (p=0.001). There was a significant difference in CVS scores between the postintervention groups (p=0.006) with the mean delta CVS scores between groups being significantly different (p=0.002). There was no correlation between AA scores and CVS scores (p=0.126). Conclusion: "PERMATA-KU" exercise for 4 weeks was shown to significantly increase the value of amplitude of accommodation and decrease CVS scores, but the increase in accommodation amplitude did not correlate with a decrease in CVS scores.
Implementation of Integrated People-Centered Eye Care at Sub-District Level in Barru Rakatama, Rahmat Priyangga; Amalius, Ahmad Ashraf; Faisal, Andi Akhmad; Kamaruddin, Muhammad Irfan
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/6nhwk522

Abstract

Purpose: Integrated People-Centered Eye Care (IPCEC) was initiated by the World Health Organization as a global strategy in community-centred and integrated health services. In Indonesia, the Rapid Assessment of Avoidable Blindness survey showed the largest number of moderate and severe visual impairment was found in South Sulawesi, particularly uncorrected refractive error (33.8%). The results of this study are expected to initiate and introduce IPCEC-based eye health services and promotion at the sub-district level. Methods: The program started with advocacy of eye health programs at the sub-district level to policy makers. In schools, education and training for visual acuity examination were given to teachers. All children who failed the screening or have ocular abnormalities are referred to eye care center. Mass counseling and examination were also carried out at the health center simultaneously with screening for mass cataract surgery at the Barru District Hospital. Results: Implementation of IPCEC was welcomed by Barru District government. School eye health program conducted by the teachers in 5 schools screened 1263 students with 90.74% of the students had normal visual acuity. Mass screening at the Pekkae and Pancana Public Health Centers found that most participants had cataracts (58%) followed by refractive error (38%). Conclusion: Visual acuity examination among school-age children by the teacher will improve early detection of refractive errors. Screening by eye health worker at public health center needs to be carried out to identify blindness causes often found in the community, and proceed with prescribing drugs, eyeglasses, and mass cataract surgery as definitive step in eradicating blindness.
EFFECT OF “SENAM PERMATA-KU” COMPARED WITH WARM COMPRESS ON THE AMPLITUDE OF ACCOMMODATION IN COMPUTER VISION SYNDROME PATIENTS Setiawan, Teguh; Nugroho, Trilaksana; Dharma, Andhika Guna; Rahmi, Fifin L.; Sadasih, Wisnu
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/425ad398

Abstract

Introduction and Objective: The COVID-19 pandemic has virtually made many work activities, resulting in increased use of Visual Display Terminals (VDT) at work and home. Excessive close-range activities due to the use of VDT causes Computer Vision Syndrome (CVS). Various therapies, such as ocular yoga and warm compress, have been created to reduce CVS-related complaints. Diponegoro University developed “Senam PERMATA-KU” as an alternative therapy to reduce complaints related to CVS. This study compares the effect of “Senam PERMATA-KU” and periocular warm compress on the amplitude of accommodation (AA) value in patients with CVS. Methods: The study subjects were divided into “Senam PERMATA-KU” group (22 people) and periocular warm compress group (20 people) with each treatment for two weeks. CVS score was measured using CVS-Questionnaire and AA using Prince’s rule. Both variables were assessed before and after treatment. Data were collected and analyzed using a statistical computer program. Result: “Senam PERMATA-KU” group experienced a significant increase in monocular and binocular AA (p<0.001 and p=0.006), while periocular warm compress did not show a significant difference (p=0.982 and p=0.483). The mean delta of monocular and binocular AA between groups differed significantly (p=0.001 and p=0.034). The mean CVS scores in both groups have significant improvement (p<0.001), while the mean delta CVS scores between groups was not significant (p=0.522). Conclusion: “Senam PERMATA-KU” for two weeks significantly increased monocular and binocular AA, while periocular warm compress showed no significant difference. “Senam PERMATA-KU” and periocular warm compress can significantly reduce CVS score, whereas the difference between the two is insignificant.
UNVEILING OPHTHALMOLOGICAL FINDINGS IN CORNELIA DE LANGE SYNDROME: A RARE CASE REPORT Dian Estu Yulia; Tan, Sabrina
Majalah Oftalmologi Indonesia Vol 50 No 1 (2024): Ophthalmologica Indonesiana
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/cbyqa786

Abstract

Introduction: Cornelia de Lange syndrome (CdLS) is a rare congenital disorder with a distinctive combination of physical, cognitive, and behavioral features. This syndrome impacts multiple systems in the body, including the eyes. Case Report: A three-year-old boy with classic CdLS, emphasizing the ophthalmological findings of left eye ptosis, high myopia and astigmatism, microcornea, bilateral “dot opacities” cataracts, and tigroid fundus appearance. The patient was prescribed corrective eyeglasses to prevent amblyopia. Discussion: The clinical scoring system devised by the International CdLS Consensus Group aids in classifying CdLS cases into classic and non-classic variants, as well as guiding clinical genetic testing decisions. In all instances of suspected or confirmed CdLS, it is imperative that an ophthalmologist performs an initial eye examination promptly. Therefore, acquiring familiarity with the potential ophthalmological findings of CdLS is crucial. Common ocular presentations encompass features such as synophrys, thick eyebrows, long eyelashes, ptosis, myopia, microcornea, nasolacrimal duct obstruction, peripapillary pigment ring, and blepharitis. Meanwhile, less frequently encountered ocular manifestations include hyperopia and astigmatism, cataracts, microphalmia, glaucoma, optic nerve pallor and hypoplasia, nystagmus, and strabismus. Conclusion: Timely diagnosis, precise interventions, and regular ophthalmological monitoring are pivotal in preventing complications and enhancing visual function, thus improving the quality of life of individuals with CdLS.

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