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M. Rizky Mahaputra
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INDONESIA
Dinasti Health and Pharmacy Science
Published by Dinasti Research
ISSN : -     EISSN : 30252326     DOI : https://doi.org/10.38035/dhps.v1i1
Core Subject : Health,
Dinasti Health and Pharmacy Science (DHPS) focuses on the health and pharmaceutical sciences including the preventive, promotive, curative and rehabilitative domains which publishes "original articles" and "review articles". The scientific scope of the DHPS Journal includes: Public health Health Education and Promotion Health Management Disease Prevention Midwifery and Child Care Health and Social Behavior Health Traditional (HATTRA) Nutrition (Clinical Nutrition and Community Nutrition) Food safety Food security Cleanliness Food Technology related to Disease Prevention and Rehabilitation Environmental Health Pharmaceutical Technology, Pharmacology and Toxicology, Pharmaceutical Chemistry, drug discovery, Pharmacokinetics, Pharmaceutical Biology, Herbal medicines, Pharmaceutical sciences, Pharmaceutical Microbiology and Biotechnology, Community and Clinical Pharmacy, Complementary and Alternative Medicine (CAAM), Pharmaceutical Treatment.
Articles 131 Documents
Analisis Persepsi Pasien Terhadap Kejelasan Etiket dan Efektivitas Penjelasan Tenaga Kefarmasian Dalam Pelayanan Informasi Obat di Klinik Pratama Nur Hidayah Sani Sholehatun Nisa; Hasna Latipah Sakinah
Dinasti Health and Pharmacy Science Vol. 4 No. 1 (2026): Dinasti Health and Pharmacy Science (July - September 2026)
Publisher : Dinasti Research & Yayasan Dharma Indonesia Tercinta (DINASTI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.38035/dhps.v4i1.3817

Abstract

Pelayanan Informasi Obat (PIO) merupakan bagian penting dari pelayanan kefarmasian untuk meningkatkan keselamatan pasien melalui penyampaian informasi obat yang jelas dan mudah dipahami. Penelitian ini bertujuan menganalisis persepsi pasien terhadap kejelasan etiket dan efektivitas penjelasan tenaga kefarmasian di Klinik Pratama Nur Hidayah. Penelitian menggunakan metode deskriptif dengan pendekatan kuantitatif terhadap 20 responden menggunakan kuesioner terstruktur yang dianalisis secara deskriptif. Hasil penelitian menunjukkan bahwa seluruh responden (100%) menyatakan tulisan pada etiket mudah dibaca, sebanyak 95% responden menyatakan instruksi aturan pakai pada etiket sesuai dengan penjelasan petugas, sedangkan 80% menyatakan petugas menjelaskan cara penggunaan obat dengan jelas. Sebanyak 95% responden menyatakan petugas menjelaskan aturan penggunaan obat dan penjelasan terdengar jelas, sedangkan 90% menyatakan petugas memastikan pemahaman pasien. Namun, 30% responden belum memahami frekuensi dan jarak waktu penggunaan obat serta 40% belum memahami kegunaan obat. Penelitian ini menunjukkan bahwa kejelasan etiket dan efektivitas penjelasan tenaga kefarmasian telah dipersepsikan baik oleh pasien, namun penyampaian informasi mengenai frekuensi penggunaan dan kegunaan obat masih perlu ditingkatkan.
Effects of Clinical Leadership and Intrinsic Motivation on Patient Safety Culture Through Effective Communication in the Outpatient Unit of Mandaya Puri Hospital William Wilson; Intan Silviana Mustikawati; Nofierni
Dinasti Health and Pharmacy Science Vol. 4 No. 1 (2026): Dinasti Health and Pharmacy Science (July - September 2026)
Publisher : Dinasti Research & Yayasan Dharma Indonesia Tercinta (DINASTI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.38035/dhps.v4i1.3833

Abstract

Patient safety culture is an important component of hospital quality and safe healthcare delivery. This study aimed to determine the effects of clinical leadership and intrinsic motivation on patient safety culture through effective communication as a mediating variable among healthcare workers in the outpatient unit of Mandaya Puri Hospital. This was a quantitative explanatory study with a cross-sectional design involving 110 doctors and nurses selected using total sampling. Data were collected using a four-point Likert questionnaire and analyzed using partial least squares structural equation modeling (PLS-SEM) with SmartPLS. Descriptive analysis used the Three-Box Method. All variables were categorized as high: clinical leadership 85.94, intrinsic motivation 87.80, effective communication 84.63, and patient safety culture 86.21. The structural model explained 97.4% of the variance in patient safety culture (R²=0.974) and 94.6% of the variance in effective communication (R²=0.946). Clinical leadership significantly affected effective communication (β=0.912; p<0.001) and patient safety culture (β=0.282; p=0.026). Effective communication significantly affected patient safety culture (β=0.421; p<0.001), while intrinsic motivation significantly affected patient safety culture (β=0.296; p=0.001) but not effective communication (β=0.062; p=0.588). Effective communication partially mediated the effect of clinical leadership on patient safety culture (β=0.384; VAF=57.66%), but did not mediate the effect of intrinsic motivation (β=0.026; p=0.625; VAF=8.07%). These findings indicate that strengthening clinical leadership, intrinsic motivation, and effective communication is important for improving patient safety culture
Hubungan Kebiasaan Konsumsi Junk Food Dengan Kadar Gula Darah Sewaktu Pada Mahasiswi Politeknik Piksi Ganesha Sindi Parida Santika; Restiani Alia Pratiwi
Dinasti Health and Pharmacy Science Vol. 4 No. 1 (2026): Dinasti Health and Pharmacy Science (July - September 2026)
Publisher : Dinasti Research & Yayasan Dharma Indonesia Tercinta (DINASTI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.38035/dhps.v4i1.3834

Abstract

Changes in the lifestyles of female college students, particularly regarding junk food consumption, have the potential to affect blood sugar levels. This study aimed to analyze the relationship between junk food consumption habits and random blood sugar levels among female students at Politeknik Piksi Ganesha. An observational analytic method with a cross-sectional design was employed, involving 30 respondents selected via purposive sampling. Data on junk food consumption were obtained using a Food Frequency Questionnaire (FFQ), while blood sugar levels were measured using the Point of Care Testing (POCT) method. Data were analyzed using Fisher’s Exact Test. The results showed that 50% of respondents consumed junk food frequently and 50% infrequently, with the majority (86.7%) exhibiting normal blood sugar levels. Statistical analysis yielded a p-value of 0.100 (p > 0.05), indicating no significant relationship. However, a descriptive trend toward higher blood sugar levels was observed in the frequent consumption group. It is concluded that while no significant relationship was found, junk food consumption should still be limited to prevent metabolic disorders.
Refractive Errors in Down Syndrome: An Integrative Review of Emmetropization Failure, Corneal Biomechanics, and Accommodative Dysfunction Mohammad Aulia Molid Ogest Putra Calisanie; Ramzi Amin; Rusdianto Rusdianto
Dinasti Health and Pharmacy Science Vol. 4 No. 1 (2026): Dinasti Health and Pharmacy Science (July - September 2026)
Publisher : Dinasti Research & Yayasan Dharma Indonesia Tercinta (DINASTI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.38035/dhps.v4i1.3840

Abstract

Down syndrome is the most common chromosomal disorder compatible with life and is associated with multisystem manifestations, including visual abnormalities. Refractive errors are among the most frequent ocular manifestations in Down syndrome, occurring at substantially higher rates than in the general population. Unlike typically developing children, who largely achieve emmetropia through a homeostatic process called emmetropization, children with Down syndrome show a low proportion of emmetropia and persistently heterogeneous refractive errors. This integrative review searched PubMed/MEDLINE, Scopus, Google Scholar, and the Cochrane Library to synthesize evidence on three domains hypothesized to interact in producing emmetropization failure in Down syndrome: corneal biomechanical alteration, accommodative dysfunction, and disrupted retinal blur signalling. Available evidence suggests that trisomy 21 is associated with dysregulated extracellular matrix and collagen organization that reduces corneal biomechanical stability, together with accommodation lag markedly greater than in children without Down syndrome. Both mechanisms appear to converge on persistent retinal image degradation, which may disrupt the visual signals required for refractive growth regulation and contribute to persistent ametropia, increased amblyopia risk, and long-term impairment of visual development. An integrated understanding of these mechanisms has important implications for longitudinal ophthalmologic screening strategies, early amblyopia detection, and more routine evaluation of accommodative function in the Down syndrome population.
Tinjauan Efektivitas Pengimplementasian Aplikasi Biometrik Bpjs pada Unit Rawat Jalan di Rs Muhammadiyah Bandung Emilia Septiani; Diansyah
Dinasti Health and Pharmacy Science Vol. 4 No. 1 (2026): Dinasti Health and Pharmacy Science (July - September 2026)
Publisher : Dinasti Research & Yayasan Dharma Indonesia Tercinta (DINASTI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.38035/dhps.v4i1.3849

Abstract

Transformasi digital dalam pelayanan kesehatan mendorong penerapan teknologi biometrik sebagai sarana verifikasi identitas peserta BPJS Kesehatan melalui Face Recognition Integrated System Technology Application (FRISTA). Penelitian ini bertujuan mengevaluasi efektivitas implementasi aplikasi biometrik BPJS pada unit rawat jalan di RS Muhammadiyah Bandung. Penelitian menggunakan metode deskriptif dengan pendekatan kualitatif melalui observasi, wawancara, dan studi dokumentasi terhadap Kepala Rekam Medis, petugas pendaftaran, petugas coding, dan petugas teknologi informasi.Hasil penelitian diharapkan dapat memberikan gambaran mengenai efektivitas implementasi sistem FRISTA dalam proses verifikasi identitas pasien BPJS, mengidentifikasi faktor-faktor yang memengaruhi keberhasilan maupun kendala pelaksanaannya, serta menjadi bahan evaluasi bagi rumah sakit dan BPJS Kesehatan dalam meningkatkan kualitas verifikasi biometric.
Anti-VEGF Therapy in Diabetic Retinopathy: A Synthesis of Efficacy, Durability, and a Clinical Decision-Making Framework in the Context of Developing Countries Mohammad Aulia Molid Ogest Putra Calisanie; Ramzi Amin; Petty Purwanita
Dinasti Health and Pharmacy Science Vol. 4 No. 1 (2026): Dinasti Health and Pharmacy Science (July - September 2026)
Publisher : Dinasti Research & Yayasan Dharma Indonesia Tercinta (DINASTI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.38035/dhps.v4i1.3850

Abstract

Diabetic retinopathy is a leading cause of preventable blindness in working-age populations, with vascular endothelial growth factor (VEGF) playing a central role in its progression. This critical narrative review aims to synthesize comparative evidence on the efficacy and durability of anti-VEGF agents and to formulate a contextual clinical decision-making framework for developing countries, particularly Indonesia. A literature search through PubMed/MEDLINE, Google Scholar, and ClinicalTrials.gov identified 143 articles; after stepwise screening with qualitative appraisal based on study design, sample size, and clinical relevance, 40 articles were included. Findings show that aflibercept demonstrated meaningful superiority in patients with poor baseline visual acuity of 20/50 or worse (approximately 2.7 ETDRS letters compared to bevacizumab, PROTOCOL T), while all three major agents yielded comparable outcomes at better baseline vision. Faricimab offered clinical durability up to 16 weeks in 53% of patients (YOSEMITE/RHINE). Approximately 30 to 40% of patients exhibit inadequate response, classifiable as primary non-response or secondary loss of response, each carrying distinct therapeutic implications. Optimal agent selection requires stratification by baseline visual acuity, durability profile, and cost-effectiveness considerations within Indonesia's National Health Insurance (JKN) system. Prospective research in the Indonesian population remains an urgent priority.
Anaphylactic Shock due to Oral Levofloxacin After Cataract Surgery: A Case Report Henny Tan; William; Suparto
Dinasti Health and Pharmacy Science Vol. 4 No. 2 (2026): Dinasti Health and Pharmacy Science (Oktober - Desember 2026)
Publisher : Dinasti Research & Yayasan Dharma Indonesia Tercinta (DINASTI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.38035/dhps.v4i2.3871

Abstract

Background: Levofloxacin is a fluoroquinolone antibiotic that is generally safe to use, but can cause severe hypersensitivity reactions such as anaphylactic shock in rare cases. Objectives: This study are use to report a case of anaphylactic shock following oral levofloxacin administration after cataract surgery and to describe its clinical manifestations and management. Methods: This study used a case study design with retrospective data collection from the patient's medical records. Data were analyzed descriptively and compared with literature findings related to fluoroquinolone hypersensitivity reactions. Results: A 60-year-old man developed a generalized erythematous rash, recurrent vomiting, diarrhea, shortness of breath, severe hypotension, and tachycardia within 15 minutes of taking oral levofloxacin following cataract surgery. Physical examination revealed widespread urticaria accompanied by a blood pressure of 70/50 mmHg, and laboratory tests revealed leukocytosis, elevated creatinine, and hypokalemia. The patient showed clinical improvement after fluid resuscitation, administration of the vasopressor norepinephrine, intravenous corticosteroids, antihistamines, and other supportive therapy, and was ultimately discharged in stable condition. Conclusions: Anaphylactic shock due to oral levofloxacin is a rare but life-threatening event that can occur even in the absence of a prior history of allergy. Early recognition and prompt and appropriate management are crucial to prevent fatal clinical outcomes.
Karakterisasi Infeksi Saluran Pernapasan Akut pada Balita di Kabupaten Tangerang Ratih Ajeng Miarsih; Elvira Purnamasari; Nurhayati
Dinasti Health and Pharmacy Science Vol. 4 No. 1 (2026): Dinasti Health and Pharmacy Science (July - September 2026)
Publisher : Dinasti Research & Yayasan Dharma Indonesia Tercinta (DINASTI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.38035/dhps.v4i1.3874

Abstract

Infeksi saluran pernapasan akut (ISPA) merupakan gangguan pernapasan yang diketahui berdampak sistemik karena dapat menyebabkan penyebaran infeksi, proses inflamasi, serta penurunan kemampuan paru-paru. Saat ini, ISPA telah menjadi penyebab utama dari penyakit mematikan di kalangan anak-anak di bawah lima tahun. Wilayah Kabupaten Tangerang merupakan salah satu wilayah dengan perkembangan industri yang cukup pesat. Di satu sisi, parameter klinis seperti frekuensi pernapasan dan saturasi oksigen (SpO₂) serta jenis kelamin di tiap wilayah merupakan indikator untuk menggambarkan kondisi respirasi dan membantu mengidentifikasi adanya gangguan pernapasan. Tujuan penelitian ini adalah untuk mengkarakterisasi kejadian ISPA pada balita di Kabupaten Tangerang berdasarkan karakteristik demografis dan parameter klinis. Metode deskriptif digunakan untuk memberikan gambaran atau analisis terhadap temuan dalam penelitian. Berdasarkan hasil pemeriksaan klinis persebaran kasus ISPA tidak merata di seluruh kecamatan Kabupaten Tangerang. Kelompok ISPA dengan rata-rata usia 4,92 didominasi oleh laki-laki dengan frekuensi pernapasan yang lebih lambat sehingga saturasi oksigen mencapai 92,9% dengan gejala klinis berupa myalgia, batuk malam, dan inflamasi. Hasil ini menegaskan bahwa radang tenggorokan, nyeri otot, dan durasi batuk malam merupakan prediktor klinis utama yang membedakan kelompok kasus dan hal ini menjadi penemuan lanjutan indikator respirasi akut seperti saturasi oksigen dan laju pernapasan relatif yang berbeda di antara kedua kelompok
Hubungan Manajemen Logistik Farmasi Dengan Pendapatan Rumah Sakit Dalam Skema Jaminan Kesehatan Nasional Dita Purnama Sari; Agusdini Banun Saptaningsih; Johanes
Dinasti Health and Pharmacy Science Vol. 4 No. 1 (2026): Dinasti Health and Pharmacy Science (July - September 2026)
Publisher : Dinasti Research & Yayasan Dharma Indonesia Tercinta (DINASTI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.38035/dhps.v4i1.3883

Abstract

Manajemen logistik farmasi merupakan faktor strategis bagi kesinambungan finansial rumah sakit kelas C swasta yang pendapatannya bergantung pada klaim INA-CBGs dalam skema Jaminan Kesehatan Nasional (JKN). Penelitian ini bertujuan menganalisis hubungan efisiensi pengelolaan stok obat dan ketepatan pengadaan dengan ketersediaan obat serta pendapatan rumah sakit, dan menjelaskan mekanisme di baliknya. Penelitian menggunakan desain kombinasi (mixed methods) sequential explanatory. Tahap  kuantitatif bersifat  asosiatif  potong  lintang  terhadap  19  pegawai instalasi farmasi RSU Kelas C Sumatera Barat yang diambil secara total sampling, dengan kuesioner skala Likert 1–4 yang dianalisis menggunakan statistik deskriptif Three-Box Method dan uji korelasi Spearman’s rho. Tahap kualitatif berupa satu sesi Focus Group Discussion terhadap sembilan informan lintas fungsi untuk menjelaskan temuan kuantitatif. Hasil uji korelasi menunjukkan kelima hubungan antar variabel bersifat positif dan signifikan, dengan ketersediaan obat memiliki keeratan tertinggi dengan pendapatan rumah sakit (ρ=0,815; p<0,001). Keempat variabel berada  pada  kategori sedang,  menandakan kinerja  yang  cukup namun belum optimal. Hasil FGD mengonfirmasi dan menjelaskan bahwa kekosongan obat, pembelian darurat, serta keterlambatan klaim berakar pada perencanaan berbasis  pola  konsumsi,  keterlambatan pemasok,  distribusi internal, dan pencatatan yang belum tertib. Ketersediaan obat menjadi simpul yang menghubungkan kapabilitas pengelolaan dan pengadaan dengan kinerja pendapatan.
Formulation and Antibacterial Activity of Anti-Acne Gel Containing Ethanol Extract of Avocado Leaves (Persea americana Mill.) Against Staphylococcus epidermidis Dinda Sari Utami; Haris Munandar Nasution; Zulmai Rani; Nur Aini Khairunnisa; Halimah Raina Nasution
Dinasti Health and Pharmacy Science Vol. 4 No. 1 (2026): Dinasti Health and Pharmacy Science (July - September 2026)
Publisher : Dinasti Research & Yayasan Dharma Indonesia Tercinta (DINASTI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.38035/dhps.v4i1.3885

Abstract

Acne is a chronic inflammatory skin disorder associated with bacterial colonization, including Staphylococcus epidermidis, which contributes to acne lesion development. The increasing concern regarding antibiotic resistance has encouraged the exploration of natural antibacterial agents from medicinal plants. This study aimed to formulate an anti-acne gel containing ethanol extract of avocado leaves (Persea americana Mill.) and evaluate its antibacterial activity against Staphylococcus epidermidis. Ethanol extract was obtained using the maceration method and subjected to phytochemical screening. The antibacterial activity of the extract was evaluated by determining the Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) using the microdilution method. The extract was subsequently formulated into gel preparations and evaluated for physical characteristics, including organoleptic properties, homogeneity, pH, viscosity, spreadability, adhesion, and antibacterial activity using the agar diffusion method. The results showed that avocado leaf ethanol extract exhibited antibacterial activity with an MIC value of 64,000 µg/mL, while the MBC was not determined within the tested concentrations. The formulated gels met the physical quality requirements, with inhibition zones of 15.0 ± 1.7 mm and 11.0 ± 3.6 mm against Staphylococcus epidermidis for Formula I and Formula II, respectively. In conclusion, ethanol extract of avocado leaves can be incorporated into an anti-acne gel preparation with acceptable physicochemical characteristics and antibacterial potential against Staphylococcus epidermidis. This study provides preliminary evidence supporting the development of plant-based topical formulations as potential alternatives for acne management.