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Mochamad Nashrullah
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Journal of Medical Genetics and Clinical Biology (JMGCB)
Published by Antis Publisher
ISSN : -     EISSN : 30321085     DOI : https://doi.org/10.61796/jmgcB
Core Subject : Health, Science,
Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing
Journal of Medical Genetics and Clinical Biology is a peer-reviewed forum for advances at the intersection of human genetics and clinical medicine. The journal welcomes original research, reviews, brief reports, and case reports that translate genomic discoveries into clinical utility—spanning diagnostic workflows, risk stratification, therapeutic decision-making, and implementation in real-world care. Areas of interest include Mendelian and complex disorders, cancer genetics, pharmacogenomics, biomarkers, clinical genomics (panel testing, WES/WGS), bioinformatics and data integration, as well as ethical and counseling considerations. By bridging molecular insights and bedside applications, the journal aims to support precision health and improve outcomes across diverse patient populations.
Arjuna Subject : Imunologi dan Mikrobiologi (semua kategori) - Imunologi dan Mikrobiologi (Lain-Lain)
Articles 372 Documents
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DIRECT EFFECT OF COMORBID MENTAL DISORDERS ON THE CLINICAL COURSE OF ALCOHOLISM Axmadjonovich, Gaybiyev Akmal; Mirxamzayevna, Mamurova Mavludaxon; Temirpulotovich, Turayev Bobir
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 2 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i2.1215

Abstract

Objective: This study focuses on the growing concern of mental disorders combined with alcohol addiction, highlighting the need for medical examination by both narcology and psychiatry specialists. The objective is to explore the challenges related to the prevention, treatment, and rehabilitation of this comorbid condition. Methods: A comprehensive review of existing research and clinical practices was conducted, with an emphasis on the collaboration between narcologists and psychiatrists in managing patients with this dual diagnosis. Various case studies and treatment protocols were analyzed to understand the multidisciplinary approach required for effective care. Results: The study reveals significant complexities in treating individuals with both mental disorders and alcohol addiction. The findings suggest that integrated care from both narcology and psychiatry specialists leads to better patient outcomes. However, challenges remain in providing effective prevention and rehabilitation strategies due to the multifaceted nature of the disorder. Novelty: This research introduces a novel perspective on the importance of a dual-specialist approach to managing comorbid mental health and alcohol addiction issues. It emphasizes the need for a more unified and collaborative treatment framework that can address the intertwined nature of these conditions.
EXPLORING BIOMARKERS FOR EARLY DETECTION OF NEURODEGENERATIVE DISORDERS Khalaf, Tabarak Hadi; Kadhim, Fatima Assad; Faraj, Ali Dakheel; Mansour, Hussein Yahya; Mohammed, Zainab Ali; Sadiq, Zahraa Subhi
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 4 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i4.1223

Abstract

Objective: Neurodegenerative disorders, including Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis, present significant challenges due to their progressive nature and the lack of definitive early diagnostic methods. Biomarkers have emerged as essential tools for early detection, enabling timely intervention and personalized treatment strategies. Methods: This review explores recent advancements in biomarker research, emphasizing genetic, proteomic, metabolic, and imaging-based markers. It examines cerebrospinal fluid (CSF) and blood-based biomarkers, such as amyloid-beta, tau proteins, and neurofilament light chain. Additionally, innovative techniques like liquid biopsy and artificial intelligence-driven biomarker discovery are discussed. Results: The study highlights the potential of biomarkers in revolutionizing early diagnosis and patient management. Despite significant progress, challenges remain in biomarker validation, standardization, and clinical translation. The integration of biomarkers into clinical practice can improve diagnostic accuracy and facilitate the development of neuroprotective therapies. Novelty: This review underscores the importance of multi-modal biomarker approaches and the application of machine learning algorithms to enhance diagnostic precision and predictive capabilities. The combination of traditional and emerging biomarker technologies holds promise for transforming neurodegenerative disease diagnostics and treatment strategies.
OXIDATIVE STRESS INDUCED BY CIPROFLOXACIN IN STAPHYLOCOCCUS AUREUS: MECHANISMS, IMPLICATIONS, AND POTENTIAL THERAPEUTIC STRATEGIES Yaqoob Rahi, Alaa
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 2 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i2.1239

Abstract

Objective: This study investigates the oxidative stress mechanisms induced by ciprofloxacin in Staphylococcus aureus, focusing on reactive oxygen species (ROS) generation, antioxidant responses, and cellular damage. Method: Using biochemical assays and gene expression analysis, we quantified ROS levels, lipid peroxidation, and protein carbonylation in a dose-dependent manner. Antioxidant enzyme activity and the bacterial SOS response were also examined to assess cellular defense mechanisms. Additionally, the potential protective effects of N-acetylcysteine (NAC) supplementation were evaluated. Results: Ciprofloxacin exposure significantly increased ROS production, leading to oxidative damage marked by elevated lipid peroxidation and protein carbonylation. Antioxidant enzyme activity was impaired, and the induction of the SOS response suggested an adaptive stress mechanism. NAC supplementation reduced ROS levels and partially restored bacterial viability, indicating a role for oxidative stress modulation in antimicrobial strategies. Novelty: This study provides novel insights into the oxidative stress-based bactericidal action of ciprofloxacin, demonstrating its impact on bacterial redox homeostasis and potential links to resistance mechanisms. The findings highlight the therapeutic potential of oxidative stress modulation to enhance antibiotic efficacy and mitigate resistance development in S. aureus.
ECHINOCOCCOSIS OF THE KIDNEY IN CHILDREN (BRIEF REVIEW OF THE LITERATURE) N.N, Nazarov; E.A, Yakubov
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 3 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i3.1255

Abstract

Objective: This study aims to provide a comprehensive review of hepatic echinococcosis in pediatric patients, focusing on diagnostic modalities, surgical treatment options, and associated complications. Method: A literature-based analysis was conducted, evaluating current clinical practices, imaging techniques, surgical approaches—including open and minimally invasive procedures—and adjunct pharmacological therapies. Results: The review highlights the central role of precise imaging and serological testing in early diagnosis. Surgical strategies should be tailored to cyst characteristics, with open surgery remaining crucial for complex cases. Minimally invasive techniques, while promising, require refinement to match the effectiveness of conventional approaches. Antiparasitic chemotherapy serves as a supportive measure in select patients. Recurrence is primarily linked to the thoroughness of surgical intervention rather than the choice of technique. Novelty: This study underscores the clinical relevance of emerging technologies such as laser devitalization and addresses ongoing controversies in the classification of surgical methods. It offers a nuanced evaluation of echinococcectomy in children, contributing to a better understanding of optimizing treatment outcomes and minimizing recurrence.
A FUNDAMENTAL ANALYSIS OF BREAST CANCER'S ESTROGEN RECEPTOR SIGNALING PATHWAYS Abbas Sadiq Alqaisi, Ali; Haider Abbas Jasim, Hawraa; Haider Saleh, Areej; Ayad Kazem, Rafal; Abbas Fadhel, Afnan; Ali Kashkul, Saja
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 3 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i3.1257

Abstract

Objective: This mini-review aims to provide a comprehensive overview of estrogen receptor (ER) signaling pathways in breast cancer, emphasizing their implications for therapeutic resistance and novel treatment strategies. Method: A critical analysis of recent literature was conducted, focusing on molecular mechanisms associated with ER signaling, including alterations in the ESR1 gene, PI3K pathway activation, and dysregulation of cell cycle control. Results: Findings reveal that approximately two-thirds of breast cancers are hormone-dependent and rely on estrogen and progesterone receptor signaling for growth. While antiestrogens remain the cornerstone of hormone therapy, resistance often emerges through diverse molecular pathways. The development of resistance has driven the advancement of targeted therapies such as selective estrogen receptor degraders (SERDs) and combination regimens involving CDK4/6 or PI3K inhibitors. Novelty: This review highlights the evolving understanding of ER signaling in breast cancer and underscores the necessity of targeting specific molecular alterations to overcome resistance. By integrating recent advances in molecular oncology, the study supports the development of more personalized and effective therapeutic strategies for hormone receptor-positive breast cancer.
LASER-TISSUE INTERACTION: A BIOPHYSICAL STUDY FOR PRECISION SURGICAL APPLICATIONS Sabah Mhana, Malak; Ahmed Hadad, Mariam; salam obaed, Rusul; Abd Al-Abbas Hassan Haddahood, Walaa; Najm, Samara Salih
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 4 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i4.1271

Abstract

Objective: This study aims to deepen the understanding of laser-tissue interactions in precision surgery by evaluating the biophysical mechanisms influenced by specific laser parameters and tissue characteristics. Method: A literature-based analytical approach was employed to explore the effects of key laser-tissue interaction types—photothermal, photochemical, photomechanical, and photoablation—focusing on variables such as wavelength, pulse duration, and fluence. Results: The analysis revealed that different laser systems, including CO₂, Nd:YAG, and femtosecond lasers, exhibit distinct interaction profiles across clinical applications, significantly affecting surgical outcomes. Furthermore, the integration of artificial intelligence, nanotechnology, and real-time feedback systems was found to enhance the precision, safety, and personalization of laser-based procedures. Novelty: This study provides a comprehensive synthesis of wavelength-specific and tissue-dependent laser effects, while highlighting the emerging potential of interdisciplinary innovations to transform laser-assisted surgeries. It underscores the critical role of smart technologies in advancing minimally invasive techniques and calls for further cross-domain research to optimize future clinical applications.
DISTRIBUTION OF VIBRIO CHOLERA IN URBAN AREAS OF IRAQ Arkan Altayar, Mostafa; Bassim Rasul Aldbagh, Mayyada; Habeeb Al-Hilfi, Kareema
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 12 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i12.1278

Abstract

Objective: This study aims to examine the distribution, epidemiological characteristics, and public health response to Vibrio cholerae outbreaks in urban areas of Iraq. Method: The research employed a literature-based analysis supported by epidemiological surveillance data, case reports, and antibiotic resistance profiles, focusing on outbreaks from 2003 to 2022. Results: Findings reveal recurring cholera outbreaks with seasonal peaks during summer months, primarily affecting regions such as Baghdad and Sulaymaniyah. Demographic analysis indicates a higher prevalence among individuals aged 15–44, with variability in gender distribution across regions. The bacteria showed sensitivity to Ciprofloxacin and Tetracycline, while oral cholera vaccination (OCV) campaigns demonstrated high effectiveness in refugee and internally displaced populations. Novelty: This study offers a localized, data-driven understanding of cholera’s urban distribution in Iraq, highlighting the integration of demographic trends, antibiotic resistance, and the role of vaccination campaigns—an approach that remains underrepresented in existing regional literature. These insights are essential for developing more targeted and effective public health strategies.
MOLECULAR TYPING OF MULTI DRUG RESISTANCE E.COLI THAT ISOLATES FROM PATIENT WITH URINARY TRACT INFECTIONS IN NAJAF PROVINCE Abdulhadi, Ali M Hussein
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 2 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i2.1279

Abstract

Objective: This study aimed to detect the diversity of multidrug-resistant Escherichia coli strains isolated from urinary tract infection (UTI) patients and to assess their potential for biofilm formation. Method: Twenty bacterial isolates were obtained from urine cultures of UTI patients hospitalized at Najaf Teaching Hospital. The isolates were cultured on blood agar and MacConkey's agar, identified using the Vitek 2 system, and subjected to antibiotic susceptibility testing with the AST card. Genetic diversity among the isolates was further analyzed using ERIC-PCR. Results: The findings revealed high levels of antibiotic resistance among the E. coli isolates: 100% resistance to amoxicillin and ampicillin, 90% to ceftriaxone and ceftazidime, 70% to amikacin, and 55% to meropenem. ERIC-PCR results demonstrated genetic variation among isolates, which were grouped into five distinct clusters with similarity indices ranging from 40% to 90%. Novelty: This study provides insight into the alarming resistance patterns and genetic diversity of uropathogenic E. coli, underlining the critical need for tailored antibiotic stewardship and further investigation into their biofilm-forming capabilities in clinical settings.
IMMUNE SYSTEM DYSREGULATION IN ENDOMETRIOSIS: INFLAMMATORY PATHWAYS, IMMUNE CELL IMBALANCES, AND POTENTIAL THERAPEUTIC TARGETS Takhirovna, Djurabekova Surayyo
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 5 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i5.1285

Abstract

Objective: This study aims to investigate the immune system dysregulation in endometriosis, focusing on cytokine imbalances, immune cell malfunctions, and epigenetic modifications to identify potential diagnostic markers and individualized therapeutic options. Method: A total of 240 female participants, including 100 endometriosis patients and 50 healthy controls, were included in the study. Data were collected through cytokine measurements (IL-6, TNF-α, VEGF), immune cell profiling (Th1/Th2 dynamics, Treg/Th17 ratios, macrophage M1/M2 patterns), and epigenetic analysis (DNA methylation and microRNA expression) in blood and endometrial tissue samples. Results: Endometriosis patients exhibited significant immune imbalance with elevated levels of IL-6, TNF-α, and VEGF, disrupted Th17/Treg ratios, reduced NK cell activity, and an M2-dominant macrophage pattern, all contributing to chronic inflammation and tissue expansion. Novelty: The study highlights the role of epigenetic modifications and immune cell dysfunction in endometriosis, providing novel insights into its immunopathology. The findings support the development of precision medicine approaches targeting immune signaling pathways and biomarker-based therapies to improve treatment outcomes.
ANTIBIOTIC SUSCEPTIBILITY PROFILE AND SLIME LAYER FORMATION OF A CLINICAL ISOLATE OF STREPTOCOCCUS SANGUINIS FROM INFECTED ROOT CANALS Ramadhan, Mohammed M.; F. Ali , Jassim
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 5 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i5.1287

Abstract

Objective: This study examined susceptibility of the clinical isolate Streptococcus sanguinis, isolated from an infected root canal to various antibiotics, and tested its capacity to form a slime layer. Method: PCR and gel electrophoresis both confirmed it as bacterial identification. The 16S rRNA gene sequence of S. sanguinis was determined and compared to previously determined sequences in the NCBI (National Center for Biotechnology Information) database. Growth of the isolate was determined to consist of a strong ability to form a slime layer when grown on Congo red-modified Schaedler agar medium. Results: GenBank records for the resulting sequences are under the accession numbers PQ654829 and PQ654911. The antibiotic susceptibility profile was high to levofloxacin, moderate to gentamicin, tobramycin and vancomycin, and complete resistance to cefixime. Novelty: The results of this study provide important information about the bacterium's virulence and antibiotic resistance.

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