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Fransisca Gloria
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INDONESIA
Science and Community Pharmacy Journal
Published by Sekolah Tinggi Ilmu Kesehatan Telogorejo Semarang
ISSN : -     EISSN : 28306139     DOI : 10.63520
Core Subject : Health,
Health Professions Medicine & Pharmacology
The scope of the journal is Pharmaceutical Technology and Analysis,Phamacology, Toxicology and Pharmacokinetics, Social Behavior, Administrative Pharmacy, Pharmacoeconomics,Pharmacognosy and Phytochmistry,Herbal medicines and complementary therapy, Clinical Pharmacy
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 5 Documents
 1 
Search results for , issue "Vol. 1 No. 1 (2022): Science and Community Pharmacy" : 5 Documents clear
Molecular Docking of Betel Leaf (Piper betle L.) on Protein Dihydrofolate reductase of Mycobacterium tuberculosis Endriyatno, Nur Cholis
Science and Community Pharmacy Journal Vol. 1 No. 1 (2022): Science and Community Pharmacy
Publisher : STIKES Telogorejo Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63520/scpj.v1i1.222

Abstract

Tuberculosis is an infectious disease of global concern. The treatment challenge of tuberculosis is bacterial resistance to antibiotics. Therefore, it is necessary to search for alternative treatments, one of which is the molecular docking method of Phytol, Chavibetol, Hydroxychavicol compounds contained in betel leaves. The target proteins used were 4KL9 and 4KM2 of the Dihydrofolate reductase pathway in Mycobacterium tuberculosis bacteria. Dihydrofolate reductase is a therapeutic target in the development of antituberculosis drugs. The molecular docking results showed that the target protein 4KL9 with Phytol, Chavibetol, and Hydroxychavicol compounds had a lower binding affinity when compared to the native ligand. In the 4KM2 target protein, these three compounds have a higher binding affinity value than the native ligand. This value indicates the strength of the ligand when it binds to the target protein, the smaller the value, the stronger the bond. In addition, there are similar residues involved in the target protein 4KL9 between the native ligand and the test compound, but in the target protein 4KM2 there is no similarity in the residues between the native ligand and the test compound. Residual similarity describes the similarity of the test ligand properties to the native ligand. It can be concluded that Phytol, Chavibetol, Hydroxychavicol compounds contained in betel leaf have potential as antituberculosis in the dihydrofolate reductase pathway on the target protein 4KL9 of Mycobacterium tuberculosis.
Cause and Treatment of Severe Cutaneous Adverse Drug Reactions at RSUP Dr. Sardjito Yogyakarta Fatkhiya, Musa Fitri; Aina Urfiyya, Qarry Aina
Science and Community Pharmacy Journal Vol. 1 No. 1 (2022): Science and Community Pharmacy
Publisher : STIKES Telogorejo Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63520/scpj.v1i1.231

Abstract

SCARs is an unexpected reaction from the use of a drug which is a severe skin disorder such as SJS, TEN and DRESS. Although the incidence is low, SCAR is associated with high mortality, so needed data to show the drug that causes the biggest cause of SCAR and the treatment. The study was conducted in a retrospective descriptive with total sampling data collection techniques on the medical records of patients with a diagnosis of SJS, TEN and DRESS at RSUP Dr. Sardjito Yogyakarta from 2015 to 2019. There were 78 patients diagnosed with SCARs and 48 patients met the inclusion criteria. 23 patients diagnosed with SJS, 6 patients diagnosed with TEN and 19 patients diagnosed with DRESS. The main causative drugs in patients with SJS, TEN and DRESS were Antibiotics (50%), Analgesics (26%), Antiepileptic drugs (6%), Antidepressants, Aantifungals, Antihypertensives, Antivirals was 1% for each group and other drugs (8%). The Antibiotics that most often cause SCARs are Cephalosporins, Ceftriaxone and Cefixim. While the main therapy for SCARs, be it SJS, TEN or DRESS, is the use of systemic corticosteroids and supportive intravenous fluid therapy
Isolation and Antifungal Activity of Caryophyllene from Clove Leaf Oil (Syzygium aromaticum L.) on Mahogany Leaf Composites Alighiri, Dante
Science and Community Pharmacy Journal Vol. 1 No. 1 (2022): Science and Community Pharmacy
Publisher : STIKES Telogorejo Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63520/scpj.v1i1.248

Abstract

Mahogany leaf composites mostly consist of cellulose which is easily weathered due to rotting fungi. One way to overcome this is to use anti-weathering chemicals. Chemical potential as a natural anti-weathering and abundant in Indonesia is caryophyllene compounds as a by-product in the eugenol industry which processes it from clove leaf oil. In this work, isolation and antifungal activity of caryophyllene from clove leaf oil on mahogany leaf composites was evaluated. Based on GC-MS analysis of clove leaf oil is known that eugenol and caryophyllene has yielded 42.83% and 23.87%, respectively. Selective extraction by using sodium hydroxide solution (2,5% NaOH, the ratio of oil to solution is 1:5) and fractional distillation under reduced pressure (Distillate fraction, DF P= -76 cmHg, R=5:1) and continued redistilled are needed to isolate of caryophyllene. Redistilled can improve the purity, then distillate collected while the temperature changed with a purity of 99.10%. Meanwhile, mahogany leaf composite has been successfully synthesized from mahogany leaves by using a polyurethane binder and glass fiber as reinforcement. Minimum inhibitory concentration (MIC) of caryophyllene was determined. The composite was coated with caryophyllene and evaluated for its antifungal activity against Aspergillus fumigatus. Observation using a CCD camera (Charge Couple Device) microscope with a magnification of 50x shows the growth of fungal spores on the composite surface. As a result, A. fumigatus can be inhibited by caryophyllene oil in a 1.2% concentration on mahogany leaf composite
Validity and Realibility Test of Developed Servqual Instrument for Outpatients Pharmacy Services at Pratama Annisa Primary Healthcare Semarang Al Farizi, Gilang Rizki; Gloria, Fransisca; Maula, Vita Zulfatul
Science and Community Pharmacy Journal Vol. 1 No. 1 (2022): Science and Community Pharmacy
Publisher : STIKES Telogorejo Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63520/scpj.v1i1.249

Abstract

The quality of pharmaceutical care services has an important role and main indicator for valuation the National Health Insurance (JKN). Patient satisfaction is the goal of pharmaceutical care services that serve to improve the quality of life of patients. Servqual is a method that has often been used to measure service satisfaction. The development of servqual instruments could be deploved to the needs of services in the pharmaceutical sector to maintain service quality . This study was conducted to measure the validity and reliability test of the Indonesian version of the developed servqual instrument for outpatient pharmacy services at Pratama Annisa primary healthcare Semarang. This study was an observational method through an analytic survey with a cross-sectional approach. The number of samples was 40 outpatients using the purposive sampling technique. The validity test was performed using the Aiken V index (≥ 0,4) and construct study. Reliability test used the internal consistency technique (Cronbach alpha coefficient ≥ 0,6). The result of the validity test showed that the correlation value of each item was > 0.4 and the reliability test result showed that the Cronbach alpha coefficient was 0.932. The Developed of servqual instrument is valid and reliable for measuring the costumer satisfaction
The Potential Effect Of Ethanolic Extract Rambusa Leaf (Passiflora foetida L.) As Anti-inflamation To Male Mice (Mus musculus) Wijaya, Duma Aji; Ovikariani; Saptawati, Tunik
Science and Community Pharmacy Journal Vol. 1 No. 1 (2022): Science and Community Pharmacy
Publisher : STIKES Telogorejo Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63520/scpj.v1i1.250

Abstract

One of the plants known as herbal medicine in Central Java is Brambutan or Rambusa. This research conducted on experimental animal using ethanol extract of rambusa leaf (Passiflora foetida L.) which has an anti-inflammation effect on reducing edema. The carrageenan used-induced feet edema was 1 % and animal subjects were grouped into 5 categories for different treatments, namely the administration of 1 % colloidal Na-CMC solution, diclofenac sodium solution, ethanol extract with various doses of 250 mg/kg body weight, 500 mg/kg body weight, and 750 mg/kg body weight given orally. By the time after 1 hour, the edema volume on mice feet measured until 6 hours. The data showed that the 1 % Na-CMC colloidal solution given did not affect the percentage of edema reduction (0 %), the subject group was given 250 mg/kg body weight and 500 mg/kg body weight showed a decrease level of edema (0.01 %), the group was given 750 mg/kg body weight decreased edema (0.02 %), and diclofenac sodium solution group showed decrease level of edema (0.04 %). In this study, it can be concluded that the ethanol extract of rambusa leaf (Passiflora foetida L.) has the highest anti-inflammation and anti-inflammation effect at a dose variation of 750 mg/kg body weight with a 0.02 % reduction in edema

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