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Fransisca Gloria
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INDONESIA
Science and Community Pharmacy Journal
Published by Sekolah Tinggi Ilmu Kesehatan Telogorejo Semarang
ISSN : -     EISSN : 28306139     DOI : 10.63520
Core Subject : Health,
Health Professions Medicine & Pharmacology
The scope of the journal is Pharmaceutical Technology and Analysis,Phamacology, Toxicology and Pharmacokinetics, Social Behavior, Administrative Pharmacy, Pharmacoeconomics,Pharmacognosy and Phytochmistry,Herbal medicines and complementary therapy, Clinical Pharmacy
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 31 Documents
 1   2   3   4 
Molecular Docking of Betel Leaf (Piper betle L.) on Protein Dihydrofolate reductase of Mycobacterium tuberculosis Endriyatno, Nur Cholis
Science and Community Pharmacy Journal Vol. 1 No. 1 (2022): Science and Community Pharmacy
Publisher : STIKES Telogorejo Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63520/scpj.v1i1.222

Abstract

Tuberculosis is an infectious disease of global concern. The treatment challenge of tuberculosis is bacterial resistance to antibiotics. Therefore, it is necessary to search for alternative treatments, one of which is the molecular docking method of Phytol, Chavibetol, Hydroxychavicol compounds contained in betel leaves. The target proteins used were 4KL9 and 4KM2 of the Dihydrofolate reductase pathway in Mycobacterium tuberculosis bacteria. Dihydrofolate reductase is a therapeutic target in the development of antituberculosis drugs. The molecular docking results showed that the target protein 4KL9 with Phytol, Chavibetol, and Hydroxychavicol compounds had a lower binding affinity when compared to the native ligand. In the 4KM2 target protein, these three compounds have a higher binding affinity value than the native ligand. This value indicates the strength of the ligand when it binds to the target protein, the smaller the value, the stronger the bond. In addition, there are similar residues involved in the target protein 4KL9 between the native ligand and the test compound, but in the target protein 4KM2 there is no similarity in the residues between the native ligand and the test compound. Residual similarity describes the similarity of the test ligand properties to the native ligand. It can be concluded that Phytol, Chavibetol, Hydroxychavicol compounds contained in betel leaf have potential as antituberculosis in the dihydrofolate reductase pathway on the target protein 4KL9 of Mycobacterium tuberculosis.
Cause and Treatment of Severe Cutaneous Adverse Drug Reactions at RSUP Dr. Sardjito Yogyakarta Fatkhiya, Musa Fitri; Aina Urfiyya, Qarry Aina
Science and Community Pharmacy Journal Vol. 1 No. 1 (2022): Science and Community Pharmacy
Publisher : STIKES Telogorejo Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63520/scpj.v1i1.231

Abstract

SCARs is an unexpected reaction from the use of a drug which is a severe skin disorder such as SJS, TEN and DRESS. Although the incidence is low, SCAR is associated with high mortality, so needed data to show the drug that causes the biggest cause of SCAR and the treatment. The study was conducted in a retrospective descriptive with total sampling data collection techniques on the medical records of patients with a diagnosis of SJS, TEN and DRESS at RSUP Dr. Sardjito Yogyakarta from 2015 to 2019. There were 78 patients diagnosed with SCARs and 48 patients met the inclusion criteria. 23 patients diagnosed with SJS, 6 patients diagnosed with TEN and 19 patients diagnosed with DRESS. The main causative drugs in patients with SJS, TEN and DRESS were Antibiotics (50%), Analgesics (26%), Antiepileptic drugs (6%), Antidepressants, Aantifungals, Antihypertensives, Antivirals was 1% for each group and other drugs (8%). The Antibiotics that most often cause SCARs are Cephalosporins, Ceftriaxone and Cefixim. While the main therapy for SCARs, be it SJS, TEN or DRESS, is the use of systemic corticosteroids and supportive intravenous fluid therapy
Isolation and Antifungal Activity of Caryophyllene from Clove Leaf Oil (Syzygium aromaticum L.) on Mahogany Leaf Composites Alighiri, Dante
Science and Community Pharmacy Journal Vol. 1 No. 1 (2022): Science and Community Pharmacy
Publisher : STIKES Telogorejo Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63520/scpj.v1i1.248

Abstract

Mahogany leaf composites mostly consist of cellulose which is easily weathered due to rotting fungi. One way to overcome this is to use anti-weathering chemicals. Chemical potential as a natural anti-weathering and abundant in Indonesia is caryophyllene compounds as a by-product in the eugenol industry which processes it from clove leaf oil. In this work, isolation and antifungal activity of caryophyllene from clove leaf oil on mahogany leaf composites was evaluated. Based on GC-MS analysis of clove leaf oil is known that eugenol and caryophyllene has yielded 42.83% and 23.87%, respectively. Selective extraction by using sodium hydroxide solution (2,5% NaOH, the ratio of oil to solution is 1:5) and fractional distillation under reduced pressure (Distillate fraction, DF P= -76 cmHg, R=5:1) and continued redistilled are needed to isolate of caryophyllene. Redistilled can improve the purity, then distillate collected while the temperature changed with a purity of 99.10%. Meanwhile, mahogany leaf composite has been successfully synthesized from mahogany leaves by using a polyurethane binder and glass fiber as reinforcement. Minimum inhibitory concentration (MIC) of caryophyllene was determined. The composite was coated with caryophyllene and evaluated for its antifungal activity against Aspergillus fumigatus. Observation using a CCD camera (Charge Couple Device) microscope with a magnification of 50x shows the growth of fungal spores on the composite surface. As a result, A. fumigatus can be inhibited by caryophyllene oil in a 1.2% concentration on mahogany leaf composite
Validity and Realibility Test of Developed Servqual Instrument for Outpatients Pharmacy Services at Pratama Annisa Primary Healthcare Semarang Al Farizi, Gilang Rizki; Gloria, Fransisca; Maula, Vita Zulfatul
Science and Community Pharmacy Journal Vol. 1 No. 1 (2022): Science and Community Pharmacy
Publisher : STIKES Telogorejo Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63520/scpj.v1i1.249

Abstract

The quality of pharmaceutical care services has an important role and main indicator for valuation the National Health Insurance (JKN). Patient satisfaction is the goal of pharmaceutical care services that serve to improve the quality of life of patients. Servqual is a method that has often been used to measure service satisfaction. The development of servqual instruments could be deploved to the needs of services in the pharmaceutical sector to maintain service quality . This study was conducted to measure the validity and reliability test of the Indonesian version of the developed servqual instrument for outpatient pharmacy services at Pratama Annisa primary healthcare Semarang. This study was an observational method through an analytic survey with a cross-sectional approach. The number of samples was 40 outpatients using the purposive sampling technique. The validity test was performed using the Aiken V index (≥ 0,4) and construct study. Reliability test used the internal consistency technique (Cronbach alpha coefficient ≥ 0,6). The result of the validity test showed that the correlation value of each item was > 0.4 and the reliability test result showed that the Cronbach alpha coefficient was 0.932. The Developed of servqual instrument is valid and reliable for measuring the costumer satisfaction
The Potential Effect Of Ethanolic Extract Rambusa Leaf (Passiflora foetida L.) As Anti-inflamation To Male Mice (Mus musculus) Wijaya, Duma Aji; Ovikariani; Saptawati, Tunik
Science and Community Pharmacy Journal Vol. 1 No. 1 (2022): Science and Community Pharmacy
Publisher : STIKES Telogorejo Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63520/scpj.v1i1.250

Abstract

One of the plants known as herbal medicine in Central Java is Brambutan or Rambusa. This research conducted on experimental animal using ethanol extract of rambusa leaf (Passiflora foetida L.) which has an anti-inflammation effect on reducing edema. The carrageenan used-induced feet edema was 1 % and animal subjects were grouped into 5 categories for different treatments, namely the administration of 1 % colloidal Na-CMC solution, diclofenac sodium solution, ethanol extract with various doses of 250 mg/kg body weight, 500 mg/kg body weight, and 750 mg/kg body weight given orally. By the time after 1 hour, the edema volume on mice feet measured until 6 hours. The data showed that the 1 % Na-CMC colloidal solution given did not affect the percentage of edema reduction (0 %), the subject group was given 250 mg/kg body weight and 500 mg/kg body weight showed a decrease level of edema (0.01 %), the group was given 750 mg/kg body weight decreased edema (0.02 %), and diclofenac sodium solution group showed decrease level of edema (0.04 %). In this study, it can be concluded that the ethanol extract of rambusa leaf (Passiflora foetida L.) has the highest anti-inflammation and anti-inflammation effect at a dose variation of 750 mg/kg body weight with a 0.02 % reduction in edema
Assesment of the Use of Antibiotics in Patients Pneumonia Inpatients in Sultan Agung RSI Semarang with Method ATC/DDD Wahyudi, Andrey; Pertiwi, Sulih
Science and Community Pharmacy Journal Vol. 1 No. 2 (2022): Science and Community Pharmacy
Publisher : STIKES Telogorejo Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63520/scpj.v1i2.319

Abstract

Pneumonia is an acute infectious disease that attacks the lung tissue, caused by viruses, bacteria, fungi and parasites that cause inflammation of the lung parenchyma and accumulation of inflammation in the respiratory tract. One of the treatments for pneumonia is antibiotics. It is necessary to control antibiotic resistance by evaluating antibiotics. This study purposed to evaluating the profile of antibiotic used in quantitative method to pneumonia patients at RSI Sultan Agung Semarang which was calculated using the ATC/DDD method. This research conducted retrospective cohort with cross sectional design. The sampling technique was used total sampling on 34 Pneumonia inpatients obtained from patient medical record. Subssquently, patient data analyzed by quantitatively using the ATC/DDD method. There are 5 types a single antibiotics used for pneumonia therapy, namely Levofloxacin (50%), Ceftriaxone (14.71%), Moxifloxacin (14.71%), Cefoperazone (11.76%), Meropenem (2.94%), and 2 types was used in combination, namely Loevofloxacin + Ciprofloxacin (2.94%) and Meropenem + Cefotaxime (2.94%). The value of DDD/100 days of hospitalization was 70.5 DDD/100 days of hospitalization with the highest antibiotic, namely Levofloxacin, of 40 DDD/100 days of hospitalization. Antibiotics included in the 90% segment were Levofloxacin (56.74%) and Moxifloxacin (18.71%). The most widely used antibiotic in pneumonia patients is Levofloxacin (50%). The total value of DDD/100 days of hospitalization for 1 period is 70.5 DDD/100 days of hospitalization. Antibiotics included in the 90% segment are Levofloxacin and Moxifloxacin.
The Evaluation of the Pharmaceutical Planning and Procurement System at Pharmacies in Western Semarang District Gloria, Fransisca; Al Farizi, Gilang Rizki; Addini, Belkis Nur
Science and Community Pharmacy Journal Vol. 1 No. 2 (2022): Science and Community Pharmacy
Publisher : STIKES Telogorejo Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63520/scpj.v1i2.323

Abstract

Pharmaceutical planning and procurement become important matters for medicine management at pharmacies. The inaccurate plan leads to budget extravagances of medicine procurement, procurement cost, overloaded medicine supply, and lack of medicine supply. Ineffective procurement led to limited medicine supplies in terms of the amount and the correct price. This research evaluated the pharmaceutical matter plan and procurement at pharmacies in Western Semarang District. This descriptive research used a cross-sectional design so this research was also non-experimental research with a qualitative approach. The data collecting technique was direct observation of the pharmaceutical plan and procurement system from various conventional pharmacies in the Western Semarang area. The results obtained from 5 pharmacies showed an average mean percentage of 91.43%. On the other hand, the average mean percentage of procurement was 85.45%. These results were categorized as "appropriate", higher than 50%. The results indicated that the pharmacies had met the 2019 Technical Term of Pharmaceutical Service Standard for Pharmacies.
The Antioxidant Test And Determination OfPhenolic Content In Packaged Green Tea Using The FRAP Method Nugraha, Novanda Satria; Listyani, Tiara Ajeng; Septiarini, Anita Dwi
Science and Community Pharmacy Journal Vol. 1 No. 2 (2022): Science and Community Pharmacy
Publisher : STIKES Telogorejo Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63520/scpj.v1i2.324

Abstract

The tea plant is one of the plants belonging to the Camellia genus which is widely spread in Southeast Asia. There is an assumption in the community that packaged green tea is good for consumption since green teadoes not undergo fermentation, consequently it has a higher antioxidant activity. Polyphenols present in tea provide an antioxidant activity that can be used to prevent cardiovascular disease, cancer, inflammation, and diabetes. This study aims to examine the antioxidants and determine thephenolic content of packaged green tea using the FRAP method. This research was carried out using a simplified assay for phenolic content determination and using a UVVisible spectrophotometer with folic ciocalteu reagent and using gallic acid as a comparison. Antioxidant activity was tested using the FRAP method with vitamin C as a comparison, which was measured using a UV-Visible Spectrophotometer. The total phenolic content contained in green tea extract A packaged was 0.2604 mg GAE/g green tea B packaged was 0.2656 mg GAE/g green tea extract C packaged was 0.2556 mg GAE/g. Packaged green teaextract A, packaged green tea B, and packaged green tea C had antioxidant capacities equivalent to ascorbic acid, namely green tea extract A 77.761 mg AAE/g, green tea extract B packaged 76.809 mg AAE/g and green tea extract C packaged which is equivalent to ascorbic acid, namely 74.904 mg AAE/g extract. The highest antioxidant value was green tea extract A packaged at 77.761 mg of Ascorbic Acid Equivalent/ gram of extract.
PHYTOCHEMICAL SCREENING OF ETHANOL EXTRACT OF TREMBESI FRUIT SEEDS (Samanea saman) Saptawati, Tunik; Dayanti, Ema; Rachma, Firstca Aulia; Ovikariani
Science and Community Pharmacy Journal Vol. 1 No. 2 (2022): Science and Community Pharmacy
Publisher : STIKES Telogorejo Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63520/scpj.v1i2.325

Abstract

Trembesi (Samanea saman) is a fast-growing plant from Central America and Northern South America. the Trembesi Tree is an easily recognize tree because it has an umbrella-shaped canopy with a canopy diameter greater than its height, the trembesi fruit is blackish-brown when ripe, with seeds embedded in the flesh of the fruit. This study aims to determine the class of compounds contained in the ethanol extract of trembesi fruit seeds extraction by maceration method using 70% ethanol solvent. The analysis uses univariates that present data with calculation results. The extract results were obtained by weight of 91% with an amendment value of 18.20%. The phytochemical screening were carried out with color tests and emphasized by the TLC test. The trembesi fruit seed ethanol extract containing alkaloid, flavonoids, saponins, and tannins compounds.
Literature Review - Sustained Release In Liposom Technology On Emulsion Cream Curcumin For Burns Adiwidjaya Kusuma, Gregorius; Aulia , Ayu; Lumayung , Censa; Kurnia Enggolan, Cahaya; Busdha , Desti; Maulana Akbar, Fatwa; Gloria, Fransisca
Science and Community Pharmacy Journal Vol. 2 No. 1 (2023): Science and Community Pharmacy
Publisher : STIKES Telogorejo Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63520/scpj.v2i1.353

Abstract

Preface : Burns is an injury on tissue caused by overexposure to flame, steam, hot liquid, chemist substances, electrical objects and radiant. Burns are classified based on its region and degree. One of the most important factors that affect the process of burns treatment is the prevention of burns infection. Turmeric is a natural resource that may be used. Its extract helps to haste re-epithelialization, cell proliferation and collagen synthesis. Proper sustain to improve the therapy is topical sustain. Liposom is one of topical sustains which is developed in pharmacy to increase efficacy. One of the efforts is to reduce the size of particles by sonication. Purpose : This research is literature review by finding national and international journals as database. Method : Literature review is done based on inclusion requirements like journals which discuss liposom sustain in form of cream for burns, original research from 2011 until 2022, and pre-clinical or clinical research journals. Result : Based on the findings, there are 5 journals that fulfill the inclusion requirement. There are two google-scholar journals and three Pubmed journals. Analysis of journal includes the effectiveness of liposom sustain in emulsion cream to treat burns. Conclusion : Curcumin increases the growth of beta factor, stimulates angiogenesis and accumulates extracellular matrix so these factors may treat burns.

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