Genbinesia Journal of Biology
The Genbinesia Journal of Biology particularly focuses on the core disciplines in biology, they are: astrobiology, bacteriology, behavioural science, biochemistry, biodiversity, bioethics, bioinformatics, biomathematics, biophysics, biopolymers, biostatistics, biotechnology, botany, cell biology, conservation, crystallography of macromolecules, developmental biology, ecology, entomology, evolutionary biology, genetics, genomics, glycobiology, immunology, macromolecules, marine & aquatic biology, mathematical & computational biology, medicine, microbiology, molecular biology, mycology, nanoscience & nanotechnology, neurobiology, neuroscience, ornithology, paleobiology, paleontology, parasitology, pharmacology, physiology, plant biology, proteins & peptides, proteomics, radiation biology, reproductive biology, soil biology, structural biology, systems biology, techniques in biology, theoretical & mathematical biology, virology, zoology, and interdisciplinary applications in biology.
Articles
51 Documents
<![CDATA[Phytofluene from Physalis peruviana as promising anti-TB via InhA of Mycobacterium tuberculosis target: an in silico research ]]>
<![CDATA[Prastiyanto, Muhammad Evy]]>;
<![CDATA[Aini, Nur Sofiatul]]>;
<![CDATA[Yuanita Rachmawati]]>
<![CDATA[ Genbinesia Journal of Biology Vol. 1 No. 2 (2022): March 2022 ]]>
Publisher : <![CDATA[Generasi Biologi Indonesia ]]>
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DOI: 10.55655/genbinesia.v1i2.47
<![CDATA[Tuberculosis (TB) is an infectious disease after severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) in developed countries including Indonesia. Drug resistance becomes major issue worldwide and needs prospective therapeutics development. Plant with medicinal properties including Physalis peruviana is one the promising object to be new anti-TB drug candidate. This study aimed to analyze the inhibitory activity of anti-TB agents from aerial parts of P. peruviana. Ligand and protein samples were obtained from PubChem and RCSB PDB, respectively. The bioactive compounds were evaluated their antibacterial prediction and drug-likeness properties throughout PASS Online and SwissADME webservers. Selected ligands then docked via PyRX and measured the output by binding affinity. Visualization of the best outputs was carried out using BIOVIA Discovery Studio. The result showed that phytofluene had the lowest binding affinity topping the isoniazid as control with -7.2 and -5.1 kcal/mol after targeting enoyl-[acyl-carrier-protein] reductase (InhA) protein of Mycobacterium tuberculosis. This concluded that phytofluene functioned as predictive anti-TB therapeutic candidate. Further in vitro and in vivo studies are needed to validate this outcome.]]>
<![CDATA[Virtual screening of phytochemical compounds from Physalis peruviana as perspective anti-schistosomiasis ]]>
<![CDATA[M. Ainul Mahbubillah]]>;
<![CDATA[Aini, Nur Sofiatul]]>;
<![CDATA[Prastiyanto, Muhammad Evy]]>
<![CDATA[ Genbinesia Journal of Biology Vol. 1 No. 3 (2022): July 2022 ]]>
Publisher : <![CDATA[Generasi Biologi Indonesia ]]>
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DOI: 10.55655/genbinesia.v1i3.48
<![CDATA[Schistosomiasis is a neglected tropical disease (NTD) causing by a Schistosoma japonicum parasite via Oncomelania hupensis snails. Even if the the number of cases decreases significantly, there is still drawbacks of conventional medication. Physalis peruviana is promising plant that rich phytochemicals as prospective drug candidiate of schistosomiasis. This study aimed to virtually screen the inhibitory activity of anti-schistososmiasis agents derived from P. peruviana body portion. Compound data were mined from PubChem and assessed their drug properties and target prediction using SwissADME and PASSOnline. Selected phytochemical compounds were screen the pharmacokinetics and toxicity by admetsar webserver. 1,2-benzenedicarboxylic acid and docosane was final filtered compounds as promising anti-schistosomiasis target. Daily dose arrangement should be confirmed through in vitro and in vivo because of the hepatoxicity characteristics of the compounds. Protein kinases of helminth projected to be next protein target of alternative therapeutics for vital roles in organism. To be concluded, 1,2-benzenedicarboxylic acid and docosane is functioned as anti-schistosomiasis candidates with further validation in different analyses.]]>
<![CDATA[Phytochemical profile, antioxidant, and antibacterial activities of Ipomoeae pes-caprae from Pantai Talang Siring Pamekasan, Madura: A promising source of natural bioactive compounds ]]>
<![CDATA[Islamy, R Adharyan]]>;
<![CDATA[Hasan, Veryl]]>;
<![CDATA[Serdiati, Novalina]]>;
<![CDATA[Kilawati, Yuni]]>;
<![CDATA[Valen, Fitri Sil]]>;
<![CDATA[Mutmainnah, Nurul]]>
<![CDATA[ Genbinesia Journal of Biology Vol. 3 No. 2 (2024): March 2024 ]]>
Publisher : <![CDATA[Generasi Biologi Indonesia ]]>
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DOI: 10.55655/genbinesia.v3i2.49
<![CDATA[This research investigates the phytochemical composition, antioxidant activity, and antibacterial efficacy of Ipomoea pes-caprae extracts collected from Pantai Talang Siring Pamekasan, Madura. Phytochemical analysis revealed the presence of alkaloids, flavonoids, phenolic compounds, terpenoids, tannins, and saponins in the extracts, indicating their rich bioactive profile. Antioxidant activity assessed via the DPPH assay demonstrated concentration-dependent scavenging of free radicals, with methanol and ethanol extracts exhibiting superior activity compared to the aqueous extract. Antibacterial assays against Escherichia coli and Staphylococcus aureus revealed significant inhibitory effects, with methanol and ethanol extracts displaying greater potency than the aqueous extract. These findings underscore the potential of Ipomoea pes-caprae as a source of natural antioxidants and antimicrobial agents, warranting further investigation into its pharmacological applications and therapeutic potential.]]>
<![CDATA[Diversity and habitat preference of orchirds in R. Soerjo Forest Park, East Java, Indonesia ]]>
<![CDATA[Rohmah, Laila Ainur]]>;
<![CDATA[Elyasa, Ayu Tya]]>;
<![CDATA[Nugraheni, Tunjung]]>;
<![CDATA[Pratama, Bella Pratiwi Kurnia]]>;
<![CDATA[Sakna, Bariznaba’us]]>
<![CDATA[ Genbinesia Journal of Biology Vol. 3 No. 1 (2023): November 2023 ]]>
Publisher : <![CDATA[Generasi Biologi Indonesia ]]>
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DOI: 10.55655/genbinesia.v3i1.50
<![CDATA[The diversity and habitat preferences of orchids in the natural tourist attraction area of R. Soerjo Forest Park (TAHURA) are not yet completely known. Lack of information and the activities of tourist visitors increase the risk of natural orchid habitat degradation. The aim of this research is to determine the diversity and habitat preferences of orchids in R. Soerjo Forest Park. The research design used a line transect method for orchid diversity data and a purposive sampling method with a plot measuring 10 × 10m for habitat preference analysis or environmental data. The research results show that there are 37 species of orchids in the natural tourist attraction area of R. Soerjo Forest Park, which is divided into 25 epiphytic orchids and 12 terrestrial orchids. The results of the Shannon-Wienner analysis show that the orchid diversity index value is 2.46, which is show a medium level of diversity. Dominant orchids grow at an altitude of 1,400–1,600 m.a.s.l. The most dominant orchid species are Nervilia punctata (558), Appendicula angustifolia (296), and A. elegans (130), with an evenness value of 0,32, 0,17, and 0,07. The dominance of N. punctata is influenced by the root shape, which is modified as a tuberous type. The results of redundancy analysis (RDA) show that the environmental variables that most influence the distribution of orchids are air temperature, soil pH levels, light intensity, and elevation.]]>
<![CDATA[Types of waste identification in Perintis Lake as an ecotourism conservation efforts Bone Bolango District, Gorontalo Province ]]>
<![CDATA[Mohamad, Danial]]>;
<![CDATA[Lanti, Syahrul]]>
<![CDATA[ Genbinesia Journal of Biology Vol. 4 No. 1 (2024): November 2024 ]]>
Publisher : <![CDATA[Generasi Biologi Indonesia ]]>
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DOI: 10.55655/genbinesia.v4i1.51
<![CDATA[Perintis Lake is a lake area with potential for ecotourism. However, as activities progress, some areas have become littered with garbage. Therefore, the purpose of this study focuses on identifying the types of waste and determining the most common types of waste in the Perintis Lake area. This study uses a quantitative descriptive research method by identifying the types of waste scattered in the lake area using a sampling method categorized based on the size characteristics of mega-debris (>1 m), macro-debris (2.5 cm–1 m), meso-debris (5 mm–2.5 cm), and micro-debris (0.33 mm–5 mm). Based on the research activities, the sample collections locations are in two different transect areas, namely the Perintis Lake tourist area and the lake area directly facing residential areas. The total identification results obtained from both transects consist of 266 types of waste in five different categories: plastic waste, rubber, metal, glass, wood, and derivatives. Among the findings, plastic waste is the most dominant type of waste in the lake area, totalling 218 types. Furthermore, in terms of waste characterization based on size, macro-debris is the most abundant category in the lake area, particularly plastic waste, with a total of 168. The abundance of plastic waste in the research location is influenced by indiscriminate disposal by visitors to the environment and also by household activities directly facing the Perintis Lake area, resulting in an increasing spread of waste distribution over time.]]>
<![CDATA[Traditional ceremonies Mahesa Lawung as a traditional ritual of the Surakarta Palace in the Krendowahono Area, Central Java, Indonesia ]]>
<![CDATA[Syamsi, Rahma Nur]]>;
<![CDATA[Safitri, Olinda Ayu]]>;
<![CDATA[Putri, Rani Rachma Astining]]>;
<![CDATA[Manullang, Raymond Hamonangan]]>;
<![CDATA[Rinoa Salsabila Izdihar]]>;
<![CDATA[Setyawan, Ahmad Dwi]]>
<![CDATA[ Genbinesia Journal of Biology Vol. 3 No. 2 (2024): March 2024 ]]>
Publisher : <![CDATA[Generasi Biologi Indonesia ]]>
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DOI: 10.55655/genbinesia.v3i2.53
<![CDATA[Traditional ceremonies are a form of culture passed down from generation to generation, reflecting a society's values, beliefs, and identity. This research aims to find out and understand the meaning of the Mahesa Lawung traditional ceremony, the types of plants and animals used, and the knowledge of local communities in the Krendowahono Karanganyar Site area, Central Java. The method used in this research is a qualitative observation method, including direct interviews with each respondent. Data was collected through interviews and direct observation at the research location. The research data collected includes regional names, common names, scientific names of plants and animals species as well as parts used for offerings at Mahesa Lawung traditional ceremony, and the philosophies of the species that used in this traditional ceremony. There are 7 plants and 4 animal species used for the Mahesa Lawung traditional ceremony. The research results show that the Mahesa Lawung traditional ceremony is still carried out today, especially at the Krendowahono Site. Of the three villages used as research locations, almost all people knew about the ceremony but only heard about it and saw it briefly. The Mahesa Lawung traditional ceremony is a cultural history that needs to be preserved and maintained over time.]]>
<![CDATA[Parasitic examination of marine ornamental fish at the Denpasar Fish Quarantine, Quality Control, and Fishery Product Safety Center ]]>
<![CDATA[Nastiti, Amayliana Ajeng]]>
<![CDATA[ Genbinesia Journal of Biology Vol. 3 No. 2 (2024): March 2024 ]]>
Publisher : <![CDATA[Generasi Biologi Indonesia ]]>
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DOI: 10.55655/genbinesia.v3i2.54
<![CDATA[The study in this research includes examination of parasites in ornamental seawater fish pathologically and clinically which includes examination of mucus, fins, intestines, and gills. This research was conducted at BKIPM Denpasar from January 06, 2020 to February 7, 2020. The samples of marine ornamental fish examined consisted of ornamental fish from various species including Chrysiptera sp., Pterapogon sp., Chromis sp., Amphirion sp., Dascyllus sp. The results showed that the types of parasites that attacked marine ornamental fish were Tricodina sp., Opegaster sp., Archigetes sp., and Camallanus sp. These four types of parasites came from 6 samples from a total of 40 samples examined at BKIPM Denpasar. The total prevalence of infecting parasites was 0.15%. Meanwhile, the prevalence of each species is 0.16% for Tricodina sp. and Opegaster sp. while for Archigetes sp. and Camallanus sp. is 0.33%. Based on the results of the prevalence calculation, the examined seawater ornamental fish samples are still classified as safe for export.]]>
<![CDATA[Application of the wet mount method as an early prevention of Enterocytozoan hepatopenaei (EHP) disease that infects vanname shrimp (Litopanaeus vannmaei) ]]>
<![CDATA[Esrarf, Hanif Nadhifa]]>
<![CDATA[ Genbinesia Journal of Biology Vol. 3 No. 3 (2024): July 2024 ]]>
Publisher : <![CDATA[Generasi Biologi Indonesia ]]>
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DOI: 10.55655/genbinesia.v3i3.55
<![CDATA[The cultivation of vannamei shrimp faces persistent challenges, particularly due to various disease outbreaks. One emerging and common disease is Enterocytozoon hepatopenaei (EHP). This disease is caused by the microsporidian parasite, which hinders shrimp growth by infecting the hepatopancreas. This study aims to evaluate the application of the wet mount method as an early prevention strategy for EHP infection in whiteleg shrimp. The research employs a laboratory-based experimental approach using the wet mount method to detect spores/microsporidia in the shrimp hepatopancreas, observed under a microscope at 1.000x magnification. Results from this method revealed a 50% prevalence of spores/microsporidia in shrimp hepatopancreas samples from VIP pond section A1 and 90% prevalence in very very important person (VVIP) pond section A2. Thus, the wet mount method is a viable technique for identifying spores/microsporidia in the hepatopancreas of Litopenaeus vannamei, offering an effective early detection approach for EHP infection.]]>
<![CDATA[Implementation of Good Manufacturing Practices (GMP) in the processing of dried anchovy (Stolephorus spp.) at PT Insan Citraprima Sejahtera, Tuban, East Java ]]>
<![CDATA[Nurhasyimi, Annisa Rizki]]>;
<![CDATA[Patmawati, P]]>
<![CDATA[ Genbinesia Journal of Biology Vol. 3 No. 3 (2024): July 2024 ]]>
Publisher : <![CDATA[Generasi Biologi Indonesia ]]>
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DOI: 10.55655/genbinesia.v3i3.56
<![CDATA[The drying process for anchovy is a preservation method aimed at minimizing spoilage risks in this highly perishable food product by reducing its water content. To ensure safety and quality, Good Manufacturing Practices (GMP) is implemented in dried anchovy processing to prevent or mitigate contamination risks. This study evaluates the implementation of GMP in the processing of dried anchovies (Stolephorus spp.) at PT Insan Citraprima Sejahtera, located in Tuban, East Java. A descriptive research approach was utilized, with data collected through observations and interviews. The findings demonstrate that PT Insan Citraprima Sejahtera effectively applies GMP at all stages of dried anchovy processing, as evidenced by well-defined procedural standards, adequate facilities and infrastructure, and rigorous quality control supervision. The resulting dried anchovy products meet the quality standards stipulated in SNI-3461:2019]]>
<![CDATA[Raw material management for frozen Parupeneus heptacanthus fillet products at PT BARUNA, Lamongan, East Java ]]>
<![CDATA[Larasati, Melani]]>
<![CDATA[ Genbinesia Journal of Biology Vol. 3 No. 3 (2024): July 2024 ]]>
Publisher : <![CDATA[Generasi Biologi Indonesia ]]>
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DOI: 10.55655/genbinesia.v3i3.57
<![CDATA[One of the processing methods for whiskered goatfish (Parupeneus heptacanthus) is converting it into frozen fillet products. The raw material management for the production of whiskered goatfish fillet includes receiving the raw materials, washing, filleting, trimming, deboning, and sizing. The aim of this article is to explore the raw material management process in the production of whiskered goatfish fillet at PT Bahari Biru Nusantara. A descriptive method was employed, utilizing both primary and secondary data sources. Data collection was conducted through observation, interviews, active participation, and literature review. Inventory planning and raw material receiving scheduling at PT Bahari Biru Nusantara are crucial to address demand fluctuations and maintain smooth production. Consideration of environmental factors such as seasonality, weather, climate, and resource sustainability also plays a role in inventory management strategies.]]>
