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Genbinesia Journal of Biology
Published by Generasi Biologi Indonesia Foundation
ISSN : 2828464X     EISSN : 28282701     DOI : 10.55655/genbinesia
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Health Professions Immunology & microbiology
The Genbinesia Journal of Biology particularly focuses on the core disciplines in biology, they are: astrobiology, bacteriology, behavioural science, biochemistry, biodiversity, bioethics, bioinformatics, biomathematics, biophysics, biopolymers, biostatistics, biotechnology, botany, cell biology, conservation, crystallography of macromolecules, developmental biology, ecology, entomology, evolutionary biology, genetics, genomics, glycobiology, immunology, macromolecules, marine & aquatic biology, mathematical & computational biology, medicine, microbiology, molecular biology, mycology, nanoscience & nanotechnology, neurobiology, neuroscience, ornithology, paleobiology, paleontology, parasitology, pharmacology, physiology, plant biology, proteins & peptides, proteomics, radiation biology, reproductive biology, soil biology, structural biology, systems biology, techniques in biology, theoretical & mathematical biology, virology, zoology, and interdisciplinary applications in biology.
Arjuna Subject : Ilmu Pertanian dan Biologi (Semua) - Ilmu Pertanian dan Biologi (Lain-Lain)
Articles 51 Documents
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A novel antiviral candidate from Moringa oleifera through dual targeting mechanism of SARS-CoV-2 protease: Computational Sscreening Listiyani, Priscilla; Dhea Kharisma, Viol
Genbinesia Journal of Biology Vol. 2 No. 2 (2023): March 2023
Publisher : Generasi Biologi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55655/genbinesia.v2i2.32

Abstract

COVID-19 is triggered by SARS-CoV-2 which is related in a similar way to SARS-CoV and MERS-CoV. RdRp is an essential component of the virus in replication and transcription. RdRp triggers polymerase activity through binding to cofactors such as nsp7 and nsp8. Mpro plays an important role in viral protease activity for the assembly process. RdRp and Mpro can be used as targets to inhibit the replicative activity of SARS-CoV-2. Moringa oleifera is used by people around the world as a traditional medicine because it has antioxidant, anti-inflammatory, and antiviral properties. This study reveals the molecular mechanism of Moringa oleifera as an inhibitor of key proteins in SARS-CoV-2 replication through a computational approach. Additionally, the in silico method in this study consists of sample preparation in the database, druglikeness prediction, antiviral probability, virtual screening, chemical bond interaction, and 3D visualization. Moringa oleifera may have potential as an antiviral candidate through Ellagic Acid activity as a dual inhibitor through inhibition of SARS-CoV-2 replication and assembly. The candidate compound can generate weak bonding interactions such as hydrogen and hydrophobic to trigger binding stability at specific domains.
Study of population dynamics silver rasbora (Rasbora argyrotaenia Bleeker, 1849) in PB Soedirman Reservoir, Banjarnegara Anggararatri, Yasinta; Muslih; Rukayah, Siti; Lestari, W.
Genbinesia Journal of Biology Vol. 2 No. 2 (2023): March 2023
Publisher : Generasi Biologi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55655/genbinesia.v2i2.33

Abstract

Silver rasbora (Rasbora argyrotaenia Bleeker, 1849) is one of the native species found in Panglima Besar (PB.) Soedirman Reservoir. High economic value of silver rasbora causes fishermen to tend overfishing. This over-exploitation threatens the native species of fish. Therefore, this study aims to determine several parameters of fish population dynamics so that they become the basis for fisheries management. Sampling was carried out at the PB. Soedirman Reservoir in November 2021, January 2022, and March 2022 using a survey method. The result of this research is, the population of silver rasbora was 3097 individuals dominated by male and small-size fish 0.5-8.5 cm. Length and weight relationship obtained b value <3 which means it is negative allometric. The condition factor ranged from 1.005 to 1.068. Total mortality value (Z) 6.21 per year, natural mortality (M) 1.69 per year, fishing mortality (F) 4.52 per year, with exploitation rate (E) 0.73 per year. The total length of silver rasbora fish obtained ranged from 0.5 to 8.5 cm. The maximum length (L∞) = 12.93 cm and K = 0.62 per year with the Von Bertalanffy growth equation, Lt = 12.93 (1-e(-0.62(t-0.3291))). The yield value per recruit analysis showed that the optimum exploitation was 0.224 and the current exploitation rate was 0.73. The population of silver rasbora was over-exploitation, especially in small-size fish.
Effect of kecombrang flower extract (Etlingera elatior) and basil leave extract (Ocimum afrinacum) to the growth of Streptococcus mutans ATCC 35668 and Staphylococcus aureus ATCC 33591 Tanahboleng, Katharina Devi Permata; Masruhim, Muh. Amir; Daru, Taufan Purwokusumaning
Genbinesia Journal of Biology Vol. 2 No. 2 (2023): March 2023
Publisher : Generasi Biologi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55655/genbinesia.v2i2.34

Abstract

Utilization of local plants is still not optimal. Experimental research has been carried out in Samarinda City by utilizing Kecombrang Flower (Etlingera elatior) and Basil Leaf (Ocimum afrinacum) extracts which were exposed to Streptococcus mutans ATCC 35668 and Staphylococcus aureus ATCC 33591. The aim of the study was to determine the effect of kecombrang flower extract (Etlingera elatior) , basil leaf extract (Ocimum afrinacum) on the growth of Streptococcus mutans ATCC 35668, and staphylococcus aures ATCC 33591. The research samples were kecombrang flowers ((Etlingera elatior) and basil leaves (Ocimum afrinacum). The research instrument was a measuring tool (ruler). Results Data analysis showed that kecombrang flower extract (Etlingera elatior), basil leaf extract (Ocimum afrinacum) significantly affected the growth of Streptococcus mutans and Staphylococcus aureus ATCC 33591 (p˂0.00).Active chemicals (secondary metabolites, namely tannins present in kecombrang flower extract and extract Basil leaves (Ocimum afrinacum) can inhibit or kill the growth of Streptococcus mutans ATCC 35668 and Staphylococcus aureus. The conclusion is kecombrang flower extract (Etlingera elatior) and basil leaf extract (Ocimum afrinacum) have a significant effect on the growth of Streptococcus mutans ATCC 35668 and Staphylococcus aureus ATCC 33591.
DNA damage, inflammation, and cellular senescence investigation in SARS-CoV-2 infection: A short review Kharisma, Viol Dhea; Ansori, Arif Nur Muhammad; Murtadlo, Ahmad Affan Ali; Turista, Dora Dayu Rahma; Tamam, Muhammad Badrut; Ullah, Md. Emdad; Jakhmola, Vikash
Genbinesia Journal of Biology Vol. 2 No. 3 (2023): July 2023
Publisher : Generasi Biologi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55655/genbinesia.v2i3.35

Abstract

SARS-2 infection is predicted to trigger DNA damage due to excessive inflammatory responses from the immune system such as cytokine storms. The cytokine storm leads to an increase in oxidative stress in cells, possibly triggering senescence through activation of the DNA damage response (DDR) signaling pathway. Alterations in the DDR pathway that induce cellular senescence have been identified due to the regulation of viral proteins that lead to impaired DNA repair. However, previous studies have not examined the relationship between DNA damage, inflammation, and cellular senescence. In this short review, we will discuss with a simple perspective why SARS-CoV-2 infection can accelerate the cellular senescence process and its relationship with the inflammatory response.
Health Impacts of Yoga: A Brief Review Ansori, Arif Nur Muhammad
Genbinesia Journal of Biology Vol. 2 No. 2 (2023): March 2023
Publisher : Generasi Biologi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55655/genbinesia.v2i2.36

Abstract

Yoga is a holistic practice that has been used for thousands of years to promote health and well-being. The physical postures, breath control, and meditation techniques used in yoga have been found to have numerous health benefits, including improving flexibility, strength, balance, and cardiovascular health, reducing stress and anxiety, and improving mental clarity and focus. Recent research has shown that yoga can also be an effective complementary therapy for a variety of health conditions, such as chronic pain, depression, anxiety, and insomnia. Yoga has been found to be particularly effective in reducing stress and anxiety, which are common risk factors for many chronic diseases. Yoga is a non-competitive practice that can be adapted to suit the needs and abilities of individuals of all ages and fitness levels. It is a safe and effective way to improve overall health and well-being, and can be easily integrated into a daily routine. Therefore, yoga is a valuable tool for promoting health and well-being on all levels - physical, mental, emotional, and spiritual. It has become increasingly popular around the world, and is now widely recognized as a valuable complementary therapy for a variety of health conditions.
The utilization of marigold (Tagetes erecta L.) for traditional ceremonies in Indonesia: A systematic review Raihandhany, Reza; Kurniawan, Bima
Genbinesia Journal of Biology Vol. 2 No. 3 (2023): July 2023
Publisher : Generasi Biologi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55655/genbinesia.v2i3.37

Abstract

Ethnobotanical heritages in Indonesia are exceptionally diverse because of the multicultural, multi-religious practice, and acculturation between them. The mega-biodiverse island nation is home to more than 800 ethnicities and naturally acts as sanctuary for the lush tropical ecosystems and its inhabitants. The hospitable nature of Indonesian land provides asylum for numbers of plants, including non-native species. Marigold (Tagetes erecta), a non-native ornamental plant that exhibits distinct showy flowers is cultivated and extensively grown in Indonesian lands. Beside being used as ornamental plants, some of the local communities are using marigold as a part in conducting their traditional ceremonies. This article provides some recorded traditional usage of marigold in traditional ceremonies of Indonesian communities from scientific articles. Significant usages of marigold are notably practiced by Hindu communities in Bali, Java (Tengger) and Lombok as part of their respective traditional-religious ceremonies. Vibrant color of the flower, its availability throughout the year, and easiness of cultivation are desirable traits that keep marigold usages significant. Local beliefs value marigold’s prominent flower color because it represents their Lord. The presence of marigold and its significant usage in the local communities provides space for native species to grow.
Biodiversity of fruit plants (edibles) at the Kentingan Campus of Universitas Sebelas Maret, Surakarta, Central Java, Indonesia Afifah, Ratih Nur; Rezapratama, Muhammad Syavy; Isa, Mukhlisah Nadya; Nugroho, Gilang Dwi; Setyawan, Ahmad Dwi
Genbinesia Journal of Biology Vol. 2 No. 3 (2023): July 2023
Publisher : Generasi Biologi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55655/genbinesia.v2i3.38

Abstract

Urban areas have the potential to support food supply even in limited quantities due to limited green open land, including edible fruits. This study aims to determine the biodiversity of fruit plants (edibles) at the Kentingan Campus of Universitas Sebelas Maret (UNS), Surakarta, Central Java, Indonesia. Data were collected by survey methods with cruising techniques, accompanied by a calculation of the ecological index in December 2022. Survey methods with cruising techniques, namely by exploring the entire campus area to collect the required primary data, including the name of plant species, the number of individuals, coordinates and fruit documentation found from each species. Data is processed and analyzed using the calculation of the ecological index. Meanwhile, secondary data was obtained from IUCN to determine the status of conservation and Plants of the World Online to determine the authenticity of species. The results obtained that there are 55 species from 25 families fruit plants with the Shannon-Wiener Index in the medium category, which is 3.17. Furthermore, the Margalef Index is in the high category, which is 7.30, and the Simpson Dominance Index is in a low category, which is 0.077. Some species have the highest number of individuals, namely Musa x paradisiaca L. (Musaceae), with 327 individuals. On the other hand, Mangifera indica L. (Anacardiaceae) is a species found in all locations. From the data obtained, according to IUCN, there are several fruit plants with 23 species of Least Concern (LC) conservation status and Data Deficient (DD) conservation status, as many as two species. Meanwhile, based on data from Plants of the World Online, several fruit plants on the Kentingan Campus of UNS are native to Indonesian plants, namely Durio zibethinus Murray, Averrhoa bilimbi L, and Averrhoa carambola L.
Structure, composition and economic potential of molluscs (gastropods and bivalves) in the Lembupurwo Lagoon Beach, Kebumen, Central Java, Indonesia Rohman, Cahya Maulidta; Kinanti, Asih; Pramudita, Desma Asty; Fadzilah, Fariz Pradana Adil; Ramadhan, Muhammad Fadhil; Faturrahman, Aqra Danial; Aurina, Devi Mayang; Dewi, Mini Ambarwati Kusuma; Ainaya, Fadia Aulianissa; Rachmalia, Fayza; Fatikha, Layyinatssyifa A’yuni; Nugroho, Gilang Dwi; Yap, Chee Kong; Setyawan, Ahmad Dwi
Genbinesia Journal of Biology Vol. 2 No. 3 (2023): July 2023
Publisher : Generasi Biologi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55655/genbinesia.v2i3.39

Abstract

The mangrove ecosystem is a productive ecosystem with economic and environmental functions. This research was conducted to determine the value of the ecological index and the economic potential of molluscs (Gastropods and Bivalvia) found in the Lembupurwo Lagoon Beach (part of Wawar River Estuary), Kebumen District, Central Java, Indonesia. First, mollusc sampling was carried out on a 10x10 meter plot. So its existence also needs to be known and studied more specifically. Then, the ecological index of the species found is calculated using the Shannon-Wiener Diversity Index, Evenness Index, Simpson Dominance Index, Margalef Species Richness Index, and individual Density of each species. In addition, for the economic potential of molluscs using secondary data from scientific journals. Analysis of the data obtained descriptively with the support of tables and pictures. The study results showed that there were 17 species of molluscs consisting of 12 species belonging to the gastropod class and five other species belonging to the bivalves. The families with the most common species are Neritidae=3, Ellobiidae=2, and Littorinidae=2. Whereas in the Bivalvia class, each family was only found one species. The total molluscs found had a density value of 3.95 ind/m2. The Diversity Index (H') of molluscs was 1.48 (moderate), Evenness Index was 0.52 (moderate), Margalef Richness Index was 1.71 (low), and Dominance Index was 0.28 (no species dominated). Then, for the economic potential of the mollusks found, the economic potential is dominated by the food sector. The species that have potential in the food sector include: Faunus ater Linnaeus 1758, Isognomon ephippium Linnaeus 1758, Pilsbryoconcha exilis I.Lea, 1838, Polymesoda expansa Mousson 1849, and Anadara antiquata Linnaeus 1758.
Molecular Mechanisms of Hepatitis C Virus (HCV) Triggering Normal Cell Transformation into Cancer: A Mini Review Dhea Kharisma, Viol; Sima, Putri Melati
Genbinesia Journal of Biology Vol. 2 No. 3 (2023): July 2023
Publisher : Generasi Biologi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55655/genbinesia.v2i3.43

Abstract

Hepatitis C virus (HCV) infection has become a serious concern because it can trigger the severity of complications leading to hepatocellular carcinoma (HCC). HCV is a virus with single-stranded RNA (ssRNA) type genetic material, with virions composed of structural proteins such as glycoprotein, envelope, and core, then HCV also has nonstructural proteins such as NS3, NS4, NS4B, NS5A, NS5B. The development of HCV infection therapy has been carried out through direct-acting antiviral agents (DAAs) with the hope of achieving a reduction in mortality and HCC risk. However, these strategies cannot fully reduce the risk of HCC in patients who have recovered from HCV infection. This review briefly reviews several factors from the virus and host to trigger cellular transformation of hepatocytes into HCC. HCV infection can trigger the transformation of hepatocytes into cancer in the case of HCC influenced by two factors consisting of pro-oncogenic and growth factors. Pro-oncogenic of HCV initiates HCC through the release of ROS that triggers genetic mutations and upregulation of proliferation in hepatocytes, it allows internal cell factors to also work in the process of transformation into cancer such as increased growth factor activity for antiapoptotic response, survival, and proliferation to trigger increased severity of HCC.
From Fences to Medicine: A Short Review on Ethnobotanical Study of Lannea coromandelica (Houtt.) Merr. (Family Anacardiaceae) in Indonesia Raihandhany, Reza
Genbinesia Journal of Biology Vol. 2 No. 1 (2022): November 2022
Publisher : Generasi Biologi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55655/genbinesia.v2i1.46

Abstract

Lannea coromandelica (Houtt.) Merr. is a deciduous tropical tree that originates and is native to India. This species belongs to the family Anacardiaceae. L. coromandelica is also found in Indonesia and is known as kayu jawa. Indonesian people often utilize L. coromandelica for medicinal purposes and as natural fences. Almost all parts of the plant, including the bark, leaves, sap, and trunk, can be utilized for medicinal purposes. This paper review aims to gather information regarding ethnobotanical studies conducted by traditional communities in Indonesia that use L. coromandelica in their daily lives. A literature review for this paper was conducted in October 2023 using scientific articles available online, including papers from various journal websites, undergraduate theses in college repositories, accessible e-books, and conference proceedings related to Lannea coromandelica through google scholar. The results indicate that L. coromandelica is widely utilized throughout Indonesia, including Sumatera, Java, Kalimantan, West and East Nusa Tenggara, Sulawesi, and North Maluku. Most of the usage of L. coromandelica is for medicinal purposes, treating various diseases such as cough, stomach ulcers, sore eyes, fever, diabetes, and post-partum care. Almost all parts of the plant are useful, including the bark, leaves, trunk, twigs, and the entire plant. Thus, bark is the most utilized plant part. However, besides its medicinal uses, L. coromandelica has numerous other utilizations, including firewood, natural fences, natural dyes, cosmetics, and materials for building and boat hulls. The conservation aspect of L. coromandelica must be considered since in several utilization trunk is used for medicinal purposes.

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