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Reza Pratama
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INDONESIA
Jurnal Farmasi Galenika
Published by Universitas Bhakti Kencana
ISSN : 24069299     EISSN : 25794469     DOI : https://doi.org/10.70410/jfg
Core Subject : Health,
Medicine & Pharmacology Public Health
The aim of JFG is to become a media for the publication of articles on Pharmaceutical and related practice-oriented subjects in the pharmaceutical sciences and technology. The scope of the journal is Pharmaceutical sciences, its research and its application. The journal aims to cover the latest outstanding developments in the field of Pharmaceutical science and Technology but not limited to the following branches: Pharmaceutics Pharmaceutical technogy International Regulatory Validation Techniques Industrial Pharmacy Nanotechnology Novel Drug Delivery Systems Quality Control Quality Assurance BioTechnology Bioinformatics Proteomics Biochemistry Pharmacognosy Herbal technology Pharmacology Toxicology Pharmacy Practice Pharmacoinformatics Phytochemistry Pharmaceutical Analysis Chiral Chemistry Synthetic Chemistry Drug Development Clinical Pharmacy Pharmacogenomics Pharmacetical Engineering
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 5 Documents
 1 
Search results for , issue "Vol 12 No 2 (2025): Jurnal Farmasi Galenika" : 5 Documents clear
Analisis Kualitatif Bahan Kimia Obat Dalam Jamu Pegel Linu Di Wilayah Temanggung Dwibara Bayuaji; Haresmita, Perdana Priya
JURNAL FARMASI GALENIKA Vol 12 No 2 (2025): Jurnal Farmasi Galenika
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v12i2.301

Abstract

Jamu pegal linu merupakan obat tradisional yang banyak diminati oleh masyarakat karena memiliki banyak manfaat. Bahan Kimia Obat (BKO) sering ditambahkan pada jamu pegal linu untuk menambah khasiatnya. Tujuan dari penelitian kali ini akan melakukan analisis kualitatif sampel jamu pegal linu dengan tujuan untuk mengetahui apakah produk yang mengandung bahan kimia obat (BKO) dengan standar pembanding prednison, asam mefenamat, natrium diklofenak dan ibuprofen. Sampel A, B, C dan D merupakan sampel jamu pegal linu yang diperoleh dari toko jamu di wilayah Temanggung. Analisis kualitatif BKO dilakukan dengan Kromatografi Lapis Tipis (KLT) menggunakan fase diam silika gel 60 F254, fase gerak Etil asetat : klorofom (4:1), etil asetat : heksana (1:4), kloroform : etanol (4,5:0,5), klorofom : Etil asetat (4,5:0,5)  dan dideteksi sinar UV 254 nm. Berdasarkan uji organoleptis diperoleh data yang bervariasi. Setiap sampel jamu memiliki bau, rasa, warna, bentuk, dan sediaan yang beragam. Berdasarkan uji KLT tidak ditemukan kandungan prednison, ibuprofen dan asam mefenamat pada seluruh sampel. Sampel B, C dan D positif mengandung natrium diklofenak.
Analisis Parameter Spesifik Dan Non Spesifik Simplisia Daun Cengkeh (Syzygium aromaticum L.) Balqis Tamatantri, Amani; Mulatasih, Endah
JURNAL FARMASI GALENIKA Vol 12 No 2 (2025): Jurnal Farmasi Galenika
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v12i2.383

Abstract

The leaves of the clove plant (Syzygium aromaticum L.) have not been optimally utilized despite containing active compounds such as flavonoids, triterpenoids, phenolics, and tannins with potential antibacterial properties. This study aims to evaluate the quality of clove leaf simplicia through specific and non-specific parameter analysis as a basis for establishing pharmaceutical raw material standards. The research employed a non-experimental design with a descriptive- analytical approach. Specific parameters assessed included simplicia identification, organoleptic characteristics, microscopic analysis, and water- and ethanol-soluble extract content. Non-specific parameters covered drying loss, moisture content, total ash, and acid-insoluble ash. The results showed that the simplicia powder had a green color, a distinct aroma, a bitter taste, and contained active compounds such as saponins, tannins, alkaloids, flavonoids, and steroids. The water-soluble extract content was 25.569%, and the ethanol-soluble extract content was 14.106%. Meanwhile, the non-specific test results indicated a drying loss of 8.8%, moisture content of 10.23%, total ash content of 3.87%, and acid-insoluble ash content of 0.85%. Based on these findings, clove leaf simplicia meets quality standards and has potential for use as a raw material in traditional medicine formulations
Tingkat Pengetahuan Dan Penggunaan Jamu Di Desa Jawa Laut Kota Martapura: Studi Cross-Sectional Fitriah, Rahmayanti; Sihombing, Yuliana; Wahyudi, Wahyudi
JURNAL FARMASI GALENIKA Vol 12 No 2 (2025): Jurnal Farmasi Galenika
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v12i2.388

Abstract

Herbal medicine is one form of traditional medicine that is still widely used by the Indonesian people. The perception that herbal medicine is safer than modern medicine is one of the reasons for the high demand for its use. However, the trend of increasing consumption of herbal medicine among the public has brought new challenges, particularly regarding safety, quality, and efficacy claims. Without adequate knowledge, the use of jamu carries the risk of side effects, interactions with modern medications, or improper dosing. Therefore, a good understanding of the proper and safe use of jamu is crucial to prevent potential hazards and ensure optimal benefits. The objective of this study is to investigate the relationship between knowledge levels and jamu use in Jawa Laut Village, Martapura City. This study employed an analytical observational method with a cross-sectional approach using non-random sampling, specifically accidental sampling, conducted from January to March 2022. In this study, univariate and bivariate data were analyzed using the Chi-Square test. The results showed that the community's knowledge was in the good category, with 79 respondents (79%), and herbal medicine use was in the high category, with 76 respondents (76%). Thus, there is a relationship between knowledge and herbal medicine use in Jawa Laut Village, Martapura City, South Kalimantan, Indonesia.
Analisis Bioinformatika Ekspresi MIER3 sebagai Biomarker Potensial dan Target Terapeutik pada Kanker Esofagus Amukti, Danang; Ria Indah Pratami
JURNAL FARMASI GALENIKA Vol 12 No 2 (2025): Jurnal Farmasi Galenika
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v12i2.389

Abstract

Esophageal cancer (ESCA) is one of the cancers with high mortality rates worldwide. Determination of prognostic biomarkers that can predict patient survival is very important to support more effective therapy management. The MIER3 gene has been reported to play a role in the regulation of gene expression and cell proliferation pathways, but its role in ESCA is still not fully understood. MIER3 gene expression data and patient clinical information were obtained from the UALCAN database based on TCGA. Survival analysis was performed using the Kaplan-Meier method to evaluate the effect of MIER3 expression levels on ESCA patient survival. Further analysis was performed by combining MIER3 expression with clinical variables such as tumor grade, race, gender, and weight status. MIER3 expression was significantly higher in tumor tissue than in normal tissue. Kaplan-Meier showed that patients with high MIER3 expression had significantly lower survival than the low expression group (p = 0.00013). The combination of MIER3 expression and clinical factors such as gender (p = 0.00046), race (p = 0.0095), and body weight (p = 0.008) also showed a prognostic relationship to survival. MIER3 has the potential as a prognostic biomarker in esophageal cancer. High MIER3 expression correlates with poor prognosis, especially when combined with certain clinical factors. These findings suggest that MIER3 may play a role in tumor progression through molecular mechanisms involving activation of proliferative pathways and inhibition of apoptotic pathways, and support the development of gene expression-based targeted therapy.
Uji Efek Ekstrak Etanol Herba Ketumbar (Coriandrum sativum L.) Sebagai Afrodisiak Terhadap Tikus Putih Jantan Galur Wistar (Rattus norvegicus) Wirasti, Wirasti; Anjani, Lestari Dwi; Waznah, Urmatul; Wahyu Permadi, Yulian
JURNAL FARMASI GALENIKA Vol 12 No 2 (2025): Jurnal Farmasi Galenika
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v12i2.303

Abstract

One of the common male sexual disorders is low libido (sexual desire). An alternative approach to overcome this problem is the use of aphrodisiacs, substances that stimulate and enhance sexual desire. Coriander (Coriandrum sativum L.) contains flavonoids, alkaloids, saponins, and terpenoids, which may improve blood circulation and potentially enhance sexual activity. This study aimed to evaluate the aphrodisiac activity of ethanolic extract of coriander herb (EHC) on the libido of male Wistar rats (Rattus norvegicus). The extract was obtained using the maceration method, while the aphrodisiac test was conducted on 25 male and 25 female rats aged 2–2.5 months with body weight ranging from 150–200 g. The animals were divided into five groups, each consisting of 5 males and 5 females: negative control (1% Na CMC), positive control (sildenafil 50 mg), and three treatment groups receiving EHC at doses of 400 mg/kgBW, 600 mg/kgBW, and 800 mg/kgBW. For five consecutive days (6:00 p.m.–7:00 a.m.), one male and one female were placed in the same cage, and sexual activities of male rats (introducing and mounting) were observed using CCTV recordings. The results showed that EHC exhibited aphrodisiac activity at a dose of 800 mg/kgBW, which was not significantly different from the positive control (sildenafil 50 mg) (p=0.571). Statistical analysis using One-Way ANOVA indicated a significant difference among groups (p<0.05), and Tukey’s post-hoc test confirmed significant differences among all EHC dose groups (p<0.05). In conclusion, the ethanolic extract of coriander herb demonstrates potential as an aphrodisiac to enhance libido in male Wistar rats.

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