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Pengaruh Pemberian Diet Restriksi Vitamin B12 Pada Tikus: Kajian Insulin dan Glukosa Plasma Imelda Rosalyn; Dewi Irawati SS; Irena Ujianti; Patwa Amani
Sanus Medical Journal Vol. 2 No. 1 (2021): Vol. 2 No. 1 (2021): Sanus Medical Journal
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/sanus.v1i1.5431

Background: Deficiency of vitamin B12 remains a health problem in both developed and developing countries. Many journal studies showed an association between deficiency of vitamin B12 and metabolic disorder, one of which is insulin resistance, one of the most significant metabolic diseases. Resistance to insulin may be assessed by changes in plasma glucose and insulin levels. This study explored a possible relationship between vitamin B12 restriction and glucose metabolism. Materials and Methods: This study used an experimental method of 18 male Sprague Dawley rats (Rattus norvegicus, 300-400 gram, age 7-8 months), divided into three groups: control (G1), four weeks treatment group (G2 ) and 12-week treatment group (G3). In the control group, regular feed, the standard diet was given, while the treatment group was assigned vitamin B12, AIN-93M deficiency feed according to the treatment age. Results: Plasma glucose increased in treatment group after 4 weeks (control vs P1= 104.7 ± 5.04 vs 206.8 ± 4.5 p = 0.000) and 12 weeks (control vs P3 = 99.9±6.3 vs 144.7±6.8 p<0.01). Plasma insulin decreased in treatment group after 4 weeks (control vs P1=63.8 ± 1.5 vs 59.9 ± 0.7 p > 0.05) and 12 weeks (control vs P3 = 61.5±0.64 vs 57.4±1 p>0.05). Conclusion: Increased homocysteine deficiency due to dietary vitamin B12 can cause insulin resistance syndrome. As a result, glucose and plasma insulin levels are disrupted Keywords: Homocysteine, vitamin B12 Deficiency, Glucose, Insulin, Insulin Resistance

Telekardiologi dan Aplikasinya: Pendekatan Rumah Sakit selama Pandemi Sidhi Laksono Purwowiyoto; Anhari Achadi; Adik Wibowo
Sanus Medical Journal Vol. 2 No. 1 (2021): Vol. 2 No. 1 (2021): Sanus Medical Journal
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/sanus.v1i1.6519

Covid19 has changed how we serve patients in all areas of health, and cardiology is no exception. Telemedicine is an option that hospitals can do during this pandemic. Telecardiology is part of telemedicine. By transmitting clinical data and electrocardiograms, telecardiology allows access to cardiology consultation services (telecardiology) without the need to travel to the practice area for both patients and cardiologists. These services can be in the form of teleconsultation, teleelectrocardiography, telerehabilitation, or teleechocardiography. Telecardiology can be applied in prehospital (teleconsultation, teleelectrocardiography,) if there is a referral for a heart attack patient or consult for chronic heart disease through online mediaÍ¾ at the hospital in the form of discussions with peripheral hospitals and referral hospitals (teleechocardiography with other small hospitals)Í¾ and posthospital treatment can be performed for cardiac telerehabilitation in patients with heart failure or teleconsultation of posttreatment patients.

Analisis Kadar Nrf2 plasma Pada Tikus dengan Defisisensi Vitamin B12 Endin Nokik Stujanna; Irena Ujianti; Etty Farida Mustifah
Sanus Medical Journal Vol. 2 No. 1 (2021): Vol. 2 No. 1 (2021): Sanus Medical Journal
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/sanus.v1i1.6545

Background. Vitamin B12 deficiency is a significant problem, particularly in developing countries. The increasing complexity of the Vitamin B12 molecule, the deficiency condition, causes a complex cell level disorder. The clinical manifestation of vitamin B12 deficiency is anemia, but it is believed that due to the complexity of vitamin B12, there are still other molecular disorders. This study aims to establish the pathway of damage caused by vitamin B12 deficiency in the Nrf2 molecule. Methods. An animal experiment involving 12 male Sprague Dawley rats were randomly divided into control and 16-week treatment. There are two research groups, namely the control group and the treatment group. The control group was given a standard diet, while the treatment group was assigned a vitamin B12 deficiency diet. At the end of treatment, The levels of vitamin B12 in the liver tissue and plasma NRF2 were measured. Statistical Analysis. Nrf2 and vitamin B12 levels were statistically analyzed using the Student's T-test, and the correlation between vitamin B12 and Hb was analyzed using the Spearmen test. Data that cannot use by Independent T-test were tested using the Mann Whitney test. Results/Conclusion. There was no significant difference between the control and treatment groups on plasma Nrf2 levels (4.02 ± 0.59 pg/ml vs 3.34 ± 0.55 pg/ml; p = 0.07) and tissue vitamin B12 (0.0035 ± 0.0016 µg/ml vs 0.0030 ± 0.0006 µg/ml ; p = 0.8). Keywords: Nrf2 Plasma, Defisiensi, Vitamin B12

Hipertensi Masa Kini dalam Perspektif Kesehatan Masyarakat Bety Semara Lakhsmi; Annisa Intan Yudyawati
Sanus Medical Journal Vol. 2 No. 1 (2021): Vol. 2 No. 1 (2021): Sanus Medical Journal
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/sanus.v1i1.6606

Hipertensi adalah penyakit yang didefinisikan sebagai peningkatan tekanan darah secara menetap. Seseorang dikatakan menderita hipertensi apabila tekanan darah sistol di atas 140 dan diastole di atas 90 mmHg. Hipertensi dibedakan menjadi dua macam, yaitu hipertensi primer (esensial) dan hipertensi sekunder. Hipertensi dipicu oleh beberapa faktor risiko, seperti seperti umur, jenis kelamin, riwayat keluarga, genetik (faktor risiko yang tidak dapat diubah/dikontrol), kebiasaan merokok, konsumsi garam, konsumsi lemak jenuh, penggunaan jelantah, kebiasaan konsumsi minum – minuman beralkohol, obesitas, kurang aktivitas fisik, stres, serta penggunaan estrogen.

Gambaran Quantitative Electroencephalography (QEEG) Anak Laki-laki Penderita Attention-Deficit Disorder (ADD) Gea Pandhita S; Sri Sutarni
Sanus Medical Journal Vol. 2 No. 1 (2021): Vol. 2 No. 1 (2021): Sanus Medical Journal
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/sanus.v1i1.6610

Background. The Diagnostic and Statistical Manual of Mental Disorders (DSM) grouping the types of ADD is based on the clinical symptoms of neurobehavioral disorders, regardless of the possible underlying etiology. This means that the same ADD type group may have a different etiology of functional brain disorders. Meanwhile, QEEG has been known to describe the possible etiology that underlies an ADD event. This study aims to identify differences in QEEG features in the same ADD type group. Methods. Subjects consisted of 40 boys with ADD. QEEG was recorded from 21 sites, and Fourier transformed to provide estimates for relative power in the delta, theta, alpha, and beta bands in the frontotemporal and central regions. These data were converted to Z-scores based on the normal value data; afterward, they were subjected to cluster analysis. Independent sample t-tests were used to determine how the total ADD group and the ADD cluster subgroups differed from the normal value. Results. The total ADD group had increased relative delta (Z-score-frontotemporal region = 3,26 ± 1,59; Z-score-central region = 4,04 ± 1,71), decreased relative alpha (Z-score-frontotemporal region = -2,78 ± 1,29; Z-score-central region = -2,86 ± 1,36), decreased relative beta (Z-score-frontotemporal region = -5,33 ± 1,61; Z-score-central region = -6,19 ± 1,86), increased rasio teta/alpha (Z-score-frontotemporal region = 2,806 ± 1,41; Z-score-central region = 2,59 ± 1,26), and increased rasio teta/beta (Z-score-frontotemporal region = 4,36 ± 1,69; Z-score-central region = 4,94 ± 1,46). Two distinct QEEG clusters subgroups were found. The first cluster was characterized by increased central relative delta (Z-score-central region = 3,02 ± 1,17), decreased relative beta (Z-score-frontotemporal region = -4,29 ± 0,73; Z-score-central region = -5,06 ± 1,19) and increased rasio teta/beta (Z-score-frontotemporal region = 3,83 ± 1,91; Z-score-central region = 4,94 ± 1,96). The second cluster was characterized by increased relative delta (Z-score-frontotemporal region = 4,71 ± 1,02; Z-score-central region = 5,72 ± 0,98), decreased relative alpha (Z-score-frontotemporal region = -3,92 ± 1,12; Z-score-central region = -4,24 ± 0,69), decreased relative beta (Z-score-frontotemporal region = -7,08 ± 1,06; Z-score-central region = -8,09 ± 0,99), increased rasio teta/alpha (Z-score-frontotemporal region = 3,08 ± 1,04; Z-score-central region = 2,86 ± 1,02), and increased rasio teta/beta (Z-score-frontotemporal region = 5,23 ± 1,16; Z-score-central region = 5,71 ± 1,35) Conclusions. These results indicate that boys with ADD do not constitute a homogenous group in QEEG profile terms. Two distinct QEEG clusters were found. The first cluster was typified by a cortically hypoaroused, while the second cluster was typified by a maturational-lag in central nervous system development. This difference in possible etiology may have implications for studies of the utility of QEEG in the diagnosis of ADD and the differences in therapeutic response between the two groups.

Pengaruh Pemberian Diet Restriksi Vitamin B12 Pada Tikus: Kajian Insulin dan Glukosa Plasma Imelda Rosalyn; Dewi Irawati SS; Ujianti, Irena; Patwa Amani
Sanus Medical Journal Vol. 2 No. 1 (2021)
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/sanus.v1i1.5431

Background: Deficiency of vitamin B12 remains a health problem in both developed and developing countries. Many journal studies showed an association between deficiency of vitamin B12 and metabolic disorder, one of which is insulin resistance, one of the most significant metabolic diseases. Resistance to insulin may be assessed by changes in plasma glucose and insulin levels. This study explored a possible relationship between vitamin B12 restriction and glucose metabolism. Materials and Methods: This study used an experimental method of 18 male Sprague Dawley rats (Rattus norvegicus, 300-400 gram, age 7-8 months), divided into three groups: control (G1), four weeks treatment group (G2 ) and 12-week treatment group (G3). In the control group, regular feed, the standard diet was given, while the treatment group was assigned vitamin B12, AIN-93M deficiency feed according to the treatment age. Results: Plasma glucose increased in treatment group after 4 weeks (control vs P1= 104.7 ± 5.04 vs 206.8 ± 4.5 p = 0.000) and 12 weeks (control vs P3 = 99.9±6.3 vs 144.7±6.8 p<0.01). Plasma insulin decreased in treatment group after 4 weeks (control vs P1=63.8 ± 1.5 vs 59.9 ± 0.7 p > 0.05) and 12 weeks (control vs P3 = 61.5±0.64 vs 57.4±1 p>0.05). Conclusion: Increased homocysteine deficiency due to dietary vitamin B12 can cause insulin resistance syndrome. As a result, glucose and plasma insulin levels are disrupted Keywords: Homocysteine, vitamin B12 Deficiency, Glucose, Insulin, Insulin Resistance

Telekardiologi dan Aplikasinya: Pendekatan Rumah Sakit selama Pandemi Purwowiyoto, Sidhi Laksono; Achadi, Anhari; Wibowo, Adik
Sanus Medical Journal Vol. 2 No. 1 (2021)
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/sanus.v1i1.6519

Covid19 has changed how we serve patients in all areas of health, and cardiology is no exception. Telemedicine is an option that hospitals can do during this pandemic. Telecardiology is part of telemedicine. By transmitting clinical data and electrocardiograms, telecardiology allows access to cardiology consultation services (telecardiology) without the need to travel to the practice area for both patients and cardiologists. These services can be in the form of teleconsultation, teleelectrocardiography, telerehabilitation, or teleechocardiography. Telecardiology can be applied in prehospital (teleconsultation, teleelectrocardiography,) if there is a referral for a heart attack patient or consult for chronic heart disease through online mediaÍ¾ at the hospital in the form of discussions with peripheral hospitals and referral hospitals (teleechocardiography with other small hospitals)Í¾ and posthospital treatment can be performed for cardiac telerehabilitation in patients with heart failure or teleconsultation of posttreatment patients.

Analisis Kadar Nrf2 plasma Pada Tikus dengan Defisisensi Vitamin B12 Stujanna, Endin Nokik; Ujianti, Irena; Mustifah, Etty Farida
Sanus Medical Journal Vol. 2 No. 1 (2021)
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/sanus.v1i1.6545

Background. Vitamin B12 deficiency is a significant problem, particularly in developing countries. The increasing complexity of the Vitamin B12 molecule, the deficiency condition, causes a complex cell level disorder. The clinical manifestation of vitamin B12 deficiency is anemia, but it is believed that due to the complexity of vitamin B12, there are still other molecular disorders. This study aims to establish the pathway of damage caused by vitamin B12 deficiency in the Nrf2 molecule. Methods. An animal experiment involving 12 male Sprague Dawley rats were randomly divided into control and 16-week treatment. There are two research groups, namely the control group and the treatment group. The control group was given a standard diet, while the treatment group was assigned a vitamin B12 deficiency diet. At the end of treatment, The levels of vitamin B12 in the liver tissue and plasma NRF2 were measured. Statistical Analysis. Nrf2 and vitamin B12 levels were statistically analyzed using the Student's T-test, and the correlation between vitamin B12 and Hb was analyzed using the Spearmen test. Data that cannot use by Independent T-test were tested using the Mann Whitney test. Results/Conclusion. There was no significant difference between the control and treatment groups on plasma Nrf2 levels (4.02 ± 0.59 pg/ml vs 3.34 ± 0.55 pg/ml; p = 0.07) and tissue vitamin B12 (0.0035 ± 0.0016 µg/ml vs 0.0030 ± 0.0006 µg/ml ; p = 0.8). Keywords: Nrf2 Plasma, Defisiensi, Vitamin B12

Hipertensi Masa Kini dalam Perspektif Kesehatan Masyarakat Lakhsmi, Bety Semara; Yudyawati, Annisa Intan
Sanus Medical Journal Vol. 2 No. 1 (2021)
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/sanus.v1i1.6606

Hipertensi adalah penyakit yang didefinisikan sebagai peningkatan tekanan darah secara menetap. Seseorang dikatakan menderita hipertensi apabila tekanan darah sistol di atas 140 dan diastole di atas 90 mmHg. Hipertensi dibedakan menjadi dua macam, yaitu hipertensi primer (esensial) dan hipertensi sekunder. Hipertensi dipicu oleh beberapa faktor risiko, seperti seperti umur, jenis kelamin, riwayat keluarga, genetik (faktor risiko yang tidak dapat diubah/dikontrol), kebiasaan merokok, konsumsi garam, konsumsi lemak jenuh, penggunaan jelantah, kebiasaan konsumsi minum – minuman beralkohol, obesitas, kurang aktivitas fisik, stres, serta penggunaan estrogen.

Gambaran Quantitative Electroencephalography (QEEG) Anak Laki-laki Penderita Attention-Deficit Disorder (ADD) Pandhita S, Gea; Sutarni, Sri
Sanus Medical Journal Vol. 2 No. 1 (2021)
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/sanus.v1i1.6610

Background. The Diagnostic and Statistical Manual of Mental Disorders (DSM) grouping the types of ADD is based on the clinical symptoms of neurobehavioral disorders, regardless of the possible underlying etiology. This means that the same ADD type group may have a different etiology of functional brain disorders. Meanwhile, QEEG has been known to describe the possible etiology that underlies an ADD event. This study aims to identify differences in QEEG features in the same ADD type group. Methods. Subjects consisted of 40 boys with ADD. QEEG was recorded from 21 sites, and Fourier transformed to provide estimates for relative power in the delta, theta, alpha, and beta bands in the frontotemporal and central regions. These data were converted to Z-scores based on the normal value data; afterward, they were subjected to cluster analysis. Independent sample t-tests were used to determine how the total ADD group and the ADD cluster subgroups differed from the normal value. Results. The total ADD group had increased relative delta (Z-score-frontotemporal region = 3,26 ± 1,59; Z-score-central region = 4,04 ± 1,71), decreased relative alpha (Z-score-frontotemporal region = -2,78 ± 1,29; Z-score-central region = -2,86 ± 1,36), decreased relative beta (Z-score-frontotemporal region = -5,33 ± 1,61; Z-score-central region = -6,19 ± 1,86), increased rasio teta/alpha (Z-score-frontotemporal region = 2,806 ± 1,41; Z-score-central region = 2,59 ± 1,26), and increased rasio teta/beta (Z-score-frontotemporal region = 4,36 ± 1,69; Z-score-central region = 4,94 ± 1,46). Two distinct QEEG clusters subgroups were found. The first cluster was characterized by increased central relative delta (Z-score-central region = 3,02 ± 1,17), decreased relative beta (Z-score-frontotemporal region = -4,29 ± 0,73; Z-score-central region = -5,06 ± 1,19) and increased rasio teta/beta (Z-score-frontotemporal region = 3,83 ± 1,91; Z-score-central region = 4,94 ± 1,96). The second cluster was characterized by increased relative delta (Z-score-frontotemporal region = 4,71 ± 1,02; Z-score-central region = 5,72 ± 0,98), decreased relative alpha (Z-score-frontotemporal region = -3,92 ± 1,12; Z-score-central region = -4,24 ± 0,69), decreased relative beta (Z-score-frontotemporal region = -7,08 ± 1,06; Z-score-central region = -8,09 ± 0,99), increased rasio teta/alpha (Z-score-frontotemporal region = 3,08 ± 1,04; Z-score-central region = 2,86 ± 1,02), and increased rasio teta/beta (Z-score-frontotemporal region = 5,23 ± 1,16; Z-score-central region = 5,71 ± 1,35) Conclusions. These results indicate that boys with ADD do not constitute a homogenous group in QEEG profile terms. Two distinct QEEG clusters were found. The first cluster was typified by a cortically hypoaroused, while the second cluster was typified by a maturational-lag in central nervous system development. This difference in possible etiology may have implications for studies of the utility of QEEG in the diagnosis of ADD and the differences in therapeutic response between the two groups.

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Irena Sutanto

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+6281290749109

Journal Mail Official
editorsmj@uhamka.ac.id

Editorial Address
Fakultas Kedokteran, Universitas Muhammadiyah Prof. DR. HAMKA, Jl. Raden Fatah No.01, RT.002/RW.006, Parung Serab, Kec. Ciledug, Kota Tangerang, Banten 13460

Location
Kota adm. jakarta timur,

Dki jakarta

INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Irena Sutanto

Contact Email smjournal@uhamka.ac.id

Phone +6281290749109

Journal Mail Official editorsmj@uhamka.ac.id

Editorial Address Fakultas Kedokteran, Universitas Muhammadiyah Prof. DR. HAMKA, Jl. Raden Fatah No.01, RT.002/RW.006, Parung Serab, Kec. Ciledug, Kota Tangerang, Banten 13460

Location Kota adm. jakarta timur, Dki jakarta INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
Irena Sutanto

Contact Email
smjournal@uhamka.ac.id

Phone
+6281290749109

Journal Mail Official
editorsmj@uhamka.ac.id

Editorial Address
Fakultas Kedokteran, Universitas Muhammadiyah Prof. DR. HAMKA, Jl. Raden Fatah No.01, RT.002/RW.006, Parung Serab, Kec. Ciledug, Kota Tangerang, Banten 13460

Location
Kota adm. jakarta timur,

Dki jakarta

INDONESIA