cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
-
Contact Email
ijcs@mail.unnes.ac.id
Phone
-
Journal Mail Official
ijcs@mail.unnes.ac.id
Editorial Address
D6 Building second floor, Department of Chemistry, Faculty of Mathematics and Science, Universitas Negeri Semarang
Location
Kota semarang,
Jawa tengah
INDONESIA
Indonesian Journal of Chemical Science
Published by Universitas Negeri Semarang
ISSN : 22526951     EISSN : 25026844     DOI : -
Core Subject : Science,
Chemistry Physics
Indonesian Journal of Chemical Science publishes basic research articles and conceptual of Chemistry, issued three (3) times a year, overall 10 articles per issued. To commemorate important events and agenda, may be issued a special edition that will include 10 articles in each issue.
Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)
Articles 73 Documents
 4   5   6   7   8 
Optimization of the Performance of a Microplate Type UV-Vis Spectrophotometer as a Protein Content Testing Instrument Based on Green Analytical Chemistry (GAC) Martin Sulistyani; Mahatmanti, F. Widhi; Huda, Nuril; Prasetyo, Ridho
Indonesian Journal of Chemical Science Vol. 14 No. 3 (2025): Indonesian Journal of Chemical Science
Publisher : Prodi Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/ijcs.v14i3.31948

Abstract

Advancements in laboratory technology have driven the adoption of more efficient and environmentally friendly analytical methods, in line with the principles of Green Analytical Chemistry (GAC). This study aims to optimize the performance of a microplate-based UV-Vis spectrophotometer for determining protein content in food samples using the Biuret method. The method is based on a colorimetric reaction between Biuret reagent and peptide bonds in proteins, forming a purple complex whose absorbance is proportional to protein concentration. Three dilution methods were evaluated: mL-microplate, µL-microplate, and mL-cuvette, based on parameters including maximum wavelength, linearity, and accuracy. All methods showed the same maximum absorbance wavelength (562 nm), indicating reaction stability. The mL-cuvette method achieved the highest linearity (R² = 0.998), while the mL-microplate method demonstrated the best accuracy (91.00%) and most consistent results in tempeh and yogurt samples. Meanwhile, the µL-microplate method offered acceptable accuracy (90.25%) with significantly reduced reagent volume, supporting the GAC approach. Therefore, the mL-microplate method is recommended as the primary technique for protein analysis using UV-Vis spectrophotometry, while the µL-microplate method provides an efficient and eco-friendly alternative for modern laboratory applications.
Synthesis Of Bio-Oil from Corn Cobs Using The Pyrolysis Process suriyanto; Ivenda Sasquea Cakradetha
Indonesian Journal of Chemical Science Vol. 15 No. 2 (2026): Indonesian Journal of Chemical Science
Publisher : Prodi Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/ijcs.v15i2.9857

Abstract

Bio-oil is a raw material that can be produced in several ways, one of which is through the biomass pyrolysis process. Biomass pyrolysis has been widely studied previously and has shown promising results as an alternative fuel due to the lignocellulose in biomass. Production of shelled corn in Indonesia reaches 23.1 million tons and leaves waste in the form of corn cobs with a ratio of 1:1 corn to cob. This research aims to produce bio-Oil from corn cobs using varying residence times of 40, 60, 80, 100, and 120 minutes. Corn cobs that have been uniform in size to 20 mesh will be inserted into the pyrolysis reactor at a temperature of 400oC for varying times. The highest yield was obtained at a size and residence time of 20 mesh 120 minutes of 72.4632% with a density of 1.3018 g/cm3, viscosity of 1.6712 mm2/s, and heating value of 6.640 Kcal/kg. The results of GC-MS analysis showed acetic acid levels of 37.49% and methyl esters of 22.19%.
Compound Content and Bioactivity of Eucalyptus sp. Species Sara Wati lesnussa Siti siompo; Andi Nurfitri Abubakar
Indonesian Journal of Chemical Science Vol. 15 No. 2 (2026): Indonesian Journal of Chemical Science
Publisher : Prodi Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/ijcs.v15i2.31158

Abstract

The genus Eucalyptus is widely recognized as a valuable natural resource, both economically and therapeutically, due to its broad distribution and chemical diversity. With increasing global concerns over antimicrobial resistance and the demand for natural alternatives, Eucalyptus essential oils (EOs) and extracts have gained significant scientific interest. This review explores the chemical composition and bioactivity of various Eucalyptus species based on data obtained through GC-MS, HPLC, and other analytical methods. The compounds found, predominantly terpenoids such as 1,8-cineole and α-pinene, vary greatly depending on species, environment, and extraction methods. Bioactivity studies indicate strong antimicrobial effects especially against Gram-positive bacteria and fungi), antioxidant capacity, anti-inflammatory and analgesic actions, as well as antidiabetic, cytotoxic, and insecticidal properties. These characteristics suggest that Eucalyptus has promising applications in pharmaceutical, cosmetic, food, and agricultural industries. However, further in vivo and clinical research is needed to support its safe and effective use.
SYNTHESIS, CHARACTERIZATION, AND APPLICATION OF MGO FROM BITTERN: A RIVIEW 2018 - 2025 Devilia Yuanita Nuni Widiarti; Nuni Widiarti
Indonesian Journal of Chemical Science Vol. 15 No. 2 (2026): Indonesian Journal of Chemical Science
Publisher : Prodi Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/ijcs.v15i2.33323

Abstract

Bittern, a liquid by-product of the salt industry, has emerged as a promising and sustainable alternative raw material for the synthesis of Magnesium Oxide (MgO). This literature review comprehensively examines recent developments within the 2018-2025 period concerning the synthesis, characterization, and diverse applications of MgO derived from bittern. Emphasis is placed on the potential of bittern as an economical magnesium source and its utilization aligning with circular economy principles. Predominant synthesis methods, such as chemical precipitation (using NaOH or Ca(OH)₂) and electrolysis, are discussed in depth, highlighting key process parameters and their influence on final product properties. Characterization results of bittern-derived MgO, including crystal structure and phase analysis using X-ray Diffraction (XRD), surface morphology analysis via Scanning Electron Microscopy (SEM) and Transmission Electron Microscopy (TEM), and specific surface area determination by the Brunauer-Emmett-Teller (BET) method, are summarized from various studies. This review also explores the various applications of MgO synthesized from bittern, including as an adsorbent for pollutant removal (dyes and heavy metal ions), a catalyst and photocatalyst in chemical reactions, an antibacterial agent against pathogenic microorganisms, a refractory material for high-temperature applications, and in agriculture as a magnesium nutrient source. The positive environmental implications of utilizing waste bittern to produce this value-added material are also emphasized. The conclusion of this review affirms the significance of research in valorizing bittern into MgO and identifies prospects and challenges for future development, including process optimization, upscaling, and exploration of innovative applications.  
A Comprehensive Review Of Produced Water Processing Technology In The Oil And Gas Industry Rizza Fadillah Fitri
Indonesian Journal of Chemical Science Vol. 15 No. 2 (2026): Indonesian Journal of Chemical Science
Publisher : Prodi Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/ijcs.v15i2.34901

Abstract

Air terproduksi (produced water, PW) merupakan limbah utama dari kegiatan industri minyak dan gas bumi yang mengandung berbagai senyawa organik, anorganik, logam berat, minyak dan lemak, serta zat kimia berbahaya. Kompleksitas komposisi PW menjadikannya salah satu limbah cair paling menantang untuk diolah sebelum dibuang atau dimanfaatkan kembali. Oleh karena itu, diperlukan pemilihan dan pengembangan teknologi pengolahan yang tepat untuk menjamin kualitas lingkungan sekaligus mendukung prinsip keberlanjutan. Artikel ini menyajikan tinjauan komprehensif mengenai enam teknologi utama dalam pengolahan PW, yaitu adsorpsi, membran, elektrodialisis, membran bioreaktor, elektrokoagulasi, dan aktivasi elektrokimia. Adsorpsi menawarkan efisiensi tinggi dalam penghilangan kontaminan organik dengan biaya relatif rendah, namun terbatas oleh kapasitas material adsorben. Teknologi membran dan elektrodialisis mampu menghasilkan pemisahan ionik dan non-ionik secara selektif, meskipun tantangan fouling masih menjadi hambatan utama. Membran bioreaktor menggabungkan proses biologis dan pemisahan membran untuk degradasi bahan organik, dengan keunggulan efisiensi tinggi namun membutuhkan biaya operasional signifikan. Elektrokoagulasi telah terbukti efektif dalam menghilangkan minyak, logam, dan partikel tersuspensi dengan konsumsi bahan kimia minimal, sementara aktivasi elektrokimia menjanjikan disinfeksi dan peningkatan kualitas air melalui produksi agen oksidatif in situ. Dari kajian ini, jelas bahwa tidak ada satu teknologi tunggal yang mampu mengatasi seluruh kompleksitas PW. Oleh karena itu, pendekatan hibrid atau integratif yang mengombinasikan beberapa metode dipandang sebagai solusi yang lebih berkelanjutan untuk pengolahan PW secara efektif.
Molecular Docking Study of Xanthone Targeting the Dihydropteroate Synthase (2VEG) Enzyme in Streptococcus pneumoniae Dia Lestari; Resti Aulia Lestari; Alien Putri Hartiwi; Emmy Yuanita; Diah Miftahul Aini
Indonesian Journal of Chemical Science Vol. 15 No. 2 (2026): Indonesian Journal of Chemical Science
Publisher : Prodi Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/ijcs.v15i2.39291

Abstract

Streptococcus pneumoniae is a pathogenic bacterium causing serious infections, with rising antibiotic resistance highlighting the need for new agents. Dihydropteroate synthase (DHPS) is crucial in bacterial folate biosynthesis and a selective drug target. This study evaluated xanthone derivatives as DHPS inhibitors via molecular docking. Three derivatives namely 1,3,7-trihydroxy-9H-xanthen-9-one (Candidate 1), 1-hydroxy-9-oxo-7-sulfo-9H-xanthene-3-carboxylic acid (Candidate 2), and 9-oxo-1,7-disulfo-9H-xanthene-3-carboxylic acid (Candidate 3), were docked against DHPS (PDB ID: 2VEG) using UCSF Chimera, AutoDock Tools, and AutoDock Vina. Interaction analyses were performed with Discovery Studio and LigPlot+. All candidates bound stably in the DHPS active site; Candidate 2 exhibited the strongest binding (−7.7 kcal/mol) with key hydrogen bonds, while Candidate 3 showed extensive hydrophobic and electrostatic interactions. These results indicate xanthone derivatives, especially Candidate 2, as promising DHPS inhibitors for novel antibacterial development.
A Study molecular docking of Scientific Herbal Medicine Compounds Against Angiotensin-1 Converting Enzyme (ACE) as an Antihypertensive Agent Faqine Ascory Sunargo; Andri Prasetiyo; Esti Mumpuni; Esti Mulatsari; Ardelia Ananda; Hyunanda Ratu Fasya; Alya Ramadhani Juanda; Neysha Olivio Redjita
Indonesian Journal of Chemical Science Vol. 15 No. 2 (2026): Indonesian Journal of Chemical Science
Publisher : Prodi Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/ijcs.v15i2.39784

Abstract

Jamu saintifik merupakan sumber daya alam terstandarisasi yang menawarkan potensi besar dalam penemuan agen antihipertensi baru serta didorong oleh kebutuhan akan alternatif yang lebih aman untuk penanganan penyakit hipertensi. Penelitian ini merupakan studi in silico yang dirancang untuk memprediksi kemampuan senyawa aktif jamu saintifik sebagai penghambat ACE. Metodologi yang diterapkan melibatkan preparasi protein target (PDB ID: 9QAU) dan optimasi ligan uji, dilanjutkan dengan penambatan molekul (molecular docking) untuk mengukur afinitas interaksi. Selain itu, analisis ADMET (Absorpsi, Distribusi, Metabolisme, Ekskresi, Toksisitas) dilakukan untuk menilai kelayakan farmakokinetik kandidat terpilih. Secara signifikan, hasil menunjukkan bahwa senyawa Isotheaflavin 3-O-gallate pada teh hijau unggul dengan docking score terbaik (−125 kcal/mol), serta memiliki profil ADMET yang menjanjikan untuk bioavailabilitas oral. Oleh karena itu, studi ini menyimpulkan bahwa Isotheaflavin 3-O-gallate adalah kandidat kuat inhibitor ACE dari Jamu Saintifik yang layak untuk divalidasi lebih lanjut melalui pengujian biologi.  
In Silico Study of Potential Anti-Cholesterol of Garlic (Allium sativum L.) Against the HMG-CoA Reductase Enzyme Vannisa Artasya; Muhamad Ali Daffa; Nisriinaa Ayu Dewanto; Sandya Amelia Febriliani; Bagus Adhinagoro; Shela Salsabila; Muchtaridi
Indonesian Journal of Chemical Science Vol. 15 No. 2 (2026): Indonesian Journal of Chemical Science
Publisher : Prodi Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/ijcs.v15i2.40740

Abstract

Dyslipidemia is a major risk factor for cardiovascular diseases, characterized by elevated total cholesterol and LDL levels. Statins, as first-line therapy, have certain limitations, highlighting the need for safer alternative candidates. Garlic (Allium sativum L.) contains various bioactive compounds with potential cholesterol-lowering activity. This study aimed to evaluate the potential of garlic active compounds as inhibitors of HMG-CoA reductase using an in silico approach. The methods included Lipinski’s Rule of Five analysis, ADME-Tox prediction, pharmacophore modeling, and molecular docking using AutoDock against the HMG-CoA reductase receptor (PDB ID: 3CCW), with simvastatin as a positive control. The results showed that all tested compounds met the drug-likeness criteria. ADME-Tox prediction indicated favorable absorption and distribution profiles for most compounds, although potential mutagenicity was observed. Pharmacophore modeling and molecular docking results revealed that tryptophan exhibited the best binding affinity with a binding energy of −6.39 kcal/mol and an inhibition constant of 20.68 μM, along with amino acid interactions similar to simvastatin. Therefore, tryptophan has potential as a cholesterol-lowering drug candidate, although further studies are required to address its safety profile.
Agonist potential of estrogen-β receptors from brown algae (Sargassum muticum) as molecular therapy for breast cancer: in-silico approach Mila Karisma Fitriawati; Fakih Haikal; Fadia Fatiha; Ervina Setiawati; Rizky Prasiska Wulandari; Halwa Aulia Nurdin; Rina Fajri Nuwarda
Indonesian Journal of Chemical Science Vol. 15 No. 2 (2026): Indonesian Journal of Chemical Science
Publisher : Prodi Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/ijcs.v15i2.41598

Abstract

Breast cancer is a malignant condition characterized by uncontrolled cell growth in breast tissue. Estrogen receptor-β have role as a tumor suppressor, so activating this receptor through specific agonists holds great promise for developing targeted and potential therapeutic agents for breast cancer treatment. This study aims to investigate the potential agonist activity of ten compounds of brown algae (Sargassum muticum) against estrogen-β receptors as candidates for breast cancer treatment through in-silico studies. The study was conducted using computational methods: Lipinski's Rule of Five (RO5) prediction, ADMET prediction, pharmacophore modeling, ligand and receptor preparation, method validation, molecular docking simulation and visualization. The results showed that of the 10 compounds evaluated from brown algae plants, all met the RO5 criteria, so they have potential as oral drug candidates. From the result, eckol compound has the smallest binding energy (-7.85) and inhibition constant (1.77 μM).  Eckol interacts with several amino acid residues similarly to the way hydroxytamoxifen, the natural ligand, binds to estrogen-β. The study shows that Eckol has the potential to act as an estrogen receptor β agonist. However, further research, such as in vitro testing, is needed to confirm this agonistic activity.
Pengaruh Waktu Reaksi Terhadap Efisiensi Penghilangan Logam Berat Pb, Cd, dan Ni Pada Proses Elektrokoagulasi nurmetania; Muhammad Bakrie; muhrinsyah fatimura
Indonesian Journal of Chemical Science Vol. 15 No. 2 (2026): Indonesian Journal of Chemical Science
Publisher : Prodi Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/ijcs.v15i2.44902

Abstract

Pencemaran air merupakan salah satu permasalahan lingkungan utama yang disebabkan oleh aktivitas industri, terutama akibat keberadaan logam berat yang bersifat toksik, persisten, dan sulit terdegradasi. Logam berat seperti timbal (Pb), kadmium (Cd), dan nikel (Ni) termasuk pencemar prioritas karena berpotensi terakumulasi dalam lingkungan perairan dan membahayakan kesehatan. Penelitian ini bertujuan untuk menganalisis pengaruh waktu reaksi terhadap kinerja proses elektrokoagulasi dalam menurunkan konsentrasi logam berat pada air limbah artifisial sistem single komponen. Proses elektrokoagulasi dilakukan secara batch menggunakan elektroda aluminium dengan variasi waktu reaksi 15, 30, 45, 60, dan 75 menit pada kondisi operasi tetap. Parameter yang dianalisis meliputi konsentrasi akhir logam berat, efisiensi penghilangan, perubahan pH, dan konsumsi energi listrik. Konsentrasi logam berat dianalisis menggunakan metode Atomic Absorption Spectrophotometry (AAS). Hasil penelitian menunjukkan bahwa peningkatan waktu reaksi berpengaruh signifikan terhadap efisiensi penghilangan logam berat hingga mencapai kondisi optimum pada waktu reaksi 60 menit. Efisiensi penghilangan pada sistem single komponen mencapai lebih dari 90% untuk Pb serta mendekati 100% untuk Cd dan Ni. Hasil ini menunjukkan bahwa elektrokoagulasi berpotensi sebagai teknologi pengolahan air limbah yang efektif dan aplikatif.

Page 7 of 8 | Total Record : 73

 4   5   6   7   8 

Filter by Year

2024 2026


Reset
Filter By Issues
All Issue Vol. 15 No. 2 (2026): Indonesian Journal of Chemical Science Vol. 14 No. 3 (2025): Indonesian Journal of Chemical Science Vol. 14 No. 2 (2025): Indonesian Journal of Chemical Science Vol. 14 No. 1 (2025): Indonesian Journal of Chemical Science Vol. 13 No. 3 (2024): Indonesian Journal of Chemical Science Vol. 13 No. 2 (2024): Indonesian Journal of Chemical Science Vol. 13 No. 1 (2024)