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Ramadhanti Salma Ulwanda
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Acta Neurologica Indonesia
Published by Universitas Indonesia
ISSN : -     EISSN : 30326303     DOI : https://doi.org/10.69868/ani.v2i02
Core Subject : Health, Science,
Medicine & Pharmacology Neuroscience Public Health
Acta Neurologica Indonesia is the official publication of the Department of Neurology, Faculty of Medicine, Universitas Indonesia under Directorate of Administration, Data, and Product Management of Research and Innovation Universitas Indonesia. This journal is published in trimonthly cycle with e-ISSN: 3032-6303. The Journal aims for continuous dissemination of updates in relation to neurology and its related fields in the form of original articles, case reports and reviews.
Arjuna Subject : Kedokteran - Neurologi Klinis
Articles 37 Documents
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Cognitive Decline Among the Middle-aged Living in the Coastal Area in Lombok Island Suryani, Dini; Harahap, Herpan Syafii; Rivarti, Arina Windri; Nurhidayati; Zubaidi, Fitriannisa Faradina; Saputri, Legis Ocktaviana
Acta Neurologica Indonesia Vol. 3 No. 01 (2025): Acta Neurologica Indonesia
Publisher : Departemen Neurologi Fakultas Kedokteran Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69868/ani.v3i01.50

Abstract

INTRODUCTION: Dementia is a leading cause of disability, dependency and poor quality of life. Its prevalence has increased consistently in recent years. Coastal communities who have limited access to health services have a higher risk of developing degenerative diseases including dementia. METHOD: A total of 154 middle-age peoples from four coastal area were recruited in this study. Participants were interviewed to obtain data on sociodemographic characteristics, lifestyle and medical history, then completed neuropsychological tests. Cognitive function was assesed by Mini-cog instruments. RESULT: The number of participants with cognitive decline was 87 people (56%) out of a total of 154 participants. 66% of all participants with cognitive decline were female. History of hypertension (67%), DM (16%), 40% with a BMI ≥22.5, 23% with a history of smoking, and 45% of participants with a low activity level. Multiple linear regression shows that Age and history of Hypertension is associated with cognitive decline (Sig.0.005 and 0.037). DM, BMI, smoking history and activity level is not associated significantly. CONCLUSION: More than half of middle age people on the coast of Lombok Island have cognitive decline. Age and history of hypertension are influencing factors.
KNOWLEDGE, ATTITUDES, AND PRACTICES OF THE DEPOK COMMUNITY TOWARDS STROKE Nathania, Valentine; Hidayat, Rakhmad
Acta Neurologica Indonesia Vol. 3 No. 02 (2025): Acta Neurologica Indonesia
Publisher : Departemen Neurologi Fakultas Kedokteran Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69868/ani.v3i02.52

Abstract

Stroke is the number one cause of disability in the world and the number two cause of death in the world. Stroke is also the ninth cause of death in hospitals in Depok. Prehospital delays contribute greatly to poor stroke management. Therefore, the knowledge, attitudes and behavior of the Depok community towards stroke need to be assessed to find out the causes of pre-hospital delays. This research uses a descriptive design with a cross-sectional approach. The sampling technique used consecutive sampling techniques. Data was obtained using a questionnaire consisting of 12 knowledge component questions, 4 attitude component questions, and 3 behavior component questions. Of the 400 respondents representing the people of Depok, 82.5% have poor knowledge about stroke. A total of 60.75% of the people of Depok have a poor attitude toward stroke, and 56.25% of the people of Depok exhibit poor behavior towards stroke. The result shows that the majority of the people of Depok have inadequate knowledge, attitudes, and behaviors regarding stroke.
The Heart-Shaped Sign Infarct: A Rare Case of Bilateral Medial Medullary Infarction Japutri, Josephine; Puspitasari , Vivien
Acta Neurologica Indonesia Vol. 3 No. 02 (2025): Acta Neurologica Indonesia
Publisher : Departemen Neurologi Fakultas Kedokteran Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69868/ani.v3i02.63

Abstract

Introduction Medullary infarction is a life-threatening condition with an incidence rate of 0.5-1.5% of all ischemic strokes. It seldom occurs bilaterally and might cause fatal respiratory complications. Here, we present a rare case of Bilateral Medial Medullary Infarct (BMMI) with unique Magnetic Resonance Imaging (MRI) findings and discuss its anatomical involvement. Case Report a 67-year-old man with poorly controlled hypertension and diabetes presented with acute visual impairment, dysphagia, dysarthria, and left hemiparesis since one day before. On the third day post-stroke, the patient developed quadriparesis along with worsening bulbar symptoms. Brain MRI revealed a heart-shaped infarct in the medial medulla, confirming the rare diagnosis of BMMI. The patient was treated with antiplatelet, and there were no further complications. Discussion Although rare, clinical findings of bulbar symptoms, quadriparesis, and respiratory involvement may aid early identification of BMMI. Brain MRI is recommended as they reveal the radiological hallmark of a heart-shaped infarct associated with the anteromedial and anterolateral branch of the vertebrobasilar artery that suplies the medullary. MRI is useful in differentiating BMMI from other neurological disorders and determining proper course of treatment. Conclusion BMMI early identification with a typical heart-shaped infarct is essential to prevent fatal respiratory failure. Risk factors management is crucial to prevent recurring infarcts.
The Analysis Study of Intravenous Immunoglobulin for Myasthenia Gravis: Insight from A Systematic Review Suwandhi
Acta Neurologica Indonesia Vol. 3 No. 02 (2025): Acta Neurologica Indonesia
Publisher : Departemen Neurologi Fakultas Kedokteran Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69868/ani.v3i02.65

Abstract

Introduction: Myasthenia gravis (MG) is a chronic autoimmune disorder characterized by impaired neuromuscular transmission, leading to muscle weakness and fatigue. Intravenous immunoglobulin (IVIg) has emerged as a key therapeutic option for MG, particularly in acute exacerbations and myasthenic crises. This systematic review evaluates the efficacy, safety, and optimal use of IVIg in MG management. Methods: Following SWiM guidelines, this review synthesizes data from randomized controlled trials, cohort studies, and other high-quality evidence published between 2015 and 2025. The analysis focuses on IVIg's mechanisms of action, including neutralization of autoantibodies, inhibition of complement activation, and modulation of cytokines. Results: Studies indicate that IVIg improves clinical outcomes in 73-76% of patients, with a favorable safety profile compared to plasma exchange (PLEX). However, questions remain regarding its role in chronic maintenance therapy, corticosteroid-sparing effects, and long-term outcomes. Emerging therapies, such as subcutaneous immunoglobulin (SCIG), FcRn inhibitors (e.g., efgartigimod), and complement inhibitors (e.g., zilucoplan), offer promising alternatives with potential advantages in convenience and specificity. Conclusion: While IVIg remains a cornerstone in MG management, the evolving therapeutic landscape provides new opportunities to enhance patient outcomes and quality of life. Future research should focus on long-term comparative studies, patient adherence, and cost-effectiveness to optimize MG treatment strategies. Keywords: Myasthenia gravis, intravenous immunoglobulin, IVIg, plasma exchange, FcRn inhibitors, complement inhibitors, corticosteroid-sparing, immunomodulation
DUAL ROLE OF MAGNESIUM IN MIGRAINE: EFFICACY & SAFETY IN TREATMENT AND PREVENTION—A META-ANALYSIS Isadora, Eugenia; Kusuma, Hendrawan Chandra; Prathama, Hans Aditya; Ann, Clara
Acta Neurologica Indonesia Vol. 3 No. 02 (2025): Acta Neurologica Indonesia
Publisher : Departemen Neurologi Fakultas Kedokteran Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69868/ani.v3i02.67

Abstract

Introduction: Magnesium deficiency has been associated with migraines, suggesting its potential as a therapeutic intervention. Objective: To assess the efficacy and safety of intravenous (IV) and oral magnesium for the treatment and prevention of migraines in adults. Material and methods: A systematic review following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines was conducted across multiple databases for randomized controlled trials (RCT) involving adult migraine patients treated with IV magnesium (1-2g) for acute attacks or oral magnesium (≥8 weeks) for prevention. Study quality was assessed using the Cochrane Risk of Bias 2 tool, and meta-analysis was conducted with Review Manager 5.4. Result: Twelve trials were included. IV magnesium showed significant benefits for acute migraines, including better headache response (p = 0.02), reduced pain intensity (p = 0.03), and less rescue medication use (p = 0.02). Oral magnesium was as effective as sodium valproate for prevention but showed limited benefits over placebo for attack frequency (p = 0.09). Gastrointestinal side effects were more common with oral magnesium (p = 0.01). Discussion: Magnesium modulates methyl-D-aspartate (NMDA) receptors, preventing excessive calcium influx and cortical spreading depression, which are key in migraine pathophysiology. IV magnesium is effective for acute treatment with a favorable safety profile. Oral magnesium shows potential for migraine prevention, with efficacy similar to sodium valproate, though gastrointestinal side effects limit its use. Conclusion: IV magnesium should be considered for acute attacks, while oral magnesium may be an alternative for prophylaxis in patients intolerant to first-line treatments.
Comprehensive Analysis of Histamine-2 Receptor Antagonists on Dementia Risk: A Systematic Review of Cohort Studies Yong, Yee Wen; Puspitasari, Vivien
Acta Neurologica Indonesia Vol. 3 No. 02 (2025): Acta Neurologica Indonesia
Publisher : Departemen Neurologi Fakultas Kedokteran Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69868/ani.v3i02.68

Abstract

Introduction : Histamine-2 Receptor Antagonist (H2RA) are widely used to manage upper gastrointestinal diseases (UGID). However, growing concerns have emerged regarding their potential neurocognitive side effect, particularly an increased dementia risk. H2RAs are often preferred over proton pump inhibitors (PPIs) for enhanced therapeutic efficacy in clinical settings. Material and methods : This research adhered to the PRISMA guidelines to select studies and assess biases. Databases (PubMed, Scopus, and Cochrane) are systematically searched from 2020-2025, and available studies are further evaluated for eligibility and risk of bias using the Cochrane risk of bias assessment tools for non-randomized studies of interventions (ROBINS-I). Discussion : Six studies were analyzed, with four cohort studies showing no significant association between H2RA use and dementia risk. However, H2RA use was associated with accelerated cognitive decline in patients with mild cognitive impairment (MCI) and Alzheimer’s disease (AD). The anticholinergic effects of H2RAs may contribute to cognitive impairment by disrupting histamine's role in the central nervous system and vitamin B12 absorption. However, the pathophysiological mechanisms remain unclear and the findings across studies are inconsistent. Further randomized controlled trials (RCTs) with larger sample sizes are needed to elucidate the potential long-term effects of H2RAs on cognitive health. Conclusion : This systematic review found no clear association between H2RA use and an increased risk of dementia, but noted accelerated cognitive decline in MCI and AD patients. Keywords: alzheimer’s disease; cognitive impairment; dementia; gastric acid-suppressive agents; histamine-2 receptor antagonists
Jaknews Proceeding Abstracts Indonesia, Acta Neurologica
Acta Neurologica Indonesia Vol. 3 No. 02 (2025): Acta Neurologica Indonesia
Publisher : Departemen Neurologi Fakultas Kedokteran Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69868/ani.v3i02.79

Abstract

This is the proceeding book of abtracts published in JAKNEWS-12

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