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JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia

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Published by Badan Analisis dan Pengembangan Ilmiah Nasional ISMKI

ISSN : 23026391 EISSN : 27211924 DOI : https://doi.org/10.53366/jimki

Core Subject : Health,

Health Professions Medicine & Pharmacology Public Health

Jurnal Ilmiah Mahasiswa Kedokteran Indonesia (JIMKI) adalah jurnal yang dikelola oleh Badan Analisis dan Pengembangan Ilmiah Nasional (BAPIN). JIMKI berfokus menjadi wadah untuk publikasi penelitian mahasiswa kedokteran.

Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)

Articles 326 Documents

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Penatalaksanaan Kegawat daruratan Gagal Jantung Kongestif secara Komprehensif pada Pasien Pediatri di Pelayanan Primer Kevin Saputra; Felix Chikita Fredy
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 1 No 2 (2012): JIMKI : Jurnal Ilmiah Mahasiswa Kedokteran Indonesia
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

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Gagal jantung pada anak merupakan suatu sindrom klinis yang disebabkan oleh ketidakmampuan miokardium untuk memenuhi metabolisme tubuh, termasuk pertumbuhan. Gagal jantung pada anak memberikan gambaran klinis dan perjalanan penyakit yang berbeda pada orang dewasa. Di samping faktor penyebab utama yaitu penyakit jantung bawaan (PJB), faktor umur menyebabkan jantung dan organ lainnya masih lebih baik regenerasinya sehingga memberikan harapan penyembuhan yang lebih baik. Anak dengan PJB 90% meninggal karena gagal jantung dalam usia kurang dari satu tahun, sedangkan sisanya terjadi pada umur 1-5 tahun. Oleh karena itu, upaya penanganan kegawatdaruratan gagal jantung pada anak yang tepat diperlukan dalam upaya menurunkan angka mortalitas. Laporan kasus ini membahas upaya penegakan diagnosis dan stabilisasi anak dengan syok kardiogenik karena PJB.

Pengaruh Induksi Cathepsin K terhadap Pembetukan Imunoglobulin (IgG) Anti-Cathepsin K, Osteosit, dan Kadar Alkaline Phosphatase (ALP) pada Tikus Putih (Rattus norvegicus L. Betina Galur Wistar Pascaovariektomi Fransisco Wahyu Santoso; Arif Ismail; Oktavia Rahayu Adianingsih; Yurike Mandrasari
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 1 No 2 (2012): JIMKI : Jurnal Ilmiah Mahasiswa Kedokteran Indonesia
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

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ABSTRACT Osteoporosis is a "silent disease" that can weaken bones and cause fractures. Two from five of Indonesia's population at risk of osteoporosis and it is estimated in 2025 that number will become tripled. It has been found a kind of drug, that serves as cathepsin K inhibitors, that shows great potential in reducing osteoporosis. Cathepsin K has an important role in tissue destruction, bone remodeling, and cartilage destruction, This study is aimed to verify the effect of the cathepsin K vaccine candidate to the decrease of bone resorption in Rattusnorvegicus strain wistar post-ovariectomy. Female Rattusnorvegicas Strain Wistar (age: 10-12 weeks) are divided into 5 groups: control (-), control (+) with ovariectomy, the treatment groups are ovariectomized and given cathepsin K 50 ng/200 µL, 100 ng/200 µL, and 200 ng/200 µL.. Surgery perform on the 30th day and then IgG titers of anti-cathepsin K and ALP serum level are measured and the number of osteocytes is counted. ANOVA test shows that the administration of the vaccine candidate, cathepsin K that are added with CFA-IFA, is significantly increase the titers of IgG anti-cathepsin K in the serum (p = 0.00). The administration of cathepsin K 50 ng/200 µL, 100 ng /200 µL, and 200 ng/200 µL do not significantly reduce the number of osteocytes. The administration of cathepsin K 50 ng/200 µL, 100 rig / 200 µL, and 200 ng/200 µL do not increase the ALP serum levels (p> 0.05) significantly. The conclusion of the study is that the administration of the cathepsin K vaccine candidate can increase the IgG anti-cathepsin K titers in Female Rattusnorvegicus Strain Wistar Rats Post-ovariectomy, but do not significantly affect the number of osteocytes and ALP serum levels. Therefore, the osteoporosis vaccine candidate with cathepsin K as a basic material still need to be researched and develop

Analisis Potensi Curcumin Kunyit (Curcuma longa) Sebagai Agen Neuroproktektor, Antiinflamasi, dan Antioksidan: Inovasi Pengembangan Terapi yang Efektif pada Penderita Alzheimer Surya Wijaya; Muthmainnah Arifin
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 1 No 2 (2012): JIMKI : Jurnal Ilmiah Mahasiswa Kedokteran Indonesia
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

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ABSTRACT Alzheimer is the most common type of dementia disorders affecting people all over the world. Alzheimer not only contribute to complications, disability, and high mortality rate, but also has implications in psychiatry and economic aspects. Unfortunately, until now there is no medical management to treat Alzheimer effectively. One of the herbs that is used as Alzheimer therapy is turmeric (Ctercuma longa) with its main components, curcumin. The aim of paper writing is to investigate the mechanism and potential applications of turmeric's curcumin as innovative therapy for Alzheimer patient. Data collection methods is literature study. whereas data analysis method is inductive. Curcumin has potential as management modality of Alzheimer because it serves as a neuroprotective agent by inhibiting the formation protein ? -arnyloid and tau protein cycle, decreasing the activity of ? -secretase and acetilcolinesterase, and antidislipidemia. Curcumin also acts as an anti-inflammatory agent through inhibition of NF-kB activity, COX-2, lipooxygenase, AP-1, iNOS, and Egr-1. In addition to these two effects, curcumin also has potential as an antioxidant agent through lowering activity of peroxidase, reactive oxygen species (ROS) and oxidative stress induced by homocysteine. This suggests that turmeric's curcumin has strong potential for fluffier development into alternative Alzheimer therapies.

Arteriovenous Shunt (AV Shunt) Sebagai Akses Hemodialisis Pada Pasien Chronic Kidney Disease (CKD): Arteriovenous Shunt (AV Shunt) Sebagai Akses Hemodialisis Pada Pasien Chronic Kidney Disease (CKD) Abed Nego Okthara Sebayang
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 8 No 2 (2020): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 8.2 Edisi Maret - Agus
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v8i2.102

Background: Arteriovenous Shunt (AV Shunt) is an anastomosis operation of an artery and vein in the arm or other body part with the aim of making the connection as hemodialysis access. AV shunt is the gold standard of creating vascular access for hemodialysis in patients with chronic kidney disease. AV shunt was created to increase the effectiveness of dialysis and reduce the risk and complications of other vascular access. Discussion: Based on its location, making the AV shunt has priority, namely the distal arm of the non-dominant arm. If this is not possible, AV shunt can be performed proximal to the non-dominant arm and finally to the proximal part of the dominant arm. The location of the wrist is a top priority in making AV shunt because it has many advantages. The arteries and veins that are commonly used are the radial arteries and vein cephalica and the brachial arteries with vein cephalica. Conclusion: AV shunt is the gold standard of creating vascular access for hemodialysis in patients with chronic kidney disease. . It is hoped that through the AV shunt action the life expectancy of patients with chronic kidney failure can increase and must be supported by other disciplines such as interna, psychologists and the patient's family.

KADAR KALSIFEDIOL SEBAGAI PREDIKTOR DERAJAT KEPARAHAN RETINOPATI DIABETIK PADA PASIEN DENGAN DIABETES MELLITUS TIPE 2 Gilbert Sterling Octavius; Alvita Suci Edgina; Stefany Tanto; Werlison Tobing
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 8 No 3 (2021): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 8.3 Edisi September 20
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v8i3.113

Pendahuluan : Terdapat peningkatan prevalensi pasien diabetes mellitus (DM) dan morbiditasnya, termasuk retinopati diabetik. Retinopati diabetik adalah penyebab paling sering dari kasus baru kebutaan di antara orang dewasa berusia 20-74 tahun yang akan mempengaruhi produktivitas kelompok usia ini jika dibiarkan atau tidak diobati. Tujuan : Mengevaluasi kemungkinan tingkat kalsifediol sebagai prediktor keparahan retinopati diabetik pada pasien dengan diabetes mellitus tipe 2. Metode : Kami mencari di PubMed, Kemajuan Oftalmologi, Laporan Ilmiah dan Ilmu Pengetahuan Langsung menggunakan istilah “25(OH)D3 Level”, “Diabetic Retinopathy”, “Prevalence of Diabetes Mellitus”, “Type 2 Diabetes Mellitus”, dan “Predictor” dalam berbagai kombinasi dan menemukan 7 studi yang digunakan dalam ulasan ini. Hasil : Kami menemukan 4 literatur yang menyatakan bahwa ada hubungan positif antara level 25 (OH) D3 sebagai prediktor untuk keparahan retinopati diabetik sementara ada 3 literatur yang menyatakan sebaliknya. Enam literatur menggunakan desain cross sectional sedangkan satu dilakukan dengan menggunakan case control. Tingkat pemotongan 25(OH)D3 pada pasien dengan masing-masing 18,9-24,3 ng/ml, 17,4-21,7 ng/ml, dan 14,7-21,1 ng/ml. Kesimpulan : Sementara penggunaan 25(OH)D3 sebagai prediktor tingkat keparahan retinopati diabetik masih tidak meyakinkan, hubungan proporsional terbalik terlihat antara kedua variabel.

PEMANFAATAN MINUMAN KEFIR SEBAGAI BAGIAN UPAYA PREVENTIF TERHADAP INFEKSI PNEUMONIA Muhammad Luthfi Adnan
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 8 No 2 (2020): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 8.2 Edisi Maret - Agus
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v8i2.114

Introduction: Pneumonia is an acute infection of the lungs and can be caused by bacteria, viruses, fungi, chemical exposure or the influence of other infections. Pneumonia is one of the diseases that cause the most deaths in the world after diarrhoea. Pneumonia caused by several microorganisms includes Haemophilus influenza type B (HiB), Streptococcus pneumonia, influenza virus and respiratory syncytial virus (RSV). The use of antibiotics is now one of the important treatments for the management of pneumonia. However, with the challenge of antimicrobial resistance, therapy is needed to eradicate pathogens and prevent resistance. One probiotic drink that has potential in the treatment of pneumonia is kefir. The development of science now shows the potential of kefir probiotic drinks to prevent pneumonia infection. Discussion: This literature study proves that probiotic drinks have an antibacterial effect to prevent pneumonia infection. The complex content of probiotic bacteria between specific lactic acid bacteria, acetic acid-producing bacteria and lactose and non-lactose fermenting bacteria that symbiotic with each other stimulates the immune system to be used for pathogens of pneumonia infection. The component of probiotic bacteria in kefir can reduce the level of antibiotic and antimicrobial consumption which can complicate the treatment of pneumonia infections. Conclusion: Probiotic drinks from kefir which have a high content of probiotic bacteria can reduce the risk of pneumonia infection

Tatalaksana Oral Non-Antimikroba Pada Pasien Akne Vulgaris Ayu Wulandari; Dwi Indria Anggraini
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 8 No 2 (2020): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 8.2 Edisi Maret - Agus
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v8i2.117

Introduction: Acne vulgaris (acne) is a non-infectious skin condition that is very common and often comes in dermatological practice. Because acne often appears chronic and can last for years, safe and effective long-term therapy is needed. Given the increasingly frequent antibiotic-resistant bacteria and the severity of the consequences if there is resistance, dermatologists are needed to maximize the use of non-antimicrobial therapy when treating patients with acne. Objective: To find out which oral non-antibiotic drugs can be used for acne vulgaris therapy Method: The article was prepared using the literature review method, involving 32 literature sourced from books and journals. Results: The emergence and potential transfer of antibiotic resistance in skin microorganisms is of current concern in treatment especially in the context of dermatology where long-term treatment with antibiotics. Remarkably, non-antibiotic therapy in the form of isotretinoin - non-antimicrobial retinoids is effective in reducing or eradicating anaerobic Propionibacterium acnes that is causally involved in the pathogenesis of the Acne vulgaris complex. Discussion: In this review of the literature we present data on the effects of the proper use of non-antimicrobial therapy for acne. There are various topical and oral treatment options that can be used gradually according to the severity and therapeutic response of the patient. Non-antimicrobial treatments can be very good at controlling acne, especially when used as maintenance therapy. While antibiotics have a role in the treatment of acne, they should not be used as monotherapy, and the use of old antibiotics is not recommended. Conclusion: Some drugs whose hormonal mechanism can be oral non-antimicrobial drugs in the treatment of acne vulgaris Keywords: Acne, Antibiotics, Isotretinoin, Spironolactone, Subantimicrobial

Terapi Imunologi Pada Melanoma Muhamad Addin Syakir; Dwi Indria Anggraini
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 8 No 2 (2020): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 8.2 Edisi Maret - Agus
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v8i2.118

Introductions: Immunotherapy for cancer is used based on the principle of the disease that the immune system is able to produce an immune response to tumor cells. Treatment is currently available for selective melanoma patients based on the response rate of the disease. Objectives: To determine the management of melanoma using immunology. Methods: This article was compiled using the literature review method, using 32 sources derived from journals and books. Results: Interferon-? was approved for the treatment of adjuvant stage III melanoma with increased survival rate. New and more innovative approaches are needed with increasing therapeutic effects. The prognosis of patients with metastatic melanoma in the world has changed dramatically since the presence of an immune checkpoint inhibitor. Discussions: Ipilimumab, which targets the cytotoxic T lymphocyte-associated protein 4 (CTLA-4) protein is the first agent that exists. Furthermore, nivolumab and pembrolizumab that bind to programmed death protein 1 (PD-1) proteins have been shown to be more effective and lower in toxicity than ipilimumab. The combination of nivolumab or pembrolizumab with ipilimumab has resulted in increased response rates and patient survival rate results. This literature review will explore important clinical trial data that have led to the use of this immunotherapy agent in the world and some clinical trial results currently reported for new combination therapies. Conclusions: At present immunology therapy for melanoma management can be applied. Keywords: Chemotherapy, immunotherapy, management, melanoma

Manajemen Tatalaksana Neuritis Optik Demielinasi Okta Della Susmitha; Muhammad Yusran
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 8 No 2 (2020): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 8.2 Edisi Maret - Agus
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v8i2.121

Introductions: Optic Neuritis (ON) is defined as inflammation of the optic nerve, which is mostly idiopathic. But it can be linked to other causes such as demyelinating lesions, autoimmune disorders, infections and inflammation. Of all these, multiple sclerosis (MS) is the most common cause of demyelinating ON. Objectives: To determine the diagnosis and management of demyelinating optic neuritis. Methods: This article was produced using the literature review method, involving 29 references, both books and national or international journals. Results: ON occurs due to an inflammatory process that leads to T-cell activation that can cross the blood brain barrier and cause hypersensitivity reactions to nerve structures. The exact mechanism is unknown. The clinical diagnosis of ON consists of three classic symptoms namely vision loss, periocular pain and dyschromatopsia. This requires careful ophthalmic, neurological and systemic examination to distinguish between specific and non-specific ON. A differential diagnosis is needed to make an appropriate management plan. Discussions: According to the Optic Neuritis Treatment Trial (ONTT), the first treatment is intravenous methylprednisolone with faster recovery and fewer possible cases of relapse and conversion to MS. However, oral prednisolone alone is contraindicated because of an increased risk of relapse. Controlled High-Risk Subjects Avonex® Multiple Sclerosis Prevention Study (CHAMPS) and Early Treatment of MS Study (ETOMS) and have reported that treatment with interferon ?-1a, with the result of reducing the risk of MS characteristic characteristics from MRI. Contrast sensitivity, color vision and visual fields are parameters that remain largely disturbed even after recovery of good visual acuity. Conclusions: Management of dominant demyelinating optic neuritis is given steroids and ?-1a interferon. Keywords: demyelination, multiple sclerosis, optic neuritis, management

Diagnosis dan Penatalaksanaan Sialadenitis Bakteri Wivan Havilian Djohan; Hanggoro Sapto
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 8 No 2 (2020): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 8.2 Edisi Maret - Agus
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v8i2.122

Introductions: Various diseases ranging from obstruction, infection, to benign and malignant tumors occur in the salivary glands. The most common problem is the blockage of the salivary gland ducts which prevents salivary drainage. Objectives: To determine the diagnosis and management of bacterial sialadenitis. Methods: This article was created using the literature review method, involving 30 references in both national and international books and journals. Results: Sialadenitis is inflammation or infection of the salivary glands which can affect the parotid, submandibular and minor salivary glands. Sialadenitis can be caused by infectious or non-communicable factors. Discussions: Bacterial or viral infections are the most frequent etiology. Staphylococcus is a common cause of bacteria, while paramyxovirus is a frequent cause of viruses. Imaging findings in this case vary between enlarged unilateral or bilateral salivary glands, atrophy, abscesses, ductal dilatation, cysts, stones and calcifications. Imaging can detect abscesses in acute bacterial suppurative sialadenitis, ductal changes with cysts in chronic adults and recurrent adolescent parotitis. The correlation of imaging findings with clinical presentation can help diagnose sialadenitis. Post-therapy sialadenitis can occur after the patient has radiotherapy, radioactive iodine or surgery. Conclusions: Proper diagnosis and management of bacterial sialadenitis can prevent complications and a good prognosis. Keywords: Abscess, inflammation, salivary glands, sialadenitis, management

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Contact Name Norbertus Marcell Prayogi

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Journal Mail Official editor@jimki.bapin.or.id

Editorial Address Jl. Dr. G.S.S.Y. Ratulangi No. 29, Menteng, Jakarta Pusat 10350

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Contact Name
Norbertus Marcell Prayogi

Contact Email
editor.jimki.bapin@gmail.com

Phone
+6281372545321

Journal Mail Official
editor@jimki.bapin.or.id

Editorial Address
Jl. Dr. G.S.S.Y. Ratulangi No. 29, Menteng, Jakarta Pusat 10350

Location
Kota adm. jakarta pusat,

Dki jakarta

INDONESIA