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Dinasti Health and Pharmacy Science
Published by Dinasti Research
ISSN : -     EISSN : 30252326     DOI : https://doi.org/10.38035/dhps.v1i1
Core Subject : Health,
Health Professions
Dinasti Health and Pharmacy Science (DHPS) focuses on the health and pharmaceutical sciences including the preventive, promotive, curative and rehabilitative domains which publishes "original articles" and "review articles". The scientific scope of the DHPS Journal includes: Public health Health Education and Promotion Health Management Disease Prevention Midwifery and Child Care Health and Social Behavior Health Traditional (HATTRA) Nutrition (Clinical Nutrition and Community Nutrition) Food safety Food security Cleanliness Food Technology related to Disease Prevention and Rehabilitation Environmental Health Pharmaceutical Technology, Pharmacology and Toxicology, Pharmaceutical Chemistry, drug discovery, Pharmacokinetics, Pharmaceutical Biology, Herbal medicines, Pharmaceutical sciences, Pharmaceutical Microbiology and Biotechnology, Community and Clinical Pharmacy, Complementary and Alternative Medicine (CAAM), Pharmaceutical Treatment.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 131 Documents
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Analysis of the Safety of Antihypertensive Drug Use in Elderly Patients Ridwan
Dinasti Health and Pharmacy Science Vol. 2 No. 2 (2024): Dinasti Health and Pharmacy Science (October 2024)
Publisher : Dinasti Research & Yayasan Dharma Indonesia Tercinta (DINASTI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.38035/dhps.v2i2.1813

Abstract

Hypertension is a common health condition among elderly individuals, requiring careful management through antihypertensive medications. However, the use of these medications in older adults raises concerns about the safety and prevalence of side effects, which can significantly impact their quality of life and adherence to treatment. This study aims to analyze the safety of antihypertensive medication use in elderly patients by evaluating the prevalence of common side effects, identifying potential drug interactions, and exploring factors influencing treatment success. A mixed-methods approach was used, combining quantitative data from structured surveys and clinical records with qualitative insights from semi-structured interviews with patients and healthcare providers. The results revealed that dizziness, fatigue, and hypotension were the most common side effects, with a prevalence of 25%, 18%, and 15%, respectively. Older patients and those with comorbid conditions such as diabetes were found to be more prone to these side effects. The study also identified the importance of personalized treatment approaches, with healthcare providers emphasizing regular monitoring, medication adjustments, and patient education as key strategies to mitigate risks. These findings underscore the need for tailored antihypertensive therapy in elderly patients, considering individual characteristics and potential side effects. The study highlights the critical role of healthcare providers in managing these medications safely and effectively, ensuring better outcomes for elderly patients with hypertension. Future research should focus on larger, longitudinal studies to assess long-term effects and explore alternative treatment options that minimize adverse reactions.
The Role of Proteolytic Activity and Computational Studies on Protease Efficiency in Wound Healing Yorasakhi Ananta; Salsabila Dwi Fitri
Dinasti Health and Pharmacy Science Vol. 2 No. 2 (2024): Dinasti Health and Pharmacy Science (October 2024)
Publisher : Dinasti Research & Yayasan Dharma Indonesia Tercinta (DINASTI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.38035/dhps.v2i2.1820

Abstract

Microbial proteases play an important role in various medical applications, especially in the wound healing process. Their proteolytic activity allows the breakdown of proteins involved in the inflammatory process and tissue regeneration. This study aims to review the role of microbial proteolytic activity in wound healing and explore the application of computational studies to predict the effectiveness of proteases in wound therapy. Molecular modeling and in silico prediction are used to identify potential proteases that are efficient in improving wound healing. This study also includes an analysis of the mechanism of action of proteases on biological molecules in wounds, as well as the challenges and prospects of using microbial proteases in modern medical therapy.
Protease Enzyme Producing Microorganisms and Their Application in Disinfection of Infected Wounds Yumna Syaza Kani Putri
Dinasti Health and Pharmacy Science Vol. 2 No. 2 (2024): Dinasti Health and Pharmacy Science (October 2024)
Publisher : Dinasti Research & Yayasan Dharma Indonesia Tercinta (DINASTI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.38035/dhps.v2i2.1822

Abstract

Wound infection is a serious clinical challenge, mainly due to increasing antibiotic resistance and biofilm formation by pathogenic microorganisms. Protease enzymes produced by various microorganisms, especially bacteria, have shown potential in decomposing necrotic tissues, destroying biofilms, and enhancing the efficacy of other antimicrobial agents. The literature shows that microorganisms such as Bacillus subtilis, Pseudomonas aeruginosa, and Streptomyces spp. produce proteases with significant pharmacological activities. The application of these enzymes in topical formulations, bioactive wound dressings, and combination therapies has become the focus of research in the fields of pharmaceuticals and medical biotechnology. This article aims to review the characteristics of protease-producing microorganisms, the mechanism of action of enzymes in the wound disinfection process, and the challenges and prospects of their future applications. This review is expected to be a scientific basis for the development of biotechnology-based wound therapy.
Literature Review on Characterization and Optimization of Protease Enzymes for Medical Applications Yorasakhi Ananta
Dinasti Health and Pharmacy Science Vol. 2 No. 2 (2024): Dinasti Health and Pharmacy Science (October 2024)
Publisher : Dinasti Research & Yayasan Dharma Indonesia Tercinta (DINASTI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.38035/dhps.v2i2.1824

Abstract

Protease enzymes are a group of enzymes that play an important role in protein breakdown and have been widely studied for medical applications, especially in the fields of wound healing, cancer therapy, and antimicrobials. This article presents a systematic review of various studies exploring the biochemical characterization and optimization of protease enzyme activity produced by microorganisms. The main focus of this review includes the optimum conditions for enzyme activity, stability to pH and temperature, and genetic engineering and fermentation methods for increasing its production. It was found that thorough characterization is very important in determining the potential for clinical application of protease enzymes. In addition, optimization of enzyme production through fermentation and biotechnology approaches has been shown to increase efficiency and reduce the risk of side effects in medical applications. This review provides a comprehensive overview of the progress and challenges in the development of proteases for use as therapeutic agents.
The Role of Bacillus pseudomycoides Isolates and Bioinformatics Modeling for Modern Pharmaceutical Applications: A Literature Review Yorasakhi Ananta; Salsabila Dwi Fitri
Dinasti Health and Pharmacy Science Vol. 2 No. 3 (2025): Dinasti Health and Pharmacy Science (January 2025)
Publisher : Dinasti Research & Yayasan Dharma Indonesia Tercinta (DINASTI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.38035/dhps.v2i3.1832

Abstract

This article presents a literature review on the role of Bacillus pseudomycoides isolates as protease enzyme producers and how bioinformatics modeling enhances their potential in modern pharmaceutical applications. B. pseudomycoides is known to produce proteases with superior characteristics such as temperature and pH stability, making them potential candidates for pharmaceutical formulations. Bioinformatics approaches such as protein structure modeling, molecular docking, and genomic analysis have accelerated the functional characterization of these enzymes. The combination of the utilization of microorganisms and computational approaches opens up new opportunities in drug development, wound therapy, and pharmaceutical biotechnology. This study recommends multidisciplinary integration in the utilization of microbial resources for future therapeutic needs.
Meningkatkan Kinerja di Lingkungan RS: Peran Budaya Kerja dan Disiplin Kerja Nadia Salima Vityarini; Deden Komar P; Eddy Suharyanto
Dinasti Health and Pharmacy Science Vol. 2 No. 3 (2025): Dinasti Health and Pharmacy Science (January 2025)
Publisher : Dinasti Research & Yayasan Dharma Indonesia Tercinta (DINASTI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.38035/dhps.v2i3.1834

Abstract

Tujuan dari penelitian ini adalah untuk mengetahui dan menganalisis Budaya Kerja, Disiplin Kerja, Kinerja Pegawai, dan Pengaruh Budaya Kerja dan Disiplin Kerja terhadap Kinerja Pegawai Instalasi Gawat Darurat Rumah Sakit Dik Pusdikkes Kramat Jati Jakarta Timur, baik secara simultan maupun parsial. Metode penelitian yang digunakan dalam penelitian ini adalah survey deskriptif dan survey eksplanatori, unit analisis dalam penelitian ini adalah para pegawai Instalasi Gawat Darurat Rumah Sakit Dik Pusdikkes Kramat Jati Jakarta Timur dengan sampel sebanyak 56 orang yang diperoleh dengan teknik random sampling. Tipe investigasinya adalah kausalitas, serta time horizon dalam penelitian ini adalah cross- sectional. Berdasarkan hasil penelitian, diperoleh bahwa Budaya Kerja yang dialami oleh Pegawai di Instalasi Gawat Darurat RSUD Dik Pusdikkes sudah baik, Disiplin Kerja dapat dikatakan baik, dan Kinerja Pegawai dinilai baik. Budaya Kerja dan Disiplin Kerja secara simultan berpengaruh langsung terhadap Kinerja Pegawai di Instalasi Gawat Darurat Rumah Sakit Dik Pusdikkes Kramat Jati Jakarta Timur, namun secara parsial Budaya Kerja lebih dominan mempengaruhi Kinerja Pegawai daripada Disiplin Kerja. Karena Budaya Kerja lebih dominan mempengaruhi Kinerja, maka menjadi prioritas utama dalam meningkatkan Budaya Kerja di Instalasi Gawat Darurat Rumah Sakit Dik Pusdikkes Kramat Jati Jakarta Timur dan disarankan untuk Budaya Kerja sebagai penggerak kedisiplinan agar pegawai dapat lebih memahami makna dari tugas yang diberikan kepada mereka.
Pengaruh Profesionalisme Dan Kinerja Pelayanan Terhadap Kualitas Pelayanan Perawat (Studi di RS TK IV Atambua) Muhammad Afif Shofwan Fa’iq; Ai Komariah; Ujang Kunadi
Dinasti Health and Pharmacy Science Vol. 2 No. 3 (2025): Dinasti Health and Pharmacy Science (January 2025)
Publisher : Dinasti Research & Yayasan Dharma Indonesia Tercinta (DINASTI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.38035/dhps.v2i3.1835

Abstract

Tujuan penelitian ini adalah untuk mengetahui dan menganalisis bagaimana: (1) Profesionalisme (2) Kinerja Pelayanan; (3) Kualitas Pelayanan Perawat; serta (4) Pengaruh Profesionalisme Dan Kinerja Pelayanan Terhadap Kualitas Pelayanan Perawat (Studi di RS TK IV Atambua) secara simultan dan parsial. Metode yang digunakan dalam penelitian ini adalah metode description survey dan explanatory survey. seluruh anggota populasi dijadikan responden yaitu pada perawat di RS TK IV Atambua sebanyak (N) 30 orang sesuai dengan karakteristik responden. Penelitian ini dirancang bersifat deskriptif dan verifikatif Kinerja pelayanan dominan mempengaruhi kualitas pelayanan perawat dengan koefisien jalur sebesar 0.801 dengan thitung sebesar 15.360 dengan nilai ttabel pada taraf signifikansi ?(0,05) =2.05, daripada Profesionalisme sebesar 0.200 dengan thitung sebesar 2.707 dengan nilai ttabel pada taraf signifikansi ?(0,05) =2.05, serta kedua variabel tersebut terbukti mempengaruhi kualitas pelayanan perawat.
Pengaruh Pengawasan Komite Medis dan Profesionalitas Dokter Terhadap Kinerja Dokter di Klinik Calysta Skin Care Kota Bandung Athaya Haura Tiza Azizah; Winna Roswina; Toni Jas
Dinasti Health and Pharmacy Science Vol. 2 No. 3 (2025): Dinasti Health and Pharmacy Science (January 2025)
Publisher : Dinasti Research & Yayasan Dharma Indonesia Tercinta (DINASTI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.38035/dhps.v2i3.1838

Abstract

Pelayanan kesehatan merupakan kebutuhan dasar manusia yang tak terpisahkan dari kehidupan. Kualitas pelayanan kesehatan yang baik sangat bergantung pada kinerja tenaga kesehatan, terutama dokter. Komite medis memiliki peran penting dalam mengawasi dan memastikan bahwa pelayanan kesehatan yang diberikan oleh dokter memenuhi standar yang telah ditetapkan. Penelitian ini bertujuan untuk mengkaji sejauh mana pengawasan yang dilakukan oleh komite medis dan tingkat profesionalisme dokter berpengaruh terhadap kinerja dokter di Klinik Calysta Skin Care Kota Bandung. Penelitian ini menggunakan pendekatan kuantitatif korelasional,dengan metode Cross Sectional. Jenis data yang digunakan adalah data primer yang diperoleh dari hasil koesioner yang disebarkan kepada responden, dan data sekunder yang merupakan data pelengkap atau penunjang yang relevan dengan kajian penelitian. Untuk menunjang metode penelitian ini, penulis menggunakan Teknik pengumpulan data observasi, wawancara, dokumentasi, kuesioner (angket), dan pengujian validitas instrument. Hasil penelitian menunjukan bahwa hipotesis Pengaruh Pengawasan Komite Medis Dan Profesionalisme Dokter Terhadap Kinerja Dokter Di Klinik Calysta Skin Care Kota Bandung dapat diterima secara simultan maupun parsial sebesar 94,2% dan sisanya 7,6% faktor lain yang tidak di teliti.
The Role of Bacterial Protease Enzymes and In Silico Prediction on the Effectiveness of Medical Applications Adi Muliawan; Yorasakhi Ananta; Salsabila Dwi Fitri
Dinasti Health and Pharmacy Science Vol. 2 No. 4 (2025): Dinasti Health and Pharmacy Science (April 2025)
Publisher : Dinasti Research & Yayasan Dharma Indonesia Tercinta (DINASTI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.38035/dhps.v2i4.1841

Abstract

Bacterial protease enzymes have a wide range of medical applications, particularly in the treatment of infected wounds and therapy for protein digestion disorders. Proteases produced by bacteria such as Bacillus pseudomycoides show great potential for medical therapy due to their ability to break down proteins in the human body. In silico prediction using bioinformatics software such as AutoDock and PyMOL allows researchers to analyze the three-dimensional structure and molecular interactions of proteases with target substrates before conducting laboratory experiments. This article examines the role of bacterial protease enzymes in medical applications and the benefits of using in silico prediction to study the therapeutic potential of proteases. With a combined approach of experimentation and in silico analysis, the process of developing protease-based therapies can be more efficient and faster. This study emphasizes the importance of bioinformatics approaches in accelerating the discovery of enzyme-based medical therapies for future clinical applications.
Pengaruh Motivasi dan Empati Terhadap Kepuasan Kerja pada Perawat di RS TK IV Atambua Nusa Tenggara Timur (NTT) Oktaviani Eka Puspasari; Deden Komar P; Toni Jas
Dinasti Health and Pharmacy Science Vol. 2 No. 4 (2025): Dinasti Health and Pharmacy Science (April 2025)
Publisher : Dinasti Research & Yayasan Dharma Indonesia Tercinta (DINASTI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.38035/dhps.v2i4.1842

Abstract

Tujuan penelitian ini adalah untuk mengetahui dan menganalisis: (1) Motivasi (2) Empati (3) Kepuasan Kerja serta (4) Pengaruh Motivasi Dan Empati Terhadap Kepuasan Kerja pada Perawat di RS TK IV Atambua Nusa Tenggara Timur (NTT), baik secara simultan maupun parsial. Metode penelitian ini jenis penelitian survei, dengan tingkat penjelasannya bersifat deskriptif. Penelitian asosiatif kausal atau sebab akibat untuk mencari Pengaruh Motivasi Dan Empati Terhadap Kepuasan Kerja pada Perawat di RS Tk IV Atambua Nusa Tenggara Timur (NTT), cara pengambilan data dengan menggunakan teknik sampling jenuh terhadap 30 responden. Berdasarkan perhitungan data tanggapan responden terhadap Motivasi, tanggapan berada pada kriterium baik, tanggapan terhadap Empati berada pada kriterium baik, sedangkan pada Kepuasan Kerja juga berada pada kriterium baik. Berdasarkan hasil perhitungan di atas diketahui nilai pengaruh tidak langsung lebih besar dibandingkan dengan nilai pengaruh langsung. Penjelasannya adalah variable yang mempengaruhi akan tetapi tidak di uji maka hasil uji analisis jalur atau analisis path menyatakan bahwa Ada Pengaruh Motivasi Dan Empati Terhadap Kepuasan Kerja pada perawat di RS Tk IV Atambua Nusa Tenggara Timur (NTT) dapat diterima secara parsial maupun simultan.

Page 11 of 14 | Total Record : 131

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