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Medical Sains : Jurnal Ilmiah Kefarmasian
Published by Universitas Muhammadiyah Ahmad Dahlan Cirebon
ISSN : 25482114     EISSN : 25412027     DOI : https://doi.org/10.37874/ms
Core Subject : Health,
Medicine & Pharmacology
The Medical Sains journal is a scientific publication media published by the Muhammadiyah Cirebon College of Pharmacy which is published 4 (four) times in 1 (one) year, namely January-March, April-June, July-September and October-December. The journal contains research in the field of pharmacy covering the fields of formulation, pharmacology, communication pharmacy, A natural chemical chemistry, pharmacognomy and other health sciences which is a means for lecturers and researchers in the health sector to share knowledge and establish cooperation in implementing the Tri Dharma of Higher Education. Purpose and Scope The objective of the publication of the Medical Science journal is to publish articles in the field of pharmacy and other health as well as application of pharmaceutical . Based on this, the editorial board of Medical Sains invites lecturers and researchers to contribute to submit research articles related to the following themes: 1. Pharmaceutical formulation technology 2. Pharmacology 3. Community pharmacy 4. Clinical Pharmacy 5. Natural material chemistry 6. Pharmacognosy 7. Pharmaceutical Analysis and Medicinal Chemistry . All papers submitted to medical science journals will be examined by peer review partners who are tailored to their respective fields.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 39 Documents
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Search results for , issue "Vol 9 No 1 (2024)" : 39 Documents clear
NANOPARTIKEL GELASI IONIK EKSTRAK KULIT BATANG POHON TIN (Ficus carica L.): IONIC GELATED NANOPARTICLES EXTRACT OF TIN TREE BARK (Ficus carica L.) Linda Fitriyani; Rachmaniar Rahmat; Deni Rahmat
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 1 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i1.678

Abstract

Ekstrak bahan alami, seperti ekstrak dari kulit batang pohon tin (Ficus carica L), mengandung metabolit sekunder yang memiliki sifat polar. Diketahui bahwa bioavailabilitas ekstrak bahan alami cenderung rendah, sehingga sulit untuk menembus membran sel yang terdiri dari lapisan lipid. Penelitian nanopartikel gelasi ionik ekstrak kulit batang pohon tin (Ficus carica L) untuk penghantaran obat dalam menembus lapisan epidermis kulit belum pernah dilakukan penelitian. Sehingga akan dilakukan penelitian nanopartikel gelasi ionik ekstrak kulit batang pohon tin (Ficus carica L). Nanopartikel dibuat dengan menggunakan metode gelasi ionik, di mana tetesan cairan diinisiasi dalam fase minyak atau organik. Proses ini melibatkan pencampuran dua fase cair, yaitu fase yang mengandung kitosan dan fase yang mengandung anion multivalen. Simplisia kulit batang pohon tin (Ficus carica L) memiliki kandungan metabolit sekunder golongan flavonoid, tanin, fenol dan triterpenoid, hal ini menunjukan bahwa benar kulit batang pohon tin (Ficus carica L) dapat digunakan juga dalam pengobatan dan ekstrak kulit batang pohon tin (Ficus carica L) dapat dibuat dalam sediaan nanopartikel sebagai bentuk modofikasi dalam penghantaran obatnya dengan metode gelasi ionik.  Kata kunci : nanopartikel, gelasi ionik, ficus carica
AKTIVITAS ANTIBAKTERI, KANDUNGAN TOTAL FENOL DAN ANALISIS KLT-BIOAUTOGRAFI EKSTRAK ETIL ASETAT JAMUR ENDOFIT DAUN TERATAI (Nymphaea nouchali Brum. F): ANTIBACTERIAL ACTIVITY, TOTAL PHENOL CONTENT AND TLC-BIOAUTOGRAPHY ANALYSIS OF ETHYL ACETATE EXTRACT OF LEAVES ENDOPHYTE FUNGI (Nymphaea nouchali Brum. F) Agnes Rendowaty; Okta Novitasari; Detha Meliyani; Alda Sanita; Dewi Fatmayuni; Yunita Listiani Imanda
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 1 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i1.707

Abstract

Jamur endofit merupakan mikroorganisme yang berada didalam jaringan inang tanaman, yang menghasilkan senyawa metabolit sekunder dengan bioaktifitas antibakteri. Ekstrak etil asetat jamur endofit daun teratai G1, G2, G3 dan G4 diperoleh dengan kultivasi menggunakan medium beras. Tujuan penelitian ini adalah mengetahui kandungan total fenol dan profil pemisahan komponen senyawa dalam menghambat aktivitas bakteri Staphylococcus aureus ATCC 25923 dengan metode KLT-Bioautografi ekstrak etil asetat jamur G1, G2, G3 dan G4. Penentuan kandungan total fenol menggunakan metode Folin-ciocalteau dengan baku standar asam galat. Kandungan total fenol ekstrak etil asetat isolat jamur endofit G1, G2, G3, G4 berturut adalah 69,75 mg GAE/gram, 30,90 mg GAE/gram, 33,11 mg GAE/gram, 43,31 mg GAE/gram. Hasil analisis KLT ekstrak etil asetat G1, G2 G3 dan G4 memiliki profil pemisahan yang berbeda-beda, hasil uji KLT bioautografi diperoleh zona daya hambat dari beberapa Rf komponen dan teridentifikasi sebagai senyawa golongan fenol. Kata kunci : folin ciocalteau; KLT; bioautografi; fenol.
UJI AKTIVITAS ANTIOKSIDAN DENGAN MENGGUNAKAN METODE FRAP PADA EKSTRAK BUTANOL DAUN JATI (Tectona grandis) laeli fitriyati; Sinta Wahyu Septiani; Muchromin Muchromin
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 1 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i1.759

Abstract

Indonesia memiliki banyak tanaman yang dapat digunakan sebagai obat tradisional. Pengobatan tradisional dengan menggunakan bahan alam telah dilakukan secara turun. Tanaman daun jati (Tectona grandis) bisa digunakan sebagai antibakteri, antioksidan, dan antitoksik karena mengandung senyawa metabolit sekunder seperti tanin, antrakuinon, fenolik, antosianin, alkaloid, flavonoid, dan naftoquinon. Penelitian ini bertujuan untuk mengevaluasi aktivitas antioksidan ekstrak butanol dari daun jati (Tectona grandis). Penelitian ini merupakan penelitian eksperimental yang melibatkan pembuatan dua ekstrak daun jati menggunakan pelarut butanol dengan metode maserasi. Evaluasi dilakukan secara kualitatif (standarisasi dan uji tabung) dan kuantitatif menggunakan metode antioksidan FRAP (Ferric Reducing Antioxidant Power). Hasil penelitian menunjukkan bahwa ekstrak butanol dari daun jati (Tectona grandis) memenuhi persyaratan standarisasi, yaitu memiliki kadar air 9,76% butanol, kadar abu 12,9% butanol, dan kadar abu tidak larut asam 0,7% butanol, serta mengandung saponin, polifenol, dan flavonoid. Nilai Inhibition Concentration 50 (IC50) untuk aktivitas antioksidan adalah 70,848 ppm dan 80,893 ppm, yang termasuk kategori kuat. Oleh karena itu, hasil penelitian ini menunjukkan bahwa ekstrak butanol dari daun jati (Tectona grandis) memiliki aktivitas antioksidan yang kuat. Kata kunci : Daun Jati, Antioksidan, FRAP
FORMULASI SEDIAAN FACE WASH EKSTRAK DAUN KELOR (Moringa oleifera L.) DAN EKSTRAK BIJI KOPI ROBUSTA (Coffea canephora P.) DALAM SEDIAAN GEL DAN CAIR Rahmat Hidayat; Nining Sugihartini; Hari Susanti
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 1 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i1.762

Abstract

Sediaan pembersih wajah (face wash) berfungsi untuk membersihkan sekaligus mencegah timbulnya masalah kulit wajah. Penambahan bahan aktif berupa ekstrak daun kelor dan ekstrak biji kopi diharapkan akan meningkatkan manfaat sediaan face wash tersebut. Tujuan dari penelitian ini untuk mengetahui jenis sediaan yang paling optimal antara sediaan gel dan cair serta variasi komposisi yang optimal antara kedua ekstrak dalam formulasi face wash. Face wash diformulasikan dalam bentuk sediaan gel dan cair dengan variasi komposisi ekstrak daun kelor (Moringa oleifera L.) dan ekstrak biji  kopi robusta (Coffea canephora P.) secara berturut-turut yaitu 1:1, 1:2, 2:1. Sediaan dievaluasi berdasarkan parameter organoleptis, pH, viskositas, tinggi busa dan stabilitas busa serta daya hambat terhadap bakteri Staphylococcus aureus. Data yang diperoleh kemudian di analisa Two Way Anova dalam aplikasi SPSS versi 23. Berdasarkan uji diketahui bahwa face wash gel lebih baik pada uji organoleptis, pH, tinggi busa dan stabilitas busa, viskositas dan daya hambat terhadap bakteri. Peningkatan komposisi ekstrak biji kopi robusta menyebabkan peningkatan pH pada jenis sediaan face wash gel maupun cair. Berdasarkan data maka dapat disimpulkan jenis sediaan face wash gel pada varian komposisi zat aktif ekstrak biji kopi robusta 10% dan ekstrak daun kelor 20% lebih baik dan paling sesuai standar yang ditetapkan SNI (Standar Nasional Indonesia). Kata kunci : Face wash, Ekstrak daun kelor, Ekstrak kopi robusta, gel
THE INFLUENCE OF EDUCATIONAL INTERVENTIONS ON DRUG CLASSIFICATION KNOWLEDGE IN WANAR VILLAGE COMMUNITIES, PUCUK SUB-DISTRICT, LAMONGAN DISTRICT Aditya Sindu Sakti; Jazilah Khikmia Suwandi; Devi Ristian Octavia; Djati Wulan Kusumo; Muhammad Syaiful Amin
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 1 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i1.769

Abstract

Drugs registered in Indonesia are classified into six drug classes, including over-the-counter (OTC) drugs, cautionary labeling required, prescription drugs, jamu, standardised herbal medicines, and fitofarmaka. Inadequate community knowledge about drug classes has implications for irrational medication. This study aimed to determine the effect of education interventions on community knowledge about the classification of drugs registered in Indonesia. The study was performed using pre-experimental pre-post intervention studies with 55 respondents, and the questionnaire was validated. Factors that affect the level of knowledge of respondents include age, education, and gender (p-value <0.05). Education interventions can increase community knowledge related to the classification of drugs in the community of Wanar Village, Pucuk District, Lamongan Regency. Keywords: Drug Classification, Education, Level of Knowledge
IDENTIFICATION OF PHYSICOCHEMICAL PROPERTIES, PHARMACOKINETICS AND TOXICITY OF ACTIVE COMPOUNDS OF Kaempferia galanga RHIZOME Laili Nailul Muna
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 1 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i1.774

Abstract

The Kencur plant has many benefits, is economically valuable, and is widely cultivated by the local community. The development of kencur compounds has not been carried out optimally because of the relatively high cost of identifying the content of each compound. This study aimed to determine the physiochemical properties of kencur compounds and their pharmacokinetics, as well as the toxicity of the herb kencur rhizome in silico. The method used in this study uses a Marvin sketch to draw the structure of the compound, which was then analyzed using Lipinski to determine its physico-chemical properties. Pharmacokinetic and toxicity analyses were performed using the pKCSM software. The results showed that all compounds followed Lipinski's rules; therefore, predictably, they could be developed into drug molecules from these compounds. In addition, all compounds had fairly high Water Solubility (log S). All HIA compounds were >90%, so they were well absorbed in the intestine and showed good permeability to CaCO-2 with a log Papp value of > 0.90. All the above compounds have low permeability to the skin due to the log Kp value > -2.5, so they are not suitable for transdermal preparations. Keywords: Physicochemistry, Pharmacokinetics, Toxicity, Kencur, In silico
ANTIOXIDANT AND ANTIBACTERIAL ACTIVITY TESTS OF BANGKAL LEAF (Nauclea subdita Leaf.) SERUM EXTRACTS Ika Buana Januarti; Andre Yanto; Cahya Monica
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 1 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i1.808

Abstract

Bangkal leaves contain polyphenols, alkaloids, flavonoids, and quinone compounds that have the potential to act as antioxidants and antibacterial agents. To maximize the use of bangkal leaves, a cosmetic preparation, serum, was prepared. Serum is composed of 3 formulas: formula 1 (3% extract concentration), formula 2 (4% extract), and formula 3 (5% extract). Serum was tested for antioxidant activity using the DPPH (2,2-Diphenyl-1-Picrylhydrazyl) method at a wavelength of 518 nm. Ascorbic acid was used for comparison. Serum was also tested to evaluate its physical properties including organoleptics, pH, spreadability and viscosity. Antibacterial activity was determined using the well diffusion method. The research results showed that the IC50 value of the extract was 171.18 ppm, the bangkal leaf extract serum preparation for formula I was 174.26 ppm, formula II was 209.97 ppm, and formula III was 237.91 ppm. The antibacterial activity of bangkal leaf extract serum (Nauclea subdita) against Staphylococcus aureus formulas 1, 2, and 3 had an average zone of inhibition of 10.67, 12.00, and 14 mm. Based on the antioxidant and antibacterial activity values, bangkal leaf extract serum has moderate antioxidant and antibacterial abilities. Keywords : Bangkal leaf extract, antioxidant activity test, antibacterial test
TEST ANTINFLAMMATION CAPSULE COMBINATION OF MORINGA LEAVES (Moringa oleifera L) AND KARUK LEAVES (Piper sarmentosum Roxb. Ex. Hunter) EXTRACT TEST AGAINST MICE (Mus musculus) Nia Kurniasih; Nurhidayati Harun; Ade Egie Prayogi
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 1 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i1.837

Abstract

Empirically utilized medicinal plants include Moringa leaves (Moringa oleifera L) and Karuk leaves (Piper sarmentosum Roxb. Ex. Hunter). Moringa leaves contain active compounds, such as vitamins, carotenoids, polyphenols, phenolic acids, flavonoids, alkaloids, glucosinolates, isothiocyanates, tannins, saponins, and oxalates. The leaves of karuk contain polyphenols, flavonoids, saponins, and tannins. This study aimed to assess the anti-inflammatory activity of combination capsules of Moringa and Karuk leaf extracts in mice (Mus musculus). Anti-inflammatory agents are drugs that can suppress or reduce inflammation. The aim of the experimental method used in this study was to determine the optimal concentration for anti-inflammatory activity. Carrageenan as an inflammatory mediator in mouse paws. The anti-inflammatory test involved five groups of animals, each consisting of five mice. The negative control group received Na-CMC, the positive control group was administered diclofenac sodium, and the test samples involved a combination capsule of Moringa and Karuk leaf extract at doses of 350, 700, and 1,050 mg. Measurements were performed every hour for 6 hours after carrageenan induction. Data analysis employed the One-way ANOVA method to ascertain whether variations in the dose of the combination capsule of Moringa and Karuk leaf extracts affected anti-inflammatory activity in mice. The results indicate that the greatest inflammation inhibition occurs with the 1,050 mg dose, resulting in 23% inhibition, followed by 22% at 700 mg and 13% at 350 mg. Statistical analysis yielded a p-value of 0.048, which was less than 0.05. This suggests a significant difference in the anti-inflammatory activity among the test groups ...
REVIEW: PENGARUH ENKAPSULASI KURKUMIN TERHADAP AKTIVITAS ANTIOKSIDAN : REVIEW: THE EFFECT OF CURCUMIN ENCAPSULATION ON ANTIOXIDANT ACTIVITIES Syamsul Ma'arif; Jason Merari Peranginangin; Wiwin Herdwiani
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 1 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i1.897

Abstract

Kurkumin memiliki aktivitas antioksidan yang rentan dipengaruhi oleh cahaya, pH, suhu, oksigen dan dapat bereaksi dengan senyawa lain. Enkapsulasi dapat melindungi senyawa bioaktif. Systematic literature review (SLR) merupakan sebuah pendekatan penelitian secara sistematis untuk mengidentifikasi, mengevaluasi dan menafsirkan semua studi yang relevan mengenai topik tertentu. Penelitian SLR ini bertujuan untuk mengetahui pengaruh enkapsulasi kurkumin terhadap aktivitas antioksidan dan rekomendasi metode serta penyalut untuk enkapsulasi kurkumin. Penelitian ini menggunakan metode SLR yang dilakukan dalam beberapa tahap yaitu perencanaan (planning) dengan menentukan elemen PICO, dataset, kata kunci pencarian, kriteria inklusi dan eksklusi. Tahap pengumpulan data (conducting) meliputi skrining data dari judul dan abstrak, seleksi teks lengkap, penilaian kualitas artikel serta analisis dan sintesis data. Tahap pelaporan (reporting) melaporkan hasil review. Hasil penelitian menunjukkan enkapsulasi mampu meningkatkan aktivitas antioksidan kurkumin. Kurkumin yang dienkapsulasi mempunyai aktivitas antioksidan yang lebih baik daripada kurkumin yang tidak dienkapsulasi. Metode electrostatic complexation, dan penyalut alami laktoferin dan pektin adalah metode dan penyalut yang direkomendasikan untuk enkapsulasi kurkumin. Hal ini berdasarkan data enkapsulasi kurkumin dengan metode dan penyalut tersebut mempunyai karakteristik enkapsulasi yang baik dan aktivitas antioksidan paling tinggi. Kata kunci: Systematic literature review, Kurkumin, Antioksidan, Enkapsulasi.
LIQUID SOAP FORMULATION FROM ETHANOLIC EXTRACT OF CASSAVA LEAVES (Manihot esculenta Crantz) WITH COCAMIDE DEA AS SURFACTANT Nooryza Martihandini; Diani Putria Angelica; Shandra Isasi Sutiswa
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 1 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i1.912

Abstract

The ethanol extract of cassava leaves contains various secondary metabolites that have antibacterial activity against Escherichia coli, Staphylococcus aureus, and Shigella sp., and thus can be used as active ingredients in liquid soap preparation. Liquid soap formulations generally use sodium lauryl sulfate (SLS) as a surfactant, which can cause irritation and skin dryness. This study aimed to formulate an ethanol extract from cassava leaves into a liquid soap preparation using cocamide DEA as a surfactant to reduce skin irritation. The study was conducted in an experimental laboratory. Cassava leaves were extracted by maceration using ethanol. Three liquid soap formulas from cassava leaf extract were developed with different extract concentrations: F1 (1%), F2 (3%), and F3 (5%). The liquid soaps were evaluated in terms of organoleptic properties, pH, homogeneity, viscosity, foam height, and foam stability. The study showed that cassava leaves extract could be formulated into a homogeneous liquid soap with a pH range of 7.0–7.5, viscosity of 143.6–306.2 cps, foam height of 53.33–60.00 mm, and foam stability of 75.01–82.36%. F3 is the optimum formula with the best physical characteristics of the preparation in terms of organoleptic properties, foam height, and foam stability. Keywords: cocamide DEA, cassava leaves, liquid soap, surfactant

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