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Dwi Endah Kusumawati
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INDONESIA
Indonesian Journal of Medical and Pharmaceutical Science
Published by Universitas Islam Sultan Agung
ISSN : -     EISSN : 28096576     DOI : -
Core Subject : Health, Science,
Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
This journal accepts and publishes academic articles focusing on theory, methods, and applications in: 1) Pharmaceutical science 2) Biomedical science 3) Herbal medicine 4) Clinical pharmacy 5) Drug discovery
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 10 Documents
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Search results for , issue "vol. 5 no. 1 (2026)" : 10 Documents clear
Aktivitas Peredaman Radikal ABTS (2,2'-azino-bis(3 - ethylbenzothiazoline-6-sulfonic acid)) oleh Ekstrak Etanol Kulit Nanas Madu (Ananas comosus L.Merr) Kusumawati, Dwi Endah; Chaqi, Muhammad Dhiya’ul
Indonesian Journal of Medical and Pharmaceutical Science Vol. 5 No. 1 (2026)
Publisher : Sultan Agung Islamic University of Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/ijmps.v5i1.572

Abstract

Background: Free radicals trigger various degenerative diseases, making the exploration of natural antioxidants essential. Honey pineapple (Ananas comosus L.) peel, often considered agricultural waste, contains bioactive compounds such as phenolics and flavonoids with potential antioxidant activity. This study aims to quantify the antioxidant activity of honey pineapple peel ethanolic extract, expressed as the IC₅₀ value. Methods: Honey pineapple peel powder was macerated using 70% ethanol. The antioxidant activity was evaluated using the ABTS cation radical assay. Extract concentrations (10, 20, 30, 40, and 50 µg/mL) were mixed with ABTS solution, and absorbance was measured at 747 nm using a UV-Vis spectrophotometer. Results: The IC₅₀ value for Vitamin C was 6.173 µg/mL, whereas the honey pineapple peel extract yielded an IC₅₀ of 61.476 µg/mL. This indicates that the antioxidant potency of the extract is 9.958 times lower than that of Vitamin C. Conclusion: The ethanolic extract of honey pineapple peel exhibits antioxidant activity with an IC₅₀ of 61.476 µg/mL. Since the inhibition percentages within the tested range did not reach 50%, this value was determined through linear regression extrapolation. Future studies should employ higher concentration ranges to confirm the inhibitory effectiveness.
Optimization of Kolang-Kaling Seed Galactomannan Serum Using Response Surface Methodology Anggraeni, Rosiana Sofia; Nurulita, Nunuk Aries; Astuti, Ika Yuni
Indonesian Journal of Medical and Pharmaceutical Science Vol. 5 No. 1 (2026)
Publisher : Sultan Agung Islamic University of Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/ijmps.v5i1.573

Abstract

Background: Ultraviolet (UV) exposure promotes free radical formation, leading to oxidative stress, lipid peroxidation, inflammation, and hyperpigmentation. Galactomannan derived from kolang-kaling (Arenga pinnata) exhibits antioxidant activity with potential protective effects against UV-induced damage. In serum formulations, carbomer and triethanolamine (TEA) are commonly combined as gelling agents to achieve desirable physicochemical properties. Objective: This study aimed to optimize a galactomannan-based facial serum by determining the most effective Carbomer–TEA concentration combination using Response Surface Methodology (RSM). Methods: A formulation optimization study was conducted employing the RSM approach with Design Expert software to evaluate the interaction effects of Carbomer and TEA concentrations on serum characteristics. Results: The optimal formulation predicted by the model consisted of 0.100% (w/v) Carbomer and 1.047% (w/v) TEA. Conclusion: Response Surface Methodology successfully optimized the galactomannan facial serum formulation. The identified combination of Carbomer and TEA is expected to provide suitable serum properties while supporting the antioxidant potential of galactomannan against UV-induced oxidative damage.
Optimasi Formula dan Karakteristik Fisik Sediaan Krim Ekstrak Daun Pegagan dengan Kombinasi Asam Stearat dan Tretanolamin Ika Buana Januarti; Ludfi Munadhiroh; Aries Badrus Sholeh
Indonesian Journal of Medical and Pharmaceutical Science Vol. 5 No. 1 (2026)
Publisher : Sultan Agung Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/ijmps.v5i1.446

Abstract

Background: Gotu kola leaves contain asiaticoside which has antioxidant properties that help skin collagen production, lighten cellulite, minimize wrinkles, and remove dark spots. Cream making requires the addition of emulsifiers or emulsifying masses, because they can affect the quality and stability of the cream product, for example triethanolamine and stearic acid. In this study, we will formulate gotu kola leaf extract in a cream preparation using stearic acid and triethanolamine emulsifiers which are expected to help stability and improve the texture of the cream to be softer. The purpose of this study was to find the optimum formula for gotu kola leaf extract cream with varying concentrations of stearic acid and triethanolamine, and to test the physical characteristics of the cream preparation. Methods: The cream making method used the emulsification method. The formula optimization method used Simplex Lattice Design with physical characteristics of pH, viscosity, adhesiveness, and spreadability. Statistical analysis used a one-sample t-test to compare experimental data with predicted data. Results: The optimum formula obtained from a combination of 3.5% TEA and 5.23% stearic acid has physical properties in accordance with the requirements of cream preparations, namely homogeneous, the cream has a milky white color, odorless, soft texture, pH 5.56, spreadability 5.8 cm, adhesive power 11.15 seconds and viscosity 11833 cps. Conclusion: In the F test, a p value> 0.05 was produced, meaning that there was no significant difference between the experimental results and the predicted results.
Evaluasi Kepuasan Pasien Terhadap Sistem Pelayanan Kefarmasian Berbasis Syariah di Puskesmas Padang Sari Asih Puji Lestari; Indah Permata Sari; Fari Rohmi Lutfiani
Indonesian Journal of Medical and Pharmaceutical Science Vol. 5 No. 1 (2026)
Publisher : Sultan Agung Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/ijmps.v5i1.548

Abstract

Background: Pharmaceutical services at primary healthcare centers are expected not only to meet quality standards but also to integrate Islamic (sharia-based) values to fulfill the spiritual and ethical needs of Muslim patients. The application of sharia principles such as trustworthiness, clarity of drug information, halal assurance, and ethical service has been shown to enhance patient trust and satisfaction. Methods: This study employed a descriptive observational design with a cross-sectional approach, employing a 15-item structured questionnaire that had been tested for validity and reliability. The collected data were tabulated using Microsoft Excel. Customer satisfaction levels were measured using the five dimensions of the SERVEQUAL measurement system. Results: Patient satisfaction results showed a very satisfactory rating across all SERVQUAL dimensions. Responsiveness scored 97%, reliability 94%, assurance 96%, empathy 95%, and tangible 95%. These findings indicate that pharmaceutical services meet professional standards, are friendly, informative, and equipped with comfortable and well-organized facilities. The majority of respondents were women of productive age, with a high school education. The implementation of Sharia values ​​such as trustworthiness, fairness, and cleanliness supports increased patient comfort and trust. Conclusion: Patient satisfaction with pharmaceutical services at Padang Sari Primary Health Center was categorized as very satisfactory across all SERVQUAL dimensions. These findings reflect high patient satisfaction with service quality and may be interpreted as being consistent with relevant sharia values; however, the implementation of sharia-based pharmaceutical services was not directly measured in this study.
Formulasi Sediaan Acne Patch Ekstrak Etanol Daun Coleus scutellarioides L. terhadap Propionibacterium acnes dan Staphylococcus epidermidis Abdul Wahid Suleman; Natasya Virginia; Nasrawati Basir; Sriyanty Sadsyam; Chikita Inaku; Nurfiddin Farid
Indonesian Journal of Medical and Pharmaceutical Science Vol. 5 No. 1 (2026)
Publisher : Sultan Agung Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/ijmps.v5i1.566

Abstract

Background: The increasing prevalence of acne vulgaris and the growing resistance of Propionibacterium acnes and Staphylococcus epidermidis to conventional antibiotics have encouraged the development of safer and more effective natural therapies. This study aimed to formulate and evaluate the physical stability of an acne patch containing ethanolic extract of miana leaves (Coleus scutellarioides L.) and to determine its antibacterial activity against P. acnes and S. epidermidis. Methods: Miana leaves were extracted by maceration using 96% ethanol and formulated into acne patches at concentrations of 0.5%, 1%, and 2% using hydroxypropyl methylcellulose (HPMC) as the film-forming polymer. The formulations were evaluated for organoleptic properties, weight uniformity, pH, thickness, moisture content, and stability through a cycling test. Antibacterial activity was assessed in vitro using the agar diffusion method. Results: All formulations exhibited acceptable physical characteristics and remained stable throughout the cycling test. Statistical analysis revealed significant differences in antibacterial activity among the formulations (p < 0.05). The inhibition zones increased proportionally with extract concentration, indicating a concentration-dependent antibacterial effect. The formulation containing 2% miana leaf extract demonstrated the highest antibacterial activity against both P. acnes and S. epidermidis and showed significantly greater inhibition than the lower concentrations (p < 0.05). Furthermore, this formulation maintained satisfactory physical stability and quality parameters. Conclusion: These findings indicate that the 2% miana leaf extract acne patch is the optimal formulation and has potential as a safe, stable, and effective natural anti-acne product.
Evaluasi Profil Penyimpanan Obat di Rumah Sakit X Kabupaten Semarang Terhadap Pelayanan Kefarmasian Rissa Maharani Dewi; Zuspita Yanti; Nala Evania; Salvira Anindya; Launiz Zamarda Julianty
Indonesian Journal of Medical and Pharmaceutical Science Vol. 5 No. 1 (2026)
Publisher : Sultan Agung Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/ijmps.v5i1.571

Abstract

Background: Drug storage practices in the pharmaceutical warehouse of Hospital X are generally well implemented,indicators meeting operational requirements. However, specific improvements are still required, particularly in the management of high-risk drug categories and temperature monitoring practices, to strengthen patient safety and maintain optimal pharmaceutical quality. Methods: This study used a descriptive observational design. Data were collected prospectively through direct observation using a structured checklist consisting of four assessment domains: storage requirements, storage components, storage methods, and storage facilities. Each item was scored as compliant (1) or non-compliant (0), and the final score was converted into a compliance percentage. Results: Storage requirement indicators demonstrated full compliance (100%). Storage component indicators showed a compliance level 75%, nonconformities identified in the security and labeling of concentrated electrolytes. Storage methods achieved 100% compliance, reflecting consistent implementation of FIFO FEFO,alphabetical ordering, therapeutic grouping, and LASA separation. Facilities and infrastructure obtained an 81% compliance score, with gaps identified in temperature recording practices and flooring specifications. Overall compliance for drug storage was 80%. Conclusion: Drug storage practices in the pharmaceutical warehouse of Hospital X are categorized as good; however, improvements are required in high-alert medication management and temperature monitoring to enhance safety and ensure continuous pharmaceutical quality.
The Effect of Secretome MSCs on the expression of MCP-1 and PDGF in Subtotal Nephrectomy Animal Model Mohammad Ariq Nazar; Nurul Hidayah; Dian Respati Ayu; Nadya Audina Nurkhafiya Sadikin; Naufal Sebastian Anggoro
Indonesian Journal of Medical and Pharmaceutical Science Vol. 5 No. 1 (2026)
Publisher : Sultan Agung Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/ijmps.v5i1.577

Abstract

Background: Secretome MSCs [TDPR1.1]have ability to modulation of inflammation, induce angiogenesis, and inhibition of apoptosis of renal cells. Objective: To investigate the role of secretome MSCs administration on the expression of MCP-1 and PDGF in STN animal model. Methods: Subtotal nephrectomy performed in the flank region for unilateral nephrectomy on the right kidney, followed by ablation of superior and inferior poles of the left kidney. The subject rats were equally divided into three groups, six rats each group, namely: Sham operation (SO), Control (CO) and Secretome MSCs (SM). After 14 days of SN induction, established CKD was injected with 250 µL secretome MSCs in the intravenous tail, with the administration repeated every 4 days. The CO received 250 µL saline. The animal sacrifice was carried out 4 days after the last secretome MSCs administration. Results: Relative expression of mRNA MCP-1 of the kidney SN rats showed a significant decrease (P<0.05) and Relative expression of mRNA PDGF of the kidney SN rats showed a significant decrease (P<0.05). Conclusion: In this study, we demonstrate that administration of secretome MSCs was able to reduce MCP-1 and PDGF gene expression, which may contribute to mitigating inflammation in a subtotal nephrectomy-induced CKD animal model.
Persepsi Swamedikasi Berbasis Syariah pada Pasien Geriatri di Apotek Khotidjah Inesya Febrianing Rizki; Henny Setyo Tur Istanto; Rizky Achmad Faizin
Indonesian Journal of Medical and Pharmaceutical Science Vol. 5 No. 1 (2026)
Publisher : Sultan Agung Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/ijmps.v5i1.579

Abstract

Background: Self-medication is the practice of treating common ailments with remedies that can generally be obtained at pharmacies without a doctor's recommendation. While expert guidance is crucial for safe and appropriate self-medication, especially for geriatric patients with declining organ function and degenerative diseases, integrating Islamic values into pharmaceutical services can also influence patient perception. This study aimed to assess the perception of Shariah-based self-medication among geriatric patients at Khotidjah Pharmacy. Methods: This was an observational study using a cross-sectional approach, conducted at Khotidjah Pharmacy from March to April 2024. Data were collected via questionnaires distributed to geriatric patients (aged 45-59) practicing self-medication. A total sampling technique was used, and the questionnaire was validated to have r > 1 and a reliability score of α > 0.831. Results: The study was conducted with 95 respondents. Most had a professional school background (31%) and were self-employed (96%). Regarding customer service perception, in terms of reliability, 100% agreed services were as expected. For responsiveness, 92% agreed employees offered assistance. In assurance, 97% agreed needed medicines were always available. Regarding empathy, 100% agreed employees were ready to help. In tangibility, 98% agreed with neat medicine arrangement. Regarding Shariah-based services, for Rabbaniyyah, 100% agreed the pharmacy encouraged prayer and dhikr. For Akhlaqiyyah, 100% agreed employees greeted patients with "salam" and were friendly and polite. Conclusion: The findings indicate that geriatric patients have a positive perception of Shariah-based self-medication services. Pharmacists at Khotidjah Pharmacy successfully incorporate Islamic values, such as encouraging prayer, greeting with "salam," and providing compassionate and Shariah-compliant services to geriatric patients during self-medication.
Efek Perlindungan Saraf dari Ekstrak Metanol Styrax paralleloneurum terhadap Kerusakan Otak yang Diinduksi oleh Etoposide pada Tikus Wistar Armansyah Maulana Harahap; Indra Priawan; Putri Diannisa Siregar; Muhammad Aldi Rivai Ginting
Indonesian Journal of Medical and Pharmaceutical Science Vol. 5 No. 1 (2026)
Publisher : Sultan Agung Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/ijmps.v5i1.591

Abstract

Background: Chemotherapy-induced cognitive impairment (chemobrain) is a significant side effect associated with anticancer agents such as etoposide. This study aimed to evaluate the neuroprotective potential of Styrax paralleloneurum (SP) methanol extract against etoposide-induced oxidative stress in Wistar rats Methods: Adult Wistar rats were randomly divided into six groups (n = 6 per group): normal control, etoposide-treated group (45 mg/kg), etoposide combined with SP at doses of 200, 300, and 400 mg/kg, and SP control group. Brain tissue homogenates were analyzed for markers of oxidative stress, including nitric oxide (NO), protein carbonyls (PC), superoxide dismutase (SOD), and brain-derived neurotrophic factor (BDNF). Results: Etoposide administration significantly increased PC levels and SOD activity while significantly reducing NO levels, indicating increased oxidative stress in brain tissue. Treatment with SP methanol extract, particularly at doses of 300 and 400 mg/kg, significantly reduced PC and SOD levels and restored NO levels (p < 0.01). No statistically significant differences were observed in BDNF levels among the experimental groups Conclusion: The findings of this study suggest that the methanol extract of Styrax paralleloneurum attenuates etoposide-induced oxidative stress in brain tissue. These results suggest that SP may possess neuroprotective properties and could serve as a potential adjunct strategy to mitigate chemotherapy-induced cognitive impairment
Formulation and Evaluation of Acne Spot Gel Preparations of Salicylic Acid and Sulfur with a Combination of Propylene Glycol and Carbomer Yuyun Darma Ayu Ningrum; Rizal Roffada Hanif; Elizza Risqi Sanaya
Indonesian Journal of Medical and Pharmaceutical Science Vol. 5 No. 1 (2026)
Publisher : Sultan Agung Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/ijmps.v5i1.557

Abstract

Background: Acne vulgaris is a skin condition with a high prevalence in Indonesia, especially among adolescents. Salicylic acid and sulfur are known to have keratolytic, antibacterial, and anti-inflammatory activities, making them widely used in acne treatment. In this study, salicylic acid and sulfur were formulated as an acne spot gel preparation using a combination of propylene glycol and carbomer. The physical properties of the acne spot gel preparation are significantly influenced by the concentration of propylene glycol and carbomer. Therefore, optimization of these two components is necessary to produce a stable and effective gel preparation. Methods: Eight formulas were developed using the Simplex Lattice Design (SLD) method. All formulas were evaluated for their physical characteristics to determine the optimum formula. The optimum formulas were subjected to cycling tests and analyzed using the Paired T-Test method. Results: The optimum formula for an acne spot gel containing salicylic acid and sulfur has physical characteristics including a yellow color, a distinctive sulfur aroma, and a gel texture with a homogeneous mixture. The preparation has a pH of 6.47, a spreadability of 5.96 cm, an adhesiveness of 10.13 seconds, and a viscosity of 11,291 cPs. The optimum formula is obtained from a combination of 14% propylene glycol and 1% carbomer. Conclusion: The optimum acne spot gel formula containing salicylic acid and sulfur meets the criteria for a good gel preparation and shows adequate physical stability.

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