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Contact Name
mahardika
Contact Email
p3i@umsida.ac.id
Phone
6282143483630
Journal Mail Official
perpus@umsida.ac.id
Editorial Address
jl. Mojopahit No. 666B Sidoarjo, Jawa Timur
Location
Kab. sidoarjo,
Jawa timur
INDONESIA
Indonesian Journal Health Science and Medicine
ISSN : -     EISSN : 30638186     DOI : https://doi.org/10.21070/ijhsm
Core Subject : Health,
Focus: The Indonesian Journal on Health Science and Medicine (IJHSM) focus to advance the field of health science and medicine by publishing high-quality, peer-reviewed research articles, reviews, and case studies. Our journal serves as a platform for researchers, clinicians, and healthcare professionals to share innovative findings, critical insights, and emerging trends in the broad domain of health science and medicine. Scope: Clinical Research and Practice Studies on the diagnosis, treatment, and prevention of diseases. Clinical trials and evidence-based practices. Advances in medical technology and therapeutics. Public Health Epidemiology and health statistics. Health policy and management. Community health initiatives and health education. Biomedical Science Research on cellular and molecular biology. Genetics and genomics. Pharmacology and toxicology. Health Care Systems and Services Health care delivery and management. Quality improvement in health care services. Health economics and health informatics. Global Health Health issues affecting populations worldwide. International health regulations and practices. Global health governance and diplomacy. Health Promotion and Disease Prevention Lifestyle and behavioral interventions. Preventive medicine and early detection. Nutritional science and physical activity. Mental Health Research on mental health disorders and treatments. Psychological well-being and mental health promotion. Integration of mental health services in primary care. Innovations in Health Education and Training Medical and health science education methodologies. Training programs for health professionals. Continuing education and professional development.
Articles 268 Documents
A Survey Study to Determine the Prevalence of Obesity Among Primary School Students in Baqubah District: Studi Survei untuk Menentukan Prevalensi Obesitas di Kalangan Siswa Sekolah Dasar di Distrik Baqubah Ahmed , Amjad Adham; Al-Ezee , Ali Shakir; Ali , Abdulrahman Subhe
Indonesian Journal on Health Science and Medicine Vol. 2 No. 1 (2025): July
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v2i1.114

Abstract

The current study aimed to know the prevalence of overweight and obesity rates among primary school children in Baquba district. The total number of samples was (105) samples (59 males and 46 females). The samples were obtained from children in primary schools from a special form prepared by the researcher that included (Sex, age, height, weight, mass, residence ). The results show that the number of overweight males is higher than the number of overweight females, as the number of males was 35 males, representing 59.32%, while the number of females was 24 females, representing 40.67%. The number of obese males is higher than the number of obese females, as the number of males was 32 males, representing 69.56%, while the number of females was 14 females, representing 30.43%. The results showed that the highest rate of overweight was among males living in the city, where the number of those infected was 23 males, and that the highest rate of obesity was among males living in the city, where the number of those infected was 21. We note that the lowest rate of infection was among females suffering from obesity living in the village, where the number of those infected was 4 females, representing 8.69%. Highlights: Higher overweight and obesity rates in males than females. Urban males have the highest overweight and obesity prevalence. Rural females have the lowest obesity rate (8.69%). Keywords: obesity , Overweight , primary schools
The effect of Vaginal Ph on Ewes’ Fertility: Pengaruh Ph Vagina terhadap Kesuburan Sapi Betina Hussein, Wathiq Faraon
Indonesian Journal on Health Science and Medicine Vol. 1 No. 3 (2024): Desember
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v2i1.115

Abstract

Arabi ewes were used to determine the extent of the effect of the pH of the vaginal mucus on the fertility rate, vaginal sponges enriched with the progesterone hormone were used and the vaginas of the ewes were washed with different pH solutions. The fertility rate was 69.5%. There was no significant effect of the vaginal pH on this characteristic, and a positive correlation coefficient (0.821) was found between the two characteristics Highlights: Arabi ewes studied for vaginal mucus pH effect on fertility. Progesterone-enriched sponges, pH solutions used; fertility rate 69.5%. No significant effect, but strong positive correlation (0.821) found. Keywords: ewes, fertility, pH, buffers, phosphate
Successfully Treating an Odontogenic Keratocyst with Surgery and Carnoy’s Solution: A Case Study: Berhasil Mengobati Keratokista Odontogenik dengan Pembedahan dan Solusi Carnoy: Sebuah Kasus Studi Al_Sheikhly , Athraa A. Ahmed
Indonesian Journal on Health Science and Medicine Vol. 2 No. 1 (2025): July
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v2i1.116

Abstract

Odontogenic keratocyst (OKC) is a type of cyst found in the jaw that has sparked debate on whether it should be classified as a cyst or a tumor. While it was briefly categorized as a tumor (KCOT) due to its aggressive behavior and unique microscopic appearance, it has since been reclassified as a cyst in the latest World Health Organization guidelines. (1) This study presents the case of an 18-year-old male who underwent successful surgical removal of a large OKC in his lower jaw. The procedure involved carefully removing the cyst, trimming surrounding bone, and applying a solution to minimize recurrence. After six months, the patient showed no signs of the cyst returning. This case highlights the effectiveness of a conservative surgical approach in treating OKC, leading to minimal complications, quick healing, and restored jaw function Highlights: Classification: OKC is reclassified as a cyst by WHO guidelines. Case: Successful surgical removal of OKC in an 18-year-old male. Outcome: Conservative surgery ensured minimal complications and no recurrence after six months Keywords: Bone Cysts. Odontogenic keratocyst. Enucleation. Bone healing.
DNA Fragmentation and Vitamin K2 Levels in Sperm Maturation and Apoptosis: Fragmentasi DNA dan Tingkat Vitamin K2 dalam Pematangan Sperma dan Apoptosis Ismael, Khaleel Ibrahim; Al-Maliki, Rehab Shafiq; Al-Tameem, Amina Akram
Indonesian Journal on Health Science and Medicine Vol. 2 No. 1 (2025): July
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v2i2.117

Abstract

Background: There is mounting evidence that vitamin K2 (menaquinones) plays a role as a hormone and transcriptional regulator, which has raised interest in its possible impact on male reproductive health. The vitamin K series as a whole has a long history of therapeutic use around the world. Because of its essential function in removing damaged germ cells and preserving the quality of spermatozoa, vitamin K may have an antioxidant impact that is advantageous to spermatogenesis, a process regulated by apoptosis. Aim of the study: Association of DNA fragmentation as an apoptotic marker and Vit K2 levels with sperm maturation. Patients, materials and methods: Sixty-seven infertile men were included in this Cross-sectional study. All the patients underwent Vit K assessment by ELISA, Seminal fluid analysis according to WHO 2021 and DNA fragmentation test using aniline blue staining. Results: The study found highly significant inverse correlation between vit K2 level and DNA fragment proportion of the study sample of semen but there is inverse insignificant correlation of fragmentation with sperm motility while other semen parameters showed insignificant positive correlation including concentration, vitality and normal morphology. Progressive motile sperms (AB) and immotile sperms (D) were found with high significant difference between sperm DNA fragmentation and non-sperm DNA fragmentation. Also, there were no significant differences between infertile men with and without sperm DNA fragmentation in age, smoking, alcohol conception, varicocele and type of infertility.  Conclusions: The findings revealed a highly significant negative correlation between vitamin K2 levels and sperm with DNA fragmentation, as well as a highly significant positive correlation between vitamin K2 levels and sperm without DNA fragmentation. The findings indicate that vitamin K2 may play a protective function in protecting sperm DNA integrity. Highlights : Vitamin K2 Protects Sperm DNA – Higher K2 levels correlate with lower DNA fragmentation. Minimal Impact on Motility – Fragmentation shows weak links to sperm motility and other parameters. No Link to Lifestyle – Factors like smoking and varicocele show no significant effect. Keywords : Vit K, Apoptosis, DNA Fragmentation, Biomarker, ROS
Cytokines' Impact on Postpartum Hair Loss After First C-Section in Women 28-38: Dampak Sitokin terhadap Kerontokan Rambut Pasca Persalinan Setelah Operasi Caesar Pertama pada Wanita 28-38 Almohaisen, Farooq L.J.; Hadi, Abdulrhman M. Hassan; Kadhim, Shaymaa Jawad; Mohsein, Osama A.
Indonesian Journal on Health Science and Medicine Vol. 2 No. 1 (2025): July
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v2i1.119

Abstract

Background; Postpartum hair loss is a common condition affecting women after childbirth, particularly in those who have undergone cesarean delivery. Cytokines, which are key regulators of immune responses, are believed to play a significant role in the pathogenesis of this condition by influencing the hair growth cycle and immune function during the postpartum period. Aims of the study; Investigate the role of cytokines, including IL-6, TNF-α, IL-10, and CRP, in postpartum hair loss in women aged 28-38 after their first cesarean delivery, and to explore their potential correlation with changes in thyroid function and lipid profiles during the postpartum period. Methodology; This cross-sectional study aimed to determine biomarker levels in women aged 28-38 after their first cesarean section. It included 150 participants: 100 women post-first cesarean and 50 healthy controls. Ethical approval was obtained, and informed consent was given by all participants. Exclusion criteria included multiple cesarean sections, chronic diseases, or medication affecting biomarkers. Blood samples were collected after an overnight fast, and biomarkers like IL-6, TNF-α, IL-10, CRP, adiponectin, FBS, lipid profile, TSH, and Free T3 were measured using appropriate assays. Statistical analysis was performed, with p < 0.05 considered significant. Result; The comparative results between patients (n=100) and healthy controls (n=50) showed no significant difference in age (33.5 ± 3.4 vs. 30.2 ± 3.1 years, p=0.12). However, patients had a significantly higher BMI (29.5 ± 3.2 kg/m²) compared to controls (26.1 ± 3.0 kg/m², p<0.001). Levels of inflammatory markers (IL-6, TNF-α, IL-10, CRP) were significantly higher in patients (p<0.001), while adiponectin levels were lower (14.2 ± 7.5 ng/mL vs. 20.8 ± 9.1 ng/mL, p=0.02). Metabolic markers such as fasting blood sugar, cholesterol, triglycerides, and LDL-C were significantly elevated in patients (p<0.001). The severity of hair loss was also greater in patients (p<0.001). Additionally, TSH levels were significantly higher in patients (p=0.02), while Free T3 showed no significant difference (p=0.12). Conclusions; In conclusion, elevated inflammatory markers (IL-6, TNF-α, IL-10) and metabolic disturbances (higher BMI, fasting blood sugar, cholesterol) in postpartum women after cesarean delivery may contribute to hair loss. These alterations reflect the body's response to stress and hormonal changes following delivery. Highlights: Inflammatory Response & Hair Loss – Elevated levels of IL-6, TNF-α, IL-10, and CRP in postpartum women after cesarean delivery suggest a strong link between inflammation and hair loss. Metabolic & Hormonal Changes – Higher BMI, increased fasting blood sugar, cholesterol, and TSH levels indicate metabolic disturbances that may contribute to postpartum hair loss. Clinical Implications – Understanding these biomarker changes could help in developing targeted interventions to manage postpartum hair loss and associated metabolic risks. Keyword: Postpartum, Cesarean Delivery, Inflammatory Markers, Hair Loss, Metabolic Disturbances, Hormonal Changes
Inflammatory Biomarkers in Tissue Remodeling and Fibrosis Progression: Biomarker Inflamasi dalam Remodeling Jaringan dan Perkembangan Fibrosis Abbas, Marwa Ismail
Indonesian Journal on Health Science and Medicine Vol. 2 No. 1 (2025): July
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v2i2.120

Abstract

Background; Inflammatory biomarkers play a crucial role in tissue remodeling and fibrosis progression by mediating the inflammatory response and influencing extracellular matrix deposition. Aims of the study; Investigate the role of inflammatory biomarkers in tissue remodeling and the progression of fibrosis. Methodology; A case-control study of 90 patients, conducted from November 1, 2024, to February 1, 2025, aimed to examine the role of inflammatory biomarkers in tissue remodeling and fibrosis progression. The study included 60 patients diagnosed with fibrosis and 30 healthy controls. Blood samples were collected, processed, and analyzed for biomarkers (CRP, IL-6, IFN-γ, MCP-1, adiponectin) using ELISA. Fibrosis severity was assessed using FibroScan elastography and histopathology with Masson's trichrome stain to evaluate collagen deposition. These methods helped correlate systemic inflammatory biomarker levels with fibrosis progression. Result; The study showed no significant age difference between patients with tissue fibrosis (48.6 ± 10.4 years) and controls (47.2 ± 9.8 years, p = 0.52). However, patients had significantly higher BMI (27.8 ± 3.5 kg/m², p = 0.01) and a higher smoking rate (38%, p = 0.03). Inflammatory markers, including CRP, IL-6, IFN-γ, and MCP-1, were significantly elevated in patients. Adiponectin levels were lower (7.8 ± 1.9 μg/mL, p < 0.001). Strong correlations were found between inflammatory markers and fibrosis severity, with MCP-1 showing the strongest association. Conclusions; The study concluded that elevated inflammatory markers (CRP, IL-6, IFN-γ, MCP-1) and decreased adiponectin levels are strongly associated with tissue fibrosis progression. The inflammatory response, characterized by these biomarkers, promotes fibrosis through immune activation and tissue remodeling. Adiponectin's protective role against inflammation and fibrosis underscores its potential as a therapeutic target. Highlights: Biomarker Impact: Elevated CRP, IL-6, IFN-γ, and MCP-1 levels correlate with fibrosis severity. Protective Role: Lower adiponectin levels suggest its antifibrotic potential. Clinical Relevance: MCP-1 shows the strongest association, making it a key fibrosis indicator. Keyword: Inflammatory Biomarkers, Tissue Remodeling, Fibrosis Progression, CRP, Adiponectin, MCP-1
Viral Infection in Enhance the Inflammatory Bowel Disease in Children: A Review: Infeksi Virus dalam Meningkatkan Penyakit Radang Usus pada Anak: Sebuah Tinjauan Mohammad, Noor J.; Kadhim, Nuha Saeed; Shreef, Noor Salah
Indonesian Journal on Health Science and Medicine Vol. 2 No. 1 (2025): July
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v2i1.121

Abstract

Viral infections, which typically have a high rate of morbidity and mortality, are more challenging to identify. In particular, studies on rotavirus, hepatitis B virus, bacteriophages, enteric viruses, cytomegalovirus, and Epstein-Barr virus were evaluated for IBD. These results suggest that IBD patients are more likely to get viral infections. Therefore, medical practitioners should be more aware of the increased risk of viral infections in patients with inflammatory bowel disease. The incidence and prevalence of childhood-onset inflammatory bowel diseases (IBD), which include ulcerative colitis and Crohn's disease subtypes, have significantly increased in recent years, making them important pediatric chronic diseases on a global scale. Childhood-onset IBD is more widespread and dangerous than adult-onset IBD. The biological treatment for juvenile IBD is anti-tumor necrosis factor therapy, and more treatment options are urgently needed. Currently, this patient population is prescribed off-label other biologic medicines such as Steinman, and vedolizumab. Understanding the viral infection's causes, diagnosing and tracking the illness, treating patients, and managing the psychological and physical effects of having IBD are all crucial. Globally, the frequency of IBD varies greatly; estimates place the number of affected individuals at 2.2 million in Europe and 1.6 million in the United States. Highlights: Viral infections increase risk in IBD patients; awareness is crucial. Childhood-onset IBD is rising; better treatments are urgently needed. Global IBD cases exceed 3.8 million; management and diagnosis are vital. Keywords: Viral Infection, Enhanced, Inflammatory Bowel Disease
Production and diagnosis of Vitamin B12 from Lactobacillus reuteri LBIQ1 and its application as a therapeutic food supplement: Produksi dan diagnosis Vitamin B12 dari Lactobacillus reuteri LBIQ1 dan aplikasinya sebagai suplemen makanan terapeutik Mohammed, Abdulmutalib Abdulla
Indonesian Journal on Health Science and Medicine Vol. 2 No. 1 (2025): July
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v2i1.122

Abstract

Vitamin B12 is an essential biological nutrient with multifaceted roles in human physiology and the diet is the main source of it because the human body cannot synthesize it. The photo stability nature of vitamin B12 is a major challenge, as its stability is affected by exposure to light in various industries. Absorption of VB12 also needs to be mediated by internal gastrointestinal factors, and abnormalities of the stomach or lack of such factors result in impaired absorption of VB12. Innovative strategies are therefore required to maintain its stability, effectiveness and ease of absorption, as the current strategies are generally very expensive and are still in the development stage. Thus, The objectives of the current study are to produce and test the therapeutic efficacy of the vitamin in a dietary supplement to the yogurt product, to help increase its intestinal absorption and enhance its optical stability, which can be produced in a formula with a balanced cost. Methods: VB12 was produced in the fermented medium of Lactobacillus reuteri LBIQ1 isolate and then extracted and diagnosed using infrared spectroscopy with the standard vitamin before being added to a laboratory yogurt product and subjected to sensory evaluation to be applied as a therapeutic dietary supplement to a group of skin eczema patients and followed up for three months for exploring its therapeutic effects. Results: Vitamin B12 was successfully produced and extracted from the fermentation medium of the bacterial isolate. The infrared absorption spectrum also demonstrated a high similarity between the extracted and standard samples. Sensory evaluation showed no significant difference between the vitamin-fortified yogurt product and the unfortified control product. The results of applying the fortified product to patients, during the treatment period, proved its effect in reducing the symptoms of skin infections by ≤ 25% in the first month, and (50-75%) in the second month , and (75-100%) at the end of the third month, which gives the possibility that the product has significantly enhanced the intestinal absorption of vitamin B12 and led to stabilization and increased effectiveness (P ≤ 0.05). Conclusion: The preparation and production of vitamin B12 in a fortification yogurt supplement can increase its stability and intestinal absorption and enhance its therapeutic effectiveness as a simple and inexpensive method that can be adopted for commercial and pharmaceutical manufacture. Highlights: Production: VB12 was fermented, extracted, and added to yogurt. Efficacy: Improved stability, absorption, and reduced eczema symptoms significantly. Application: Affordable supplement for commercial and pharmaceutical use. Keywords: Vitamin B12 ; Lactobacillus reuteri LBIQ1 ; Therapeutic food supplement.
Some Hormonal And Hematological Changes Accompanied With Type 2 Diabetes Mellitus: Beberapa Perubahan Hormonal dan Hematologi yang Disertai dengan Diabetes Melitus Tipe 2 Hamza, Duaa Hamad
Indonesian Journal on Health Science and Medicine Vol. 2 No. 3 (2025): Desember
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v2i3.123

Abstract

The goal of this research to examine the alterations in a few and hormonal and hematological markers that took place in persons with type 2 diabetes Mellitus T2DM. The current research is being conducted at the Al-Hussein Hospital's diabetes and endocrinology center in the province of Al-Muthanna. There were 200 participants in the study: 100 were T2DM patients and 100 were controls. Patients and controls ranged in age from 24 to 50. In this study, spectrophotometry was used to assess fasting blood sugar (FBS) at 546 nm, the Sysmax-Kx-21 was used to measure hematological parameters (RBC, Hb, RDW, WBC, PLT, and MPV), and the ELSA technique was used to detect hormones (TSH, T3, and T4).The FBS of T2DM patients is considerably upper than that of control patients (P<0.05), according to the results. However, the findings indicate that patients with T2MD had meaningfully lower ranks of TSH, T3, and T4 when paralleled to the control grouping. Hematological parameter data indicate that patients with T2DM had significantly lower RBC and Hb when paralleled to the control grouping, but considerably upper RDW, WBC, PLT, and MPV (P<0.05) when paralleled to the control grouping. Highlights: Higher FBS in T2DM patients compared to healthy controls. Lower TSH, T3, T4 in T2DM group than controls. Altered blood markers: Low RBC, Hb; high RDW, WBC, PLT, MPV. Keywords: T2DM , Hormones , Blood parameters
Exploring Group A Streptococcus Infections in Infants: A Comprehensive Analysis of Detection, Genotyping, and Antibiotic Resistance Trends in Baghdad: Mengeksplorasi Infeksi Streptokokus Grup A pada Bayi: Analisis Komprehensif tentang Deteksi, Genotipe, dan Tren Resistensi Antibiotik di Baghdad Mohan, Fatima Rashid
Indonesian Journal on Health Science and Medicine Vol. 2 No. 1 (2025): July
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v2i1.124

Abstract

This study aimed to investigate the prevalence, genetic diversity, and antibiotic resistance of Group A Streptococcus (GAS) infections among pediatric populations in Baghdad, addressing the critical public health challenge posed by rising antibiotic resistance and limited surveillance. GAS infections, caused by Streptococcus pyogenes , range from mild pharyngitis to severe invasive diseases like necrotizing fasciitis. The study analyzed 226 pharyngeal swab samples from children aged 3–14, identifying 21 confirmed GAS isolates. Genotyping revealed significant genetic diversity, with prevalent emm types including emm-1, emm-4, and emm-12, alongside virulence genes such as speB and speA . Household contact with infected individuals significantly increased infection risk (p<0.01), emphasizing transmission dynamics. Antibiotic susceptibility testing highlighted alarming resistance levels, particularly to penicillin (29%) and amoxicillin (6%), contrasting with global trends where penicillin resistance remains low. However, azithromycin (93%) and cefuroxime (90%) demonstrated high efficacy, while macrolide resistance, such as erythromycin (45%), is rising. Linezolid maintained 80% susceptibility, crucial for treating multidrug-resistant infections. Clinical manifestations included fever, respiratory disorders, and hemodynamic instability, consistent with invasive GAS disease. Highlights: GAS prevalent with diverse emm types, virulence genes detected. High resistance to penicillin; azithromycin, cefuroxime effective. Infection risk higher with household exposure; severe symptoms observed. Keywords: Group A Streptococcus, antibiotic resistance, genotyping, pediatric infections, public health interventions

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