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Juvita Herdianty
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INDONESIA
Strada Journal of Pharmacy
Published by Universitas Strada Indonesia
ISSN : 27763544     EISSN : 27979180     DOI : https://doi.org/10.30994/sjp
Core Subject : Health, Science,
Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology
The journal includes various fields of pharmaceuticals sciences such as: Pharmacology and Toxicology; Pharmacokinetics; Community and Clinical Pharmacy; Pharmaceutical Chemistry; Pharmaceutical Biology; Pharmaceutics; Pharmaceutical Technology; Biopharmaceutics; Pharmaceutical Microbiology and Biotechnology; Alternative Medicines;
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 102 Documents
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Formulation and Physical Quality Evaluation of Cyperus rotundus L. Water Fraction Gel Alfara Derista Felany; Juvita Herdianty; Devita Riafinola Andaririt; Ivan Junius Mesak; Bilal Subchan
Strada Journal of Pharmacy Vol. 8 No. 1 (2026): April
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v8i1.202

Abstract

The development of topical preparations from natural ingredients requires rigorous physical quality evaluation to ensure their safety, stability, and efficacy. This study aimed to formulate and evaluate the physical quality of a gel preparation containing the water fraction of Cyperus rotundus L. at various concentrations. The water fraction of the rhizome was formulated into gel preparations with concentrations of 5% (F1), 10% (F2), 15% (F3), and 20% (F4) using Carbopol 940 as a gelling agent. The physical quality evaluation included organoleptic tests, homogeneity, pH, spreadability, adhesion, and viscosity. The results showed that all gel formulas met the established physical quality requirements. An increase in the concentration of the water fraction significantly affected the physical characteristics of the preparation, such as a more intense color, as well as an increase in pH, adhesion, and viscosity. All formulas exhibited a pH suitable for the physiological range of the skin (5.53–6.80), good spreadability (5.49–6.77 cm), and adequate adhesion (>2 seconds). It was concluded that the nut grass rhizome water fraction gel has stable and acceptable physical characteristics, making it a potential candidate for further development as a topical preparation.
The Effects of a Low-Carbohydrate Diet on Glycemic Control and Weight in Patients with Type 2 Diabetes Mellitus: Literature Review Tri Budi Julianti; Tania Putri; Dewi Lutfania Syahrani; Javier Ammar; Siti Khadijah; Rizki Nur Azmi
Strada Journal of Pharmacy Vol. 8 No. 1 (2026): April
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v8i1.241

Abstract

Type 2 diabetes mellitus (T2DM) is an increasing global health problem characterized by chronic hyperglycemia due to insulin resistance and/or insulin secretion deficiency. T2DM management often focuses on glycemic control and weight loss through lifestyle interventions, including diet. Low-carbohydrate diets (LCDs) have been one of the most debated and researched dietary interventions, with claims of improving glycemic control and facilitating weight loss. This literature review aims to synthesize the current scientific evidence on the effect of DRK on glycemic control (HbA1c, fasting glucose) and weight in T2DM patients. A systematic review method will be used to identify, evaluate and summarize relevant studies from electronic databases. The review will present key findings from studies, discuss underlying mechanisms, and identify potential benefits, risks, and limitations of DRK. This literature review is expected to provide a more comprehensive understanding for clinical practitioners, patients, and researchers in considering DRK as a T2DM management strategy.
Analysis of the Relationship Between HIV/AIDS Clinical Stage and Opportunistic Infections at Hospital X Chinthia Devientasari; Selly Septi Fandinata
Strada Journal of Pharmacy Vol. 8 No. 1 (2026): April
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v8i1.287

Abstract

Opportunistic infections remain a major cause of morbidity and mortality among people living with Human Immunodeficiency Virus (HIV). The progressive decline in immune function increases susceptibility to infections such as tuberculosis, candidiasis, and toxoplasmosis. The World Health Organization (WHO) clinical staging system is widely used to assess HIV disease progression and is often associated with the occurrence of opportunistic infections. This study aimed to analyze the association between HIV clinical stage and opportunistic infections among HIV/AIDS patients at Hospital X. This study employed an observational analytic design with a cross-sectional approach. Data were obtained from medical records of HIV/AIDS patients, with a total sample of 193 patients selected using total sampling. Statistical analyses included univariate and bivariate analyses using the chi-square test. The majority of patients were in clinical stage III (80.3%). The prevalence of opportunistic infections was 14.0%. The results of the chi-square test showed no significant association between clinical stage and opportunistic infections (p = 0.206). Although opportunistic infections were more frequently observed in advanced stages, the relationship was not statistically significant.
Forced Degradation Study of Flavonoid in Portulaca grandiflora extract using Spectrophotometric UV-Vis Erlien Dwi Cahyani; Titah Amalia Suharyanto; Maria Fatmadewi Imawati
Strada Journal of Pharmacy Vol. 8 No. 1 (2026): April
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v8i1.288

Abstract

Exploration of the effectiveness from magenta purslane herb extract in traditional medicine is still ongoing. Flavonoid is the major compound that allegedly have pharmacology effect in magenta purslane herb extract. To ensure the stability of the flavonoid content in the magenta purslane herb extract, a stability test was carried out using forced degradation. The aim of this study was to determine the effect of forced degradation by acid hydrolysis, alkaline hydrolysis, oxidation and heat substanes on the quercetin content of magenta purslane herb extract using a UV-Vis Spectrophotometer at a wavelength of 424 nm. The results showed in the form of a linear regression equation y=0.0127x + 0.0437 with a value of r2 = 0.9912 with a quercetin content of 10.59 %w/w. It was concluded that statistically there was a significant difference with the decrease content in the acid, base and oxidation forced degradation treatments after 2 consecutive hours of 1,65 %w/w; 3,86 %w/w; 2,38 %w/w whereas no significant reduction was observed under thermal degradation.
The First-Year Effect of Indonesia’s Free Health Screening Program on Drug Planning and Use in Primary Health Centre Hanie Kusuma Wardani; Adi Wibisono; Janik Kurniawati
Strada Journal of Pharmacy Vol. 8 No. 1 (2026): April
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v8i1.289

Abstract

Background: The implementation of the Indonesia’s Free Health Screening Program increases healthcare utilization and may alter drug demand in primary healthcare settings. This study aimed to evaluate the conformity between drug planning and actual utilization during Indonesia’s Free Health Screening Program implementation and to assess its implications for drug management efficiency. Methods: This study employed an analytical observational design with a retrospective comparative approach by analyzing Drug Requirement Plans for 2025, drug consumption data from 2023, and actual drug utilization in 2025. Results: The conformity of drugs with the National Formulary was high (88.93–91.89%). However, planning accuracy was suboptimal, with overplanning (50%) and under planning (38%) dominating, and overall item conformity at 81.51%. Increased service utilization due to Indonesia’s Free Health Screening Program significantly influenced changes in drug consumption patterns that were not captured by historical-based planning. Conclusion: The findings indicate that drug planning systems based solely on historical consumption are insufficient in the context of large-scale health programs. Adaptive planning models incorporating real-time data and service utilization trends are required to improve the efficiency of drug management in primary healthcare settings.
Formulation and Determination of Sun Protection Factor (SPF) of Sunscreen Gel Preparations Containing Epigallocatechin Gallate (EGCG) Using the Spectrophotometric Method Oppy Aesaiw
Strada Journal of Pharmacy Vol. 1 No. 1 (2019): April
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v1i1.123

Abstract

Long-term exposure to the sun causes various kinds of abnormalities in human skin so it requires skin protection from the outside. Sunscreen is a cosmetic therapy that can shield the skin and face against UV radiation, including the potential to induce accelerated ageing, sunburn, and skin cancer. Tea leaf-derived polyphenol compounds, particularly EGCG, have the most potent and plentiful antioxidant action. The objective of this work is to investigate the impact of variations in epigallocatechin gallate (EGCG) levels on the physical properties and effectiveness of sunscreen gel. This study used an experimental design with four EGCG gel formulas (negative control (0%), F1 (0.1%), F2 (0.2%), F3 (0.4%)) and tested with a UV-Vis spectrophotometer with the resulting absorbance calculated using the Mansur formula.The results showed that the SPF value increased with increasing EGCG concentrations (negative control, F1, F2, F3, positive control: 18.94 (moderate), 22.55 (moderate), 29.10 (moderate), 41.58 (high), 48.11 (high)). The highest SPF value on Formulation 3 indicates a high level of sunscreen capability. EGCG gel with a concentration of 0.4% has good physical characteristics (slightly thick texture, odorless, transparent white color, homogeneous, pH 6.57, adhesion 3.30, diffusion 6.36) and the highest SPF value (41.58). The statistical test using Kruskall-Wallis followed by the Man-Whitney test showed a significant difference in a p-value of 0.05.
Antibacterial Test Of Telang Flower Extract (Clitorea Ternatea L.) Against Pseudomonas Aeruginosa Luluk Aniqoh Meliana Putri; Chinthia Devientasari; Devita Riafinola Andaririt; Ivan Junius Mesak; Anggi Restyana
Strada Journal of Pharmacy Vol. 5 No. 2 (2023): October
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v5i2.96

Abstract

The butterfly pea flower is a shrub that can grow and live for years (perennial), can reach a height of 5 meters, has fine hair, and is woody at the base, the flower color is bright blue with a yellowish white color in the middle. Butterfly pea flower (Clitoria ternatea L.) is a plant that has long been used in medicine and has been proven to contain alkaloid and flavonoid secondary metabolite compounds which have antibacterial potential. Antibacterials are substances that can interfere with the growth or even kill bacteria by interfering with the metabolism of harmful microbes. The aim of this research was to determine the inhibitory power of telang flower simplicia extract (Clitoria ternatea L.) on the growth of Pseudomonas aeruginosa bacteria. This research aims to test the activity of butterfly pea flowers, namely by maceration using 70% ethanol solvent. For antibacterial testing using the disk diffusion method. Extracts are made in various concentrations of 10%, 20%, 30%. The positive control used was Chloramphenicol. The results of this research were that the average zone of inhibition of butterfly pea flower extract against Pseudomonas aeruginosa bacteria was 1.48 mm at 10% concentration, 2.41 mm at 20% concentration, and 5.70 mm at 30% concentration. These results show that butterfly pea flower extract has antibacterial activity against Pseudomonas aeruginosa bacteria, although the resulting inhibitory power is not strong. At a concentration of 30% butterfly pea flower extract, it has the greatest inhibitory effect on the growth of Pseudomonas aeruginosa bacteria than concentrations of 10% and 20%.
The Effectivity Of Juwet (Syzygium Cumini) Leaf Ethanolic Extract In Rabbit’s Wound Healing Miranda Susanti Putri
Strada Journal of Pharmacy Vol. 5 No. 2 (2023): October
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v5i2.97

Abstract

Medical plant which has fewer side effects than chemical drugs, is used by people as an alternative to treat wound. Juwet as a medicinal plant has the potential to be developed as a wound healer. The purpose of this study was to determine the ability or activity of juwet leaf extract (Syzygium cumini) in wound healing. The test was carried out using New Zealand rabbits by making wounds on the rabbit's back which were then divided into 5 treatment groups. The treatment group consisted of Group I given aquadestilata, Group II given povidone iodine, Group III given 25% juwet leaf extract, Group IV given 50% juwet leaf extract, and Group V given 75% juwet leaf extract. The results showed that juwet leaf extract (Syzygium cumini) affected wound healing. Average wound diameter consecutively 6,69±1,34, 5,79±2,19, and 4,50±1,70 on day-7. 0,70±0,99, 0,46±0,65, and 0,00±0,00 on the day-10. Based on the results of the research conducted, it can be concluded that juwet leaf extract (Syzygium cumini) has a wound-healing effect on rabbits and the best concentration of juwet leaf extract (Syzygium cumini) for wound-healing activity is 75%.
Activity Testing Of Katuk Leaf Ethyl Acetate Fraction Gel Preparation (Sauropus Androgynus (L.) Merr.) On Healing Wistar Strain White Rat Burns Mintarti; Juvita Herdianty
Strada Journal of Pharmacy Vol. 5 No. 2 (2023): October
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v5i2.98

Abstract

Burns are a condition of loss or damage to skin tissue due to contact between the skin and a heat source. The ethyl acetate fraction of katuk leaves (Sauropus Androgynus (L.) Merr.) is known to be able to help accelerate the healing process of burns because it contains flavonoids, alkaloids, tannins and saponins. The purpose of this study was to analyze the effect of giving the ethyl acetate fraction of katuk leaves and to find out the best concentration of the fraction in healing burns. This study was a laboratory experimental study using the Post Test Control Only Group Design approach using 25 male white rats divided into 5 groups (each group consisted of 5 rats). The treatment groups were K+ (bioplacenton), K- (base), the ethyl acetate fraction of katuk leaves which consisted of several concentrations, namely F I (5%), F II (10%), F III (20%). The parameters observed were a decrease in the diameter of the burn wound and healing of the skin of the rats. Based on the results of observations of healing of burns, statistically showed a significant difference between groups with a p value <0.05. The best concentration in healing burns on the rat's back was a concentration of 20% with a healing percentage of 83.11%, followed by a concentration of 10% (66.71%), a concentration of 5% (56.00%). The healing activity of burns in the positive control with a healing percentage of 82.35%. So the best burn healing activity was in the ethyl acetate fraction of katuk leaves with a concentration of 20% with a healing percentage of 83.11%.
Testing the Anti-Bacterial Activity of Star Gooseberry Leaves (Souropus Androgynus L) Using the Disc Diffusion Method Using the n-Hexane Fraction Against Propionic Bacterium Acnes Devita Riafinola Andaririt; Ardi Broto
Strada Journal of Pharmacy Vol. 5 No. 2 (2023): October
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v5i2.100

Abstract

Acne vulgaris or acne, is a common inflammatory condition in the polysebaceous unit that occurs in teenagers and young adults and is characterized by comedones, papules, pustules, and nodules. One of the factors that causes acne is the Propionic bacterium acnes bacteria. One type of plant with antibacterial properties for acne is the Star Gooseberry Leaf plant (Souropus Androgynus L), which contains alkaloids, saponins, tannins, and flavonoids that act as antibacterials. Susanti (2012). This research aimed to obtain data on the antibacterial activity of the compound components contained in the n-hexane fraction of Star Gooseberry Leaves (Souropus Androgynus L) against the Propionic bacterium acnes bacteria, which can be seen from the inhibition zone. The method used was disc diffusion with three groups of control, namely (K(S), K(+), and K(-)). The test bacteria Propionic bacterium acnes, where the Control Sample consists of 4 test concentrations, namely 30 mg, 60 mg, 120 mg, and 240 mg. The positive control used two µg/disc Clindamycin, while the negative control was 2% DMSO. The results of the disc diffusion test of the ethanol fraction of Star Gooseberry Leaves (Souropus Androgynus L) using the disc diffusion method with concentrations of 30 mg/ml and 60 mg/ml did not provide an inhibition zone, the concentration of 120 mg/ml was 11.1 ± 0.10 mm, the concentration was 240 mg/ml was 14.63 ± 0.25 mm. The negative control DMSO 2% did not provide an inhibitory zone diameter, whereas the positive control Clindamycin 2 µg/disk provided an inhibition zone of 25.47 ± 0.70 mm.

Page 10 of 11 | Total Record : 102

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