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INDONESIA
Jurnal Farmasi Galenika
Published by Universitas Bhakti Kencana
ISSN : 24069299     EISSN : 25794469     DOI : https://doi.org/10.70410/jfg
Core Subject : Health,
Medicine & Pharmacology Public Health
The aim of JFG is to become a media for the publication of articles on Pharmaceutical and related practice-oriented subjects in the pharmaceutical sciences and technology. The scope of the journal is Pharmaceutical sciences, its research and its application. The journal aims to cover the latest outstanding developments in the field of Pharmaceutical science and Technology but not limited to the following branches: Pharmaceutics Pharmaceutical technogy International Regulatory Validation Techniques Industrial Pharmacy Nanotechnology Novel Drug Delivery Systems Quality Control Quality Assurance BioTechnology Bioinformatics Proteomics Biochemistry Pharmacognosy Herbal technology Pharmacology Toxicology Pharmacy Practice Pharmacoinformatics Phytochemistry Pharmaceutical Analysis Chiral Chemistry Synthetic Chemistry Drug Development Clinical Pharmacy Pharmacogenomics Pharmacetical Engineering
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 190 Documents
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Evaluasi Penggunaan Antibiotik pada Pasien Faringitis Di Suatu Rumah Sakit Di Kota Bandung Ida Lisni
JURNAL FARMASI GALENIKA Vol 2 No 01 (2015): JURNAL FARMASI GALENIKA
Publisher : Universitas Bhakti Kencana

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Abstract

Acute respiratory infections (ARI) is a very serious health problem in the world or in Indonesia. Period prevalence of ARI in Indonesia according Riskesdas 2013 amounted to 25.0%. Respiratory tract infections such as pharyngitis represent the vast majority of cases. Pharyngitis is largely caused by the bacterium Streptococcus group A β-haemolytic. One of the main drug is an antibiotic to treat pharyngitis. Improper use of antibiotics in the treatment of pharyngitis can lead to resistance and side effects, it is necessary to drugs use evaluate as a form of quality assurance of drug use to assess the suitability of the use of antibiotics in the treatment of pharyngitis. Research conducted an observational study with descriptive data presentation and data collection retrospectively. Based on the results of research in the period January to April 2015 obtained 56 patients studied. Patients with pharyngitis is pediatric (53.57%) and 46.43% is adult patients. All patients studied using antibiotic therapy. Antibiotics are widely used cephalosporins (89.29%), with sefiksim (60.71%). Results of the qualittive analysis known that patients received appropriate indication of antibiotic is 100%, appropriate doses of 96.49%, duration of therapy appropriate for 87.72%, the use of antibiotic combination that has a synergistic effect in 1(one) patient. There is no duplication, but there are 14 cases that have the potential occur drug interactions.
ANALISIS IN SILICO GENISTEIN DAN ANALOGNYA SEBAGAI INHIBITOR KANKER PAYUDARA RESEPTOR ESTROGEN ALFA POSITIF (ERα+) Fauzan Zein M
JURNAL FARMASI GALENIKA Vol 2 No 02 (2015): JURNAL FARMASI GALENIKA
Publisher : Universitas Bhakti Kencana

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Abstract

Breast cancer is the highest mortality disease on women in the world and about 60-80% of the cases are ERα+ breast cancer. The discovery of more selective to HERα, safe, and potential new anticancer agent is expected to help the treatment of ERα+ breast cancer. In silico analysis had been carried out by computational chemistry methods, including determination of physicochemical parameters such as lipophilicity/CLogP, molar refractivity/CMR, bond energy/HOMO-LUMO and E-Gap, partial charge reactivity; determination of structural similarity by overlaying, and the interaction analysis of genistein and its analogues against HERα by docking method. The result showed that group of -7OH on the C ring and group of -4'OH on the A ring of genistein were the major pharmacophore. More number of hydrogen bonds (especially to Arg394), shorter distance, and lower free binding energy resulted higher inhibitory activity, it was shown by MA6 which had 4 of hydrogen bonds (14,51 kcal/mol) and each of them bound to Arg394 (=N- aromatic, substituent of -4'OR), Arg394 (-4'OR), His524 (-7OR), and Leu391 (=N- aromatic, substituent of -4'OR). Genistein, MA6, and MA8 had similar activity to tamoxifen even predicted more potent (MA6), it was correlated to its binding with Arg394. The complete result of in silico analysis confirmed the activity of genistein and its analogues as an inhibitor of ERα+ breast cancer.
Formulasi Dan Uji Pelepasan Pada Mikroemulsi Ovalbumin Sebagai Sistem Penghantaran Protein Ida Kristianingsih
JURNAL FARMASI GALENIKA Vol 2 No 02 (2015): JURNAL FARMASI GALENIKA
Publisher : Universitas Bhakti Kencana

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Abstract

Microemulsions are thermodynamically stable colloidal dispersions of water and oil stabilized by a surfactant and a cosurfactant. The aim of the present study was to developmicroemulsion as a protein delivery based on proteins released by using ovalbumin (OVA) as a model protein. W/O microemulsion with the concentration ratio of surfactant (Tween 80-Span 80) cosurfactant (butanol) 5:1, 6:1, 7:1 were investigated. All formulation showed similarity organoleptic (yellow, transparent, low viscosity). Ovalbumin release test were analyzed using UV-Vis spectrophotometric method at wavelength 584 nm. Comomassie Brilliant Blue (CBB) were use detection of ovalbumin. Franz diffusion cells with the cellophane membraneswere used. The amount of released OVA was measured with UV-spectrophotometric and the percentage of drug released was calculated. The highest AUC of released ovalbumin from microemulsion were formula 5:1. Based on the results obtained that the w/o microemulsion 5:1 could be used as a possible alternative to protein delivery system. Keywords : Kata kunci :
LARVACIDAL ACTIVITY OF EXTRACT AND ESSENTIAL OIL OF CURCUMA MANGGA RHIZOME (Curcuma mangga VAL.) AGAINST LARVAEAedesaegypti Dudi Runadi
JURNAL FARMASI GALENIKA Vol 2 No 02 (2015): JURNAL FARMASI GALENIKA
Publisher : Universitas Bhakti Kencana

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Abstract

Dengue Hemorrhagic Fever (DHF) causedby Aedesaegypti is a pestilentdisease. Many people commonlyuselarvacidefromthehazardous syntheticmaterials for preventingthis disease.In this study, larvacidal activity of ethanolextractandessential oil of Curcuma mangga rhizome was investigated.Test solutions prepared by diluting each extract and essential oil in order to obtain100 µg/mL, 50 µg/mL, 10 µg/mL, 5 µg/mL, 1 µg/mL and 0.5 µg/mLconcentrations in 100 ml water.Larvae Aedesaegyptiinstar 3-4 were used in this study.The results of larvacidal test showed that the extract of Curcuma mangga rhizome was not significantly performed the larvacidal activity, whereas the essential oil of Curcuma mangga significantly performed the larvacidal activity with the values of LC50 as 61.025 µg/mL.
AKTIVITAS ANTIDIABETES DARIEKSTRAK ETANOL BIJI HANJELI (Coix lacryma-jobi) PADAMENCITGALUR SWISS WEBSTER YANG DIINDUKSI ALOKSAN Elis Susilawati
JURNAL FARMASI GALENIKA Vol 2 No 02 (2015): JURNAL FARMASI GALENIKA
Publisher : Universitas Bhakti Kencana

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Abstract

Diabetes mellitus is a disease which is marked by increasing glucose blood levels because of absolut or relative insulin deficiency. Hanjeli seeds (Coix lacryma Jobi) was expected to have an antidiabetic activites. This study aimed to determine the antidiabetic activity of ethanol extract of hanjeli seeds (Coix lacryma Jobi). This study was conducted by in – vivo, in which the male Swiss Webster mice was induced by alloxan intravenously with dose 50-55 mg/Kg. The 30 mice were randomly divided into six groups, the positive control group, negative control group, the dose I group (100 mg/kg bw), the dose II group (200 mg / kg bw), dose III group (400 mg/Kg bw), and the glibenclamide 0,65 mg/kg bw group. The data were analyzed using One Way Anova and Post-hoc LSD test. The results showed that there were no significant difference in the decreasing of glucose blood level between hanjeli seed etanol extract doses of 100 mg/kg bw, 200 mg/Kg bw, and 400 mg/Kg bw compared to the positive control. In conclusion, the ethanol extract of hanjeli seeds can not decrease glucose blood levels. Keywords: Kata kunci:
ANTIHYPERGLICEMIA ACTIVITY OF WATER FRACTION, ETHYL ACETATE FRACTION, AND N- HEXANE FRACTION OF SPINACH LEAVES EXTRACT (Amaranthus Cruentus L) ON MALE MICE SWISS Tita Nofianti
JURNAL FARMASI GALENIKA Vol 2 No 02 (2015): JURNAL FARMASI GALENIKA
Publisher : Universitas Bhakti Kencana

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Abstract

The activity test ofthe water fraction, ethyl acetate and n-hexane fraction of spinach leaves (Amaranthus cruentus L) has been conducted using the glucose tolerance method on male mice Swiss webster strain. The dose were water fraction 0.086 g/kg bw, ethyl acetate fraction 0.03g/kg body weight and n-hexane fraction 0.055 g/kg bw. Time measurement of blood glucose levels was conducted every 30 minutes for 120 minutes using a glucometer. The results showed that administration of water fraction, ethyl acetate fraction and n-hexane fraction of spinach leaves can lowering the blood glucose level of white male mice. While the best group that lowering the blood glucose level was ethyl acetate fraction 0,03 g/kg bw when compared to water fraction and n-hexane fraction. It can be concluded that spinach leaves showed antihyperglicemia.
MICROMERITIC CHARACTERISTIC OF SPHERICAL AGGLOMERATED ACETAMINOPHEN CRYSTAL BY SPHERICAL NEUTRALIZATION METHOD Lilis Tuslinah
JURNAL FARMASI GALENIKA Vol 2 No 02 (2015): JURNAL FARMASI GALENIKA
Publisher : Universitas Bhakti Kencana

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Abstract

Direct tableting method needs to increase compressibility and flowability of the bulk powder in order to maintain a steady supply of powder mixture to tableting machine and sufficient mechanical strength of compacted tablet. Acetaminophen exhibits poor water solubility and flow properties.Spherical agglomerates of acetaminophen were prepared by neutralization method. Spherical agglomerates were characterized by differential scanning calorimetry, Infrared spectroscopy and X-ray diffactometry. Micromeritic behavior of pure and spherical agglomerates of acetaminophen were carried out. Spherical agglomerates exhibited improved micromeritic properties compared with pure Acetaminophen.
Aktivitas Antidiare Seduhan Kayu Secang (Caesalpinia sappan L.) Pada Mencit (Mus musculus) Parawansah P
JURNAL FARMASI GALENIKA Vol 2 No 02 (2015): JURNAL FARMASI GALENIKA
Publisher : Universitas Bhakti Kencana

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Sappan (Caesalpinia sappan L.) is one of the plants that has efficacy in treating some diseases. One of them is as an antidiarrheal. The nature of the Caesalpinia sappan are adstringens which can relieve diarrhea with intestinal mucous membrane collapse. The purpose of this study was to determine the effect of antidiarrheal of C.sappan steeped and to know how much concentration that has an effect as an antidiarrheal in mice. The type of this research was experimental study consisting of five treatments with three repetitions. Research carried out by observing the frequency of diarrhea to change to be normal feces after oral administration with C.sappan steeped with a concentration of 1%, 2%, 3%, Loperamideas a positive control, Na CMC as a negative control and the time of observation for 10 hours.The results showed that C.sappan steeped showed the most good antidiarrheal effect that was at a concentration of 2% b/v with an average frequency of bowel movements as much as 1.6 times. Anova statistical analysis results showed that the data hypothesis was accepted or there were significant differences between treatment groups. This research concluded that C. sappan steeped could give antidiarrheal effects that accelerated the changes of feces consistency to be normal.
NAPAK TILAS JAHE GAJAH (Zingiber officinale Roscoe var officinale) DAN JAHE MERAH (Zingiber officinale var rubrum) I Ketut Adnyana
JURNAL FARMASI GALENIKA Vol 3 No 01 (2016): JURNAL FARMASI GALENIKA
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Abstract

Penelitian tentang jahe merah kini marak dilakukan menyusul akan penelitian yang menunjukkan keunggulan jahe merah terhadap jahe gajah. Dalam review ini dibahas perbandingan beberapa aktivitas farmakologi dari jahe merah dan jahe gajah. Pencarian data dilakukan dengan menggunakan search engine berupa Scopus, Science Direct, Google Scholar, dan Pubmed dengan menggunakan kata kunci berupa nama ilmiah tanaman dan aktivitas farmakologinya
ETHANOL EXTRACT FORMULATION OF TUNJUK LANGIT RHIZOME AS TABLET BY WET GRANULATION METHOD Fitrya A
JURNAL FARMASI GALENIKA Vol 3 No 01 (2016): JURNAL FARMASI GALENIKA
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Tunjuk langit rhizome (Helminthostahcys zeylanica (Linn) Hook) has been used traditionally as an anticancer and antiinflammatory agent. Previous studies have proved the potency of ethanol extract from this rhizome as an antihyperuricemic agent. In this study, the ethanol extract of the rhizome, was formulated into tablet dosage forms by a wet granulation method. Three tablet formulas with different types of disintegrant and binder were formula A (starch: PVA), formula B (Avicel®PH102: PVP), and formula C (sodium alginate: methylcellulose). Physical properties (such as weight variation, tablet diameter, thickness, friability, hardness, and disintegration time) and dissolution of tablets were evaluated. The analysis results showed that formula A produced the best physical properties and dissolution characteristics.

Page 3 of 19 | Total Record : 190

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