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<![CDATA[Penggunaan Ester Asam Fumarat Oral Dalam Pengobatan Kasus Dermatologi ]]>
<![CDATA[Elina Rahma]]>;
<![CDATA[Dwi Indria Anggraini]]>
<![CDATA[ JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 8 No 2 (2020): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 8.2 Edisi Maret - Agus ]]>
Publisher : <![CDATA[BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia) ]]>
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DOI: 10.53366/jimki.v8i2.138
<![CDATA[Introduction: Oral fumaric esters acid (FAE) are interesting compounds in the field of dermatology. FAE works on skin cells and cytokine tissue. So far only a mixture of dimethylfumarate (DMF) and monoethylfumarate (MEF) has been approved for oral treatment of moderate to severe plaque psoriasis. Objective: To determine the use of oral fumaric acid esters (FAE) in the treatment of dermatology Method: The article was prepared using the literature review method, involving 34 literature sourced from books and journals. Results: DMF appears to be a major active component. It is important to emphasize the difference between fumaric acid and fumaric acid esters. Fumaric acid formulations are available as health supplements and are often marketed as natural alternative medicines for treating psoriasis. However, it is poorly absorbed by the intestine and excreted through urine without having any therapeutic effect. Discussion: Although the mode of action of FAE and its mechanism of action in psoriasis therapy is still unclear, the evidence shows that it has nothing to do with the Krebs cycle and the main active compound DMF. There is evidence that FAE is not only effective and safe in psoriasis but also non-granulomatous infectious diseases like annulare granulomas, necrobiosis lipoidica, and sarcoidosis. In vitro and animal studies show some activity in malignant melanoma as well. Conclusion: Oral fumaric acid (FAE) esters are widely used in some dermatology cases. Keywords: Dermatology, fumaric acid, psoriasis, sarcoidosis]]>
<![CDATA[Hubungan Perilaku Personal Hygiene dengan Prestasi Belajar pada Siswa MA Ar Risalah Padang ]]>
<![CDATA[Devin Mahendika Munaf]]>
<![CDATA[ JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 8 No 2 (2020): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 8.2 Edisi Maret - Agus ]]>
Publisher : <![CDATA[BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia) ]]>
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DOI: 10.53366/jimki.v8i2.140
<![CDATA[ABSTRACT Background: The final value of a student's educational process can be seen from the optimal learning achievement. Many things that affect learning achievement, like a personal hygiene behavior as a determinant of health issues. Objective: To determine the relation of personal hygiene behavior to the achievement learing on Ar Risalah Padang of Senior High School. Methods: This research was an analytic study with cross-sectional design. Research subjects were obtained using a proportionate stratified random sampling method from a population of ninety of Ar Risalah Padang of senior high school students. This research used a personal hygiene behavior questionnaire that include knowledge, attitude, and action domain. Results: The results showed fifty five point six percent students had a good level of knowledge, fifty six point seven percent students had a positive attitude, fifty four point four percent students had a good actions, and sixty percent students had good learning achievement. The significance value of knowledge was zero point zero fourty two, attitude was zero point zero fourty, and action was zero point zero fourty four. Conclusions: knowledge, attitude, and actions of personal hygiene were significantly related to the learning achievement because of p value smaller than zero point zero five. Special attention is expected by Ar Risalah Padang of senior high school and local health agencies are regarding personal hygiene education to produce optimal learning achievement.]]>
<![CDATA[Matriks Metalloproteinase (MMP) sebagai Biomarker Terjadinya Perforasi pada Apendisitis Akut ]]>
<![CDATA[Ahmad Razi Maulana Alnaz]]>;
<![CDATA[Abdul Hakim Nasution]]>;
<![CDATA[Aqyl Hanif Abdillah]]>
<![CDATA[ JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 8 No 2 (2020): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 8.2 Edisi Maret - Agus ]]>
Publisher : <![CDATA[BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia) ]]>
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DOI: 10.53366/jimki.v8i2.141
<![CDATA[Background: Acute appendicitis is one cause of emergency surgery in gastroenterohepatology. Only complicated appendicitis such as perforation needs surgical treatment. There is no examination able to determine patient with acute appendicitis require a surgical treatment or conservative treatment with antibiotic today. One examination could be related to appendicitis is Matrix Metalloproteinase (MMP). This literature review aims to know the potency and sensitivity of MMP as biomarker of the risk of perforated appendicitis. Method: Artivle is made by literature review from textbook and 21 journals, with 10 main journal. The journals are obtained from search engine such as Pubmed, Cochrane, and Google Scholar. Discussion: MMP has a proteolytic activity on extracellular matrix of connective tissue which increases during inflammation. The imbalance of MMP to Tissue Inhibitor of Metalloproteinase (TIMP) in appendix causes elevated proteolysis activity that injures the wall of the appendix which serves as the pathophysiology of perforation. Expression and concentration of MMP found increased significantly on biopsies, immunohistochemistry, peritoneal effluents, and serum of patients with complicated appendicitis compared to uncomplicated appendicitis. MMP is able to distinguish complicated with noncomplicated appendicitis, but requires combination with TIMP examination to determine the complication of appendicitis. Conclusion: MMP and TIMP is potential to be a biomarker of perforated appendicitis. Suggestion: Future research to find out cut off level in appendicitis is required.]]>
<![CDATA[Antibacterial Activities of Ethyl Acetic Fraction of Robusta Coffee on Staphylococcus aureus and Salmonella typhi ]]>
<![CDATA[Dwi Puji Rahayu]]>
<![CDATA[ JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 8 No 2 (2020): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 8.2 Edisi Maret - Agus ]]>
Publisher : <![CDATA[BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia) ]]>
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DOI: 10.53366/jimki.v8i2.143
<![CDATA[Infectious diseases are still a major problem in the world, especially in developing countries like Indonesia. Staphylococcus aureus and Salmonella typhi are gram-positive and gram-negative bacteria that are still the most common cause of infection. Improper use of antibiotics can damage normal flora and cause resistance. Coffee contains flavonoid and alkaloid chemical compounds that have antibacterial activity. The purpose of this study was to determine the antibacterial activity of the ethyl acetate fraction from ethanol extract of robusta coffee beans on the growth of Salmonella typhi and Staphylococcus aureus bacteria. The extraction method used was maceration with 70% ethanol solvent and fractionation using the liquid-liquid method using ethyl acetate solvent. Antibacterial testing uses the disk diffusion method with concentrations of 2.5%, 5%, 10% and 15%. The results of the ethyl acetate fraction with a concentration of 15% for Salmonella typhi bacteria had an inhibition zone of 8.13 mm and Staphylococcus aureus bacteria had a inhibition zone of 3.8 mm. The greater the concentration of ethyl acetate fraction the greater the inhibition zone formed on agar media.]]>
<![CDATA[Penggunaan Masker Kain dalam Pencegahan Penularan COVID-19 ]]>
<![CDATA[Rudi Saputra]]>
<![CDATA[ JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 8 No 2 (2020): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 8.2 Edisi Maret - Agus ]]>
Publisher : <![CDATA[BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia) ]]>
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DOI: 10.53366/jimki.v8i2.146
<![CDATA[Introduction: COVID-19 (Coronavirus Disease 2019) is a new disease due to SARS-CoV-2 (Severe Acute Respiratory Syndrome-Coronavirus-2) which can be transmitted through droplets. One effort to prevent transmission of COVID-19 is to use a mask. Medical masks are effective in preventing transmission of COVID-19, but their numbers are very limited and are very much needed by medical personnel when treating COVID-19 patients. Therefore, to prevent the spread of COVID-19 more broadly, alternative medical masks are needed, namely by using cloth masks which have not been discussed much about the purpose of their use to the public. Discussion: SARS-CoV-2 is a cause of COVID-19 and infects the respiratory tract, especially in the lungs (pulmo) through the ACE2 receptor (Angiotensin-Converting Enzyme 2). SARS-CoV-2 has a diameter of around 120 nm. Cloth masks as an alternative to the scarcity of medical masks are recommended for public use. The recommended cloth masks are made of cotton or a cloth towel. A cloth mask is able to hold large droplets (> 5 ?m), but not small droplets. Conclusion: Cloth masks can be used by the community in an effort to minimize transmission of COVID-19 by holding large droplets, but it is not effective in preventing transmission of COVID-19 because it can still be passed by SARS-CoV-2. Suggestion: Cloth masks can be optimized using nanoparticles to resist SARS-CoV-2.]]>
<![CDATA[A Hidrocloroquin tatalaksana COVID-19, Apakah sudah tepat dan adakah alternatif lain? ]]>
<![CDATA[Mohammad Ridho Devantoro]]>
<![CDATA[ JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 8 No 2 (2020): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 8.2 Edisi Maret - Agus ]]>
Publisher : <![CDATA[BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia) ]]>
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DOI: 10.53366/jimki.v8i2.148
<![CDATA[There has been a pandemic phenomenon known as COVID-19, but WHO has not yet established a medical management guidelines for the disease. a lot of debate about the use of hydrocloroquine / cloroquin with various in vitro studies and some drugs such as anti-inflammatory proposed to be an alternative therapy with a combination therapy mechanism because it is more effective than monotherapy.]]>
<![CDATA[Potensi X-Box Binding Protein (XBP1) dalam Meregulasi Stres Retikulum Endoplasma sebagai Pencegahan Diabetik Retinopati pada Penderita Diabetes Melitus Tipe 2 ]]>
<![CDATA[Ayu Widyanti]]>;
<![CDATA[Mien Dwi Cahyani]]>;
<![CDATA[Dian Pratita Lestari]]>
<![CDATA[ JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 1 No 2 (2012): JIMKI : Jurnal Ilmiah Mahasiswa Kedokteran Indonesia ]]>
Publisher : <![CDATA[BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia) ]]>
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<![CDATA[Diabetik retinopati (DR) merupakan komplikasi yang paling sering terjadi pada penderita diabetes dan penyebab utama kebutaan pasien usia 20-64 tahun populasi di Amerika Serikat. Insiden diabetik retinopati meningkat menjadi 50% setelah 10 tahun menderita DMT2 dan menjadi 90% setelah 25 tahun. Kasus kebutaan total akbiat diabetik retinopati ditemukan setelah 20 tahun menderita DM dengan angka kebutaan DMT2 mencapai 60%. Modalitas pengobatan DR selama ini memerlukan biaya yang relatif tinggi dan menyebabkan komplikasi. Stres Retikulum Endoplasma (RE) dan inflamasi adalah dua faktor penting dalam patogenesis DR karena berpotensi merusak BRB, tanda patologis DR stadium awal. X-Box Binding Protein 1 (XBP1) yaitu gen pengkode faktor transkripsi yang meregulasi stres RE mampu memberikan perlindungan terhadap sistem vaksuler retina dengan mengatasi stres RE serta sebagai agen anti inflamasi yang nantinya mampu mencegah kerusakan BRB. XBP1 dapat mengatasi Stres RE dengan meningkatkan ekspresi kaperon RE dan aktivasi gen-gen yang terlibat dalam ERAD dan meningkatkan protein yang terlibat dalam ERAD dengan berikatan pada protein yang misfold. XBP1 dapat menurunkan ekspresi molekul adhesi ICAM-1 dan VCAM-1 dan NF-kB yang diinduksi oleh TNF-? dan IKK. Dalam pengadministrasiannya, XBP1 dimasukkan ke dalam adenovirus vektor kemudian diinjeksikan secara intravitreal pada penderita DMT2.]]>
<![CDATA[The Correlation between Gestational Age and Stress Level in Pregnant Women, in Ciracas Health Care Service, East Jakarta ]]>
<![CDATA[Anggia Widyasari]]>;
<![CDATA[Elfikri Asril]]>;
<![CDATA[Fahmi Rusnanta]]>;
<![CDATA[Irene Sinta Febriana]]>;
<![CDATA[Susie Susilawati]]>;
<![CDATA[Yuditiya Purwosunu]]>
<![CDATA[ JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 1 No 2 (2012): JIMKI : Jurnal Ilmiah Mahasiswa Kedokteran Indonesia ]]>
Publisher : <![CDATA[BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia) ]]>
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<![CDATA[Abstrak Kehamilan merupakan masa yang rentan terjadi stres. American college of Obstetrician and Gynecologist (ACOG) mengeluarkan rekomendasi terkait skrining stres psikososial selama kehamilan. Tujuan studi ini untuk mengetahui hubungan antara usia gestasi dan tingkat stres pada ibu hamil. Studi ini menggunakan desain potong lintang dengan total sampel sebesar 100 subjek penelitian yang dipilih dengan teknik consecutive sampling. Data diambil dengan menggunakan metode kuesioner untuk menilai data demografik, riwayat obstetri, dan tingkat stres yang mengacu pada The Prenatal Psychosocial Profile Hassles Scale. Hasil studi menunjukkan terdapat korelasi bermakna antara usia gestasi dengan skor stres (p=0,022), Korelasi bersifat negatif yang berarti semakin bertambah usia gestasi maka skor stres akan berkurang, tetapi kekuatan korelasi yang dimiliki masih lemah (R=-0,230). Berdasarkan analisis regresi linier, setiap pertambahan usia gestasi sebesar satu minggu akan menurunkan skor stres sebanyak 0,053. Studi ini menyimpulkan bahwa semakin bertambah usia gestasi akan menurunkan tingkat stres. Oleh karena itu, skrining stres psikososial selama kehamilan sangat diperlukan, terutama pada trimester pertama]]>
<![CDATA[Kelainan Sistem Lakrimal Pada Anak ]]>
<![CDATA[Atikah Landani]]>;
<![CDATA[Rani Himayani]]>
<![CDATA[ JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 8 No 2 (2020): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 8.2 Edisi Maret - Agus ]]>
Publisher : <![CDATA[BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia) ]]>
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DOI: 10.53366/jimki.v8i2.151
<![CDATA[Introductions: The lacrimal system consists of various glands in producing tears and drainage systems. Epiphora, or excessive tears, is a problem that occurs in children, baby or infants. Discussions: The most frequent etiology of this disorder is nasolacrimal duct obstruction. The most frequent abnormalities are defects or blockages in the drainage system, blocked nasolacrimal ducts. Most of the evidence supports conservative management in this case, examinations are conducted for those who fail to resolve at the age of one year. There are several other conditions, some of which can be serious, which can cause a lot of tears. Infections of the eyelids and conjunctiva, foreign bodies that have not been found, and congenital glaucoma are some conditions that must be ruled out when there are children who experience excessive tears. Conclusions: Proper diagnosis and management of the lacrimal system in children will get a better prognosis Keywords: Children, diagnosis, infant, lacrimal, tears]]>
<![CDATA[PERBEDAAN PENGETAHUAN KADER SEBELUM DAN SESUDAH DILAKUKAN TELEEDUKASI MENCUCI TANGAN DI TENGAH WABAH COVID-19 DI KELURAHAN BURANGRANG, BANDUNG ]]>
<![CDATA[Fachreza Aryo Damara]]>
<![CDATA[ JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 8 No 2 (2020): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 8.2 Edisi Maret - Agus ]]>
Publisher : <![CDATA[BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia) ]]>
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DOI: 10.53366/jimki.v8i2.154
<![CDATA[Background: Health prevention and promotion are both important in making better public health. In order to actualize both aspects, Posyandu cadre play major role. Cadre have bigger chance and impact to educate the people who are living around them. However, doing a direct education has become more difficult since physical contacts were minimalized during this COVID-19 outbreak. Therefore, an effective tele-education is needed as an effort to prevent COVID-19 transmission. The study aims to evaluate the effect of tele-education through Youtube and Whatsapp to enhance people's understanding on COVID-19 transmission prevention Method: The study was a cross-sectional study with observational descriptive-analytical methods and quantitatively approach. Subject of the study was Posyandu cadre in Burangrang Village, Lengkong District, Bandung with the subject total was 19. Results: After given a tele-education, there was an increase in total score means between pretest and posttest with p=0.000 (p<0.001). Moreover, there were increases in both social media’s impression and engagement on educational video which was uploaded on Youtube. Discussion: In doing tele education to Posyandu cadre, video as a media to deliver the content was more preferred. Sharing the knowledge through video along with evaluating participants' understanding of the given topics could enhance cadre knowledge about handwashing as a prevention in the middle of COVID-19 outbreak. Conclusion: Tele education using video could enhance cadre’s understanding about handwashing. The media that has been used was able to deliver the content based on impression and engagement evaluations.]]>
