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Ophthalmologica Indonesiana
Published by Perhimpunan Dokter Spesialis Mata Indonesia
ISSN : 01261193     EISSN : 2460545X     DOI : 10.35749
Core Subject : Health,
Health Professions Medicine & Pharmacology Public Health
Ophthalmologica Indonesiana is an open accessed online journal and comprehensive peer-reviewed ophthalmologist journal published by the Indonesian Ophthalmologist Association / Perhimpunan Dokter Spesialis Mata (PERDAMI). Our main mission is to encourage the important science in the clinical area of the ophthalmology field. We welcome authors for original articles (research), review articles, interesting case reports, special articles, clinical practices, and medical illustrations that focus on the clinical area of ophthalmology medicine.
Arjuna Subject : Kedokteran - Ophthalmology
Articles 869 Documents
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Efficacy of Sambiloto Extracts, Andrographis paniculate, (Burm. F) in Inhibiting Diabetic Retinopathy Progression: An in Vivo Study: Oral Presentation - Experimental Study - Resident Shariff, Muhammad Apriliandy; Amin, Ramzi; Ansyori, AK.
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/1ww79n21

Abstract

Introduction & ObjectivesDiabetic retinopathy (DR) is one of diabetes mellitus complication and occurred in retinalmicrovascular. This study was aimed to investigate the efficacy of Sambiloto, Andrographispaniculate (A. paniculata) extract on glycemic profile, antioxidant and inflammatory cytokineparameters in diabetic rats, and phytochemical analysis of A. paniculata. MethodsA. paniculata extract (APE) was carried out by maceration with ethanol. Diabetes mellitus in Wistarmale rats was induced with streptozotocin. Retinal vessel diameters were estimated using a methodby Vucetic. Inflammatory cytokine and antioxidant parameters were evaluated in retinal tissue. Thealkaloid and flavonoid contents in extract were analyzed using thin layer chromatography method. ResultsFunduscopic examination presented some changes in the diameter of the blood vessels. The vesseldiameter in the diabetic retinopathy group with APE in concentration of 100 and 200 mg/kg BWgroups was significantly lower than in the DR group (p<0.05). The administration of APE in dosagesof 100 and 200 mg/kg BW showed reduced glutathione, SOD, and catalase levels compared to theDR group (p<0.05). ConclusionA. paniculata extract doses of 100 and 200 mg/kg BW improved diabetic retinopathy in rats throughhypoglycemic effects, antioxidant effects, and anti-inflammatory mechanisms.
Treatment of Vitreous Hemorrhage due to Proliferative Diabetic Retinopathy in Cipto Mangunkusumo Hospital During Pandemic Era (March 2020 - March 2022): Oral Presentation - Observational Study - Resident RAHAYU, TSANIA RACHMAH; Andayani, Gitalisa
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/11wn7q74

Abstract

Introduction & ObjectivesProliferative diabetic retinopathy (PDR) is the most common etiology for vitreous hemorrhage (VH)and can be sight-threatening. Current treatment modalities for VH in PDR included anti-VEGFinjection, panretinal photocoagulation (PRP) laser, and vitrectomy. We conducted study to evaluatetreatment modalities and outcomes of VH in PDR during the pandemic era. MethodsA retrospective study of VH in PDR was conducted at Cipto Mangunkusumo Hospital, Indonesia,from March 2020 to March 2022. Primary treatment was the therapy planned at the initial visit,while secondary treatment was subsequent treatment after follow-ups. Good anatomical outcomewas defined as vitreous clearing at last follow-up, while functional outcome was visual acuity (VA)improvement in LogMAR. ResultsThis study included 83 patients (97 eyes), which is smaller than the previous study in our centerbefore the pandemic. Mean age was 54,28±8,57 years, with almost equal males and females. InitialVA was LogMAR 2,48 (0,15 – 2,80). The most frequent treatment for VH in PDR was vitrectomy(53,5%), followed by anti-VEGF injection, PRP laser, and observation. Glaucoma after vitrectomy wasthe most common complication (5,2%). Vitreous clearing was achieved in 85,5% of cases, which wassignificantly associated with vitrectomy surgery (p=0,013) and initial treatment time (p=0,023). TheVA improvement was LogMAR -0,48(-2,48–2,40) which was related to initial VA (p<0.05), yet therewas no significant association with treatment modality. ConclusionVitrectomy is essential to achieve vitreous clearing in VH caused by PDR. Initial visual acuity, notthe type of treatment modality, is a significant factor in vision improvement.
Mean Platelet Volume As Retinopathy Diabetic Predictive Factor in Peripheral Hospital: Could it be? Oral Presentation - Observational Study - General practitioner Maulana, Denny Indra; Masniah
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/6fwsdw68

Abstract

Introduction & ObjectivesSeveral studies conducted that diabetic retinopathy (DR) pathogenesis may be linked tomicrocirculation disorders and microvascular damage. Platelets have a significant role inmicrocirculation changes that lead to microvascular injury. Mean Platelet Volume (MPV) is used as amarker to indicate the platelet’s average size and activity. The association between MPV and DR in apatient’s blood sample has been established. Aim of this study is to evaluate the association of MPVwith DR in our population. MethodsThis was a cross-sectional study in Brigjend H. Hasan Hospital within 183 patients which classifiedinto three groups including: I. DM without DR (n=61), II. DM with Non-proliferative DR (n=61), andIII. DM with proliferative DR (n=61). Data about gender, age and laboratory markers (MVP, HbA1C,fasting blood glucose) were collected, then analyzed using SPSS. ResultsMPV value was significantly higher in group II and III compared to group I (p<0.001). The MPVvalue was also significantly higher in PDR Group compared to NPDR Group (adj. OR 7.91, 95% CI:3.79-16.5). The FBG value also significantly higher in group II and III compared to group I(p=0.012). On the other hand, HbA1C value mean was higher in group II and III but not statisticallysignificant (p=0.052). ConclusionThis study demonstrated relationship between higher MPV with DR and its severity. Consideringthat MPV can be easily measured and suitable as parameter reflective platelet function, DR and itsprogressivity can be clinically monitored using this method.
Clinical Outcomes of Scleral Buckling combined with Vitrectomy Pars Plana for Rhegmatogenous Retinal Detachment: Oral Presentation - Observational Study - Resident Andry Lukandy; Sumanti, Eugeni
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/0tkfba50

Abstract

Introduction & ObjectivesThe various types of primary interventions for rhegmatogenous retinal detachment (RRD) includepars plana vitrectomy (PPV), scleral buckling (SB), and combination of both. Intraocular tamponadewith silicone oil (SO) or expanding gas. This research was conducted to evaluate the clinicaloutcomes of SB combined with PPV as a treatment for RRD. MethodsThis research was prospective descriptive study with total sampling for RRD treated by SB combinedwith PPV from August 2022 to January 2023 in RSUP. Prof. Dr. R.D. Kandou. We observed the BCVA,IOP before and after the surgeries. Clinical findings, intraocular tamponade and complications afterthe surgeries were observed. ResultsMost of the patients was male with average age of 28 ± 40 years. RRD was observed in 6 eyes andlaterality on right eye. BCVA was 2.5 ± 2 logMAR before the surgery and 2.3 ± 1 logMAR 1 monthafter the surgery. Preoperative IOP was 7 ± 11 mmHg and 13.6 ± 10 mmHg 1 month after thesurgery. Macular detachment, 1 Quadrant Detachment, 1 Number of retina break mostly on superotemporalquadrant were found the most. Proliferative vitreoretinopathy was found in 1 eye.Intraoperative triamcinolone used in 4 eyes and perfluorocarbon in 1 eyes. Subconjunctival bleedingwas found the most, followed by corneal edema and subretinal hemorrhage as postoperativecomplications respectively. ConclusionThere were several clinical condition seen such as BCVA after the surgery that didn’t improve asexpected, High IOP found in several eyes and subconjunctival bleeding was the complication foundthe most in these eyes.
DIABETES DURATION AND RETINAL NERVE FIBER LAYER THICKNESS RELATED DEGREE OF DIABETIC RETINOPATHY: Oral Presentation - Observational Study - Resident Nadia, Felanda Ahsanu; Sari, Masitha Dewi; Delfi
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/857sg474

Abstract

Introduction & ObjectivesDiabetic retinopathy is an ocular complication of diabetes mellitus (DM). Several studies have shownthat neurodegenerative changes in the retina occur earlier than microvascular changes.Measurement of retinal nerve fiber layer thickness can detect neurodegeneration at an early stage.This study aims to analyze the relationship of diabetes duration and retinal nerve fiber layerthickness with degree of diabetic retinopathy in type 2 diabetes mellitus patients. MethodsThis research was analytic observational research with cross-sectional design. The sample was type2 diabetes mellitus patients with diabetic retinopathy who visited the eye clinic at the University ofSumatera Utara General Hospital. The sample were then analyzed with the Kruskal Wallis test tofind relationship of diabetes duration and retinal nerve fiber layer thickness with degree of diabeticretinopathy in type 2 diabetes mellitus patients. ResultsThe sample of this study were 20 subjects with diabetic retinopathy and 20 subjects without diabeticretinopathy as the control group. The mean duration of having DM in the group of patients with mildNPDR was 5.33 years, with moderate NPDR was 9.13 years and with PDR was 15.33 years. Usingthe Kruskal Wallis test revealed that there was no significant relationship between degree ofdiabetic retinopathy with Avg RNFL (p=0.495), superior RNFL (p=0.385), inferior RNFL (p=0.111),temporal RNFL (p=0.064), nasal RNFL (p=0.535). ConclusionThere was a significant difference between diabetes duration with degree of diabetic retinopathy butno significant between retinal nerve fiber layer thickness with degree of diabetic retinopathy.
Clinical Characteristics and Compliance of Diabetic Macular Edema Patients to Intravitreal Anti-VEGF Injection Loading Dose at Cipto Mangunkusumo Hospital: Oral Presentation - Observational Study - Resident Kania, Theresia; Yudhanta, Anggun R
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/e74s1782

Abstract

Introduction & ObjectivesDiabetic retinopathy is the fifth most common cause of preventable blindness. In cases of diabeticmacular edema (DME), loading dose is a critical phase to achieve a stable concentration ofintravitreal vascular endothelial growth factor (VEGF) in order to prevent progressivity. This studyaims to determine the demographic and clinical characteristics, waiting time, compliance, as well asthe relationship between education, domicile and clinical outcomes to compliance during loadingdose in DME patients. MethodsIn this retrospective descriptive study, we reviewed medical records of DME patients who receivedanti-VEGF intravitreal injection between 1 January 2019 and 31 December 2020, while alsocomparing records in 2019 (pre-Covid-19) and 2020 (during Covid-19). ResultsThere were 160 patients (207 eyeballs) in 2019 and 83 patients (114 eyeballs) in 2020 who receivedloading dose with similar profiles of sex, age, education, initial visual acuity and central macularthickness (CMT). Median waiting times in 2019 and 2020 were 19 days and 23.5 days, respectively(p=0.016). Only 25 (30.5%) and 15 (35.7%) patients were punctual in 2019 and 2020, respectively.There was no significant relationship between education and domicile with compliance (p= 0.45, p=0.51). Furthermore, there were visual acuity improvements of -0.18 logMAR and -0.0 logMAR in thepunctual and unpunctual group, respectively, as well as CMT decrease of -181 ?m and -156 ?m,respectively. ConclusionMost patients who received loading dose were unpunctual. There was no significant relationshipbetween education and domicile with compliance. Furthermore, there were more significantimprovements in clinical outcomes among the punctual patients.
From the Eye to the Heart: Association between Age-Related Macular Degeneration and Cardiovascular Disease (a Systematic Review): Oral Presentation - Observational Study - General practitioner Sausan; Presialia, Athira; Khalifah, Rasyad; Adriono, Gitalisa Andayani
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/ax8d9687

Abstract

Introduction & ObjectivesAge-related macular degeneration (AMD) is the third leading cause of global blindness, whilecardiovascular disease (CVD) is recognized as a major cause of morbidity and mortality. Both arecomplex diseases associated with aging. It has recently been argued that there is an associationbetween AMD and CVD. This study examined whether AMD increased the risk of CVD and/ or CVDmortality. MethodsA systematic review was conducted through three databases (Pubmed, Scopus, and Embase) forrelevant studies published between 2016-2023. We selected studies which focused on subjects withAMD, regardless of stages, and their risks for developing CVD and/or CVD mortality. ResultsTwo cohort studies and one case-control study are included, involving 93.388 patients aged >40years old. One cohort study found that subjects with choroidal neovascularization were associatedwith an increased rate of cardiovascular mortality (HR 3.16 95% CI 1.62-6.15). Another study alsofound that AMD was associated with a 1.58 fold increased risk of heart failure (adjusted OR, 1.56;95% CI, 1.16–1.87; P<0.001) after adjustment for confounders. Moreover, aside from the variableson which this systematic review focused on, the cohort studies also found AMD correlation withother diseases and causes of mortality. ConclusionIndividuals with AMD have higher risk for developing CVD. Thus, screening for AMD may bebeneficial in preventing CVD.
Outlook of Diabetic Retinopathy Management through Universal Health Care in Indonesia from 2015 – 2020: Oral Presentation - Observational Study - Resident Zaharo, Alfia Fatma; Wardhana, Firman Setya; Supanji; Sasongko, Muhammad Bayu
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/fcwc9x44

Abstract

Introduction & ObjectivesTo identify the National Health Expenditure associated with diabetic retinopathy (DR) from theperspective of Jaminan Kesehatan Nasional [JKN]. MethodsA dataset of 1% of all individuals registered in JKN database was used from 2015 to 2020. Weretrieved primary diagnosis with type 2 diabetes mellitus (T2DM) (ICD-10 E11) and/or T2DM withophthalmic complications (E11.3). Further diagnosis with DR (H36) was retrieved. Four groups ofmedical procedures related to DR management were developed according to Indonesian Case BaseGroups (INA-CBGs): diagnostic, laser photocoagulation and cryotherapy, minor (intravitrealinjection), and major surgical procedures (e.g., vitrectomy). We performed descriptive analyses forthe annual costs incurred for procedures, premium classifications, and regions. ResultsOverall DR costs were US $41.5 million from 156,752 individuals with DR in JKN database sample.The total cost and per unit procedures cost specifically increased annually from 2015 to 2019 butdeclined substantially in 2020. The largest amount was spent on intravitreal injection ($36.3 million[87.5%]), whereas vitrectomy was the least ($145.0 million [0.3%]). Region 1 (Java Island) with nonbeneficiariesof government subsidies (PBPU and PPU) was the major number of claims ($12.5million [30.1%] and ($7.3 million [17.7%]), while beneficiaries of government subsidies (PBI) outsideJava Island, conversely, were under average. ConclusionThere was significant increase in health expenditure associated with DR in Indonesia from 2015 to2019, but decreased in 2020 possibly due to COVID-19 pandemic. Majority of funding was spent totreat severe spectrum of DR and concerned in urban area.
Brolucizumab for Wet Aged-Related Macular Degeneration Patients : too Good to be True: Oral Presentation - Observational Study - Resident Purbonegoro, Tania; Prayogo, M. Eko; Agni, A. Nurini; W., Tri Wahyu; Supanji; W., Firman S.; Sasongko, M.B
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/jtysr533

Abstract

Introduction & ObjectivesBrolucizumab is the newest anti-vascular endothelial growth factor (anti-VEGF). It showed superioranatomic outcomes and noninferiority best corrected visual acuity (BCVA) results for Wet Aged-Related Macular Degeneration (Wet-AMD) compared to other anti-VEGF. In Yogyakarta, it's beenonly used in a few patients and we want to report the effectiveness and safety of brolucizumab inWetAMD MethodsIn this retrospective study, all wetAMD patients who underwent Brolucizuab intravitreal injectionsbetween December 2021 and January 2023 at Dr YAP Eye Hospital were studied. Patient’sdemographic data, before and after intravitreal brolucizumab injections (central macular thickness,intraocular pressure, and BCVA) were assessed. ResultsThis study included 6 eyes of 6 patients (3 women) with a mean age of 69.5 years old. The meanfollow-up period was 27 ± 10.1 weeks after the first injection of brolucizumab. Three patients werenaïve wetAMD patients, three anti-VEGF experienced wetAMD patients. The mean BCVA at baseline(before brolucizumab injection) was 0.12 decimal (6/48) and 0.29 decimal (6/20) at the last followup.Five out of six patients' visual acuity were improved. In four out of six patient central macularthickness were reduced (mean difference 29,2 um). None of the patient's intraocular pressureincreased over 21 mmHg. None of the patients reported any signs of inflammation, vasculitis, ocularor systemic adverse effects. ConclusionThis limited data demonstrated that brolucizumab was relatively safe and effective in stabilizingBCVA for both WetAMD patients who had previous treatment with other anti-VEGF agents andnaive. Larger sample sizes studies & future multicenter collaborative are warranted
Sutureless Scleral Fixation of Intraocular Lens in Aphakia: Characteristics and Visual Outcomes: Oral Presentation - Observational Study - Resident Rahma, Fatkhati Saida; W., Firman S.; A, Angela Nurini; W, Tri Wahyu; Supanji; Sasongko, M. Bayu
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/gqh2r204

Abstract

Introduction & ObjectivesSutureless scleral fixation (SSF) surgery is one of the secondary intraocular lens (IOL) implantationprocedures for aphakic patients with absent or deficient capsular bag support that is beingincreasingly performed these days. This study aimed to describe the characteristics, indications for,and visual outcomes of patients who had undergone sutureless scleral fixation of intraocular lensesat Sardjito Hospital. MethodsA retrospective cross-sectional study of 43 eyes that SSF intraocular lens at Sardjito Hospital,Yogyakarta. The data were collected from electronic medical records of patients from October 2020to December 2022. The data were analyzed descriptively by presenting numbers and percentages forcategorical variables and mean ± standard deviation (SD) for numerical variables. Outcomesincluded pre- and postoperative uncorrected visual acuity (UCVA). ResultsThere were 43 eyes obtained from 40 patients who underwent SSF intraocular lens in this study,consisting of 35 males (79.55%) and 9 females (20.45%). The mean age of the subjects was 50.04 ±19.2 years. Lens subluxation was the most common indication for surgery (32.5%), followed bydropped nucleus (20.45%), intraocular lens luxation (18.18%), lens luxation (15.91%), intraocularlens decentration (9.09%), and endophthalmitis (4.55%). Before surgery, most of the patients hadvisual acuity of less than 3/60 (81.4%) and after surgery, 32.56% had ?6/18, 34.88% had <6/18-6/60,and 18.60% had <6/60-3/60. ConclusionMales predominantly underwent SSF intraocular lens surgery at Sardjito Hospital. Lens subluxationwas the most common indication for the surgery. There was an improvement in visual outcome.

Page 38 of 87 | Total Record : 869

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