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Vincentius Widya Iswara
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Jurnal Widya Medika
Published by Universitas Katolik Widya Mandala Surabaya
ISSN : 23380373     EISSN : 26232723     DOI : https://doi.org/10.33508/jwm
Core Subject : Health,
Medicine & Pharmacology
Jurnal Widya Medika is the official publication media of Widya Mandala Surabaya Catholic University, Faculty of Medicine. Jurnal Widya Medika publishes original research articles, case reports, and literature reviews from scientists of various medical education and research institutions, including select scientific works from medical students. All articles published had undergone plagiarism checks, editorial review by the editorial board, and peer review by experts from their respective fields in order to maintain the high standard of articles published in Jurnal Widya Medika.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 214 Documents
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AGE, RANDOM BLOOD GLUCOSE, SERUM LIPIDS, AND LIPASE ACTIVITY IN TYPE 2 DIABETES MELLITUS: A TWO-STAGE CROSS-SECTIONAL ANALYSIS Farah Abbas Fadhil
JURNAL WIDYA MEDIKA Vol. 13 No. 1 (2027): MARCH
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwm.v13i1.8945

Abstract

Dyslipidemia is common in type 2 diabetes mellitus (T2DM), but it is unclear whether there is any association between circulating levels of lipase activity and glycemic or lipid parameters. To characterize age, sex and random blood glucose (RBG) in an archived dataset of T2DM and investigate RBG, triglycerides, total cholesterol, and serum lipase in a smaller biochemical data sub-set. This secondary exploratory analysis included 100 records of which age, sex, and RBG (Stage 1); and 20 records with complete age, sex, RBG, triglyceride, total-cholesterol, and lipase (Stage 2). Documentation was not available that Stage 2 participants were a random or nested sample of Stage 1, so the components were analyzed separately. Two-sided Mann Whitney U tests were used for sex comparisons, and Spearman correlation for associations. In Stage 1, mean age was 57.9±11.7 years and mean RBG was 213.8±44.1 mg/dL. Age was not associated with RBG (rho=0.025, p=0.807). In Stage 2, mean RBG, triglycerides, total cholesterol, and lipase were 254.1±50.4 mg/dL, 194.9±52.3 mg/dL, 193.7±58.2 mg/dL, and 129.4±36.0 U/mL, respectively. There was a positive correlation between triglycerides and total cholesterol (rho=0.678, p=0.001), while lipase was not significantly correlated with RBG or either of the lipid parameters. The data demonstrate both glycemic and lipid abnormalities, but fail to prove a relationship between serum lipase and metabolic parameters. The results presented are preliminary and need to be validated on a cohort with a prospective characterization.
COMPLETE BLOOD COUNT PARAMETERS AND PERIPHERAL BLOOD MORPHOLOGY IN ADULTS WITH TYPE 2 DIABETES MELLITUS: A SYSTEMATIC REVIEW Michael Alexander; Aditya Mahardika Wahono; Nadya Shita Herwindha; Herdy Primanda Ikhwani Alamsyah; Salsabila Auliahadi; Moh Fathi Ilmawan; Pramita Anindya Nugraheni
JURNAL WIDYA MEDIKA Vol. 13 No. 1 (2027): MARCH
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwm.v13i1.8956

Abstract

Type 2 diabetes mellitus can alter complete blood count parameters and peripheral blood morphology through chronic hyperglycemia, inflammation, oxidative stress, and endothelial dysfunction, changes that may support clinical monitoring and risk stratification. This systematic review synthesized current evidence on these hematological alterations in adults with type 2 diabetes mellitus. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement, four databases were searched for studies published between January 2020 and December 2025, and findings from twenty eligible studies were narratively synthesized due to substantial heterogeneity. Most studies reported reduced hemoglobin, hematocrit, red blood cell count, and red blood cell indices, alongside consistently elevated red cell distribution width, particularly in patients with poor glycemic control or complications. Increased white blood cell count, neutrophil-to-lymphocyte ratio, mean platelet volume, and platelet distribution width reflected inflammation and platelet activation, while peripheral smears frequently showed anisocytosis, poikilocytosis, echinocytes, and spherocytes. These parameters are consistently associated with type 2 diabetes mellitus, but the predominance of observational studies limits causal and prognostic interpretation, highlighting the need for prospective studies to establish their clinical utility.
ANTIPARASITIC POTENTIAL OF BIOACTIVE COMPOUNDS FROM LOCAL INDONESIAN PLANTS AGAINST ENTAMOEBA HISTOLYTICA AND GIARDIA LAMBLIA: A LITERATURE REVIEW Amanda Trilana; Bertha Arviani Sugianto
JURNAL WIDYA MEDIKA Vol. 13 No. 1 (2027): MARCH
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwm.v13i1.8959

Abstract

Intestinal protozoan infections, particularly Entamoeba histolytica and Giardia lamblia, remain important health concerns associated with sanitation, water safety, and environmental conditions. Conventional treatment commonly relies on nitroimidazole drugs; however, adverse effects and reports of reduced drug sensitivity encourage the exploration of natural antiparasitic alternatives. Indonesia possesses diverse medicinal plants with potential bioactive compounds, including turmeric (Curcuma longa), betel leaf (Piper betle), and moringa (Moringa oleifera). This article aims to review the potential of bioactive compounds from these plants against intestinal protozoa, particularly E. histolytica and G. lamblia. A literature review was conducted using scientific publications from 2016–2026, supplemented by earlier studies when relevant. Curcumin showed the strongest evidence against both protozoa, including inhibition of growth and viability, disruption of cellular integrity, and suppression of virulence and invasion. Piper betle demonstrated antigiardial potential, although evidence against E. histolytica remains limited. Moringa oleifera showed activity against G. lamblia in diverse experimental models, while evidence against E. histolytica remains limited. Further studies are needed to confirm efficacy, safety, active compounds, and molecular mechanisms.
LIFESTYLE RISK FACTORS AND SELF-MANAGEMENT IN TYPE 2 DIABETES: A CASE STUDY AT OEPOI HEALTH CENTER Maria Magalena Dwi Wahyuni; Angelina Elyta Inya Kondo; Erick Ndjuru Mbaha; Novia Selviana Maria; Riany Lalasantri Oan
JURNAL WIDYA MEDIKA Vol. 13 No. 1 (2027): MARCH
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwm.v13i1.8608

Abstract

Diabetes mellitus is a chronic metabolic disease and a major cause of illness and death globally. It arises from defective insulin secretion, insulin resistance, or both, producing sustained hyperglycemia that leads to progressive organ dysfunction and reduced quality of life. Poorly controlled diabetes is associated with serious complications, including cardiovascular disease, stroke, chronic kidney disease, vision loss, peripheral neuropathy, chronic wounds, and lower-limb amputation. Modifiable behaviors, including high intake of sugary foods and drinks, physical inactivity, smoking, and harmful alcohol use, markedly increase the risk of type 2 diabetes mellitus (T2DM). The rising prevalence of T2DM is a significant public health concern in Kupang City. This study aimed to explore the determinants associated with T2DM among patients attending Oepoi Community Health Center, Kupang City. A descriptive case study design was used. Data were gathered through structured, in-depth interviews with three purposively selected T2DM patients, covering demographics, medical history, risk factors, clinical manifestations, treatment experiences, and blood glucose self-management practices. All participants were women aged 55–70 years who had lived with T2DM for two to more than five years. Excessive consumption of sugary foods and beverages was the predominant behavioral risk factor, while some participants also reported tobacco and alcohol use. Commonly reported symptoms included fatigue, polydipsia, frequent urination, headache, chest pain, and shortness of breath. These findings suggest that unhealthy lifestyle behaviors may contribute to the onset and progression of T2DM among vulnerable urban populations, underscoring the need for targeted health promotion and preventive interventions.

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